The Mre11p/Rad50p/Xrs2p complex and the Tellp function in a single pathway for telomere maintenance in yeast

Genetics

Volumn 155, Issue 1, 2000, Pages 475-479

  Ritchie, Kim B ^a   Petes, Thomas D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA REPAIR; DNA STRAND BREAKAGE; GENE FUNCTION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; TELOMERE; YEAST;

DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; EXODEOXYRIBONUCLEASES; FUNGAL PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TELOMERE;

SACCHAROMYCES CEREVISIAE;

EID: 0034013797     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ALANI, E., S. SUBBIAH and N. KLECKNER, 1989 The yeast RAD50 gene encodes a predicted 153-kD protein containing a purine nucleotide-binding domain and two large heptad-repeat regions. Genetics 122: 47-57.
2. ALANI, E., R. PADMORE and N. KLECKNER, 1990 Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61: 419-436.
3. BOULTON, S. J., and S. P. JACKSON, 1998 Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17: 1819-1828.
4. BRUSH, G. S., M. M. MORROW, P. HEITER and T. J. KELLY, 1996 The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc. Natl. Acad. Sci. USA 93: 15075-15080.
5. EMILI, A., 1998 MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol. Cell 2: 183-189.
6. GREENWELL, P. W., S. L. KRONMAL, S. E. PORTER, J. GASSENHUBER, B. OBERMAIER et al., 1995 TEL1, a gene involved in controlling telomere length in S. cerevisae, is homologous to the human ataxia telangiectasia gene. Cell 82: 823-829.
7. HABER, J. E., 1998 The many interfaces of Mrell. Cell 95: 583-586.
8. JOHZUKA, K., and H. OGAWA, 1995 Interaction of Mrell and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisae. Genetics 139: 1521-1532.
9. KANAAR, R., and J. H. J. HOEIJMAKERS, 1997 Recombination and joining: different means to the same ends. Genes Funct. 1: 165-174.
10. KHANNA, K. K., K. E. KEATING, S. KOZLOV, S. SCOTT, M. GATEI et al., 1998 ATM associates with and phosphorylates p53: mapping the region of interaction. Nat. Genet. 20: 398-400.
11. KIRONMAI, K. M., and K. MUNIYAPPA, 1997 Alleration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 2: 443-455.
12. LE, S., J. K. MOORE, J. E. HABER and C. W. GREIDER, 1999 RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152: 143-152.
13. LUNDBLAD, V., and E. H. BLACKBURN, 1993 An alternative pathway for yeast telomere maintenance rescues est-senescence. Cell 73: 347-360.
14. LUSTIG, A. J., and T. D. PETES, 1986 Identification of yeast mutants with altered telomere structure. Proc. Natl. Acad. Sci. USA 83: 1398-1402.
15. MORROW, D. M., D. A. TAGLE, Y. SHILOH, F. S. COLLINS and P. HEITER, 1995 TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82: 831-840.
16. NUGENT, C. I., G. BOSCO, L. O. ROSS, S. K. EVANS, A. P. SALINGER et al., 1998 Telomere maintenance is dependent on activities required for end repair of double-strand breaks. Curr. Biol. 8: 657-660.
17. PAUL, T. T., and M. GELLERT, 1998 The 3′-5′ exonuclease activity of Mrell facilitates repair of DNA double-strand breaks. Mol. Cell 1: 969-979.
18. PAULL, T. T., and M. GELLERT, 1999 Nhs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mrell/Rad50 complex. Genes Dev. 13: 1276-1288.
19. PORTER, S. E., P. W. GREENWELL, K. B. RITCHIE and T. D. PETES, 1996 The DNA-binding protein Hdflp (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisae. Nucleic Acids Res. 24: 582-585.
20. RAYMOND, W. E., and N. KLECKNER, 1993 RAD50 protein of S. cerevisiae exhibits ATP-dependent DNA binding. Nucleic Acids Res. 21: 3851-3856
21. RITCHIE, K. B., J. C. MALLORY and T. D. PETES, 1999 Interactions of TLCI (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisae. Mol. Cell. Biol. 19: 6065-6075.
22. SANCHEZ, Y., B. A. DESANY, W. L. JONES, Q. LIU, B. WANG, et al., 1996 Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271: 357-360.
23. THOMAS, B. J., and R. ROTHSTEIN, 1989 Elevated recombination rates in transcriptionally active DNA. Cell 56: 619-630.
24. USUL T., T. OHTA, H. OSHUMI, J. TOMIZAWA, H. OGAWA et al., 1998 Complex formation and functional versatility of Mrell of budding yeast in recombination. Cell 95: 705-716.
25. WACH, A., A. BRACHAT, R. POHLMANN and P. PHILIPPSEN, 1994 New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10: 1793-1808.
26. WEINERT, T., 1988 DNA damage checkpoints update: getting molecular. Curr. Opin. Genet. Dev. 8: 185-193.