Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

Cell

Volumn 132, Issue 6, 2008, Pages 945-957

  Venteicher, Andrew S ^a   Meng, Zhaojing ^b   Mason, Philip J ^c   Veenstra, Timothy D ^b   Artandi, Steven E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAIC FREDERICK INC   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CELLBIO; PROTEINS

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DYSKERIN; HOLOENZYME; MULTIPROTEIN COMPLEX; PONTIN; REPTIN; RIBONUCLEOPROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE RNA COMPONENT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOGENESIS; CELL CYCLE S PHASE; CHROMOSOME; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; NEOPLASM; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TELOMERE;

EID: 40749135820     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2008.01.019     Document Type: Article

References (45)

1. Allsopp R.C., Morin G.B., DePinho R., Harley C.B., and Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102 (2003) 517-520
2. Armanios M., Chen J.L., Chang Y.P., Brodsky R.A., Hawkins A., Griffin C.A., Eshleman J.R., Cohen A.R., Chakravarti A., Hamosh A., and Greider C.W. Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc. Natl. Acad. Sci. USA 102 (2005) 15960-15964
3. Bell S.P., and Dutta A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71 (2002) 333-374
4. Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
5. Cohen S.B., Graham M.E., Lovrecz G.O., Bache N., Robinson P.J., and Reddel R.R. Protein composition of catalytically active human telomerase from immortal cells. Science 315 (2007) 1850-1853
6. Collins K. The biogenesis and regulation of telomerase holoenzymes. Nat. Rev. Mol. Cell Biol. 7 (2006) 484-494
7. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
8. Dickins R.A., Hemann M.T., Zilfou J.T., Simpson D.R., Ibarra I., Hannon G.J., and Lowe S.W. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat. Genet. 37 (2005) 1289-1295
9. Dragon F., Pogacic V., and Filipowicz W. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20 (2000) 3037-3048
10. Flores I., Cayuela M.L., and Blasco M.A. Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309 (2005) 1253-1256
11. Fu D., and Collins K. Human telomerase and Cajal body ribonucleoproteins share a unique specificity of Sm protein association. Genes Dev. 20 (2006) 531-536
12. Fu D., and Collins K. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol. Cell 28 (2007) 773-785
13. Gallant P. Control of transcription by Pontin and Reptin. Trends Cell Biol. 17 (2007) 187-192
14. Holt S.E., Aisner D.L., Baur J., Tesmer V.M., Dy M., Ouellette M., Trager J.B., Morin G.B., Toft D.O., Shay J.W., et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13 (1999) 817-826
15. Jady B.E., Richard P., Bertrand E., and Kiss T. Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. Mol. Biol. Cell 17 (2006) 944-954
16. Jonsson Z.O., Jha S., Wohlschlegel J.A., and Dutta A. Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex. Mol. Cell 16 (2004) 465-477
17. Kim J.H., Kim B., Cai L., Choi H.J., Ohgi K.A., Tran C., Chen C., Chung C.H., Huber O., Rose D.W., et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes. Nature 434 (2005) 921-926
18. Lee H.W., Blasco M.A., Gottlieb G.J., Horner II J.W., Greider C.W., and DePinho R.A. Essential role of mouse telomerase in highly proliferative organs. Nature 392 (1998) 569-574
19. Loayza D., and De Lange T. POT1 as a terminal transducer of TRF1 telomere length control. Nature 423 (2003) 1013-1018
20. Marcand S., Brevet V., Mann C., and Gilson E. Cell cycle restriction of telomere elongation. Curr. Biol. 10 (2000) 487-490
21. Marrone A., Walne A., and Dokal I. Dyskeratosis congenita: telomerase, telomeres and anticipation. Curr. Opin. Genet. Dev. 15 (2005) 249-257
22. Matias P.M., Gorynia S., Donner P., and Carrondo M.A. Crystal structure of the human AAA+ protein RuvBL1. J. Biol. Chem. 281 (2006) 38918-38929
23. Meier U.T. The many facets of H/ACA ribonucleoproteins. Chromosoma 114 (2005) 1-14
24. Mitchell J.R., Cheng J., and Collins K. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19 (1999) 567-576
25. Mitchell J.R., Wood E., and Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402 (1999) 551-555
26. Newman D.R., Kuhn J.F., Shanab G.M., and Maxwell E.S. Box C/D snoRNA-associated proteins: two pairs of evolutionarily ancient proteins and possible links to replication and transcription. RNA 6 (2000) 861-879
27. Pogacic V., Dragon F., and Filipowicz W. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol. Cell. Biol. 20 (2000) 9028-9040
28. Prathapam R., Witkin K.L., O'Connor C.M., and Collins K. A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nat. Struct. Mol. Biol. 12 (2005) 252-257
29. Rottbauer W., Saurin A.J., Lickert H., Shen X., Burns C.G., Wo Z.G., Kemler R., Kingston R., Wu C., and Fishman M. Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell 111 (2002) 661-672
30. Sarin K.Y., Cheung P., Gilison D., Lee E., Tennen R.I., Wang E., Artandi M.K., Oro A.E., and Artandi S.E. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436 (2005) 1048-1052
31. Schnapp G., Rodi H.P., Rettig W.J., Schnapp A., and Damm K. One-step affinity purification protocol for human telomerase. Nucleic Acids Res. 26 (1998) 3311-3313
32. Seto A.G., Zaug A.J., Sobel S.G., Wolin S.L., and Cech T.R. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 401 (1999) 177-180
33. Shen X., Mizuguchi G., Hamiche A., and Wu C. A chromatin remodelling complex involved in transcription and DNA processing. Nature 406 (2000) 541-544
34. Smogorzewska A., van Steensel B., Bianchi A., Oelmann S., Schaefer M.R., Schnapp G., and de Lange T. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20 (2000) 1659-1668
35. Tomlinson R.L., Ziegler T.D., Supakorndej T., Terns R.M., and Terns M.P. Cell cycle-regulated trafficking of human telomerase to telomeres. Mol. Biol. Cell 17 (2006) 955-965
36. Vulliamy T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P.J., and Dokal I. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413 (2001) 432-435
37. Vulliamy T.J., Marrone A., Knight S.W., Walne A., Mason P.J., and Dokal I. Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation. Blood 107 (2006) 2680-2685
38. Wang F., Podell E.R., Zaug A.J., Yang Y., Baciu P., Cech T.R., and Lei M. The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445 (2007) 506-510
39. Watkins N.J., Lemm I., Ingelfinger D., Schneider C., Hossbach M., Urlaub H., and Luhrmann R. Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol. Cell 16 (2004) 789-798
40. Weinrich S.L., Pruzan R., Ma L., Ouellette M., Tesmer V.M., Holt S.E., Bodnar A.G., Lichtsteiner S., Kim N.W., Trager J.B., et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17 (1997) 498-502
41. Wenz C., Enenkel B., Amacker M., Kelleher C., Damm K., and Lingner J. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20 (2001) 3526-3534
42. Witkin K.L., and Collins K. Holoenzyme proteins required for the physiological assembly and activity of telomerase. Genes Dev. 18 (2004) 1107-1118
43. Wu Y.L., Dudognon C., Nguyen E., Hillion J., Pendino F., Tarkanyi I., Aradi J., Lanotte M., Tong J.H., Chen G.Q., and Segal-Bendirdjian E. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J. Cell Sci. 119 (2006) 2797-2806
44. Xin H., Liu D., Wan M., Safari A., Kim H., Sun W., O'Connor M.S., and Songyang Z. TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445 (2007) 559-562
45. Yong J., Wan L., and Dreyfuss G. Why do cells need an assembly machine for RNA-protein complexes?. Trends Cell Biol. 14 (2004) 226-232