Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats

Journal of Molecular and Cellular Cardiology

Volumn 30, Issue 3, 1998, Pages 519-535

  Nitahara, James A ^a   Cheng, Wei ^a   Liu, Yu ^a   Li, Baosheng ^a   Leri, Annarosa ^a   Li, Peng ^a   Mogul, Doug ^a   Gambert, Steven R ^a   Kajstura, Jan ^a   Anversa, Piero ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Bcl 2 and Bax expression in myocytes; Cytosolic Ca2+ transients; DNA laddering in myocytes; DNase I and DNase II; Intracellular pH; p53

Indexed keywords

CALCIUM ION; DEOXYRIBONUCLEASE I; DEOXYRIBONUCLEASE II; FURA 2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

AGING; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL PH; CONTROLLED STUDY; DIASTOLE; ENZYME ACTIVITY; FLUORESCENCE; GENE EXPRESSION; HEART MUSCLE CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT;

EID: 0032032941     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1997.0616     Document Type: Article

References (49)

1. ANVERSA P, HILER B, RICCI R, GUIDERI G, OLIVETTI G, 1986. Myocyte loss and myocyte hypertrophy in the aging rat heart. J Am Coll Cardiol 8: 1441-1448.
2. ANVERSA P, LI P, SONNENBLICK EH, OLIVETTI G, 1994. Effects of aging on quantitative structural properties of coronary vasculature and microvasculature in rats. Am J Physiol 267: H1062-H1073.
3. ATADJA P, WONG H, GARKAVTSEV I, VEILLETTE C, RIABOWOL K, 1995. Increased activity of p53 in senescing fibroblasts. Proc Natl Acad Sci USA 92: 8348-8352.
4. BARRY MA, EASTMAN A, 1993. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch Biochem Biophys 300: 440-450.
5. 2+ concentration and DNA fragmentation. Cancer Res 52: 1342-1346.
6. BORZAK S, KELLY RA, KRAMER BK, MATOBA Y, MARSH JD, REERS M, 1990. In situ calibration of fura-2 and BCECF fluorescence in adult rat ventricular myocytes. Am J Physiol 259: H973-H981.
7. CAPASSO JM, LI P, ANVERSA P, 1993. Cytosolic calcium transients in myocytes isolated from rats with ischemic heart failure. Am J Physiol 265: H1953-H1964.
8. 2+ homeostasis of cardiac myocytes. Circ Res 69: 540-550.
9. Ras in Ras-induced apoptosis. J Biol Chem 271: 2376-2379.
10. CHENG W, LI B, KAJSTURA J, WOLIN MS, SONNENBLICK EH, HINTZE TH, OLIVETTI G, ANVERSA P, 1995. Stretch-induced programmed myocyte cell death. J Clin Invest 96: 2247-2259.
11. CHENG W, KAJSTURA J, NITAHARA JA, LI B, REISS K, LIU Y, CLARK WA, KRAJEWSKI S, REED JC, OLIVETTI G, ANVERSA P, 1996. Programmed myocyte cell death affects the viable myocardium after infarction in rats. Exp Cell Res 226: 316-327.
12. 2+ ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ Res 66: 554-564.
13. 2+. Biochem Biophys Res Commun 181: 915-920.
14. GO LO, MOSCHELLA MC, WATRAS J, HANDA KK, FYFE BS, MARKS AR, 1995. Differential regulation of two types of intracellular calcium release channels during endstage heart failure. J Clin Invest 95: 888-894.
15. GOLD R, SCHMIED M, GIEGERICH G, BREITSCHOPE H, HARTUNG HP, TOYKA KV, LASSMANN H, 1995. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 71: 219-225.
16. GONG J, TRAGANOS F, DARZYNKIEWICZ Z, 1994. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem 218: 314-319.
17. GOTTLIEB E, HAFFNER R, VON RUDEN T, WAGNER EF, OREN M, 1994. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J 13: 1368-1374.
18. 2+ indicators with greatly improved fluorescent properties. J Biol Chem 260: 3440-3450.
19. GWATHMEY JK, MORGAN JP, 1985. Altered calcium handling in experimental pressure-overload hypertrophy in the ferret. Circ Res 57: 836-843.
20. HALDAR S, JENA N, CROCE CM, 1995. Inactivation of Bcl-2 by phosphorylation. Proc Natl Acad Sci USA 92: 4507-4511.
21. HOCKENBERY DM, OLTVAI ZN, YIN XM, MILLIMAN CL, KORSMEYER SJ, 1993. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75: 241-251.
22. JONES DP, MCCONKEY DJ, NICOTERA P, ORRENIUS S, 1989. Calcium-activated DNA fragmentation in rat liver nuclei. J Biol Chem 264: 6398-6403.
23. KAJSTURA J, CHENG W, SARANGARAJAN R, LI P, LI B, NITAHARA JA, CHAPNICK S, REISS K, OLIVETTI G, ANVERSA P, 1996a. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am J Physiol 271: H1215-H1228.
24. KAJSTURA J, CHENG W, REISS K, CLARK WA, SONNENBLICK EH, KRAJEWSKI S, REED JC, OLIVETTI G, ANVERSA P, 1996b. Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab Invest 74: 86-107.
25. 3 symport through a phosphoinositide-independent mechanism in cardiac cells. J Biol Chem 270: 20432-20438.
26. KOIZUMI T, 1995. Deoxyribonuclease II (DNase II) activity in mouse tissue and body fluids. Jikken Dobutsu 44: 169-171.
27. KRAJEWSKI S, BODRUG S, KRAJEWSKA M, SHABAIK A, GASCOYNE R, BEREAN K, REED JC, 1995. Immunohistochemical analysis of Mcl-1 protein in human tissue: differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo. Am J Pathol 146: 1309-1319.
28. KRAJEWSKI S, KRAJEWSKA M, REED JC, 1996. Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Res 56: 2849-2855.
29. LACKS AS, 1981. Deoxyribonuclease I in mammalian tissues. Specificity of inhibition by actin. J Biol Chem 256: 2644-2648.
30. LAKATTA EG, 1993. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73: 413-467.
31. LI P, PARK C, MICHELETTI R, LI B, CHENG W, SONNENBLICK EH, ANVERSA P, BIANCHI G, 1995. Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine. Am J Physiol 268: H1702-H1713.
32. LI Q, LI B, WANG X, LERI A, JANA KP, LIU Y, KAJSTURA J, BASERGA R, ANVERSA P, 1997. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress and cardiac hypertrophy. J Clin Invest 100: 1991-1999.
33. 2+. Oncogene 12: 2259-2266.
34. MIYASHITA T, REED JC, 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299.
35. i in perfused rabbit hearts. Circ Res 69: 1525-537.
36. MORGAN JP, ERNY RE, ALLEN PD, GROSSMAN W, GWATHMEY JK, 1990. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81: (Suppl. III): III-21-III-32.
37. MUNDLE SD, RAZA A, 1995. The two in situ techniques do not differentiate between apoptosis and necrosis but rather reveal distinct patterns of DNA fragmentation in apoptosis. Lab Invest 72: 611-612.
38. OLIVETTI G, MELISSARI M, CAPASSO JM, ANVERSA P, 1991. Cardiomyopathy of the aging human heart: myocyte loss and reactive cellular hypertrophy. Circ Res 68: 1560-1568.
39. OLIVETTI G, GIORDANO G, CORRADI D, MELISSARI M, LAGRASTA C, GAMBERT SR, ANVERSA P, 1995. Gender differences and aging: effects on the human heart. J Am Coll Cardiol 26: 1068-1079.
40. OLIVETTI G, ABBI R, QUAINI F, KAJSTURA J, CHENG W, NITAHARA JA, QUAINI E, DI LORETO C, BELTRAMI CA, KRAJEWSKI S, REED JC, ANVERSA P, 1997. Apoptosis in the failing human heart. N Engl J Med 336: 1131-1141.
41. QUAINI F, CIGOLA E, LAGRASTA C, SACCANI G, QUAINI E, ROSSI C, OLIVETTI G, ANVERSA P, 1994. End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. Circ Res 75: 1050-1063.
42. RAKUSAN K, FLANAGAN MF, GEVE T, SOUTHERN J, VAN PRAAGH R, 1992. Morphometry of human coronary capillaries during normal growth and the effects of age in left ventricular pressure overload hypertrophy. Circulation 86: 38-46.
43. REED JC, 1994. Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6.
44. SIRI FM, KRUEGER JW, NORDIN C, MING Z, ARONSON RS, 1991. Depressed intracellular calcium transients and contraction in myocytes from hypertrophied and failing guinea pig hearts. Am J Physiol 261: H514-H530.
45. SYMONDS H, KRALL L, REMINGTON L, SAENZ-ROBLES M, LOWE S, JACKS T, VAN DYKE T, 1994. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78: 703-711.
46. TILLY JL, HSUEH AJW, 1993. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J Cell Physiol 154: 519-526.
47. VOGELSTEIN B, KINZLER KW, 1992. p53 function and dysfunction. Cell 70: 523-526.
48. WANG H-G, RAPP UR, REED JC, 1996. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 629-638.
49. YAO M, KEOGH A, SPRATT P, DOS REMEDIOS C, KIEBLING PC, 1996. Elevated DNase I levels in human idiopathic dilated cardiomyopathy: an indicator of apoptosis? J Mol Cell Cardiol 28: 95-101.