Plasma cytokine profiles in elderly humans

Mechanisms of Ageing and Development

Volumn 124, Issue 4, 2003, Pages 487-493

  Forsey, R J ^a   Thompson, J M ^a   Ernerudh, J ^b,f   Hurst, T L ^a   Strindhall, J ^c   Johansson, B ^d   Nilsson, B O ^b,e   Wikby, A ^c  

^a UNILEVER RESEARCH   (United Kingdom)

^b LINKÖPING UNIVERSITY   (Sweden)

^c JÖNKÖPING UNIVERSITY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e University Teaching Hospital Ryhov   (Sweden)

^f LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Ageing; Cytokine; IL 10; IL 6; sICAM 1; TGF

Indexed keywords

CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGE; AGED; AGING; BLOOD SAMPLING; CONFERENCE PAPER; CONTROLLED STUDY; DETERIORATION; FEMALE; HEALTH STATUS; HIGH RISK POPULATION; HUMAN; IMMUNE STATUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENESCENCE; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; SWEDEN; VOLUNTEER;

EID: 0037396220     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(03)00025-3     Document Type: Conference Paper

References (40)

1. Beharka A.A., Meydani M., Wu D.Y., Leka L.S., Meydani A., Meydani S.N. Interleukin-6 production does not increase with age. J. Gerontol. A Biol. Sci. Med. Sci. 56:2001;B81-B88.
2. Blann A.D., Mccollum C.N. Circulating endothelial cell/leukocyte adhesion molecules in atherosclerosis. Thromb. Haemostasis. 72:1994;151-154.
3. Blobe G.C., Schiemann W.P., Lodish H.F. Mechanisms of disease: role of transforming growth factor beta in human disease. N. Engl. J. Med. 342:2000;1350-1358.
4. Borish L. Updates on cells and cytokines. IL-10: evolving concepts. J. Allergy Clin. Immunol. 101:1998;293-297.
5. Castle S.C., Uyemura K., Crawford W., Wong W., Klaustermeyer W.B., Makinodan T. Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in both IL-10 and IL-12. Exp. Gerontol. 34:1999;243-252.
6. Caulin-Glaser T., Farrell W.J., Pfau S.E., Zaret B., Bunger K., Setaro J.F., Brennan J.J., Bender J.R., Cleman M.W., Cabin H.S., Remetz M.S. Modulation of circulating cellular adhesion molecules in postmenopausal women with coronary artery disease. J. Am. Coll. Cardiol. 31:1998;1555-1560.
7. Cohen H.J., Pieper C.F., Harris T., Rao K.M., Currie M.S. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J. Gerontol. A Biol. Sci. Med. Sci. 52:1997;M201-M208.
8. Ershler W.B. Interleukin-6: a cytokine for gerontologists. J. Am. Geriatr. Soc. 41:1993;176-181.
9. Ershler W.B., Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51:2000;245-270.
10. Ferguson F.G., Wikby A., Maxson P., Olsson J., Johansson B. Immune parameters in a longitudinal study of a very old population of Swedish people - a comparison between survivors and nonsurvivors. J. Gerontol. A Biol. Sci. Med. Sci. 50:1995;B378-B382.
11. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., Havlik R.J. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47:1999;639-646.
12. Franceschi C., Monti D., Sansoni P., Cossarizza A. The immunology of exceptional individuals - the lesson of centenarians. Immunol. Today. 16:1995;12-16.
13. 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276:2001;2531-2537.
14. Goudev A., Kyurkchiev S., Gergova V., Karshelova E., Georgiev D., Atar D., Kehayov I., Nachev C. Reduced concentrations of soluble adhesion molecules after antioxidant supplementation in postmenopausal women with high cardiovascular risk profiles - a randomized double-blind study. Cardiology. 94:2000;227-232.
15. Hager K., Machein U., Krieger S., Platt D., Seefried G., Bauer J. Interleukin-6 and selected plasma-proteins in healthy persons of different ages. Neurobiol. Aging. 15:1994;771-772.
16. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger W.H. Jr., Heimovitz H., Cohen H.J., Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106:1999;506-512.
17. Ikata J., Wakatsuki T., Oishi Y., Oki T., Ito S. Leukocyte counts and concentrations of soluble adhesion molecules as predictors of coronary atherosclerosis. Coronary Artery Dis. 11:2000;445-449.
18. Kudravi S.A., Reed M.J. Aging, cancer, and wound healing. In Vivo. 14:2000;83-92.
19. Langlois D., Le Roy C., Penhoat A., Lebrethon M.C., Saez J.M. Autocrine role of TGF beta 1 in adrenal. Horm. Metab. Res. 30:1998;411-415.
20. Lebrethon M.C., Jaillard C., Naville D., Begeot M., Saez J.M. Regulation of corticotropin and steroidogenic enzyme messenger RNAs in human fetal adrenal-cells by corticotropin, angiotensin-II and transforming growth factor beta(1). Mol. Cell. Endocrinol. 106:1994;137-143.
21. Lebrethon M.C., Jaillard C., Naville D., Begeot M., Saez J.M. Effects of transforming growth-factor-beta-1 on human adrenaocortical fasciculata-reticularis cell differentiated functions. J. Clin. Endocrinol. Metab. 79:1994;1033-1039.
22. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man - the SENIEUR protocol. Mech. Ageing Dev. 28:1984;47-55.
23. Mariotti S., Sansoni P., Barbesino G., Caturegli P., Monti D., Cossarizza A., Giacomelli T., Passeri G., Fagiolo U., Pinchera A. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet. 339:1992;1506-1508.
24. McMahon G.A., Dignam J.D., Gentry L.E. Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide. Biochem. J. 313:1996;343-351.
25. Miles E.A., Thies F., Wallace F.A., Powell J.R., Hurst T.L., Newsholme E.A., Calder P.C. Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin. Sci. 100:2001;91-100.
26. Morisaki N., Saito I., Tamura K., Tashiro J., Masuda M., Kanzaki T., Watanabe S., Masuda Y., Saito Y. New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis. 131:1997;43-48.
27. Mysliwska J., Bryl E., Foerster J., Mysliwski A. Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status. Mech. Ageing Dev. 100:1998;313-328.
28. Nilsson, B.O., Ernerudh, J., Johansson, B., Evrin, P.t., Löfgren, S., Ferguson, F.G., Wikby, A., 2003. Morbidity does not influence the T-cell immune risk phenotype in the elderly: findings in the Swedish NONA Immune Study using sample selection protocols. Mech. Ageing Dev. 124, 469-476.
29. Noguchi T., Tsujisaki M., Imai K., Dodo M., Tabuchi Y., Nakajima T., Kajita A., Hayashi I., Sugiura T., Kumahara Y. Relationship among risk factors of atherosclerosis, leukocyte count, and soluble intercellular adhesion molecule-1. Int. Med. 37:1998;123-126.
30. Pawelec G., Mariani E., Bradley B., Solana R. Longevity in vitro of human CD4+T helper cell clones derived from young donors and elderly donors, or from progenitor cells: age-associated differences in cell surface molecule expression and cytokine secretion. Biogerontology. 1:2000;247-254.
31. Peterson P.K., Chao C.C., Carson P., Hu S., Nichol K., Janoff E.N. Levels of tumour-necrosis-factor-alpha.interleukin-6, interleukin-10 and transforming growth-factor-beta are normal in the serum of the healthy elderly. Clin. Infect. Dis. 19:1994;1158-1159.
32. Rohde L.E., Lee R.T., Rivero J., Jamacochian M., Arroyo L.H., Briggs W., Rifai N., Libby P., Creager M.A., Ridker P.M. Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arteroscler. Thromb. Vasc. Biol. 18:1998;1765-1770.
33. Sadeghi H.M., Schnelle J.F., Thoma J.K., Nishanian P., Fahey J.L. Phenotypic and functional characteristics of circulating monocytes of elderly persons. Exp. Gerontol. 34:1999;959-970.
34. Saharinen J., Hyytiainen M., Taipale J., Keski-Oja J. Latent transforming growth factor-beta binding proteins (LTBPs) - structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev. 10:1999;99-117.
35. Straub R., Konecna L., Hrach S., Rothe G., Kreutz M., Scholmerich J., Falk W., Lang B. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence. J. Clin. Endocrinol. Metab. 83:1998;2012-2017.
36. Straub R.H., Miller L.E., Scholmerich J., Zietz B. Cytokines and hormones as possible links between endocrinosenescence and immunosenescence. J. Neuroimmunol. 109:2000;10-15.
37. Wikby A., Johansson B., Ferguson F., Olsson J. Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study. Exp. Geront. 29:1994;531-541.
38. Wikby A., Maxson P., Olsson J., Johansson B., Ferguson F. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech. Ageing Dev. 102:1998;187-198.
39. Yamamoto T., Matsuda T., Muraguchi A., Miyazono K., Kawabata M. Cross-talk between IL-6 and TGF-beta signaling in hepatoma cells. FEBS Lett. 492:2001;247-253.
40. Young D.G., Skibinski G., Mason J.I., James K. The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-beta 1) levels in normal healthy blood donors. Clin. Exp. Immunol. 117:1999;476-481.