Mitochondrial DNA mutations and apoptosis in mammalian aging

Cancer Research

Volumn 66, Issue 15, 2006, Pages 7386-7389

  Kujoth, Gregory C ^a   Leeuwenburgh, Christiaan ^b   Prolla, Tomas A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; TRANSFER RNA;

AGING; APOPTOSIS; CANCER; CARCINOGENICITY; CELL DEATH; CELL PROLIFERATION; CELL TYPE; DISEASE PREDISPOSITION; GENE EXPRESSION; GENE MUTATION; GENOME; HUMAN; MAMMAL; MITOCHONDRIAL GENETICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW; TRANSLATION INITIATION; TUMOR CELL; TUMOR GROWTH;

AGING; ANIMALS; APOPTOSIS; DNA, MITOCHONDRIAL; HUMANS; MICE; MUTATION; NEOPLASMS;

EID: 33747877025     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4670     Document Type: Review

References (29)

1. Munscher C, Muller-Hocker J, Kadenbach B. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biol Chem Hoppe Seyler 1993;374:1099-104.
2. Nekhaeva E, Bodyak ND, Kraytsberg Y, et al. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci U S A 2002;99:5521-6.
3. Khaidakov M, Heflich RH, Manjanatha MG, Myers MB, Aidoo A. Accumulation of point mutations in mitochondrial DNA of aging mice. Mutat Res 2003;526:1-7.
4. Michikawa Y, Mazzucchelli F, Bresolin N, Scarlato G, Attardi G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 1999;286:774-9.
5. Wang E, Wong A, Cortopassi G. The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat Res 1997;377:157-66.
6. Chomyn A, Attardi G. MtDNA mutations in aging and apoptosis. Biochem Biophys Res Commun 2003;304:519-29.
7. Wang Y, Michikawa Y, Mallidis C, et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 2001;98:4022-7.
8. Wanagat J, Cao Z, Pathare P, Aiken JM. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J 2001;15:322-32.
9. Taylor RW, Barron MJ, Borthwick GM, et al. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003;112:1351-60.
10. Kujoth GC, Hiona A, Pugh TD, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005;309:481-4.
11. Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004;429:417-23.
12. Trifunovic A, Hansson A, Wredenberg A, et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci U S A 2005;429:357-9.
13. Mott JL, Zhang D, Stevens M, Chang S, Denniger G, Zassenhaus HP. Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations. Mutat Res 2001;474:35-45.
14. Zheng W, Khrapko K, Coller HA, Thilly WG, Copeland WC. Origins of human mitochondrial point mutations as DNA polymerase γ-mediated errors. Mutat Res Epub 2006 [doi: 10.1016/j.mrfmmm.2005.12.012].
15. Mott JL, Zhang D, Freeman JC, Mikolajczak P, Chang SW, Zassenhaus HP. Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A. Biochem Biophys Res Commun 2004;319:1210-5.
16. Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 2005;122:221-33.
17. Barja G, Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J 2000;14:312-8.
18. Pamplona R, Barja G, Portero-Otin M. Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation? Ann N Y Acad Sci 2002;959:475-90.
19. Pamplona R, Portero-Otin M, Requena JR, Thorpe SR, Herrero A, Barja G. A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat. Mech Ageing Dev 1999;106:283-96.
20. Barja G. Free radicals and aging. Trends Neurosci 2004;27:595-600.
21. Gredilla R, Sanz A, Lopez-Torres M, Barja G. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart FASEB J 2001;15:1589-91.
22. Schriner SE, Linford NJ, Martin GM, et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005;308:1909-11.
23. Van Remmen H, Ikeno Y, Hamilton M, et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003;16:29-37.
24. Chang S, Multani AS, Cabrera NG, et al. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 2004;36:877-82.
25. Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer 2002;1:9.
26. Polyak K, Li Y, Zhu H, et al. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 1998;20:291-3.
27. Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG. High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet 2001;28:147-50.
28. Shidara Y, Yamagata K, Kanamori T, et al. Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis. Cancer Res 2005;65:1655-63.
29. Petros JA, Baumann AK, Ruiz-Pesini E, et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A 2005;102:719-24.