Generation of telomeric G strand overhangs involves both G and C strand cleavage

Molecular Cell

Volumn 11, Issue 4, 2003, Pages 1021-1032

  Jacob, Naduparambil K ^a   Kirk, Karen E ^b   Price, Carolyn M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b LAKE FOREST COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; NUCLEASE; TELOMERASE;

ARTICLE; CHROMOSOME; CONTROLLED STUDY; DEPLETION; DNA CLEAVAGE; DNA SEQUENCE; DNA STRAND; ENZYME ACTIVITY; NONHUMAN; TELOMERE; TETRAHYMENA;

TETRAHYMENA;

EID: 0037623348     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00131-X     Document Type: Article

References (48)

1. Autexier C., Greider C.W. Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev. 8:1994;563-575.
2. Baumann P., Cech T.R. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 292:2001;1171-1175.
3. Baumann P., Podell E., Cech T.R. Human Pot1 (protection of telomeres) protein. cytolocalization, gene structure, and alternative splicing Mol. Cell. Biol. 22:2002;8079-8087.
4. Cervantes R.B., Lundblad V. Mechanisms of chromosome-end protection. Curr. Opin. Cell Biol. 14:2002;351-356.
5. Chan S.W., Blackburn E.H. New ways not to make ends meet. telomerase, DNA damage proteins and heterochromatin Oncogene. 21:2002;553-563.
6. Collins K. Ciliate telomerase biochemistry. Annu. Rev. Biochem. 68:1999;187-218.
7. Collins K., Greider C.W. Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev. 7:1993;1364-1376.
8. Collins K., Gandhi L. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc. Natl. Acad. Sci. USA. 95:1998;8485-8490.
9. Coyne R.S., Chalker D.L., Yao M.C. Genome downsizing during ciliate development. nuclear division of labor through chromosome restructuring Annu. Rev. Genet. 30:1996;557-578.
10. de Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
11. Dionne I., Wellinger R.J. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc. Natl. Acad. Sci. USA. 93:1996;13902-13907.
12. Fu W., Begley J.G., Killen M.W., Mattson M.P. Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem. 274:1999;7264-7271.
13. Gaertig J., Gao Y., Tishgarten T., Clark T.G., Dickerson H.W. Surface display of a parasite antigen in the ciliate Tetrahymena thermophila. Nat. Biotechnol. 17:1999;462-465.
14. Gilley D., Lee M.S., Blackburn E.H. Altering specific telomerase RNA template residues affects active site function. Genes Dev. 9:1995;2214-2226.
15. Gonzalez-Suarez E., Samper E., Flores J.M., Blasco M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26:2000;114-117.
16. Gray J.T., Celander D.W., Price C.M., Cech T.R. Cloning and expression of genes for the Oxytricha telomere-binding protein. specific subunit interactions in the telomeric complex Cell. 67:1991;807-814.
17. Greene E.C., Bednenko J., Shippen D.E. Flexible positioning of the telomerase-associated nuclease leads to preferential elimination of nontelomeric DNA. Mol. Cell. Biol. 18:1998;1544-1552.
18. Greider C. Telomerase Biochemistry and Regulation. 1995;Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
19. Griffith J.D., Comeau L., Rosenfield S., Stansel R.M., Bianchi A., Moss H., de Lange T. Mammalian telomeres end in a large duplex loop. Cell. 97:1999;503-514.
20. Hemann M.T., Greider C.W. G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res. 27:1999;3964-3969.
21. Henderson E.R., Moore M., Malcolm B.A. Telomere G-strand structure and function analyzed by chemical protection, base analogue substitution, and utilization by telomerase in vitro. Biochemistry. 29:1990;732-737.
22. Horvath M.P., Schweiker V.L., Bevilacqua J.M., Ruggles J.A., Schultz S.C. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single-strand DNA. Cell. 95:1998;963-974.
23. Jacob N.K., Skopp R., Price C.M. G-overhang dynamics at Tetrahymena telomeres. EMBO J. 20:2001;4299-4308.
24. Jahn C.L., Klobutcher L.A. Gene remodeling in ciliated protozoa. Annu. Rev. Microbiol. 56:2002;489-520.
25. Klobutcher L.A., Swanton M.T., Donini P., Prescott D.M. All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus. Proc. Natl. Acad. Sci. USA. 78:1981;3015-3019.
26. Lai C.K., Miller M.C., Collins K. Template boundary definition in Tetrahymena telomerase. Genes Dev. 16:2002;415-420.
27. Larson D.D., Spangler E.A., Blackburn E.H. Dynamics of telomere length variation in Tetrahymena thermophila. Cell. 50:1987;477-483.
28. Lustig A.J. Cdc13 subcomplexes regulate multiple telomere functions. Nat. Struct. Biol. 8:2001;297-299.
29. Makarov V.L., Hirose Y., Langmore J.P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell. 88:1997;657-666.
30. Melek M., Greene E.C., Shippen D.E. Processing of nontelomeric 3′ ends by telomerase. default template alignment and endonucleolytic cleavage Mol. Cell. Biol. 16:1996;3437-3445.
31. Miller M.C., Collins K. The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability. Mol. Cell. 6:2000;827-837.
32. Miller M.C., Liu J.K., Collins K. Template definition by Tetrahymena telomerase reverse transcriptase. EMBO J. 19:2000;4412-4422.
33. Munoz-Jordan J.L., Cross G.A., de Lange T., Griffith J.D. T-loops at trypanosome telomeres. EMBO J. 20:2001;579-588.
34. Niu H., Xia J., Lue N.F. Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex. Mol. Cell. Biol. 20:2000;6806-6815.
35. Peersen O.B., Ruggles J.A., Schultz S.C. Dimeric structure of the Oxytricha nova telomere end-binding protein α-subunit bound to ssDNA. Nat. Struct. Biol. 9:2002;182-187.
36. Pennock E., Buckley K., Lundblad V. Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell. 104:2001;387-396.
37. Petcherskaia, M., McGuire, J.M., Pherson, J.M., and Kirk, K.E. (2003). Loss of cap structure causes mitotic defects in T. thermophila telomerase mutants. Chromosoma, in press.
38. Prescott J., Blackburn E.H. Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev. 11:1997;2790-2800.
39. Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., Gorovsky M.A. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc. Natl. Acad. Sci. USA. 99:2002;3734-3739.
40. Smogorzewska A., de Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21:2002;4338-4348.
41. Stewart S.A., Hahn W.C., O'Connor B.F., Banner E.N., Lundberg A.S., Modha P., Mizuno H., Brooks M.W., Fleming M., Zimonjic D.B.et al. Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc. Natl. Acad. Sci. USA. 99:2002;12606-12611.
42. Taggart A.K., Teng S.C., Zakian V.A. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science. 297:2002;1023-1026.
43. Wei C., Price C.M. Protecting the terminus. t-loops and telomere end-binding proteins Cell. Mol. Life Sci. in press:2003.
44. Wellinger R.J., Ethier K., Labrecque P., Zakian V.A. Evidence for a new step in telomere maintenance. Cell. 85:1996;423-433.
45. Yao M.C., Duhacourt S., Chalker D.L. Genome-wide rearrangements of DNA in ciliates. Craig N.L., Craigie R., Gellert M., Lambowitz A. Mobile DNA II. 2002;730-758 Academic Press, New York.
46. Yu G.L., Blackburn E.H. Developmentally programmed healing of chromosomes by telomerase in Tetrahymena. Cell. 67:1991;823-832.
47. Yu G.L., Bradley J.D., Attardi L.D., Blackburn E.H. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature. 344:1990;126-132.
48. Zhu H., Fu W., Mattson M.P. The catalytic subunit of telomerase protects neurons against amyloid β-peptide-induced apoptosis. J. Neurochem. 75:2000;117-124.