Hemodynamic effects of unloading the old heart

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 277, Issue 5 46-5, 1999, Pages

  Nussbacher, Amit ^a,c   Gerstenblith, Gary ^b   O'Connor, Frances C ^a   Becker, Lewis C ^b   Kass, David A ^b   Schulman, Steven P ^b   Fleg, Jerome L ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Afterload; Aging; Exercise hemodynamics; Myocardial function; Preload

Indexed keywords

NITROPRUSSIDE SODIUM;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; HEART FUNCTION; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART OUTPUT; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

EID: 0032714470     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1999.277.5.h1863     Document Type: Article

References (34)

1. Anliker, M., M. B. Histand, and E. Ogden. Dispersion and attenuation of small artificial pressure waves in the canine aorta, Circ. Res. 23: 539-551, 1968.
2. Aronow, W. S., P. D. Stein, H. N. Sabbah, and M. Koenigsbeg. Resting left ventricular ejection fraction in elderly patients without evidence of heart disease. Am. J. Cardiol. 63: 368-369, 1989.
3. Avolio, A. P., S. G. Chen, R. P. Wang, C. L. Zhang, M. P. Li, and M. F. O'Rourke. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68: 50-58, 1983.
4. Bland, J. M., and D. G. Altman, Statistical methods for accessing agreement between two methods of clinical measurement. Lancet 1: 307-310, 1986.
5. Callaghan, F. J., L. A. Geddes, C. F. Babbs, and J. D. Bourland. Relationship between pulse-wave velocity and arterial elasticity. Med. Biol. Eng. Comput. 24: 248-254, 1986.
6. Carroll, J. D., S. Shroff, P. Wirth, M. Halsted, and S. I. Rajfer. Arterial mechanical properties in dilated eardiomyopathy. Aging and the response to nitroprusside. J. Clin. Invest. 87: 1002-1009, 1991.
7. Chen, C.-H., M. Nakayama, M. Talbot, E. Nevo, B. Fetics, G. Gerstenblith, L. C. Becker, and D. A. Kass. Verapamil acutely reduces ventricular-vascular stiffening and improves exercise performance in elderly individuals. J. Am. Coll. Cardiol. 33: 1602-1609, 1999.
8. Fitchett, D. H., G. J. Simkus, J. P. Beaudry, and D. G. F. Marpole. Reflected pressure waves in the ascending aorta: effect of glycerol trinitrate. Cardiovasc. Res. 22: 494-500, 1988.
9. Fleg, J. L., F. O'Connor, G. Gerstenblith, L. C. Becker, J. Clulow, S. P. Schulman, and E. G. Lakatta. Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women. J. Appl. Physiol. 78: 890-900, 1995.
10. Fleg, J. L., S. Schulman, F. C. O'Connor, L. C. Becker, G. Gerstenblith, J. F. Clulow, D. G. Renlund, and E. G. Lakatta. Effects of acute β-adrenergic receptor blockade on age-associated changes in cardiovascular performance during dynamic exercise. Circulation 90: 2333-2341, 1994.
11. Gerstenblith, G., J. Frederiksen, F. C. Yin, N. J. Fortuin, E. G. Lakatta, and M. L. Weisfeldt. Echocardiographic assessment of a normal adult aging population. Circulation 56: 273-278, 1977.
12. Kelly, R., C. Hayward, A. Avolio, and M. O'Rourke. Noninvasive determination of age-related changes in the human arterial pulse. Circulation 80: 1652-1659, 1989.
13. Kelly, R. P., H. H. Gibbs, M. F. O'Rourke, J. E. Daley, K. Mang, J. J. Morgan, and A. P. Avolio. Nitroglycerin has more favorable effects on left ventricular afterload than apparent from measurement of pressure in a peripheral artery. Eur. Heart J. 11: 138-144, 1990.
14. Kelly, R. P., C. T. T. Ting, T. M. Yang, C. P. Liu, W. L. Maughan, M. S. Chang, and D. A. Kass. Effective arterial elastance as index of vascular load in humans. Circulation 86: 513-521, 1992.
15. Lakatta, E. G. Cardiovascular regulatory mechanisms in advanced age. Physiol. Rev. 73: 413-467, 1993.
16. Lakatta, E. G. Deficient neuroendocrine regulation of the cardiovascular system with advancing age in healthy humans. Circulation 87: 631-636, 1993.
17. Lakatta, E. G. Length modulation of muscle performance: Frank-Starling law of the heart. In: The Heart and Cardiovascular System, edited by H. M. Fozzard, E. Haber, R. B. Jennings, A. M. Katz, and H. E. Morgan. New York: Raven, 1986, vol. 2, chapt. 40, p. 819-843.
18. Laskey, W. K., and W. G. Kussmaul. Arterial wave reflection in heart failure. Circulation 75: 711-722, 1987.
19. Latson, T. W., W. C. Hunter, N. Katoh, and K. Sagawa. Effect of nitroglycerin on aortic impedance, diameter and pulse wave velocity. Circ. Res. 62: 884-890, 1988.
20. Links, A. J., L. C. Becker, J. G. Shindledecker, P. Guzman, R. D. Burrow, E. L. Nickoloff, P. O. Alderson, and H. N. Wagner. Measurement of absolute left ventricular volume from gated blood pool studies. Circulation 65: 82-91, 1982.
21. Manyari, D. E., Z. Wang, J. Cohen, and J. V. Tyberg. Assessment of the human splanchnic venous volume-pressure relation using radionuclide plethysmography: effect of nitroglycerin. Circulation 87: 1142-1151, 1993.
22. Miletich, D. J., and A. D. Ivankovich. Sodium nitroprusside and cardiovascular hemodynamics. Int. Anesthesiol. Clin. 16: 31-49, 1978.
23. Miller, R. R., W. H. Fennell, J. B. Young, A. R. Palomo, and M. A. Quinones. Differential systemic arterial and venous actions and consequent cardiac effects of vasodilator drugs. Prog. Cardiouasc. Dis. 24: 353-374, 1982.
24. Murgo, J. P., N. Westerhof, J. P. Giolma, and S. A. Altobeli. Aortic input impedance in normal man: relationship to pressure wave forms. Circulation 62: 105-116, 1980.
25. Nichols, W. M., M. F. O'Rourke, A. P. Avolio, T. Yaginuma, J. P. Murgo, C. J. Pepine, and C. R. Conti. Effects of age on ventricular-vascular coupling. Am. J. Cardiol. 55: 1179-1184, 1985.
26. Oates, J. A. Antihypertensive agents and the drug therapy of hypertension. In: Goodman and Gilman's the Pharmacological Basis of Therapeutics (9th ed.), edited by J. G. Hardman, L. E. Limbrid, P. B. Molinoff, R. W. Ruddon, and A. G. Gilman. New York: McGraw Hill, 1996, p. 797-799.
27. Port, S., F. R. Cobb, R. E. Coleman, and R. H. Jones. Effect of age on the response of the left ventricular ejection fraction during exercise. N. Engl. J. Med. 303: 1133-1137, 1980.
28. Renlund, D., G. Gerstenblith, J. L. Fleg, L. C. Becker, and E. G. Lakatta. Interaction between left ventricular end-diastolic and end-systolic volumes in normal humans. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H473-H481, 1990.
29. Renlund, D. G., E. G. Lakatta, J. L. Fleg, L. C. Becker, J. F. Clulow, M. L. Weisfeldt, and G. Gerstenblith. Prolonged decrease in cardiac volumes after maximal upright bicycle exercise. J. Appl. Physiol. 63: 1947-1955, 1987.
30. Rodeheffer, R. J., G. Gerstenblith, L. C. Becker, J. L. Fleg, M. L. Weisfeldt, and E. G. Lakatta. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 69: 203-213, 1984.
31. Ross, J., Jr., J. W. Covell, E. H. Sonnenblick, and E. Braunwald. Contractile state of the heart characterized by force-velocity relations in variably afterloaded and isovolumic beats. Circ. Res. 18: 149-163, 1966.
32. Vaitkevicius, P. V., J. L. Fleg, J. H. Engel, F. C. O'Connor, J. G. Wright, L. E. Lakatta, F. C. P. Yin, and E. G. Lakatta. Effects of age and aerobic capacity on arterial stiffness in healthy adults. Circulation 88: 1456-1462, 1993.
33. Yaginuma, T., A. Avolio, M. O'Rourke, W. Nichols, J. J. Morgan, P. Roy, D. Baron, J. Branson, and M. Feneley. Effect of glycerol trinitrate on peripheral arteries alters left ventricular hydraulic load in man. Cardiovasc. Res. 20: 153-160, 1986.
34. Yin, F. C. P., G. S. Raizes, T. Guarnieri, H. A. Spurgeon, E. G. Lakatta, N. J. Fortuin, and M. L. Weisfeldt. Age-associated decrease in ventricular response to haemodynamic stress during β-adrenergic blockade. Br. Heart J. 40: 1349-1355, 1978.