Increased myogenic repressor Id mRNA and protein levels in hindlimb muscles of aged rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 282, Issue 2 51-2, 2002, Pages

  Alway, Stephen E ^a,b,c   Degens, Hans ^a,b,c   Lowe, Dawn A ^a,b,c   Krishnamurthy, Gururaj ^a,b,c  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

E proteins; Muscle atrophy; Repressors of transcription; Sarcopenia; Transcription factors

Indexed keywords

CYCLOPHILIN; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; MESSENGER RNA; MYOD1 PROTEIN; MYOGENIC FACTOR; MYOGENIN; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AGED; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; GASTROCNEMIUS MUSCLE; GENE AMPLIFICATION; GENE CONTROL; GENETIC TRANSCRIPTION; HINDLIMB; MALE; MUSCLE ATROPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANTARIS MUSCLE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; SOLEUS MUSCLE;

EID: 0036081474     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00332.2001     Document Type: Article

References (42)

1. Overload-induced C-Myc oncoprotein is reduced in aged skeletal muscle
2. The effects of age and hindlimb suspension on the levels of expression of the myogenic regulatory factors MyoD and myogenin in rat fast and slow skeletal muscles
3. Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats. Relation to the number of soleus muscle fibers
4. Spatial distribution of motor unit fibres in fast- and slow-twitch rat muscles with special reference to age
5. Id: A negative regulator of helix-loop-helix DNA binding proteins. Control of terminal myogenic differentiation
6. The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
7. Lack of skeletal muscle hypertrophy in very aged male Fischer 344 × Brown Norway rats
8. Muscle determination: Another key player in myogenesis?
9. Helix-loop-helix transcription factors in electrically active and inactive skeletal muscles
10. Myogenin mRNA is elevated during rapid, slow, and maintenance phases of stretch-induced hypertrophy in chicken slow-tonic muscle
11. Inhibition of muscle-specific gene expression by Id3: Requirement of the C-terminal region of the protein for stable expression and function
12. A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats
13. Clenbuterol reduces soleus muscle fatigue during disuse in aged rats
14. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene
15. Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise
16. Functional and metabolic consequences of sarcopenia
17. What is sarcopenia?
18. Sarcopenia and age-related changes in body composition and functional capacity
19. The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist
20. Repression of muscle-specific gene activation by the murine Twist protein
21. Overexpression of Id protein inhibits the muscle differentiation program: In vivo association of Id with E2A proteins
22. Helix-loop-helix proteins in the regulation of immunoglobulin gene transcription
23. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors
24. Motor units: Remodeling in aged animals
25. The rat Mist1 gene: Structure and promoter characterization
26. The basic helix-loop-helix transcription factor Mistl functions as a transcriptional repressor of myoD
27. Regulation of the mouse desmin gene: Transactivated by MyoD, myogenin, MRF4 and Myf5
28. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein
29. Stretch-induced myogenin, MyoD, and MRF4 expression and acute hypertrophy in quail slow-tonic muscle are not dependent upon satellite cell proliferation
30. Glyceraldehyde-3-phosphate dehydrogenase varies with age in glycolytic muscles of rats
31. Hypertrophy-stimulated myogenic regulatory factor mRNA increases are attenuated in fast muscle of aged quails
32. Protein synthesis and degradation during aging and senescence
33. Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats
34. Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy
35. Myogenin, MyoD, and myosin heavy chain isoform expression following hindlimb suspension
36. Enhanced expression of myogenic regulatory genes in aging skeletal muscle
37. The effect of age on protein metabolism
38. Temporal expression of myogenic regulatory genes during activation, proliferation, and differentiation of rat skeletal muscle satellite cells
39. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
40. The myoD gene family: Nodal point during specification of the muscle cell lineage
41. Muscle-specific transcriptional activation by MyoD
42. Paired MyoD-binding sites regulate myosin light chain gene expression