ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis

Journal of Cell Science

Volumn 113, Issue 22, 2000, Pages 3897-3905

  Norton, J D ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Cell cycle; Cell differentiation; Cell growth; Helix loop helix protein; Transcription factor; Tumorigenesis

Indexed keywords

HELIX LOOP HELIX PROTEIN; ONCOPROTEIN;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; BIOCHEMISTRY; CANCER INVASION; CARCINOGENESIS; CELL CYCLE; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL GROWTH; CELL IMMORTALIZATION; CELL LINE; CELL LINEAGE; CELL TYPE; CONTROLLED STUDY; DNA BINDING; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; IN VIVO STUDY; LYMPHOPOIESIS; MAMMAL; METASTASIS; METAZOON; MOLECULAR BIOLOGY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RODENT; TIME; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUMOR GROWTH;

ANIMALIA; MAMMALIA; METAZOA; MUS MUSCULUS; RODENTIA;

EID: 0034471262     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.113.22.3897     Document Type: Note

References (77)

1. Immortalisation of primary human keratinocytes by the helix-loop-helix protein, ID1
2. Id genes encoding inhibitors of transcription are expressed during in vitro astrocyte differentiation and in cell lines derived from astrocytic tumours
3. Id4 expression induces apoptosis in astrocytic cultures and is down-regulated by activation of the cAMP-dependent signal transduction pathway
4. Id genes in nervous system development
5. Notch signalling: Cell fate control and signal integration in development
6. Regulation of cell differentiation in C2C12 myoblasts by the ID3 helix-loop-helix protein
7. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
8. Relationships between extramacrochaetae and Notch signalling in Drosophila wing development
9. Dual role of extramacrochaetae in cell proliferation and differentiation during wing morphogensis in Drosophila
10. ID proteins control growth induction in mammalian cells
11. The protein ID - A negative regulator of helix-loop-helix DNA binding proteins
12. A human ID-like helix-loop-helix protein expressed during early development
13. Disruption of αβ but not γδ T cell development by overexpression of the helix-loop-helix protein ID3 in committed T cell progenitors
14. Degradation of ID proteins by the ubiquitin-proteasome pathway
15. Identification of a novel transcriptional activity of mammalian ID proteins
16. An ID-related helix-loop-helix protein encoded by a growth factor inducible gene
17. Differential expression of Id genes in multipotent myeloid progenitor cells: Id1 is induced by early and late-acting cytokines while Id2 is selectively induced by cytokines that drive terminal granulocytic differentiation
18. Nuclear localisation of ID protein through an E protein-mediated chaperone mechanisms
19. An immediate early human gene encodes an ID-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types
20. Regulation of ID3 cell cycle function by Cdk2-dependent phosphorylation
21. Structural organisation and chromosomal mapping of the human Id3 gene
22. Lymphoid-specific expression of the Id3 gene in hematopoietic cells: Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukaemia cells
23. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein, ID1
24. A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein, ID1
25. Extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins
26. Ectopic expression of E47 or E12 promotes the cell death of E2A-deficient lymphomas
27. ID2 promotes apoptosis by a novel mechanism independent of dimerisation to basic helix-loop-helix factors
28. The Drosophila extramacrochaetae locus, an antagonist of pro-neural genes that like these genes encodes a helix-loop-helix protein
29. Cdk2-dependent phosphorylation of ID2 modulates activity of E2A-related transcription factors
30. Id-related genes encoding HLH proteins are required for G1 progression and are repressed in senescent human fibroblasts
31. Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix-loop-helix factor, ID3
32. Identification of ID2 as a globin regulatory protein by representational difference analysis of K562 cells induced to express gamma-globin with a fungal compound
33. The helix-loop-helix protein ID2 enhances cell proliferation and binds to the Retinoblastoma protein
34. MIDA1, an ID-associated protein, has two distinct DNA binding activities that are converted by the association with Id1: A novel function of Id protein
35. MIDA1 is a sequence-specific DNA binding protein with novel DNA binding properties
36. Id2 expression increases with differentiation of human myeloid cells
37. Id gene expression as a key mediator of tumour cell biology
38. Genetic modification of human B cell development: B cell development is inhibited by the dominant negative helix-loop-helix factor, ID3
39. HLH proteins, fly neurogenesis and vertebrate myogenesis
40. Overexpression of ID with protein inhibits the muscle differentiation programme: In vivo association of ID with E2A proteins
41. Massive apoptosis of thymocytes in T cell deficient Id1 transgenic mice
42. The helix-loop-helix protein, ID2, is overexpressed in human pancreatic cancer
43. The ID4 HLH protein and the timing of oligodendrocyte differentiation
44. Differential interactions of ID proteins with basic helix-loop-helix transcription factors
45. ID2 specifically alters regulation of the cell cycle by tumour suppressor proteins
46. A role for ID1 in the aggressive phenotype and steroid response of human breast cancer cells
47. Helix-loop-helix proteins
48. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularisation of tumour xenografts
49. Regulation of the proneural gene achaete by helix-loop-helix proteins
50. Neural crest specification regulated by the helix-loop-helix repressor, ID2
51. Id1 and Id2 are overexpressed in pancreatic cancer and in dysplastic lesions in chronic pancreatitis
52. Helix-loop-helix proteins: Regulators of transcription in eukaryotic organisms
53. Differential biological activities of mammalian ID proteins in muscle cells
54. Functional antagonism between inhibitor of DNA binding (ID) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the promoter in adipocytes
55. Overexpression of the helix-loop-helix inhibitor protein, ID2, blocks T cell development at multiple stages
56. Co-expression of adenovirus E1A and ID proteins indices apoptosis in rat cells carrying p53 mutation
57. Coupling of cell growth control and apoptosis functions of ID proteins
58. ID helix-loop-helix proteins in cell growth and differentiation
59. Impaired immune responses and B cell proliferation in mice lacking the Id3 gene
60. Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukaemia cells
61. Regulation of G1 progression by E2A and ID helix-loop-helix proteins
62. Regulation of expression of the cyclin dependent kinase inhibitor p21 by E2A and ID proteins
63. E2A activity is induced during B cell activation to promote immunoglobulin class switch recombination
64. The expression pattern of Id4, a novel dominant negative helix-loop-helix protein is distinct from Id1, Id2 and Id3
65. Thymocyte selection is regulated by the helix-loop-helix inhibitor, ID3
66. Stage- and subcellular-specific expression of ID proteins in male germ and sertoli cells implicates distinct regulatory roles for ID proteins during meiosis, spermatogenesis and sertoli cell differentiation
67. CDK inhibitors: Positive and negative regulators of G1-phase progression
68. MIDA1, a protein associated with ID regulates cell growth
69. Constitutive expression of the Id1 gene impairs mouse B cell development
70. ID proteins, ID1 and ID2 selectively inhibit DNA binding by one class of helix-loop-helix proteins
71. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism
72. Transcription of the dominant negative helix-loop-helix protein ID1 is regulated by a protein complex containing the immediate early response gene, Egr-1
73. Forced expression of Id1 in the adult mouse small intestineal epithelium is associated with development of adenomas
74. High incidence of T cell tumours in E2A-null mice and E2A/Id1 double knock-out mice
75. ID helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF-ETS domain transcription factors
76. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor, ID2