Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

Current Biology

Volumn 11, Issue 15, 2001, Pages 1192-1196

  D'Adda di Fagagna, Fabrizio ^a   Hande, M Prakash ^b   Tong, Wei Min ^c   Roth, David ^d   Lansdorp, Peter M ^b   Wang, Zhao Qi ^c   Jackson, Stephen P ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0035822641     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00328-1     Document Type: Article

References (26)

1. Protection of telomeres by the Ku protein in fission yeast
2. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
3. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
4. Yeast Ku as a regulator of chromosomal DNA end structure
5. Hypersensitivity of Ku80 deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development
6. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
7. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
8. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
9. Analysis of chromatin structure by in vivo formaldehyde cross-linking
10. Ku is associated with the telomere in mammals
11. Ku binds telomeric DNA in vitro
12. Telomere maintenance by recombination in human cells
13. Ku86 deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
14. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
15. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
16. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
17. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
18. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
19. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
20. Elongated telomeres in scid mice
21. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
22. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient
23. Homologous and non-homologous recombination differentially affect DNA damage repair in mice
24. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
25. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
26. Saccharomyces cerevisiae LIF1: A function involved in DNA double strand break repair related to mammalian XRCC4