Aging and apoptosis in muscle

Handbook of the Biology of Aging

Volumn , Issue , 2011, Pages 63-118

  Alway, Stephen E ^a,b   Morissette, Michael R ^a,b   Siu, Parco M ^c  

^a Department of Exercise Physiology ^*  (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80052404775     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-378638-8.00004-X     Document Type: Chapter

References (461)

1. Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation. Molecular Cell 2002, 9:423-432.
2. Adams G.R. Satellite cell proliferation and skeletal muscle hypertrophy. Applied Physiology, Nutrition and Metabolism 2006, 31:782-790.
3. Adams V., Doring C., Schuler G. Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. Frontiers in Bioscience 2008, 13:302-311.
4. Adams V., Jiang H., Yu J., Mobius-Winkler S., Fiehn E., Linke A., et al. Apoptosis in skeletal myocytes of patients with chronic heart failure is associated with exercise intolerance. Journal of the American College of Cardiology 1999, 33:959-965.
5. Adhihetty P.J., Hood D.A. Mechanisms of apoptosis in skeletal muscle. European Journal of Translational Myology: Basic Applied Myology 2003, 13:171-179.
6. Adhihetty P.J., Irrcher I., Joseph A.M., Ljubicic V., Hood D.A. Plasticity of skeletal muscle mitochondria in response to contractile activity. Experimental Physiology 2003, 88:99-107.
7. Adhihetty P.J., Ljubicic V., Hood D.A. Effect of chronic contractile activity on SS and IMF mitochondrial apoptotic susceptibility in skeletal muscle. American Journal of Physiology: Endocrinology and Metabolism 2007, 292:E748-E755.
8. Adhihetty P.J., O'Leary M.F., Chabi B., Wicks K.L., Hood D.A. Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle. Journal of Applied Physiology 2007, 102:1143-1151.
9. Adhihetty P.J., O'Leary M.F., Hood D.A. Mitochondria in skeletal muscle: Adaptable rheostats of apoptotic susceptibility. Exercise and Sport Sciences Reviews 2008, 36:116-121.
10. Adhihetty P.J., Uguccioni G., Leick L., Hidalgo J., Pilegaard H., Hood D.A. The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. American Journal of Physiology: Cell Physiology 2009, 297:C217-C225.
11. Afilalo J., Karunananthan S., Eisenberg M.J., Alexander K.P., Bergman H. Role of frailty in patients with cardiovascular disease. American Journal of Cardiology 2009, 103:1616-1621.
12. Alcendor R.R., Gao S., Zhai P., Zablocki D., Holle E., Yu X., et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circulation Research 2007, 100:1512-1521.
13. Alcendor R.R., Kirshenbaum L.A., Imai S., Vatner S.F., Sadoshima J. Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. Circulation Research 2004, 95:971-980.
14. Aldridge J.E., Horibe T., Hoogenraad N.J. Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements. PLoS ONE 2007, 2:e874.
15. Allen D.L., Linderman J.K., Roy R.R., Bigbee A.J., Grindeland R.E., Mukku V., et al. Apoptosis: A mechanism contributing to remodeling of skeletal muscle in response to hindlimb unweighting. American Journal of Physiology 1997, 273:C579-C587.
16. Allen D.L., Roy R.R., Edgerton V.R. Myonuclear domains in muscle adaptation and disease. Muscle & Nerve 1999, 22:1350-1360.
17. Allen D.L., Yasui W., Tanaka T., Ohira Y., Nagaoka S., Sekiguchi C., et al. Myonuclear number and myosin heavy chain expression in rat soleus single muscle fibers after spaceflight. Journal of Applied Physiology 1996, 81:145-151.
18. Alway S.E. Is fiber mitochondrial volume density a good indicator of muscle fatigability to isometric exercise?. Journal of Applied Physiology 1991, 70:2111-2119.
19. Alway S.E., Coggan A.R., Sproul M.S., Abduljalil A.M., Robitaille P.M. Muscle torque in young and older untrained and endurance-trained men. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 1996, 51:B195-B201.
20. Alway S.E., Degens H., Krishnamurthy G., Chaudhrai A. Denervation stimulates apoptosis but not Id2 expression in hindlimb muscles of aged rats. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2003, 58:687-697.
21. Alway S.E., Degens H., Krishnamurthy G., Smith C.A. Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats. American Journal of Physiology: Cell Physiology 2002, 283:C66-C76.
22. Alway S.E., Degens H., Lowe D.A., Krishnamurthy G. Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2002, 282:R411-R422.
23. Alway S.E., Lowe D.A., Chen K.D. The effects of age and hindlimb suspension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles. Experimental Physiology 2001, 86:509-517.
24. Alway S.E., MacDougall J.D., Sale D.G., Sutton J.R., McComas A.J. Functional and structural adaptations in skeletal muscle of trained athletes. Journal of Applied Physiology 1988, 64:1114-1120.
25. Alway S.E., Martyn J.K., J. Ouyang, Chaudhrai A., Murlasits Z.S. Id2 expression during apoptosis and satellite cell activation in unloaded and loaded quail skeletal muscles. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2003, 284:R540-R549.
26. Alway S.E., Siu P.M. Nuclear apoptosis contributes to sarcopenia. Exercise and Sport Sciences Reviews 2008, 36:51-57.
27. Amara C.E., Shankland E.G., Jubrias S.A., Marcinek D.J., Kushmerick M.J., Conley K.E. Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:1057-1062.
28. Ames B.N., Shigenaga M.K., Hagen T.M. Mitochondrial decay in aging. Biochimica et Biophys Acta 1995, 1271:165-170.
29. Annis M.G., Zamzami N., Zhu W., Penn L.Z., Kroemer G., Leber B., et al. Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event. Oncogene 2001, 20:1939-1952.
30. Antonsson B., Montessuit S., Lauper S., Eskes R., Martinou J.C. Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria. Biochemical Journal 2000, 345(Pt 2):271-278.
31. Anversa P., Palackal T., Sonnenblick E.H., Olivetti G., Meggs L.G., Capasso J.M. Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart. Circulation Research 1990, 67:871-885.
32. Asakura A., Hirai H., Kablar B., Morita S., Ishibashi J., Piras B.A., et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:16552-16557.
33. Attaix D., Ventadour S., Codran A., Bechet D., Taillandier D., Combaret L. The ubiquitin-proteasome system and skeletal muscle wasting. Essays in Biochemistry 2005, 41:173-186.
34. Azhar G., Gao W., Liu L., Wei J.Y. Ischemia-reperfusion in the adult mouse heart: Influence of age. Experimental Gerontology 1999, 34:699-714.
35. Azhar G., Liu L., Zhang X., Wei J.Y. Influence of age on hypoxia/reoxygenation-induced DNA fragmentation and bcl-2, bcl-xl, bax and fas in the rat heart and brain. Mechanisms of Ageing and Development 1999, 112:5-25.
36. Bakarev M.A., Nepomnyashchikh L.M. Structural manifestations of mitochondrial dysfunction in skeletal muscles of early aging OXYS rats. Bulletin of Experimental Biology and Medicine 2004, 138:598-602.
37. Baker D.J., Hepple R.T. Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. Experimental Gerontology 2006, 41:1149-1156.
38. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 2008, 3:e2264.
39. Barry M.A., Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Archives of Biochemistry and Biophysics 1993, 300:440-450.
40. Basanez G., Nechushtan A., Drozhinin O., Chanturiya A., Choe E., Tutt S., et al. Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:5492-5497.
41. 2+ homeostasis and apoptosis. EMBO Journal 2004, 23:1207-1216.
42. Batkai S., Rajesh M., Mukhopadhyay P., Hasko G., Liaudet L., Cravatt B.F., et al. Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. American Journal of Physiology: Heart and Circulatory Physiology 2007, 293:H909-H918.
43. Benayoun B., Baghdiguian S., Lajmanovich A., Bartoli M., Daniele N., Gicquel E., et al. NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A. FASEB Journal: 0fficial 2008, 22:1521-1529.
44. Benezra R., Davis R.L., Lockshon D., Turner D.L., Weintraub H. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins. Cell 1990, 61:49-59.
45. Bernardi P., Rasola A. Calcium and cell death: The mitochondrial connection. Subcellular Biochemistry 2007, 45:481-506.
46. Bernardi P., Krauskopf A., Basso E., Petronilli V., Blachly-Dyson E., Di L.F., et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS Journal 2006, 273:2077-2099.
47. Bernardi P., Petronilli V., Di L.F., Forte M. A mitochondrial perspective on cell death. Trends in Biochemical Sciences 2001, 26:112-117.
48. Bernardi P., Scorrano L., Colonna R., Petronilli V., Di L.F. Mitochondria and cell death: Mechanistic aspects and methodological issues. European Journal of Biochemistry/FEBS 1999, 264:687-701.
49. Berridge M.J., Bootman M.D., Roderick H.L. Calcium signalling: Dynamics, homeostasis and remodelling. Nature Reviews Molecular and Cell Biology 2003, 4:517-529.
50. Bhuiyan M.S., Fukunaga K. Inhibition of HtrA2/Omi ameliorates heart dysfunction following ischemia/reperfusion injury in rat heart in vivo. European Journal of Pharmacology 2007, 557:168-177.
51. Bianchi G., Di Giulio C., Rapino C., Rapino M., Antonucci A., Cataldi A. p53 and p66 proteins compete for hypoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia. Gerontology 2006, 52:17-23.
52. Blink E., Maianski N.A., Alnemri E.S., Zervos A.S., Roos D., Kuijpers T.W. Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils. Cell Death and Differentiation 2004, 11:937-939.
53. Brack A.S., Rando T.A. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Reviews 2007, 3:226-237.
54. Brack A.S., Bildsoe H., Hughes S.M. Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy. Journal of Cell Science 2005, 118:4813-4821.
55. Brack A.S., Conboy M.J., Roy S., Lee M., Kuo C.J., Keller C., et al. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007, 317:807-810.
56. Braga M., Sinha Hikim A.P., Datta S., Ferrini M.G., Brown D., Kovacheva E.L., et al. Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis: an International Journal on Programmed Cell Death 2008, 13:822-832.
57. Brini M., Carafoli E. Calcium pumps in health and disease. Physiological Reviews 2009, 89:1341-1378.
58. Bruunsgaard H. Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations. European Cytokine Network 2002, 13:389-391.
59. Bruunsgaard H., Andersen-Ranberg K., Hjelmborg J.B., Pedersen B.K., Jeune B. Elevated levels of tumor necrosis factor alpha and mortality in centenarians. American Journal of Medicine 2003, 115:278-283.
60. Bruunsgaard H., Ladelund S., Pedersen A.N., Schroll M., Jorgensen T., Pedersen B.K. Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clinical and Experimental Immunology 2003, 132:24-31.
61. Bruunsgaard H., Pedersen M., Pedersen B.K. Aging and proinflammatory cytokines. Current Opinion in Hematology 2001, 8:131-136.
62. Bruusgaard J.C., Liestol K., Gundersen K. Distribution of myonuclei and microtubules in live muscle fibers of young, middle-aged, and old mice. Journal of Applied Physiology 2006, 100:2024-2030.
63. Burstein E., Duckett C.S. Dying for NF-kappaB? Control of cell death by transcriptional regulation of the apoptotic machinery. Current Opinion in Cell Biology 2003, 15:732-737.
64. Butler D.C., Haramizu S., Williamson D.L., Alway S.E. Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts. PLoS ONE 2009, 4:e6302.
65. Cacciapaglia F., Spadaccio C., Chello M., Gigante A., Coccia R., Afeltra A., et al. Apoptotic molecular mechanisms implicated in autoimmune diseases. European Review for Medical and Pharmacological Sciences 2009, 13:23-40.
66. Campisi J., Sedivy J. How does proliferative homeostasis change with age? What causes it and how does it contribute to aging?. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64:164-166.
67. Cande C., Cecconi F., Dessen P., Kroemer G. Apoptosis-inducing factor (AIF): Key to the conserved caspase-independent pathways of cell death?. Journal of Cell Science 2002, 115:4727-4734.
68. Cande C., Cohen I., Daugas E., Ravagnan L., Larochette N., Zamzami N., et al. Apoptosis-inducing factor (AIF): A novel caspase-independent death effector released from mitochondria. Biochimie 2002, 84:215-222.
69. Canto C., Auwerx J. Caloric restriction, SIRT1 and longevity. Trends in Endocrinology and Metabolism 2009, 20:325-331.
70. Carafoli E. Calcium signaling: A tale for all seasons. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:1115-1122.
71. Carbo N., Busquets S., van R.M., Alvarez B., Lopez-Soriano F.J., Argiles J.M. TNF-alpha is involved in activating DNA fragmentation in skeletal muscle. British Journal of Cancer 2002, 86:1012-1016.
72. Carson J.A., Alway S.E. Stretch overload-induced satellite cell activation in slow tonic muscle from adult and aged Japanese quail. American Journal of Physiology 1996, 270:C578-C584.
73. Cartron P.F., Moreau C., Oliver L., Mayat E., Meflah K., Vallette F.M. Involvement of the N-terminus of Bax in its intracellular localization and function. FEBS Letters 2002, 512:95-100.
74. Cesari M., Pahor M. Target population for clinical trials on sarcopenia. Journal of Nutrition, Health and Aging 2008, 12:470-478.
75. Chabi B., Adhihetty P.J., O'Leary M.F., Menzies K.J., Hood D.A. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse. Journal of Applied Physiology 2009, 107:1730-1735.
76. Chabi B., Ljubicic V., Menzies K.J., Huang J.H., Saleem A., Hood D.A. Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell 2008, 7:2-12.
77. Chang H.Y., Yang X. Proteases for cell suicide: Functions and regulation of caspases. Microbiology and Molecular Biology Reviews 2000, 64:821-846.
78. Chao D.T., Korsmeyer S.J. BCL-2 family: Regulators of cell death. Annual Review of Immunology 1998, 16:395-419.
79. Chao D.T., Linette G.P., Boise L.H., White L.S., Thompson C.B., Korsmeyer S.J. Bcl-XL and Bcl-2 repress a common pathway of cell death. Journal of Experimental Medicine 1995, 182:821-828.
80. Charette S.L., McEvoy L., Pyka G., Snow-Harter C., Guido D., Wiswell R.A., et al. Muscle hypertrophy response to resistance training in older women. Journal of Applied Physiology 1991, 70:1912-1916.
81. Chatterjee S., Stewart A.S., Bish L.T., Jayasankar V., Kim E.M., Pirolli T., et al. Viral gene transfer of the antiapoptotic factor Bcl-2 protects against chronic postischemic heart failure. Circulation 2002, 106:I212-I217.
82. Chen C.N., Brown-Borg H.M., Rakoczy S.G., Ferrington D.A., Thompson L.V. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2010, 65:129-137.
83. Chipuk J.E., Green D.R. PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle 2009, 8.
84. Choi S.Y., Gonzalvez F., Jenkins G.M., Slomianny C., Chretien D., Arnoult D., et al. Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis. Cell Death and Differentiation 2007, 14:597-606.
85. Chowdhury I., Tharakan B., Bhat G.K. Caspases-an update. Comparative Biochemistry and Physiology, Part B, Biochemistry and Molecular Biology 2008, 151:10-27.
86. Christy B.A., Sanders L.K., Lau L.F., Copeland N.G., Jenkins N.A., Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:1815-1819.
87. Chung H.Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A.Y., et al. Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Research Reviews 2009, 8:18-30.
88. Chung L., Ng Y.C. Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle. Biochimica et Biophys Acta 2006, 1762:103-109.
89. Civitarese A.E., Carling S., Heilbronn L.K., Hulver M.H., Ukropcova B., Deutsch W.A., et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Medicine 2007, 4:e76.
90. Coggan A.R., Abduljalil A.M., Swanson S.C., Earle M.S., Farris J.W., Mendenhall L.A., et al. Muscle metabolism during exercise in young and older untrained and endurance-trained men. Journal of Applied Physiology 1993, 75:2125-2133.
91. Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004, 305:390-392.
92. 2 production and oxidative damage. Cardiovascular Research 2007, 74:456-465.
93. Combaret L., Dardevet D., Bechet D., Taillandier D., Mosoni L., Attaix D. Skeletal muscle proteolysis in aging. Current Opinion in Clinical Nutrition and Metabolic Care 2009, 12:37-41.
94. Communal C., Sumandea M., de T.P., Narula J., Solaro R.J., Hajjar R.J. Functional consequences of caspase activation in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:6252-6256.
95. Condorelli G., Morisco C., Stassi G., Notte A., F. Farina, Sgaramella G., et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. Circulation 1999, 99:3071-3078.
96. Conley K.E., Amara C.E., Jubrias S.A., Marcinek D.J. Mitochondrial function, fibre types and ageing: New insights from human muscle in vivo. Experimental Physiology 2007, 92:333-339.
97. Conley K.E., Jubrias S.A., Amara C.E., Marcinek D.J. Mitochondrial dysfunction: Impact on exercise performance and cellular aging. Exercise and Sport Sciences Reviews 2007, 35:43-49.
98. Conley K.E., Jubrias S.A., Esselman P.C. Oxidative capacity and ageing in human muscle. Journal of Physiology 2000, 526(Pt 1):203-210.
99. Conraads V.M., Hoymans V.Y., Vermeulen T., Beckers P., Possemiers N., Maeseneer M.D., et al. Exercise capacity in chronic heart failure patients is related to active gene transcription in skeletal muscle and not apoptosis. European Journal of Cardiovascular Prevention and Rehabilitation 2009, 16:325-332.
100. Crompton M. Bax, Bid and the permeabilization of the mitochondrial outer membrane in apoptosis. Current Opinion in Cell Biology 2000, 12:414-419.
101. Csiszar A., Labinskyy N., Jimenez R., Pinto J.T., Ballabh P., Losonczy G., et al. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1. Mechanisms of Ageing and Development 2009, 130:518-527.
102. Csukly K., Ascah A., Matas J., Gardiner P.F., Fontaine E., Burelle Y. Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D. Journal of Physiology 2006, 574:319-327.
103. Cutlip R.G., Baker B.A., Geronilla K.B., Mercer R.R., Kashon M.L., Miller G.R., et al. Chronic exposure to stretch-shortening contractions results in skeletal muscle adaptation in young rats and maladaptation in old rats. Applied Physiology, Nutrition and Metabolism 2006, 31:573-587.
104. Dalla L.L., Sabbadini R., Renken C., Ravara B., Sandri M., Betto R., et al. Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine. Journal of Molecular and Cellular Cardiology 2001, 33:1871-1878.
105. Danial N.N., Korsmeyer S.J. Cell death: Critical control points. Cell 2004, 116:205-219.
106. Davies K.J., Quintanilha A.T., Brooks G.A., Packer L. Free radicals and tissue damage produced by exercise. Biochemical and Biophysical Research Communications 1982, 107:1198-1205.
107. De Giorgi F., Lartigue L., Bauer M.K., Schubert A., Grimm S., Hanson G.T., et al. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. FASEB Journal 2002, 16:607-609.
108. Degens H. Age-related skeletal muscle dysfunction: Causes and mechanisms. Journal of Musculoskeletal & Neuronal Interactions 2007, 7:246-252.
109. Degens H., Alway S.E. Skeletal muscle function and hypertrophy are diminished in old age. Muscle & Nerve 2003, 27:339-347.
110. Degens H., Alway S.E. Control of muscle size during disuse, disease, and aging. International Journal of Sports Medicine 2006, 27:94-99.
111. Degens H., Swisher A.K., Heijdra Y.F., Siu P.M., Dekhuijzen P.N., Alway S.E. Apoptosis and Id2 expression in diaphragm and soleus muscle from the emphysematous hamster. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2007, 293:R135-R144.
112. Degterev A., Boyce M., Yuan J. A decade of caspases. Oncogene 2003, 22:8543-8567.
113. Dejean L.M., Martinez-Caballero S., Guo L., Hughes C., Teijido O., Ducret T., et al. Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel. Molecular Biology of the Cell 2005, 16:2424-2432.
114. Dejean L.M., Martinez-Caballero S., Kinnally K.W. Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?. Cell Death and Differentiation 2006, 13:1387-1395.
115. Dejean L.M., Martinez-Caballero S., Manon S., Kinnally K.W. Regulation of the mitochondrial apoptosis-induced channel, MAC, by BCL-2 family proteins. Biochimica et Biophys Acta 2006, 1762:191-201.
116. Desagher S., Martinou J.C. Mitochondria as the central control point of apoptosis. Trends in Cell Biology 2000, 10:369-377.
117. Deschenes M.R., Kraemer W.J. Performance and physiologic adaptations to resistance training. American Journal of Physical Medicine and Rehabilitation 2002, 81:S3-16.
118. Deveraux Q.L., Reed J.C. IAP family proteins-suppressors of apoptosis. Genes & Development 1999, 13:239-252.
119. Deveraux Q.L., Roy N., Stennicke H.R., Van A.T., Zhou Q., Srinivasula S.M., et al. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases. EMBO Journal 1998, 17:2215-2223.
120. Deveraux Q.L., Stennicke H.R., Salvesen G.S., Reed J.C. Endogenous inhibitors of caspases. Journal of Clinical Immunology 1999, 19:388-398.
121. Dirks A., Leeuwenburgh C. Apoptosis in skeletal muscle with aging. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2002, 282:R519-R527.
122. Dirks A.J., Jones K.M. Statin-induced apoptosis and skeletal myopathy. American Journal of Physiology: Cell Physiology 2006, 291:C1208-C1212.
123. Dirks A.J., Leeuwenburgh C. Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12. Free Radical Biology & Medicine 2004, 36:27-39.
124. Dirks A.J., Leeuwenburgh C. The role of apoptosis in age-related skeletal muscle atrophy. Sports Medicine 2005, 35:473-483.
125. Dirks A.J., Leeuwenburgh C. Tumor necrosis factor alpha signaling in skeletal muscle: Effects of age and caloric restriction. Journal of Nutritional Biochemistry 2006, 17:501-508.
126. Dirks Naylor A.J., Leeuwenburgh C. Sarcopenia: The role of apoptosis and modulation by caloric restriction. Exercise and Sport Sciences Reviews 2008, 36:19-24.
127. Drew B., Phaneuf S., Dirks A., Selman C., Gredilla R., Lezza A., et al. Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2003, 284:R474-R480.
128. Duke R.C., Ojcius D.M., Young J.D. Cell suicide in health and disease. Scientific American 1996, 275:80-87.
129. Dupont-Versteegden E.E., Strotman B.A., Gurley C.M., Gaddy D., Knox M., Fluckey J.D., et al. Nuclear translocation of EndoG at the initiation of disuse muscle atrophy and apoptosis is specific to myonuclei. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2006, 291:R1730-R1740.
130. Dutta J., Fan Y., Gupta N., Fan G., Gelinas C. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene 2006, 25:6800-6816.
131. Earnshaw W.C., Martins L.M., Kaufmann S.H. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annual Review of Biochemistry 1999, 68:383-424.
132. Ellis R.E., Yuan J.Y., Horvitz H.R. Mechanisms and functions of cell death. Annual Review of Cell Biology 1991, 7:663-698.
133. Er E., Lalier L., Cartron P.F., Oliver L., Vallette F.M. Control of Bax homo-dimerization by its carboxy-terminal. Journal of Biological Chemistry 2007, 282:24938-24947.
134. Essen-Gustavsson B., Borges O. Histochemical and metabolic characteristics of human skeletal muscle in relation to age. Acta Physiologica Scandinavia 1986, 126:107-114.
135. Evans W.J. What is sarcopenia? [Special issue]. Journals of Gerontology Series A, Biological Sciences and Medical Sciences 1995, 50:5-8.
136. Fan Y., Dutta J., Gupta N., Fan G., Gelinas C. Regulation of programmed cell death by NF-kappaB and its role in tumorigenesis and therapy. Advances in Experimental Medicine and Biology 2008, 615:223-250.
137. Ferguson M., Rebrin I., Forster M.J., Sohal R.S. Comparison of metabolic rate and oxidative stress between two different strains of mice with varying response to caloric restriction. Experimental Gerontology 2008, 43:757-763.
138. Ferketich A.K., Kirby T.E., Alway S.E. Cardiovascular and muscular adaptations to combined endurance and strength training in elderly women. Acta Physiologica Scandinavia 1998, 164:259-267.
139. Fidzianska A. Suicide muscle cell programme-apoptosis. Ultrastructural study. Folia Neuropathologica/Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences 2002, 40:27-32.
140. Figueiredo P.A., Powers S.K., Ferreira R.M., Appell H.J., Duarte J.A. Aging impairs skeletal muscle mitochondrial bioenergetic function. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64:21-33.
141. Figueras M., Busquets S., Carbo N., Almendro V., Argiles J.M., Lopez-Soriano F.J. Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. International Journal of Oncology 2005, 27:855-860.
142. Forsey R.J., Thompson J.M., Ernerudh J., Hurst T.L., Strindhall J., Johansson B., et al. Plasma cytokine profiles in elderly humans. Mechanisms of Ageing and Development 2003, 124:487-493.
143. Forte M., Bernardi P. The permeability transition and BCL-2 family proteins in apoptosis: Co-conspirators or independent agents?. Cell Death and Differentiation 2006, 13:1287-1290.
144. Foulstone E.J., Meadows K.A., Holly J.M., Stewart C.E. Insulin-like growth factors (IGF-I and IGF-II) inhibit C2 skeletal myoblast differentiation and enhance TNF alpha-induced apoptosis. Journal of Cellular Physiology 2001, 189:207-215.
145. Garcia-Martinez C., Agell N., Llovera M., Lopez-Soriano F.J., Argiles J.M. Tumour necrosis factor-alpha increases the ubiquitinization of rat skeletal muscle proteins. FEBS Letters 1993, 323:211-214.
146. Garcia-Martinez C., Llovera M., Agell N., Lopez-Soriano F.J., Argiles J.M. Ubiquitin gene expression in skeletal muscle is increased during sepsis: Involvement of TNF-alpha but not IL-1. Biochemical and Biophysical Research Communications 1995, 217:839-844.
147. Garcia-Martinez C., Lopez-Soriano F.J., Argiles J.M. Acute treatment with tumour necrosis factor-alpha induces changes in protein metabolism in rat skeletal muscle. Molecular and Cellular Biochemistry 1993, 125:11-18.
148. Ghosh A.P., Walls K.C., Klocke B.J., Toms R., Strasser A., Roth K.A. The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis. Journal of Neuropathology and Experimental Neurology 2009, 68:747-756.
149. Ghosh S.P., Perkins M.W., Hieber K., Kulkarni S., Kao T.C., Reddy E.P., et al. Radiation protection by a new chemical entity, Ex-Rad: Efficacy and mechanisms. Radiation Research 2009, 171:173-179.
150. 2. Biochemical and Biophysical Research Communications 1991, 181:915-920.
151. Gillick K., Crompton M. Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release. Journal of Cell Science 2008, 121:618-626.
152. Giorgio M., Migliaccio E., Orsini F., Paolucci D., Moroni M., Contursi C., et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005, 122:221-233.
153. Gomez L.A., Monette J.S., Chavez J.D., Maier C.S., Hagen T.M. Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. Archives of Biochemistry and Biophysics 2009, 490:30-35.
154. Gonzalvez F., Gottlieb E. Cardiolipin: Setting the beat of apoptosis. Apoptosis: An International Journal on Programmed Cell Death 2007, 12:877-885.
155. Gorman A.M., Ceccatelli S., Orrenius S. Role of mitochondria in neuronal apoptosis. Developmental Neuroscience 2000, 22:348-358.
156. Grazette L.P., Boecker W., Matsui T., Semigran M., Force T.L., Hajjar R.J., et al. Inhibition of ErbB2 causes mitochondrial dysfunction in cardiomyocytes: Implications for herceptin-induced cardiomyopathy. Journal of the American College of Cardiology 2004, 44:2231-2238.
157. Grinberg M., Schwarz M., Zaltsman Y., Eini T., Niv H., Pietrokovski S., et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Molecular and Cellular Biochemistry 2005, 25:4579-4590.
158. Grutter M.G. Caspases: Key players in programmed cell death. Current Opinion in Structural Biology 2000, 10:649-655.
159. Gustafsson A.B., Tsai J.G., Logue S.E., Crow M.T., Gottlieb R.A. Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation. Journal of Cellular Physiology 2004, 279:21233-21238.
160. Hacker T.A., McKiernan S.H., Douglas P.S., Wanagat J., Aiken J.M. Age-related changes in cardiac structure and function in Fischer 344 × Brown Norway hybrid rats. American Journal of Physiology: Heart and Circulatory Physiology 2006, 290:H304-H311.
161. 2max. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2004, 59:1099-1110.
162. Hagen T.M., Yowe D.L., Bartholomew J.C., Wehr C.M., Do K.L., Park J.Y., et al. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:3064-3069.
163. Harman D. Aging: A theory based on free radical and radiation chemistry. Journals of Gerontology 1956, 11:298-300.
164. Harman D. The free radical theory of aging. Antioxidants & Redox Signaling 2003, 5:557-561.
165. Harman D. Free radical theory of aging: An update: Increasing the functional life span. Annals of the New York Academy of Sciences 2006, 1067:10-21.
166. Hawke T.J., Garry D.J. Myogenic satellite cells: Physiology to molecular biology. Journal of Applied Physiology 2001, 91:534-551.
167. Hegde R., Srinivasula S.M., Zhang Z., Wassell R., Mukattash R., Cilenti L., et al. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. Journal of Biological Chemistry 2002, 277:432-438.
168. Heikaus S., Kempf T., Mahotka C., Gabbert H.E., Ramp U. Caspase-8 and its inhibitors in RCCs in vivo: The prominent role of ARC. Apoptosis: An International Journal on Programmed Cell Death 2008, 13:938-949.
169. Henriques-Pons A., Nagaraju K. Nonimmune mechanisms of muscle damage in myositis: Role of the endoplasmic reticulum stress response and autophagy in the disease pathogenesis. Current Opinion in Rheumatology 2009.
170. Hepple R.T. Why eating less keeps mitochondria working in aged skeletal muscle. Exercise and Sport Sciences Reviews 2009, 37:23-28.
171. Hepple R.T., Baker D.J., Kaczor J.J., Krause D.J. Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function. FASEB Journal 2005, 19:1320-1322.
172. Herbst A., Pak J.W., McKenzie D., Bua E., Bassiouni M., Aiken J.M. Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: Evidence for a causal role in muscle fiber loss. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2007, 62:235-245.
173. Hikida R.S., Van Nostran S., Murray J.D., Staron R.S., Gordon S.E., Kraemer W.J. Myonuclear loss in atrophied soleus muscle fibers. Anatomical Record 1997, 247:350-354.
174. Hirota H., Chen J., Betz U.A., Rajewsky K., Gu Y., Ross J., et al. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 1999, 97:189-198.
175. Holly T.A., Drincic A., Byun Y., Nakamura S., Harris K., Klocke F.J., et al. Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo. Journal of Molecular and Cellular Cardiology 1999, 31:1709-1715.
176. Honda K., Kato K., Dairaku N., Iijima K., Koike T., Imatani A., et al. High levels of intracellular ATP prevent nitric oxide-induced apoptosis in rat gastric mucosal cells. International Journal of Experimental Pathology 2003, 84:281-288.
177. Hood D.A. Mechanisms of exercise-induced mitochondrial biogenesis in skeletal muscle. Applied Physiology Nutrition and Metabolism 2009, 34:465-472.
178. Horibe T., Hoogenraad N.J. The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response. PLoS ONE 2007, 2:e835.
179. L during apoptosis. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:3668-3672.
180. Hu A., Jiao X., Gao E., Li Y., Sharifi-Azad S., Grunwald Z., et al. Tonic beta-adrenergic drive provokes proinflammatory and proapoptotic changes in aging mouse heart. Rejuvenation Research 2008, 11:215-226.
181. Huang J.H., Joseph A.M., Ljubicic V., Iqbal S., Hood D.A. Effect of age on the processing and import of matrix-destined mitochondrial proteins in skeletal muscle. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2010, 65:138-146.
182. Huang Z., Jiang J., Tyurin V.A., Zhao Q., Mnuskin A., Ren J., et al. Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis. Free Radical Biology & Medicine 2008, 44:1935-1944.
183. Hunter R.B., Mitchell-Felton H., Essig D.A., Kandarian S.C. Expression of endoplasmic reticulum stress proteins during skeletal muscle disuse atrophy. American Journal of Physiology: Cell Physiology 2001, 281:C1285-C1290.
184. Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388:190-195.
185. Irrcher I., Adhihetty P.J., Joseph A.M., Ljubicic V., Hood D.A. Regulation of mitochondrial biogenesis in muscle by endurance exercise. Sports Medicine 2003, 33:783-793.
186. Izyumov D.S., Avetisyan A.V., Pletjushkina O.Y., Sakharov D.V., Wirtz K.W., Chernyak B.V., et al. "Wages of fear": Transient threefold decrease in intracellular ATP level imposes apoptosis. Biochimica et Biophys Acta 2004, 1658:141-147.
187. Jackson M.J., Pye D., Palomero J. The production of reactive oxygen and nitrogen species by skeletal muscle. Journal of Applied Physiology 2007, 102:1664-1670.
188. Jang Y.C., Lustgarten M.S., Liu Y., Muller F.L., Bhattacharya A., Liang H., et al. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB Journal 2010.
189. Jejurikar S.S., Henkelman E.A., Cederna P.S., Marcelo C.L., Urbanchek M.G., Kuzon W.M. Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis. Experimental Gerontology 2006, 41:828-836.
190. Jejurikar S.S., Marcelo C.L., Kuzon W.M. Skeletal muscle denervation increases satellite cell susceptibility to apoptosis. Plastic and Reconstructive Surgery 2002, 110:160-168.
191. Jiang J., Huang Z., Zhao Q., Feng W., Belikova N.A., Kagan V.E. Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis. Biochemical and Biophysical Research Communications 2008, 368:145-150.
192. Jin H., Wu Z., Tian T., Gu Y. Apoptosis in atrophic skeletal muscle induced by brachial plexus injury in rats. Journal of Trauma 2001, 50:31-35.
193. Johnson C.R., Jarvis W.D. Caspase-9 regulation: An update. Apoptosis: An International Journal on Programmed Cell Death 2004, 9:423-427.
194. Joza N., Oudit G.Y., Brown D., Benit P., Kassiri Z., Vahsen N., et al. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Molecular and Cellular Biochemistry 2005, 25:10261-10272.
195. Joza N., Susin S.A., Daugas E., Stanford W.L., Cho S.K., Li C.Y., et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 2001, 410:549-554.
196. Jubrias S.A., Esselman P.C., Price L.B., Cress M.E., Conley K.E. Large energetic adaptations of elderly muscle to resistance and endurance training. Journal of Applied Physiology 2001, 90:1663-1670.
197. Jung K.J., Lee E.K., Kim J.Y., Zou Y., Sung B., Heo H.S., et al. Effect of short term calorie restriction on pro-inflammatory NF-κB and AP-1 in aged rat kidney. Inflammation Research 2009, 58:143-150.
198. Jung K.J., Lee E.K., Yu B.P., Chung H.Y. Significance of protein tyrosine kinase/protein tyrosine phosphatase balance in the regulation of NF-κB signaling in the inflammatory process and aging. Free Radical Biology & Medicine 2009, 47:983-991.
199. Kadenbach B., Arnold S., Lee I., Huttemann M. The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases. Biochimica et Biophys Acta 2004, 1655:400-408.
200. Kadenbach B., Ramzan R., Vogt S. Degenerative diseases, oxidative stress and cytochrome c oxidase function. Trends in Molecular Medicine 2009, 15:139-147.
201. Kagan V.E., Bayir H.A., Belikova N.A., Kapralov O., Tyurina Y.Y., Tyurin V.A., et al. Cytochrome c/cardiolipin relations in mitochondria: A kiss of death. Free Radical Biology & Medicine 2009.
202. Kajstura J., Cheng W., Sarangarajan R., Li P., Li B., Nitahara J.A., et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. American Journal of Physiology 1996, 271:H1215-H1228.
203. Kakarla S.K., Rice K.M., Katta A., Paturi S., Wu M., Kolli M., et al. Possible molecular mechanisms underlying age-related cardiomyocyte apoptosis in the F344×BN rat heart. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2010, 65:147-155.
204. Kearns J.D., Hoffmann A. Integrating computational and biochemical studies to explore mechanisms in NF-κB signaling. Journal of Biological Chemistry 2009, 284:5439-5443.
205. Keefe D.L. Trastuzumab-associated cardiotoxicity. Cancer 2002, 95:1592-1600.
206. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer 1972, 26:239-257.
207. Kim J.H., Kwak H.B., Leeuwenburgh C., Lawler J.M. Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Experimental Gerontology 2008, 43:317-329.
208. Kim J.S., He L., Lemasters J.J. Mitochondrial permeability transition: A common pathway to necrosis and apoptosis. Biochemical and Biophysical Research Communications 2003, 304:463-470.
209. Kim J.S., Ohshima S., Pediaditakis P., Lemasters J.J. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Hepatology 2004, 39:1533-1543.
210. Kondo H., Miura M., Itokawa Y. Oxidative stress in skeletal muscle atrophied by immobilization. Acta Physiologica Scandinavia 1991, 142:527-528.
211. Kondo H., Miura M., Itokawa Y. Antioxidant enzyme systems in skeletal muscle atrophied by immobilization. Pflügers Archiv: European Journal of Physiology 1993, 422:404-406.
212. Kondo H., Miura M., Nakagaki I., Sasaki S., Itokawa Y. Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization. American Journal of Physiology 1992, 262:E583-E590.
213. Kondo H., Nakagaki I., Sasaki S., Hori S., Itokawa Y. Mechanism of oxidative stress in skeletal muscle atrophied by immobilization. American Journal of Physiology 1993, 265:E839-E844.
214. Kondo H., Nishino K., Itokawa Y. Hydroxyl radical generation in skeletal muscle atrophied by immobilization. FEBS Letters 1994, 349:169-172.
215. Korolchuk V.I., Mansilla A., Menzies F.M., Rubinsztein D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Molecular Cell 2009, 33:517-527.
216. Korsmeyer S.J. Regulators of cell death. Trends in Genetics 1995, 11:101-105.
217. Korsmeyer S.J. BCL-2 gene family and the regulation of programmed cell death. Cancer Research 1999, 59:1693s-1700s.
218. Korsmeyer S.J., Yin X.M., Oltvai Z.N., Veis-Novack D.J., Linette G.P. Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochimica et Biophys Acta 1995, 1271:63-66.
219. Koseki T., Inohara N., Chen S., Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:5156-5160.
220. Krajnak K., Waugh S., Miller R., Baker B., Geronilla K., Alway S.E., et al. Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats. Muscle & Nerve 2006, 34:720-730.
221. Krauskopf A., Eriksson O., Craigen W.J., Forte M.A., Bernardi P. Properties of the permeability transition in VDAC1(-/-) mitochondria. Biochimica et Biophys Acta 2006, 1757:590-595.
222. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiological Reviews 2007, 87:99-163.
223. Kujoth G.C., Hiona A., Pugh T.D., Someya S., Panzer K., Wohlgemuth S.E., et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005, 309:481-484.
224. Kujoth G.C., Leeuwenburgh C., Prolla T.A. Mitochondrial DNA mutations and apoptosis in mammalian aging. Cancer Research 2006, 66:7386-7389.
225. Kwak H.B., Song W., Lawler J.M. Exercise training attenuates age-induced elevation in Bax/Bcl-2 ratio, apoptosis, and remodeling in the rat heart. FASEB Journal 2006, 20:791-793.
226. Lakatta E.G. Hemodynamic adaptations to stress with advancing age. Acta Medica Scandinavica Supplementum 1986, 711:39-52.
227. Lakatta E.G., Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part II. The aging heart in health: Links to heart disease. Circulation 2003, 107:346-354.
228. Lalier L., Cartron P.F., Juin P., Nedelkina S., Manon S., Bechinger B., et al. Bax activation and mitochondrial insertion during apoptosis. Apoptosis: An International Journal on Programmed Cell Death 2007, 12:887-896.
229. Lanza I.R., Nair K.S. Mitochondrial function as a determinant of life span. Pflügers Archiv: European Journal of Physiology 2010, 459:277-289.
230. Lanza I.R., Short D.K., Short K.R., Raghavakaimal S., Basu R., Joyner M.J., et al. Endurance exercise as a countermeasure for aging. Diabetes 2008, 57:2933-2942.
231. Lee C.K., Allison D.B., Brand J., Weindruch R., Prolla T.A. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:14988-14993.
232. Lee D.H., Rhee J.G., Lee Y.J. Reactive oxygen species up-regulate p53 and Puma: A possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. British Journal of Pharmacology 2009, 157:1189-1202.
233. Lee H.C., Wei Y.H. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Experimental Biology and Medicine (Maywood, NJ) 2007, 232:592-606.
234. Lee S.C., Pervaiz S. Apoptosis in the pathophysiology of diabetes mellitus. International Journal of Biochemistry & Cell Biology 2007, 39:497-504.
235. Lee W.L., Chen J.W., Ting C.T., Ishiwata T., Lin S.J., Korc M., et al. Insulin-like growth factor I improves cardiovascular function and suppresses apoptosis of cardiomyocytes in dilated cardiomyopathy. Endocrinology 1999, 140:4831-4840.
236. Lees S.J., Rathbone C.R., Booth F.W. Age-associated decrease in muscle precursor cell differentiation. American Journal of Physiology: Cell Physiology 2006, 290:C609-C615.
237. Lees S.J., Zwetsloot K.A., Booth F.W. Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor-alpha response. Aging Cell 2009, 8:26-35.
238. Leeuwenburgh C. Role of apoptosis in sarcopenia. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2003, 58:999-1001.
239. Leeuwenburgh C., Gurley C.M., Strotman B.A., Dupont-Versteegden E.E. Age-related differences in apoptosis with disuse atrophy in soleus muscle. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2005, 288:R1288-R1296.
240. Leivo I., Kauhanen S., Michelsson J.E. Abnormal mitochondria and sarcoplasmic changes in rabbit skeletal muscle induced by immobilization. Acta Pathologica, Microbiologica, et Immunologica Scandinavica 1998, 106:1113-1123.
241. Lenaz G., Bovina C., Formiggini G., Parenti C.G. Mitochondria, oxidative stress, and antioxidant defences. Acta Biochimica Polonica 1999, 46:1-21.
242. Lesnefsky E.J., Hoppel C.L. Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat. Biochimica et Biophys Acta 2008, 1777:1020-1027.
243. Li H., Zhu H., Xu C.J., Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998, 94:491-501.
244. Li L.Y., Luo X., Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001, 412:95-99.
245. Li Z., Bing O.H., Long X., Robinson K.G., Lakatta E.G. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. American Journal of Physiology 1997, 272:H2313-H2319.
246. Libera L.D., Ravara B., Gobbo V., Betto D.D., Germinario E., Angelini A., et al. Skeletal muscle proteins oxidation in chronic right heart failure in rats: Can different beta-blockers prevent it to the same degree?. International Journal of Cardiology 2009.
247. Lim H., Fallavollita J.A., Hard R., Kerr C.W., Canty J.M. Profound apoptosis-mediated regional myocyte loss and compensatory hypertrophy in pigs with hibernating myocardium. Circulation 1999, 100:2380-2386.
248. Lin S.S., Bassik M.C., Suh H., Nishino M., Arroyo J.D., Hahn W.C., et al. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. Journal of Cellular Physiology 2006, 281:23003-23012.
249. Linke A., Adams V., Schulze P.C., Erbs S., Gielen S., Fiehn E., et al. Antioxidative effects of exercise training in patients with chronic heart failure: Increase in radical scavenger enzyme activity in skeletal muscle. Circulation 2005, 111:1763-1770.
250. Lipton S.A., Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 2002, 111:147-150.
251. Liu L., Azhar G., Gao W., Zhang X., Wei J.Y. Bcl-2 and Bax expression in adult rat hearts after coronary occlusion: Age-associated differences. American Journal of Physiology 1998, 275:R315-R322.
252. Liu P., Xu B., Cavalieri T.A., Hock C.E. Age-related difference in myocardial function and inflammation in a rat model of myocardial ischemia-reperfusion. Cardiovascular Research 2002, 56:443-453.
253. Liu X., Kim C.N., Yang J., Jemmerson R., Wang X. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 1996, 86:147-157.
254. li-Youcef N., Lagouge M., Froelich S., Koehl C., Schoonjans K., Auwerx J. Sirtuins: The 'magnificent seven', function, metabolism and longevity. Annals of Medicine 2007, 39:335-345.
255. Ljubicic V., Menzies K.J., Hood D.A. Mitochondrial dysfunction is associated with a pro-apoptotic cellular environment in senescent cardiac muscle. Mechanisms of Ageing and Development 2010, 131:79-88.
256. Llovera M., Garcia-Martinez C., Agell N., Lopez-Soriano F.J., Argiles J.M. TNF can directly induce the expression of ubiquitin-dependent proteolytic system in rat soleus muscles. Biochemical and Biophysical Research Communications 1997, 230:238-241.
257. Llovera M., Garcia-Martinez C., Agell N., Lopez-Soriano F.J., Authier F.J., Gherardi R.K., et al. Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients. International Journal of Molecular Medicine 1998, 2:69-73.
258. Lloyd B.D., Williamson D.A., Singh N.A., Hansen R.D., Diamond T.H., Finnegan T.P., et al. Recurrent and injurious falls in the year following hip fracture: A prospective study of incidence and risk factors from the Sarcopenia and Hip Fracture Study. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64:599-609.
259. Ma Y.S., Wu S.B., Lee W.Y., Cheng J.S., Wei Y.H. Response to the increase of oxidative stress and mutation of mitochondrial DNA in aging. Biochimica et Biophys Acta 2009, 1790:1021-1029.
260. Malhotra A., Vashistha H., Yadav V.S., Dube M.G., Kalra S.P., Abdellatif M., et al. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. American Journal of Physiology: Heart and Circulatory Physiology 2009, 296:H380-H388.
261. Malinska D., Kudin A.P., Debska-Vielhaber G., Vielhaber S., Kunz W.S. Quantification of superoxide production by mouse brain and skeletal muscle mitochondria. Methods in Enzymology 2009, 456:419-437.
262. Marcinek D.J. Mitochondrial dysfunction measured in vivo. Acta Physiologica Scandinavia 2004, 182:343-352.
263. Marcinek D.J., Schenkman K.A., Ciesielski W.A., Lee D., Conley K.E. Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle. Journal of Physiology 2005, 569:467-473.
264. Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R., et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes & Development 2004, 18:3066-3077.
265. Martin C., Dubouchaud H., Mosoni L., Chardigny J.M., Oudot A., Fontaine E., et al. Abnormalities of mitochondrial functioning can partly explain the metabolic disorders encountered in sarcopenic gastrocnemius. Aging Cell 2007, 6:165-177.
266. Marzani B., Balage M., Venien A., Astruc T., Papet I., Dardevet D., et al. Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats. Journal of Nutrition 2008, 138:2205-2211.
267. Marzetti E., Anne L.H., Eva W.S., Leeuwenburgh C. Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction. BioFactors (Oxford, England) 2009, 35:28-35.
268. Marzetti E., Carter C.S., Wohlgemuth S.E., Lees H.A., Giovannini S., Anderson B., et al. Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mechanisms of Ageing and Development 2009, 130:272-280.
269. Marzetti E., Groban L., Wohlgemuth S.E., Lees H.A., Lin M., Jobe H., et al. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2008, 294:R558-R567.
270. Marzetti E., Hwang J.C., Lees H.A., Wohlgemuth S.E., Dupont-Versteegden E.E., Carter C.S., Bernabei R., Leeuwenburgh C. Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy. Biochimica et Biophys Acta 2010, 1800:235-244.
271. Marzetti E., Lawler J.M., Hiona A., Manini T., Seo A.Y., Leeuwenburgh C. Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radical Biology & Medicine 2008, 44:160-168.
272. Marzetti E., Privitera G., Simili V., Wohlgemuth S.E., Aulisa L., Pahor M., et al. Multiple pathways to the same end: Mechanisms of myonuclear apoptosis in sarcopenia of aging. ScientificWorldJournal 2010, 10:340-349.
273. Marzetti E., Wohlgemuth S.E., Lees H.A., Chung H.Y., Giovannini S., Leeuwenburgh C. Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mechanisms of Ageing and Development 2008, 129:542-549.
274. Mayhew D.L., Kim J.S., Cross J.M., Ferrando A.A., Bamman M.M. Translational signaling responses preceding resistance training-mediated myofiber hypertrophy in young and old humans. Journal of Applied Physiology 2009, 107:1655-1662.
275. McArdle A., Jackson M.J. Exercise, oxidative stress and ageing. Journal of Anatomy 2000, 197(Pt 4):539-541.
276. McArdle A., Pattwell D., Vasilaki A., Griffiths R.D., Jackson M.J. Contractile activity-induced oxidative stress: Cellular origin and adaptive responses. American Journal of Physiology: Cell Physiology 2001, 280:C621-C627.
277. McKenzie D., Bua E., McKiernan S., Cao Z., Aiken J.M. Mitochondrial DNA deletion mutations: A causal role in sarcopenia. European Journal of Biochemistry/FEBS 2002, 269:2010-2015.
278. McMullen C.A., Ferry A.L., Gamboa J.L., Andrade F.H., Dupont-Versteegden E.E. Age-related changes of cell death pathways in rat extraocular muscle. Experimental Gerontology 2009, 44:420-425.
279. Meadows K.A., Holly J.M., Stewart C.E. Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. Journal of Cellular Physiology 2000, 183:330-337.
280. Meissner C. Mutations of mitochondrial DNA. Zeitschrift für Gerontologie und Geriatrie: Organ der Deutschen Gesellschaft für Gerontologie und Geriatrie 2007, 40:325-333.
281. Meissner C., Bruse P., Mohamed S.A., Schulz A., Warnk H., Storm T., et al. The 4977 bp deletion of mitochondrial DNA in human skeletal muscle, heart and different areas of the brain: A useful biomarker or more?. Experimental Gerontology 2008, 43:645-652.
282. Metter E.J., Talbot L.A., Schrager M., Conwit R. Skeletal muscle strength as a predictor of all-cause mortality in healthy men. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2002, 57:B359-B365.
283. Migheli A., Mongini T., Doriguzzi C., Chiado-Piat L., Piva R., Ugo I., et al. Muscle apoptosis in humans occurs in normal and denervated muscle, but not in myotonic dystrophy, dystrophinopathies or inflammatory disease. Neurogenetics 1997, 1:81-87.
284. Mikhailov V., Mikhailova M., Degenhardt K., Venkatachalam M.A., White E., Saikumar P. Association of Bax and Bak homo-oligomers in mitochondria: Bax requirement for Bak reorganization and cytochrome c release. Journal of Biological Chemistry 2003, 278:5367-5376.
285. Mikhailov V., Mikhailova M., Pulkrabek D.J., Dong Z., Venkatachalam M.A., Saikumar P. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. Journal of Biological Chemistry 2001, 276:18361-18374.
286. Molina E.J., Gupta D., Palma J., Torres D., Gaughan J.P., Houser S., et al. Novel experimental model of pressure overload hypertrophy in rats. Journal of Surgical Research 2009, 153:287-294.
287. Muller-Hocker J., Schneiderbanger K., Stefani F.H., Kadenbach B. Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing-a cytochemical-immunohistochemical study. Mutation Research 1992, 275:115-124.
288. Murray A.J., Edwards L.M., Clarke K. Mitochondria and heart failure. Current Opinion in Clinical Nutrition and Metabolic Care 2007, 10:704-711.
289. Nagaraju K., Casciola-Rosen L., Rosen A., Thompson C., Loeffler L., Parker T., et al. The inhibition of apoptosis in myositis and in normal muscle cells. Journal of Immunology 2000, 164:5459-5465.
290. Nakagawa T., Yuan J. Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis. Journal of Cell Biology 2000, 150:887-894.
291. Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
292. Narita M., Shimizu S., Ito T., Chittenden T., Lutz R.J., Matsuda H., et al. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:14681-14686.
293. Narula J., Haider N., Virmani R., DiSalvo T.G., Kolodgie F.D., Hajjar R.J., et al. Apoptosis in myocytes in end-stage heart failure. New England Journal of Medicine 1996, 335:1182-1189.
294. Narula J., Pandey P., Arbustini E., Haider N., Narula N., Kolodgie F.D., et al. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:8144-8149.
295. Navarro A., Boveris A. The mitochondrial energy transduction system and the aging process. American Journal of Physiology: Cell Physiology 2007, 292:C670-C686.
296. Nemoto S., Combs C.A., French S., Ahn B.H., Fergusson M.M., Balaban R.S., et al. The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism. Journal of Biological Chemistry 2006, 281:10555-10560.
297. Nickson P., Toth A., Erhardt P. PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress. Cardiovascular Research 2007, 73:48-56.
298. Nitahara J.A., Cheng W., Liu Y., Li B., Leri A., Li P., et al. Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats. Journal of Molecular and Cellular Cardiology 1998, 30:519-535.
299. Norton J.D. Id helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. Journal of Cell Science 2000, 113(Pt 22):3897-3905.
300. Norton J.D., Atherton G.T. Coupling of cell growth control and apoptosis functions of Id proteins. Molecular and Cellular Biology 1998, 18:2371-2381.
301. Norton J.D., Deed R.W., Craggs G., Sablitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends in Cell Biology 1998, 8:58-65.
302. Nussbacher A., Gerstenblith G., O'Connor F.C., Becker L.C., Kass D.A., Schulman S.P., et al. Hemodynamic effects of unloading the old heart. American Journal of Physiology 1999, 277:H1863-H1871.
303. Oakes S.A., Lin S.S., Bassik M.C. The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Current Molecular Medicine 2006, 6:99-109.
304. Oakes S.A., Scorrano L., Opferman J.T., Bassik M.C., Nishino M., Pozzan T., et al. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:105-110.
305. Obreztchikova M., Elouardighi H., Ho M., Wilson B.A., Gertsberg Z., Steinberg S.F. Distinct signaling functions for Shc isoforms in the heart. Journal of Biological Chemistry 2006, 281:20197-20204.
306. Ogata T., Machida S., Oishi Y., Higuchi M., Muraoka I. Differential cell death regulation between adult-unloaded and aged rat soleus muscle. Mechanisms of Ageing and Development 2009, 130:328-336.
307. Olivetti G., Abbi R., Quaini F., Kajstura J., Cheng W., Nitahara J.A., et al. Apoptosis in the failing human heart. New England Journal of Medicine 1997, 336:1131-1141.
308. Olivetti G., Giordano G., Corradi D., Melissari M., Lagrasta C., Gambert S.R., et al. Gender differences and aging: Effects on the human heart. Journal of the American College of Cardiology 1995, 26:1068-1079.
309. Olivetti G., Melissari M., Capasso J.M., Anversa P. Cardiomyopathy of the aging human heart: Myocyte loss and reactive cellular hypertrophy. Circulation Research 1991, 68:1560-1568.
310. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993, 74:609-619.
311. Orsini F., Migliaccio E., Moroni M., Contursi C., Raker V.A., Piccini D., et al. The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. Journal of Biological Chemistry 2004, 279:25689-25695.
312. Orsini F., Moroni M., Contursi C., Yano M., Pelicci P., Giorgio M., et al. Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc. Biological Chemistry 2006, 387:1405-1410.
313. Oyadomari S., Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death and Differentiation 2004, 11:381-389.
314. Ozawa T. Mechanism of somatic mitochondrial DNA mutations associated with age and diseases. Biochimica et Biophys Acta 1995, 1271:177-189.
315. Parise G., Yarasheski K.E. The utility of resistance exercise training and amino acid supplementation for reversing age-associated decrements in muscle protein mass and function. Current Opinion in Clinical Nutrition and Metabolic Care 2000, 3:489-495.
316. Parise G., Phillips S.M., Kaczor J.J., Tarnopolsky M.A. Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radical Biology & Medicine 2005, 39:289-295.
317. Park S.K., Prolla T.A. Gene expression profiling studies of aging in cardiac and skeletal muscles. Cardiovascular Research 2005, 66:205-212.
318. Pedersen M., Bruunsgaard H., Weis N., Hendel H.W., Andreassen B.U., Eldrup E., et al. Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mechanisms of Ageing and Development 2003, 124:495-502.
319. Periasamy M., Kalyanasundaram A. SERCA pump isoforms: Their role in calcium transport and disease. Muscle & Nerve 2007, 35:430-442.
320. Petersen K.F., Befroy D., Dufour S., Dziura J., Ariyan C., Rothman D.L., et al. Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 2003, 300:1140-1142.
321. Peterson J.M., Bryner R.W., Sindler A., Frisbee J.C., Alway S.E. Mitochondrial apoptotic signaling is elevated in cardiac but not skeletal muscle in the obese Zucker rat and is reduced with aerobic exercise. Journal of Applied Physiology 2008, 105:1934-1943.
322. Petronilli V., Penzo D., Scorrano L., Bernardi P., Di Lisa F. The mitochondrial permeability transition, release of cytochrome c and cell death: Correlation with the duration of pore openings in situ. Journal of Biological Chemistry 2001, 276:12030-12034.
323. Phaneuf S., Leeuwenburgh C. Cytochrome c release from mitochondria in the aging heart: A possible mechanism for apoptosis with age. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2002, 282:R423-R430.
324. Phelan J.N., Gonyea W.J. Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anatomical Record 1997, 247:179-188.
325. Phillips T., Leeuwenburgh C. Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB Journal 2005, 19:668-670.
326. Pietrangelo T., Puglielli C., Mancinelli R., Beccafico S., Fano G., Fulle S. Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology 2009, 44:523-531.
327. Pinton P., Rimessi A., Marchi S., Orsini F., Migliaccio E., Giorgio M., et al. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science 2007, 315:659-663.
328. Pistilli E.E., Alway S.E. Systemic elevation of interleukin-15 in vivo promotes apoptosis in skeletal muscles of young adult and aged rats. Biochemical and Biophysical Research Communications 2008, 373:20-24.
329. Pistilli E.E., Jackson J.R., Alway S.E. Death receptor-associated pro-apoptotic signaling in aged skeletal muscle. Apoptosis: An International Journal on Programmed Cell Death 2006, 11:2115-2126.
330. Pistilli E.E., Siu P.M., Alway S.E. Molecular regulation of apoptosis in fast plantaris muscles of aged rats. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2006, 61:245-255.
331. Pistilli E.E., Siu P.M., Alway S.E. Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy. American Journal of Physiology: Cell Physiology 2007, 292:C1298-C1304.
332. Plant P.J., Bain J.R., Correa J.E., Woo M., Batt J. Absence of caspase-3 protects against denervation-induced skeletal muscle atrophy. Journal of Applied Physiology 2009, 107:224-234.
333. Podhorska-Okolow M., Krajewska B., Carraro U., Zabel M. Apoptosis in mouse skeletal muscles after physical exercise. Folia Histochemica et Cytobiologica/Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1999, 37:127-128.
334. Podhorska-Okolow M., Sandri M., Zampieri S., Brun B., Rossini K., Carraro U. Apoptosis of myofibres and satellite cells: Exercise-induced damage in skeletal muscle of the mouse. Neuropathology and Applied Neurobiology 1998, 24:518-531.
335. Pollack M., Phaneuf S., Dirks A., Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Annals of the New York Academy of Sciences 2002, 959:93-107.
336. Powers S.K., Kavazis A.N., Deruisseau K.C. Mechanisms of disuse muscle atrophy: Role of oxidative stress. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2005, 288:R337-R344.
337. Precht T.A., Phelps R.A., Linseman D.A., Butts B.D., Le S.S., Laessig T.A., et al. The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis. Cell Death and Differentiation 2005, 12:255-265.
338. Primeau A.J., Adhihetty P.J., Hood D.A. Apoptosis in heart and skeletal muscle. Canadian Journal of Applied Physiology 2002, 27:349-395.
339. Puzianowska-Kuznicka M., Kuznicki J. The ER and ageing. II. Calcium homeostasis. Ageing Research Reviews 2009, 8:160-172.
340. Quindry J., French J., Hamilton K., Lee Y., Mehta J.L., Powers S. Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals. Experimental Gerontology 2005, 40:416-425.
341. Rasmussen U.F., Krustrup P., Kjaer M., Rasmussen H.N. Human skeletal muscle mitochondrial metabolism in youth and senescence: No signs of functional changes in ATP formation and mitochondrial oxidative capacity. Pflügers Archiv: European Journal of Physiology 2003, 446:270-278.
342. Rasola A., Bernardi P. The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis. Apoptosis: An International Journal on Programmed Cell Death 2007, 12:815-833.
343. Reed J.C. Double identity for proteins of the Bcl-2 family. Nature 1997, 387:773-776.
344. Reed J.C. Proapoptotic multidomain Bcl-2/Bax-family proteins: Mechanisms, physiological roles, and therapeutic opportunities. Cell Death and Differentiation 2006, 13:1378-1386.
345. Reed J.C., Jurgensmeier J.M., Matsuyama S. Bcl-2 family proteins and mitochondria. Biochimica et Biophys Acta 1998, 1366:127-137.
346. Renault V., Thornell L.E., Eriksson P.O., Butler-Browne G., Mouly V. Regenerative potential of human skeletal muscle during aging. Aging Cell 2002, 1:132-139.
347. Ricci C., Pastukh V., Mozaffari M., Schaffer S.W. Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian Journal of Physiology and Pharmacology 2007, 85:455-464.
348. Rice K.M., Blough E.R. Sarcopenia-related apoptosis is regulated differently in fast- and slow-twitch muscles of the aging F344/N × BN rat model. Mechanisms of Ageing and Development 2006, 127:670-679.
349. Rohrbach S., Gruenler S., Teschner M., Holtz J. The thioredoxin system in aging muscle: Key role of mitochondrial thioredoxin reductase in the protective effects of caloric restriction?. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2006, 291:R927-R935.
350. Roman W.J., Fleckenstein J., Stray-Gundersen J., Alway S.E., Peshock R., Gonyea W.J. Adaptations in the elbow flexors of elderly males after heavy-resistance training. Journal of Applied Physiology 1993, 74:750-754.
351. Rooyackers O.E., Adey D.B., Ades P.A., Nair K.S. Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:15364-15369.
352. Rosenblatt J.D., Yong D., Parry D.J. Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle & Nerve 1994, 17:608-613.
353. Rota M., LeCapitaine N., Hosoda T., Boni A., De Angelis A., Padin-Iruegas M.E., et al. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circulation Research 2006, 99:42-52.
354. Ryan M.J., Dudash H.J., Docherty M., Geronilla K.B., Baker B.A., HaffG.G., et al. Aging-dependent regulation of antioxidant enzymes and redox status in chronically loaded rat dorsiflexor muscles. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2008, 63:1015-1026.
355. Sandmand M., Bruunsgaard H., Kemp K., Andersen-Ranberg K., Schroll M., Jeune B. High circulating levels of tumor necrosis factor-alpha in centenarians are not associated with increased production in T lymphocytes. Gerontology 2003, 49:155-160.
356. Sandri M., Carraro U. Apoptosis of skeletal muscles during development and disease. International Journal of Biochemistry and Cell Biology 1999, 31:1373-1390.
357. Sandri M., Podhorska-Okolow M., Geromel V., Rizzi C., Arslan P., Franceschi C., et al. Exercise induces myonuclear ubiquitination and apoptosis in dystrophin-deficient muscle of mice. Journal of Neuropathology and Experimental Neurology 1997, 56:45-57.
358. Sanges D., Marigo V. Cross-talk between two apoptotic pathways activated by endoplasmic reticulum stress: Differential contribution of caspase-12 and AIF. Apoptosis: An International Journal on Programmed Cell Death 2006, 11:1629-1641.
359. Sanna M.G., da Silva C.J., Ducrey O., Lee J., Nomoto K., Schrantz N., et al. IAP suppression of apoptosis involves distinct mechanisms: The TAK1/JNK1 signaling cascade and caspase inhibition. Molecular and Cellular Biology 2002, 22:1754-1766.
360. Saris N.E., Carafoli E. A historical review of cellular calcium handling, with emphasis on mitochondria. Biochemistry (Moscow) 2005, 70:187-194.
361. Sastre J., Asensi M., Gasco E., Pallardo F.V., Ferrero J.A., Furukawa T., Vina J. Exhaustive physical exercise causes oxidation of glutathione status in blood: Prevention by antioxidant administration. American Journal of Physiology 1992, 263:R992-R995.
362. Sastre J., Borras C., Garcia-Sala D., Lloret A., Pallardo F.V., Vina J. Mitochondrial damage in aging and apoptosis. Annals of the New York Academy of Sciences 2002, 959:448-451.
363. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO Journal 1998, 17:1675-1687.
364. Schaap L.A., Pluijm S.M., Deeg D.J., Harris T.B., Kritchevsky S.B., Newman A.B., et al. Higher inflammatory marker levels in older persons: Associations with 5-year change in muscle mass and muscle strength. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2009, 64:1183-1189.
365. Schaap L.A., Pluijm S.M., Deeg D.J., Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. American Journal of Medicine 2006, 119:517-526.
366. Schmutz S., Dapp C., Wittwer M., Durieux A.C., Mueller M., Weinstein F., et al. A hypoxia complement differentiates the muscle response to endurance exercise. Experimental Physiology 2010, in press.
367. Schroder M. Endoplasmic reticulum stress responses. Cellular and Molecular Life Sciences 2008, 65:862-894.
368. Schultz E. Satellite cell behavior during skeletal muscle growth and regeneration. Medicine Science Sports and Exercise 1989, 21:S181-S186.
369. Schultz E. Satellite cell proliferative compartments in growing skeletal muscles. Developmental Biology 1996, 175:84-94.
370. Schultz E., McCormick K.M. Skeletal muscle satellite cells. Reviews of Physiology, Biochemistry and Pharmacology 1994, 123:213-257.
371. Schultz E., Darr K.C., Macius A. Acute effects of hindlimb unweighting on satellite cells of growing skeletal muscle. Journal of Applied Physiology 1994, 76:266-270.
372. Seidman A., Hudis C., Pierri M.K., Shak S., Paton V., Ashby M., et al. Cardiac dysfunction in the trastuzumab clinical trials experience. Journal of Clinical Oncology 2002, 20:1215-1221.
373. Semba R.D., Ferrucci L., Sun K., Walston J., Varadhan R., Guralnik J.M., et al. Oxidative stress and severe walking disability among older women. American Journal of Medicine 2007, 120:1084-1089.
374. Senoo-Matsuda N., Hartman P.S., Akatsuka A., Yoshimura S., Ishii N. A complex II defect affects mitochondrial structure, leading to ced-3-and ced-4-dependent apoptosis and aging. Journal of Biological Chemistry 2003, 278:22031-22036.
375. Seo A.Y., Xu J., Servais S., Hofer T., Marzetti E., Wohlgemuth S.E., et al. Mitochondrial iron accumulation with age and functional consequences. Aging Cell 2008, 7:706-716.
376. Shaltouki A., Freer M., Mei Y., Weyman C.M. Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation. Apoptosis: An International Journal on Programmed Cell Death 2007, 12:2143-2154.
377. Shi Y. Apoptosome: The cellular engine for the activation of caspase-9. Structure (London, England: 1993) 2002, 10:285-288.
378. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Molecular and Cellular Biology 2002, 9:459-470.
379. Shi Y. Caspase activation, inhibition, and reactivation: A mechanistic view. Protein Science: A Publication of the Protein Society 2004, 13:1979-1987.
380. Shigenaga M.K., Hagen T.M., Ames B.N. Oxidative damage and mitochondrial decay in aging. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:10771-10778.
381. Shih V.F., Kearns J.D., Basak S., Savinova O.V., Ghosh G., Hoffmann A. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:9619-9624.
382. Shimizu S., Narita M., Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999, 399:483-487.
383. Shiozaki E.N., Shi Y. Caspases, IAPs and Smac/DIABLO: Mechanisms from structural biology. Trends in Biochemical Sciences 2004, 29:486-494.
384. Short K.R., Bigelow M.L., Kahl J., Singh R., Coenen-Schimke J., Raghavakaimal S., et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:5618-5623.
385. Simic G. Pathogenesis of proximal autosomal recessive spinal muscular atrophy. Acta Neuropathology (Berlin) 2008, 116:223-234.
386. Simic G., Seso-Simic D., Lucassen P.J., Islam A., Krsnik Z., Cviko A., et al. Ultrastructural analysis and TUNEL demonstrate motor neuron apoptosis in Werdnig-Hoffmann disease. Journal of Neuropathology and Experimental Neurology 2000, 59:398-407.
387. Siu P.M. Muscle apoptotic response to denervation, disuse, and aging. Medicine Science Sports and Exercise 2009, 41:1876-1886.
388. Siu P.M., Alway S.E. Id2 and p53 participate in apoptosis during unloading-induced muscle atrophy. American Journal of Physiology: Cell Physiology 2005, 288:C1058-C1073.
389. Siu P.M., Alway S.E. Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle. Journal of Physiology 2005, 565:309-323.
390. Siu P.M., Alway S.E. Aging alters the reduction of pro-apoptotic signaling in response to loading-induced hypertrophy. Experimental Gerontology 2006, 41:175-188.
391. Siu P.M., Alway S.E. Deficiency of the Bax gene attenuates denervation-induced apoptosis. Apoptosis: An International Journal on Programmed Cell Death 2006, 11:967-981.
392. Siu P.M., Alway S.E. Response and adaptation of skeletal muscle to denervation stress: The role of apoptosis in muscle loss. Frontiers in Bioscience 2009, 14:432-452.
393. Siu P.M., Bae S., Bodyak N., Rigor D.L., Kang P.M. Response of caspase-independent apoptotic factors to high salt diet-induced heart failure. Journal of Molecular and Cellular Cardiology 2007, 42(678-686).
394. Siu P.M., Bryner R.W., Martyn J.K., Alway S.E. Apoptotic adaptations from exercise training in skeletal and cardiac muscles. FASEB Journal 2004, 18:1150-1152.
395. Siu P.M., Pistilli E.E., Alway S.E. Apoptotic responses to hindlimb suspension in gastrocnemius muscles from young adult and aged rats. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2005, 289:R1015-R1026.
396. Siu P.M., Pistilli E.E., Alway S.E. Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. Journal of Applied Physiology 2008, 105:1695-1705.
397. Siu P.M., Pistilli E.E., Butler D.C., Alway S.E. Aging influences cellular and molecular responses of apoptosis to skeletal muscle unloading. American Journal of Physiology: Cell Physiology 2005, 288:C338-C349.
398. Siu P.M., Pistilli E.E., Murlasits Z., Alway S.E. Hindlimb unloading increases muscle content of cytosolic but not nuclear Id2 and p53 proteins in young adult and aged rats. Journal of Applied Physiology 2006, 100:907-916.
399. Siu P.M., Pistilli E.E., Ryan M.J., Alway S.E. Aging sustains the hypertrophy-associated elevation of apoptotic suppressor X-linked inhibitor of apoptosis protein (XIAP) in skeletal muscle during unloading. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2005, 60:976-983.
400. Smith M.I., Huang Y.Y., Deshmukh M. Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. PLoS ONE 2009, 4:e5097.
401. Song W., Kwak H.B., Lawler J.M. Exercise training attenuates age-induced changes in apoptotic signaling in rat skeletal muscle. Antioxidants & Redox Signaling 2006, 8:517-528.
402. Spierings D., McStay G., Saleh M., Bender C., Chipuk J., Maurer U., Green D.R. Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis. Science 2005, 310:66-67.
403. Sprick M.R., Walczak H. The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochimica et Biophys Acta 2004, 1644:125-132.
404. Stennicke H.R., Salvesen G.S. Catalytic properties of the caspases. Cell Death and Differentiation 1999, 6:1054-1059.
405. Stennicke H.R., Deveraux Q.L., Humke E.W., Reed J.C., Dixit V.M., Salvesen G.S. Caspase-9 can be activated without proteolytic processing. Journal of Biological Chemistry 1999, 274:8359-8362.
406. Sulston J.E., Horvitz H.R. Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Developmental Biology 1977, 56:110-156.
407. Sun X.M., MacFarlane M., Zhuang J., Wolf B.B., Green D.R., Cohen G.M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. Journal of Biological Chemistry 1999, 274:5053-5060.
408. Suzuki Y., Takahashi-Niki K., Akagi T., Hashikawa T., Takahashi R. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death and Differentiation 2004, 11:208-216.
409. Szegezdi E., Duffy A., O'Mahoney M.E., Logue S.E., Mylotte L.A., O'Brien T., Samali A. ER stress contributes to ischemia-induced cardiomyocyte apoptosis. Biochemical and Biophysical Research Communications 2006, 349:1406-1411.
410. Szegezdi E., Logue S.E., Gorman A.M., Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Reports 2006, 7:880-885.
411. Szegezdi E., Macdonald D.C., Ni C.T., Gupta S., Samali A. Bcl-2 family on guard at the ER. American Journal of Physiology: Cell Physiology 2009, 296:C941-C953.
412. Tamaki T., Uchiyama S., Uchiyama Y., Akatsuka A., Yoshimura S., Roy R.R., et al. Limited myogenic response to a single bout of weight-lifting exercise in old rats. American Journal of Physiology: Cell Physiology 2000, 278:C1143-C1152.
413. Tarnopolsky M.A. Mitochondrial DNA shifting in older adults following resistance exercise training. Applied Physiology, Nutrition and Metabolism 2009, 34:348-354.
414. Terman A., Brunk U.T. Myocyte aging and mitochondrial turnover. Experimental Gerontology 2004, 39:701-705.
415. Terman A., Gustafsson B., Brunk U.T. Mitochondrial damage and intralysosomal degradation in cellular aging. Molecular Aspects of Medicine 2006, 27:471-482.
416. Tews D.S. Apoptosis and muscle fibre loss in neuromuscular disorders. Neuromuscular Disorders 2002, 12:613-622.
417. Tews D.S. Muscle-fiber apoptosis in neuromuscular diseases. Muscle & Nerve 2005, 32:443-458.
418. 2+ handling but enhances oxidative damage in senescent rat skeletal muscle. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2010, in press.
419. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 1995, 267:1456-1462.
420. Thompson L.V., Durand D., Fugere N.A., Ferrington D.A. Myosin and actin expression and oxidation in aging muscle. Journal of Applied Physiology 2006, 101:1581-1587.
421. Tonkonogi M., Fernstrom M., Walsh B., Ji L.L., Rooyackers O., Hammarqvist F., et al. Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans. Pflügers Archiv: European Journal of Physiology 2003, 446:261-269.
422. Torella D., Rota M., Nurzynska D., Musso E., Monsen A., Shiraishi I., et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circulation Research 2004, 94:514-524.
423. Tsujimoto Y., Shimizu S. VDAC regulation by the Bcl-2 family of proteins. Cell Death and Differentiation 2000, 7:1174-1181.
424. Tsujimoto Y., Nakagawa T., Shimizu S. Mitochondrial membrane permeability transition and cell death. Biochimica et Biophys Acta 2006, 1757:1297-1300.
425. Vallabhapurapu S., Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annual Review of Immunology 2009, 27:693-733.
426. Vescovo G., Dalla L.L. Skeletal muscle apoptosis in experimental heart failure: The only link between inflammation and skeletal muscle wastage?. Current Opinion in Clinical Nutrition and Metabolic Care 2006, 9:416-422.
427. Vescovo G., Volterrani M., Zennaro R., Sandri M., Ceconi C., Lorusso R., et al. Apoptosis in the skeletal muscle of patients with heart failure: Investigation of clinical and biochemical changes. Heart 2000, 84:431-437.
428. Visser M., Pahor M., Taaffe D.R., Goodpaster B.H., Simonsick E.M., Newman A.B., et al. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study. Journals of Gerontology, Series A, Biological Sciences and Medical Sciences 2002, 57:M326-M332.
429. Wajant H. The role of TNF in cancer. Results and Problems in Cell Differentiation 2009, 49:1-15.
430. Wajant H., Pfizenmaier K., Scheurich P. Tumor necrosis factor signaling. Cell Death and Differentiation 2003, 10:45-65.
431. Wallace D.C. Mitochondrial defects in cardiomyopathy and neuromuscular disease. American Heart Journal 2000, 139:S70-S85.
432. Wallace D.C. A mitochondrial paradigm for degenerative diseases and ageing. Novartis Foundation Symposium 2001, 235:247-263.
433. Wallace D.C., Fan W. The pathophysiology of mitochondrial disease as modeled in the mouse. Genes & Development 2009, 23:1714-1736.
434. Wallace D.C., Shoffner J.M., Trounce I., Brown M.D., Ballinger S.W., Corral-Debrinski M., et al. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochimica et Biophys Acta 1995, 1271:141-151.
435. Wang P., Qiu W., Dudgeon C., Liu H., Huang C., Zambetti G.P., et al. PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death and Differentiation 2009, 16:1192-1202.
436. Wang W., Fang H., Groom L., Cheng A., Zhang W., Liu J., et al. Superoxide flashes in single mitochondria. Cell 2008, 134:279-290.
437. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., et al. Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 2001, 292:727-730.
438. Wei Y.H., Lee H.C. Oxidative stress, mitochondrial DNA mutation, and impairment of antioxidant enzymes in aging. Experimental Biology and Medicine (Maywood, NJ) 2002, 227:671-682.
439. Welle S., Thornton C., Statt M. Myofibrillar protein synthesis in young and old human subjects after three months of resistance training. American Journal of Physiology 1995, 268:E422-E427.
440. Wencker D., Chandra M., Nguyen K., Miao W., Garantziotis S., Factor S.M., et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. Journal of Clinical Investigation 2003, 111:1497-1504.
441. Williams G.T. Programmed cell death: Apoptosis and oncogenesis. Cell 1991, 65:1097-1098.
442. Williamson C.L., Dabkowski E.R., Baseler W.A., Croston T.L., Alway S.E., Hollander J.M. Enhanced apoptotic propensity in diabetic cardiac mitochondria: Influence of subcellular spatial location. American Journal of Physiology: Heart and Circulatory Physiology 2010, 298:H633-H642.
443. Wohlgemuth S.E., Seo A.Y., Marzetti E., Lees H.A., Leeuwenburgh C. Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise. Experimental Gerontology 2010, 45:138-148.
444. Wolter K.G., Hsu Y.T., Smith C.L., Nechushtan A., Xi X.G., Youle R.J. Movement of Bax from the cytosol to mitochondria during apoptosis. Journal of Cell Biology 1997, 139:1281-1292.
445. Yan L., Vatner D.E., O'Connor J.P., Ivessa A., Ge H., Chen W., et al. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 2007, 130:247-258.
446. Yang F., Yang Y.P., Mao C.J., Cao B.Y., Cai Z.L., Shi J.J., et al. Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human alpha-synuclein. Neuroscience Letters 2009, 454:203-208.
447. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., et al. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 1997, 275:1129-1132.
448. Yaoita H., Ogawa K., Maehara K., Maruyama Y. Attenuation of ischemia/reperfusion injury in rats by a caspase inhibitor. Circulation 1998, 97:276-281.
449. Ye H., Cande C., Stephanou N.C., Jiang S., Gurbuxani S., Larochette N., et al. DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nature Structural Biology 2002, 9:680-684.
450. 2 modulates the ability to activate the plasma membrane Ca-ATPase. Chemical Research in Toxicology 2000, 13:103-110.
451. Yin X.M., Oltvai Z.N., Korsmeyer S.J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994, 369:321-323.
452. Yu J., Zhang L. PUMA, a potent killer with or without p53. Oncogene 2008, 27(Suppl. 1):S71-S83.
453. Yu J.W., Jeffrey P.D., Shi Y. Mechanism of procaspase-8 activation by c-FLIPL. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:8169-8174.
454. Yuan J. Evolutionary conservation of a genetic pathway of programmed cell death. Journal of Cellular Biochemistry 1996, 60:4-11.
455. Yuan J., Yankner B.A. Apoptosis in the nervous system. Nature 2000, 407:802-809.
456. Yue T.L., Ma X.L., Wang X., Romanic A.M., Liu G.L., Louden C., et al. Possible involvement of stress-activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion-induced cardiomyocyte apoptosis by carvedilol. Circulation Research 1998, 82:166-174.
457. Zha H., Aimé-Sempé C., Sato T., Reed J.C. Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. Journal of Biological Chemistry 1996, 271:7440-7444.
458. Zhang X.P., Vatner S.F., Shen Y.T., Rossi F., Tian Y., Peppas A., et al. Increased apoptosis and myocyte enlargement with decreased cardiac mass: Distinctive features of the aging male, but not female, monkey heart. Journal of Molecular and Cellular Cardiology 2007, 43:487-491.
459. 2+ entry in aged skeletal muscle. Aging Cell 2008, 7:561-568.
460. Zheng J., Edelman S.W., Tharmarajah G., Walker D.W., Pletcher S.D., Seroude L. Differential patterns of apoptosis in response to aging in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:12083-12088.
461. Zhu W., Cowie A., Wasfy G.W., Penn L.Z., Leber B., Andrews D.W. Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. EMBO Journal 1996, 15:4130-4141.