p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

Science

Volumn 283, Issue 5406, 1999, Pages 1321-1325

  Karlseder, Jan ^a   Broccoli, Dominique ^a   Yumin, Dai ^a   Hardy, Stephen ^a   De Lange, Titia ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN P53;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CHROMOSOME ABERRATION; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TELOMERE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; ATAXIA TELANGIECTASIA; B-LYMPHOCYTES; CELL CYCLE PROTEINS; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; DNA DAMAGE; DNA-BINDING PROTEINS; GENETIC VECTORS; HUMANS; IN SITU NICK-END LABELING; MICE; MITOSIS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; T-LYMPHOCYTES; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA; ATAXIA TELANGIECTASIA; MAMMALIA;

EID: 0033605145     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.283.5406.1321     Document Type: Article

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41. We thank T. Jacks and R. DePinho for MEFs and helpful discussion: N. Dyson, C. Sherr, C. Prives, and K. Kuchler for antibodies; D. Unutmaz and M. Alberts for primary human T cells; T. Jenuwein for CMV-myc TRF1; F. Isdell for expert assistance in the FACS analysis; and C. Price and members of the de Lange lab for their insights. Supported by the Human Fron-tiers Science Program (J.K.), Merck (D.B.), and grants from the New York Community Trust, Rita Allen Foundation, and NIH (GM49046) (T.d.L).