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Volumn 29, Issue 4, 2004, Pages 183-192

Telomerase RNA structure and function: Implications for dyskeratosis congenita

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEOPROTEIN; RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

EID: 1842813934     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2004.02.003     Document Type: Review
Times cited : (126)

References (74)
  • 2
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy T., et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 413:2001;432-435.
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1
  • 3
    • 0037148277 scopus 로고    scopus 로고
    • Protection of mammalian telomeres
    • de Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
    • (2002) Oncogene , vol.21 , pp. 532-540
    • De Lange, T.1
  • 4
    • 0036712072 scopus 로고    scopus 로고
    • Human telomerase and its regulation
    • Cong Y.S., et al. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66:2002;407-425.
    • (2002) Microbiol. Mol. Biol. Rev. , vol.66 , pp. 407-425
    • Cong, Y.S.1
  • 5
    • 0025944831 scopus 로고
    • A conserved secondary structure for telomerase RNA
    • Romero D.P., Blackburn E.H. A conserved secondary structure for telomerase RNA. Cell. 67:1991;343-353.
    • (1991) Cell , vol.67 , pp. 343-353
    • Romero, D.P.1    Blackburn, E.H.2
  • 6
    • 0034598919 scopus 로고    scopus 로고
    • Secondary structure of vertebrate telomerase RNA
    • Chen J.L., et al. Secondary structure of vertebrate telomerase RNA. Cell. 100:2000;503-514.
    • (2000) Cell , vol.100 , pp. 503-514
    • Chen, J.L.1
  • 8
    • 0033535962 scopus 로고    scopus 로고
    • The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein
    • Gilley D., Blackburn E.H. The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein. Proc. Natl. Acad. Sci. U. S. A. 96:1999;6621-6625.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 6621-6625
    • Gilley, D.1    Blackburn, E.H.2
  • 9
    • 0041631045 scopus 로고    scopus 로고
    • Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans
    • Mason D.X., et al. Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans. Mol. Cell. Biol. 23:2003;5606-5613.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5606-5613
    • Mason, D.X.1
  • 10
    • 0038433298 scopus 로고    scopus 로고
    • Roles for RNA in telomerase nucleotide and repeat addition processivity
    • Lai C.K., et al. Roles for RNA in telomerase nucleotide and repeat addition processivity. Mol. Cell. 11:2003;1673-1683.
    • (2003) Mol. Cell , vol.11 , pp. 1673-1683
    • Lai, C.K.1
  • 11
    • 0035144580 scopus 로고    scopus 로고
    • RNA binding domain of telomerase reverse transcriptase
    • Lai C.K., et al. RNA binding domain of telomerase reverse transcriptase. Mol. Cell. Biol. 21:2001;990-1000.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 990-1000
    • Lai, C.K.1
  • 12
    • 0037083759 scopus 로고    scopus 로고
    • Template boundary definition in Tetrahymena telomerase
    • Lai C.K., et al. Template boundary definition in Tetrahymena telomerase. Genes Dev. 16:2002;415-420.
    • (2002) Genes Dev. , vol.16 , pp. 415-420
    • Lai, C.K.1
  • 13
    • 0029128539 scopus 로고
    • Boundary elements of the Tetrahymena telomerase RNA template and alignment domains
    • Autexier C., Greider C.W. Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes Dev. 9:1995;2227-2239.
    • (1995) Genes Dev. , vol.9 , pp. 2227-2239
    • Autexier, C.1    Greider, C.W.2
  • 14
    • 0032803237 scopus 로고    scopus 로고
    • Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro
    • Tesmer V.M., et al. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19:1999;6207-6216.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6207-6216
    • Tesmer, V.M.1
  • 15
    • 0032961170 scopus 로고    scopus 로고
    • A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end
    • Mitchell J.R., et al. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19:1999;567-576.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 567-576
    • Mitchell, J.R.1
  • 16
    • 0035158605 scopus 로고    scopus 로고
    • The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
    • Peterson S.E., et al. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nat. Genet. 27:2001;64-67.
    • (2001) Nat. Genet. , vol.27 , pp. 64-67
    • Peterson, S.E.1
  • 17
    • 0036828725 scopus 로고    scopus 로고
    • A bulged stem tethers Est1p to telomerase RNA in budding yeast
    • Seto A.G., et al. A bulged stem tethers Est1p to telomerase RNA in budding yeast. Genes Dev. 16:2002;2800-2812.
    • (2002) Genes Dev. , vol.16 , pp. 2800-2812
    • Seto, A.G.1
  • 18
    • 0034608073 scopus 로고    scopus 로고
    • Template boundary in a yeast telomerase specified by RNA structure
    • Tzfati Y., et al. Template boundary in a yeast telomerase specified by RNA structure. Science. 288:2000;863-867.
    • (2000) Science , vol.288 , pp. 863-867
    • Tzfati, Y.1
  • 19
    • 0037829618 scopus 로고    scopus 로고
    • A novel pseudoknot element is essential for the action of a yeast telomerase
    • Tzfati Y., et al. A novel pseudoknot element is essential for the action of a yeast telomerase. Genes Dev. 17:2003;1779-1788.
    • (2003) Genes Dev. , vol.17 , pp. 1779-1788
    • Tzfati, Y.1
  • 20
    • 0141525391 scopus 로고    scopus 로고
    • Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends
    • Stellwagen A.E., et al. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev. 17:2003;2384-2395.
    • (2003) Genes Dev. , vol.17 , pp. 2384-2395
    • Stellwagen, A.E.1
  • 21
    • 0036118479 scopus 로고    scopus 로고
    • Essential regions of Saccharomyces cerevisiae telomerase RNA: Separate elements for Est1p and Est2p interaction
    • Livengood A.J., et al. Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol. Cell. Biol. 22:2002;2366-2374.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2366-2374
    • Livengood, A.J.1
  • 22
    • 0141557781 scopus 로고    scopus 로고
    • Comprehensive structure-function analysis of the core domain of human telomerase RNA
    • Ly H., et al. Comprehensive structure-function analysis of the core domain of human telomerase RNA. Mol. Cell. Biol. 23:2003;6849-6856.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6849-6856
    • Ly, H.1
  • 23
    • 0035937133 scopus 로고    scopus 로고
    • Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system
    • Martin-Rivera L., Blasco M.A. Identification of functional domains and dominant negative mutations in vertebrate telomerase RNA using an in vivo reconstitution system. J. Biol. Chem. 276:2001;5856-5865.
    • (2001) J. Biol. Chem. , vol.276 , pp. 5856-5865
    • Martin-Rivera, L.1    Blasco, M.A.2
  • 24
    • 0344011566 scopus 로고    scopus 로고
    • Template boundary definition in mammalian telomerase
    • Chen J.L., Greider C.W. Template boundary definition in mammalian telomerase. Genes Dev. 17:2003;2747-2752.
    • (2003) Genes Dev. , vol.17 , pp. 2747-2752
    • Chen, J.L.1    Greider, C.W.2
  • 25
    • 0037079673 scopus 로고    scopus 로고
    • A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA
    • Chen J.L., et al. A critical stem-loop structure in the CR4-CR5 domain of mammalian telomerase RNA. Nucleic Acids Res. 30:2002;592-597.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 592-597
    • Chen, J.L.1
  • 26
    • 0037082416 scopus 로고    scopus 로고
    • Analysis of the structure of human telomerase RNA in vivo
    • Antal M., et al. Analysis of the structure of human telomerase RNA in vivo. Nucleic Acids Res. 30:2002;912-920.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 912-920
    • Antal, M.1
  • 27
    • 0029312758 scopus 로고
    • Analysis of the structure of Tetrahymena nuclear RNAs in vivo: Telomerase RNA, the self-splicing rRNA intron, and U2 snRNA
    • Zaug A.J., Cech T.R. Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA. RNA. 1:1995;363-374.
    • (1995) RNA , vol.1 , pp. 363-374
    • Zaug, A.J.1    Cech, T.R.2
  • 28
    • 0035137710 scopus 로고    scopus 로고
    • Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
    • Bachand F., Autexier C. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Mol. Cell. Biol. 21:2001;1888-1897.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1888-1897
    • Bachand, F.1    Autexier, C.2
  • 29
    • 0037168615 scopus 로고    scopus 로고
    • A molecular switch underlies a human telomerase disease
    • Comolli L.R., et al. A molecular switch underlies a human telomerase disease. Proc. Natl. Acad. Sci. U. S. A. 99:2002;16998-17003.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 16998-17003
    • Comolli, L.R.1
  • 30
    • 0037457985 scopus 로고    scopus 로고
    • Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA
    • Theimer C.A., et al. Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA. Proc. Natl. Acad. Sci. U. S. A. 100:2003;449-454.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 449-454
    • Theimer, C.A.1
  • 31
    • 0038381556 scopus 로고    scopus 로고
    • The solution structure of an essential stem-]loop of human telomerase RNA
    • Leeper T., et al. The solution structure of an essential stem-]loop of human telomerase RNA. Nucleic Acids Res. 31:2003;2614-2621.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 2614-2621
    • Leeper, T.1
  • 32
    • 0344874270 scopus 로고    scopus 로고
    • YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA
    • Theimer C.A., et al. YNMG tetraloop formation by a dyskeratosis congenita mutation in human telomerase RNA. RNA. 9:2003;1446-1455.
    • (2003) RNA , vol.9 , pp. 1446-1455
    • Theimer, C.A.1
  • 33
    • 0033636897 scopus 로고    scopus 로고
    • Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
    • Mitchell J.R., Collins K. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell. 6:2000;361-371.
    • (2000) Mol. Cell , vol.6 , pp. 361-371
    • Mitchell, J.R.1    Collins, K.2
  • 34
    • 0037439107 scopus 로고    scopus 로고
    • Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
    • Chen J.L., Greider C.W. Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22:2003;304-314.
    • (2003) EMBO J. , vol.22 , pp. 304-314
    • Chen, J.L.1    Greider, C.W.2
  • 35
    • 0035912746 scopus 로고    scopus 로고
    • A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity
    • Sperger J.M., Cech T.R. A stem-loop of Tetrahymena telomerase RNA distant from the template potentiates RNA folding and telomerase activity. Biochemistry. 40:2001;7005-7016.
    • (2001) Biochemistry , vol.40 , pp. 7005-7016
    • Sperger, J.M.1    Cech, T.R.2
  • 36
    • 0142240433 scopus 로고    scopus 로고
    • A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity
    • Seto A.G., et al. A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity. RNA. 9:2003;1323-1332.
    • (2003) RNA , vol.9 , pp. 1323-1332
    • Seto, A.G.1
  • 37
    • 17944388104 scopus 로고    scopus 로고
    • Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal
    • (in press).
    • Jady, B. et al. Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal. J. Cell Biol. (in press).
    • J. Cell Biol.
    • Jady, B.1
  • 38
    • 0037013831 scopus 로고    scopus 로고
    • Cajal body-specific small nuclear RNAs: A novel class of 2′-O-methylation and pseudouridylation guide RNAs
    • Darzacq X., et al. Cajal body-specific small nuclear RNAs: a novel class of 2′-O-methylation and pseudouridylation guide RNAs. EMBO J. 21:2002;2746-2756.
    • (2002) EMBO J. , vol.21 , pp. 2746-2756
    • Darzacq, X.1
  • 39
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell J.R., et al. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 402:1999;551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1
  • 40
    • 0343183144 scopus 로고    scopus 로고
    • In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs
    • Dragon F., et al. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Mol. Cell. Biol. 20:2000;3037-3048.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3037-3048
    • Dragon, F.1
  • 41
    • 0034459569 scopus 로고    scopus 로고
    • Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10
    • Pogacic V., et al. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol. Cell. Biol. 20:2000;9028-9040.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9028-9040
    • Pogacic, V.1
  • 42
    • 0035253526 scopus 로고    scopus 로고
    • Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p
    • Dez C., et al. Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p. Nucleic Acids Res. 29:2001;598-603.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 598-603
    • Dez, C.1
  • 43
    • 0042967786 scopus 로고    scopus 로고
    • A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs
    • Richard P., et al. A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. EMBO J. 22:2003;4283-4293.
    • (2003) EMBO J. , vol.22 , pp. 4283-4293
    • Richard, P.1
  • 44
    • 0344080588 scopus 로고    scopus 로고
    • Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm
    • Jády B.E., et al. Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm. EMBO J. 22:2003;1878-1888.
    • (2003) EMBO J. , vol.22 , pp. 1878-1888
    • Jády, B.E.1
  • 45
    • 0037013939 scopus 로고    scopus 로고
    • Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments
    • Verheggen C., et al. Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments. EMBO J. 21:2002;2736-2745.
    • (2002) EMBO J. , vol.21 , pp. 2736-2745
    • Verheggen, C.1
  • 46
    • 0346099349 scopus 로고    scopus 로고
    • Telomerase RNA accumulates in Cajal bodies in human cancer cells
    • Zhu Y., et al. Telomerase RNA accumulates in Cajal bodies in human cancer cells. Mol. Biol. Cell. 15:2004;81-90.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 81-90
    • Zhu, Y.1
  • 47
    • 0033568032 scopus 로고    scopus 로고
    • Nucleolar localization signals of box H/ACA small nucleolar RNAs
    • Narayanan A., et al. Nucleolar localization signals of box H/ACA small nucleolar RNAs. EMBO J. 18:1999;5120-5130.
    • (1999) EMBO J. , vol.18 , pp. 5120-5130
    • Narayanan, A.1
  • 48
    • 0035670851 scopus 로고    scopus 로고
    • The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus
    • Lukowiak A.A., et al. The snoRNA domain of vertebrate telomerase RNA functions to localize the RNA within the nucleus. RNA. 7:2001;1833-1844.
    • (2001) RNA , vol.7 , pp. 1833-1844
    • Lukowiak, A.A.1
  • 49
    • 0038392866 scopus 로고    scopus 로고
    • Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs
    • Fu D., Collins K. Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs. Mol. Cell. 11:2003;1361-1372.
    • (2003) Mol. Cell , vol.11 , pp. 1361-1372
    • Fu, D.1    Collins, K.2
  • 50
    • 0037025334 scopus 로고    scopus 로고
    • The nucleolar localization domain of the catalytic subunit of human telomerase
    • Etheridge K.T., et al. The nucleolar localization domain of the catalytic subunit of human telomerase. J. Biol. Chem. 277:2002;24764-24770.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24764-24770
    • Etheridge, K.T.1
  • 51
    • 0036711651 scopus 로고    scopus 로고
    • Subnuclear shuttling of human telomerase induced by transformation and DNA damage
    • Wong J.M., et al. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat. Cell Biol. 4:2002;731-736.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 731-736
    • Wong, J.M.1
  • 52
    • 0036311278 scopus 로고    scopus 로고
    • Nucleolar localization of hTERT protein is associated with telomerase function
    • Yang Y., et al. Nucleolar localization of hTERT protein is associated with telomerase function. Exp. Cell Res. 277:2002;201-209.
    • (2002) Exp. Cell Res. , vol.277 , pp. 201-209
    • Yang, Y.1
  • 53
    • 0033049185 scopus 로고    scopus 로고
    • Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels
    • Yi X., et al. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol. Cell. Biol. 19:1999;3989-3997.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3989-3997
    • Yi, X.1
  • 54
    • 0036591880 scopus 로고    scopus 로고
    • The SMN complex, an assemblyosome of ribonucleoproteins
    • Paushkin S., et al. The SMN complex, an assemblyosome of ribonucleoproteins. Curr. Opin. Cell Biol. 14:2002;305-312.
    • (2002) Curr. Opin. Cell Biol. , vol.14 , pp. 305-312
    • Paushkin, S.1
  • 55
    • 0029954338 scopus 로고    scopus 로고
    • A novel nuclear structure containing the survival of motor neurons protein
    • Liu Q., Dreyfuss G. A novel nuclear structure containing the survival of motor neurons protein. EMBO J. 15:1996;3555-3565.
    • (1996) EMBO J. , vol.15 , pp. 3555-3565
    • Liu, Q.1    Dreyfuss, G.2
  • 56
    • 0036734655 scopus 로고    scopus 로고
    • The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein
    • Bachand F., et al. The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Mol. Biol. Cell. 13:2002;3192-3202.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 3192-3202
    • Bachand, F.1
  • 57
    • 0035943003 scopus 로고    scopus 로고
    • The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1
    • Pellizzoni L., et al. The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1. Curr. Biol. 11:2001;1079-1088.
    • (2001) Curr. Biol. , vol.11 , pp. 1079-1088
    • Pellizzoni, L.1
  • 58
    • 0036023953 scopus 로고    scopus 로고
    • Intracellular trafficking of yeast telomerase components
    • Teixeira M.T., et al. Intracellular trafficking of yeast telomerase components. EMBO Rep. 3:2002;652-659.
    • (2002) EMBO Rep. , vol.3 , pp. 652-659
    • Teixeira, M.T.1
  • 59
    • 0033539171 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle
    • Seto A.G., et al. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 401:1999;177-180.
    • (1999) Nature , vol.401 , pp. 177-180
    • Seto, A.G.1
  • 60
    • 0037614891 scopus 로고    scopus 로고
    • The Euplotes la motif protein p43 has properties of a telomerase-specific subunit
    • Aigner S., et al. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 42:2003;5736-5747.
    • (2003) Biochemistry , vol.42 , pp. 5736-5747
    • Aigner, S.1
  • 61
    • 0037157582 scopus 로고    scopus 로고
    • Association between aplastic anaemia and mutations in telomerase RNA
    • Vulliamy T., et al. Association between aplastic anaemia and mutations in telomerase RNA. Lancet. 359:2002;2168-2170.
    • (2002) Lancet , vol.359 , pp. 2168-2170
    • Vulliamy, T.1
  • 62
    • 0344851536 scopus 로고    scopus 로고
    • Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA
    • Fogarty P.F., et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet. 362:2003;1628-1630.
    • (2003) Lancet , vol.362 , pp. 1628-1630
    • Fogarty, P.F.1
  • 63
    • 0041592752 scopus 로고    scopus 로고
    • Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome
    • Yamaguchi H., et al. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood. 102:2003;916-918.
    • (2003) Blood , vol.102 , pp. 916-918
    • Yamaguchi, H.1
  • 64
    • 0037133563 scopus 로고    scopus 로고
    • Haploinsufficiency of mTR results in defects in telomere elongation
    • Hathcock K.S., et al. Haploinsufficiency of mTR results in defects in telomere elongation. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3591-3596.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 3591-3596
    • Hathcock, K.S.1
  • 65
    • 0035723994 scopus 로고    scopus 로고
    • Functional multimerization of the human telomerase reverse transcriptase
    • Beattie T.L., et al. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:2001;6151-6160.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6151-6160
    • Beattie, T.L.1
  • 66
    • 0035796403 scopus 로고    scopus 로고
    • Human telomerase contains two cooperating telomerase RNA molecules
    • Wenz C., et al. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20:2001;3526-3534.
    • (2001) EMBO J. , vol.20 , pp. 3526-3534
    • Wenz, C.1
  • 67
    • 0031799895 scopus 로고    scopus 로고
    • X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions
    • Heiss N.S., et al. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat. Genet. 19:1998;32-38.
    • (1998) Nat. Genet. , vol.19 , pp. 32-38
    • Heiss, N.S.1
  • 68
    • 0032520182 scopus 로고    scopus 로고
    • + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase
    • + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Genes Dev. 12:1998;527-537.
    • (1998) Genes Dev. , vol.12 , pp. 527-537
    • Lafontaine, D.L.1
  • 69
    • 0037133942 scopus 로고    scopus 로고
    • Small nucleolar RNAs: An abundant group of noncoding RNAs with diverse cellular functions
    • Kiss T. Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions. Cell. 109:2002;145-148.
    • (2002) Cell , vol.109 , pp. 145-148
    • Kiss, T.1
  • 70
    • 0032499210 scopus 로고    scopus 로고
    • Essential role of mouse telomerase in highly proliferative organs
    • Lee H.W., et al. Essential role of mouse telomerase in highly proliferative organs. Nature. 392:1998;569-574.
    • (1998) Nature , vol.392 , pp. 569-574
    • Lee, H.W.1
  • 71
    • 0037206947 scopus 로고    scopus 로고
    • Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice
    • He J., et al. Targeted disruption of Dkc1, the gene mutated in X-linked dyskeratosis congenita, causes embryonic lethality in mice. Oncogene. 21:2002;7740-7744.
    • (2002) Oncogene , vol.21 , pp. 7740-7744
    • He, J.1
  • 72
    • 0037428129 scopus 로고    scopus 로고
    • Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification
    • Ruggero D., et al. Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification. Science. 299:2003;259-262.
    • (2003) Science , vol.299 , pp. 259-262
    • Ruggero, D.1
  • 73
    • 0033754823 scopus 로고    scopus 로고
    • Dyskeratosis congenita in all its forms
    • Dokal I. Dyskeratosis congenita in all its forms. Br. J. Haematol. 110:2000;768-779.
    • (2000) Br. J. Haematol. , vol.110 , pp. 768-779
    • Dokal, I.1
  • 74
    • 0038543124 scopus 로고    scopus 로고
    • Human telomerase RNA mutations and bone marrow failure
    • Wilson D.B., et al. Human telomerase RNA mutations and bone marrow failure. Lancet. 361:2003;1993-1994.
    • (2003) Lancet , vol.361 , pp. 1993-1994
    • Wilson, D.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.