Identification of human Rap1: Implications for telomere evolution

Cell

Volumn 101, Issue 5, 2000, Pages 471-483

  Li, Bibo ^a   Oestreich, Stephanie ^a   De Lange, Titia ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HRAP 1 PROTEIN; PROTEIN; RAP PROTEIN; RAP1 PROTEIN; SCRAP 1 PROTEIN; TANKYRASE; TAZ 1 PROTEIN; TBP RELATED FACTOR 1; TBP RELATED FACTOR 2; TIN2 PROTEIN; TRF LIKE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; DNA BINDING; GENETIC TRANSCRIPTION; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; RNA TRANSLATION; SPECIES DIFFERENCE; TELOMERE;

EUKARYOTA; MAMMALIA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE; VERTEBRATA;

EID: 0034716904     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80858-2     Document Type: Article

References (76)

1. Using the two-hybrid system to detect protein-protein interaction
2. TRF1 is a dimer and bends telomeric DNA
3. TRF1 binds a bipartite telomeric site with extreme spatial flexibility
4. Telomeric localization of TRF2, a novel human telobox protein
5. The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human
6. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins
7. An essential yeast gene encoding a TTAGGG repeat-binding protein
8. Effect of telomeres on the interphase location of adjacent regions of the human X chromosome
9. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
10. Proteins that bind to double-stranded regions of telomeric DNA
11. Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae
12. Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein
13. Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast
14. From BRCA1 to RAP1: A widespread BRCT module closely associated with DNA repair
15. +-ATPase gene is controled by the promoter binding factor TUF
16. Telomere-led premeiotic chromosome movement in fission yeast
17. Meiotic nuclear reorganization: Switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe
18. A human telomeric protein
19. The carboxy termini of Sir4 and Rap1 affect Sir3 localization: Evidence for a multicomponent complex required for yeast telomeric silencing
20. RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
21. Regulation of telomere length and function by a Myb-domain protein in fission yeast
22. Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
23. Ending up with the right partner
24. Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites
25. Tight control of gene expression in mammalian cells by tetracyclin-responsive promoters
26. Stringent sequence requirements for telomere formation in human cells
27. Dissection of a carboxy-terminal region of the yeast regulatory protein RAP1 with effects on both transcriptional activation and silencing
28. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation
29. Telomere DNA structure
30. Not so peculiar: Fission yeast telomere repeats
31. Identification to a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
32. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
33. Yeast repressor α2 binds to its operator cooperatively with yeast protein Mcm1
34. TIN2, a new regulator of telomere length in human cells
35. Localization of RAP1 and Topoisomerase II in nuclei and meiotic chromosomes of yeast
36. Telomeres lead chromosome movement
37. The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA
38. Recognition of telomeric DNA
39. BRCA1 protein products: Antibody specificity…functional motifs…and secreted tumour suppressors
40. Matargidin, a membrane-anchored metalloprotease-desintegrin protein with an RGD integrin binding sequence
41. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
42. Rap1 protein regulates telomere turnover in yeast
43. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
44. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
45. Isolation and functional analysis of a Kluyveromyces lactis RAP1 homologue
46. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
47. Reverse transcriptase motifs in the catalytic subunit of telomerase
48. One billion years of Myb
49. Genetic analysis of Rap1p/Sir3p interaction in telomeric and HML silencing in Saccharomyces cerevisiae
50. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
51. A mutant with a defect in telomere elongation leads to senescence in yeast
52. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length
53. A protein-counting mechanism for telomere length regulation in yeast
54. A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts
55. Runaway telomere elongation caused by telomerase RNA gene mutations
56. Unusually large telomeric repeats in the yeast Candida albicans
57. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
58. Two modes of survival of fission yeast without telomerase
59. Telomerase catalytic subunit homologs from fission yeast and human
60. Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe
61. Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices
62. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
63. A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer
64. TRF1, a mammalian telomeric protein
65. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
66. Control of human telomere length by TRF1 and TRF2
67. Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA
68. Control of telomere length by the human telomeric protein TRF1
69. TRF2 protects human telomeres from end-to-end fusions
70. Taz1p and teb1p, two telobox proteins in Schizosaccharomyces pombe, recognize different telomere-related DNA sequences
71. Sequencing of Saccharomyces telomeres cloned using T4 DNA polymerase reveals two domains
72. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Sacharomyces cerevisiae
73. Structure of an XRCC1 BRCT domain: A new protein-protein interaction module
74. A mammalian factor that binds telomeric TTAGGG repeats in vitro