Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Science

Volumn 317, Issue 5839, 2007, Pages 807-810

  Brack, Andrew S ^a   Conboy, Michael J ^a   Roy, Sudeep ^a   Lee, Mark ^a   Kuo, Calvin J ^a   Keller, Charles ^b   Rando, Thomas A ^a,c  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; DESMIN; DICKKOPF 1 PROTEIN; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MYOD PROTEIN; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR PAX7; UNCLASSIFIED DRUG; WNT PROTEIN; WNT PROTEIN INHIBITOR;

GENE; INHIBITOR; MUSCLE; PROTEIN; RODENT;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGING; CELL FATE; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; FIBROGENESIS; MOUSE; MUSCLE CELL; MYOFIBROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TISSUE REGENERATION; TISSUE SPECIFICITY;

AGING; ANIMALS; CELL AGING; CELL LINEAGE; CELL PROLIFERATION; FIBROBLASTS; FIBROSIS; FRIZZLED RECEPTORS; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PARABIOSIS; REGENERATION; SATELLITE CELLS, SKELETAL MUSCLE; SIGNAL TRANSDUCTION; WNT PROTEINS;

ANIMALIA; MUS;

EID: 34547924424     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1144090     Document Type: Article

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19. We thank E. Fuchs for TOPGAL mice, R. Nusse for recombinant Wnt3A and LSL cells, and B. Olwin for the Syndecan-4 antibody. Supported by a grant from the NIH (DK069989) to C.J.K. and by grants from the NIH (AG23806), the Department of Veterans Affairs (Merit Review), the Ellison Medical Foundation, and an NIH Director's Pioneer Award to T.A.R.