Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase

Molecular Cell

Volumn 6, Issue 2, 2000, Pages 361-371

  Mitchell, James R ^a   Collins, Kathleen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDYLTRANSFERASE INHIBITOR; RIBONUCLEOPROTEIN; RNA; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; CANCER; CARCINOGENESIS; CATALYSIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; STRUCTURE ANALYSIS;

CILIOPHORA; VERTEBRATA;

EID: 0033636897     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)00036-8     Document Type: Article

References (31)

1. A critical role for telomeres in suppressing and facilitating carcinogenesis
2. The RNA world of the nucleolus: Two major families of small RNAs defined by different box elements with related functions
3. Reconstitution of human telomerase activity in vitro
4. Elements essential for accumulation and function of small nucleolar RNAs directing site-specific pseudouridylation of ribosomal RNAs
5. Telomerase and the maintenance of chromosome ends
6. Telomere elongation in immortal human cells without detectable telomerase activity
7. Secondary structure of vertebrate telomerase RNA
8. Telomere maintenance mechanisms and cellular immortalization
9. Mammalian telomeres and telomerase
10. Dyskeratosis congenita
11. The RNA component of human telomerase
12. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs
13. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation
14. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
15. The mouse telomerase RNA 5'-end lies just upstream of the telomerase template sequence
16. Functional requirement of p23 and Hsp90 in telomerase complexes
17. Specific association of human telomerase activity with immortal cells and cancer
18. The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase
19. Telomerase RNA function in recombinant Tetrahymena telomerase
20. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template
21. Reverse transcriptase motifs in the catalytic subunit of telomerase
22. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end
23. A telomerase component is defective in the human disease dyskeratosis congenita
24. A conserved secondary structure for telomerase RNA
25. Specific telomerase RNA residues distant from the template are essential for telomerase RNA function
26. Sno storm in the nucleolus: New roles for myriad small RNPs
27. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
28. Function and synthesis of small nucleolar RNAs
29. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
30. Method for determining RNA 3' ends and application to human telomerase RNA