Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

Nature Medicine

Volumn 3, Issue 11, 1997, Pages 1271-1274

  Bryan, Tracy M ^a   Englezou, Anna ^a   Dalla Pozza, Luciano ^b   Dunham, Melissa A ^a   Reddel, Roger R ^a  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TELOMERE;

EID: 0030697342     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1197-1271     Document Type: Article

References (39)

1. Olovnikov, A.M. Principle of marginotomy in template synthesis of polynucleotides. Doklady Biochem. 201, 394-397 (1971).
2. Harley, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
3. Hastie, N.D. et al. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346, 866-868 (1990).
4. Greider, C.W. & Blackburn, E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405-413 (1985).
5. Harley, C.B. Telomere loss: Mitotic clock or genetic time bomb? Mutat. Res. 256, 271-282 (1991).
6. Kim, N.W. et al. Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015 (1994).
7. Bacchetti, S. & Counter, C.M. Telomeres and telomerase in human cancer. Int. J. Oncology 7, 423-432 (1995).
8. Murnane, J.P., Sabatier, L., Marder, B.A. & Morgan, W.F. Telomere dynamics in an immortal human cell line. EMBO J. 13, 4953-4962 (1994).
9. Bryan, T.M., Englezou, A., Gupta, J., Bacchetti, S. & Reddel, R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14, 4240-4248 (1995).
10. INK4 expression and telomere length during spontaneous immortalisation of Li-Fraumeni syndrome fibroblasts. Mol. Cell. Biol. 15, 4745-4753 (1995).
11. Bryan, T.M. & Reddel, R.R. Telomere dynamics and telomerase activity in in vitro immortalised human cells. Eur. J. Cancer, 33, 767-773 (1997).
12. INK4 and telomerase in immortalisation of human cells. Oncogene 11, 971-976 (1995).
13. Piatyszek, M.A. et al. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Methods Cell Sci. 17, 1-15 (1995).
14. Wright, W.E., Shay, J.W. & Piatyszek, M.A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res. 23, 3794-3795 (1995).
15. Counter, C.M., Hirte, H.W., Bacchetti, S. & Harley, C.B. Telomerase activity in human ovarian carcinoma. Proc. Natl. Acad. Sci. USA 91, 2900-2904 (1994).
16. Hiyama, K. et al. Telomerase activity in small-cell and non-small-cell lung cancers. J. Natl. Cancer Inst. 87, 895-902 (1995).
17. Hiyama, E. et al. Telomerase activity in human breast tumors. J. Natl. Cancer Inst. 88, 116-122 (1996).
18. Sugino, T. et al. Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates. Int. J. Cancer 69, 301-306 (1996).
19. Taylor, R.S. et al. Detection of telomerase activity in malignant and nonmalignant skin conditions. J. Invest. Dermatol. 106, 759-765 (1996).
20. Mehle, C., Piatyszek, M.A., Ljungberg, B., Shay, J.W. & Roos, G. Telomerase activity in human renal cell carcinoma. Oncogene 13, 161-166 (1996).
21. Hiyama, E., Hiyama, K., Yokoyama, T., Ichikawa, T. & Matsuura, Y. Length of telomeric repeats in neuroblastoma: Correlation with prognosis and other biological characteristics. Jpn. J. Cancer Res. 83, 159-164 (1992).
22. Nürnberg, P., Thiel, G., Weber, F. & Epplen, J.T. Changes of telomere lengths in human intracranial tumours. Hum. Genet. 91, 190-192 (1993).
23. Klingelhutz, A.J., Foster, S.A. & McDougall, J.K. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380, 79-82 (1996).
24. Hiyama, E. et al. Telomerase activity in human intestine. Int. J. Oncology 9, 453-458 (1996).
25. Härle-Bachor, C. & Boukamp, P. Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes. Proc. Natl. Acad. Sci. USA 93, 6476-6481 (1996).
26. Yasumoto, S. et al. Telomerase activity in normal human epithelial cells. Oncogene 13, 433-439 (1996).
27. Hsiao, R., Sharma, H.W., Ramakrishnan, S., Keith, E. & Narayanan, R. Telomerase activity in normal human endothelial cells. Anticancer Res. 17, 827-832 (1997).
28. Warneford, S.G. et al. Germ-line splicing mutation of the p53 gene in a cancer-prone family. Cell Growth Differ. 3, 839-846 (1992).
29. INK4 expression. Oncogene 13, 1259-1268 (1996).
30. Levine, A.J., Momand, J. & Finlay, C.A. The p53 tumour suppressor gene. Nature 351, 453-456 (1991).
31. Duncan, E.L., Whitaker, N.J., Moy, E. L. & Reddel, R.R. Assignment of SV40-immortalized cells to more than one complementation group for immortalization. Exp. Cell Res. 205, 337-344 (1993).
32. Gupta, J., Han, L.-P., Wang, P., Gallie, B.L. & Bacchetti, S. Development of retinoblastoma in the absence of telomerase activity. J. Natl. Cancer Inst. 88, 1152-1157 (1996).
33. Kyrion, G., Boakye, K.A. & Lustig, A.J. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 5159-5173 (1992).
34. Krauskopf, A. & Blackburn, E.H. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats. Nature 383, 354-357 (1996).
35. - senescence. Cell 73, 347-360 (1993).
36. McEachern, M.J. & Blackburn, E.H. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10, 1822-1834 (1996).
37. Chadeneau, C., Hay, K., Hirte, H.W., Gallinger, S. & Bacchetti, S. Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Res. 55, 2533-2536 (1995).
38. Counter, C.M. et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929 (1992).
39. Sprung, C.N., Bryan, T.M., Reddel, R.R. & Murnane, J.P. Normal telomere maintenance in immortal ataxia telangiectasia cell lines. Mutat. Res. (in the press).