Mitochondrial DNA deletion mutations: A causal role in sarcopenia

European Journal of Biochemistry

Volumn 269, Issue 8, 2002, Pages 2010-2015

  McKenzie, Debbie ^a   Bua, Entela ^a   McKiernan, Susan ^a   Cao, Zhengjin ^a   Wanagat, Jonathan ^a   Aiken, Judd M ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NONE   (United States)

Author keywords

Aging; Intrafiber atrophy; Muscle loss

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; SUCCINATE DEHYDROGENASE; TRANSFER RNA;

AGE; DNA DAMAGE; DNA REPLICATION; ELECTRON TRANSPORT; ENERGY YIELD; ENZYME ACTIVITY; GENE REPLICATION; GENOTYPE; HUMAN; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE FUNCTION; MUSCLE MASS; MUTATION; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; SHORT SURVEY; SKELETAL MUSCLE; TISSUE HOMOGENATE; TISSUE METABOLISM;

AGING; ANIMALS; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; GENE DELETION; MITOCHONDRIA; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MUSCULAR DISEASES; OXIDATIVE STRESS; RATS; SUCCINATE DEHYDROGENASE;

EID: 0036239678     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.02867.x     Document Type: Short Survey

References (52)

1. Diseases of the mitochondrial DNA
2. What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men
3. Age changes in size and number of muscle fibers in human minor pectoral muscle
4. Effects of ageing and exercise on soleus and extensor digitorum longus muscles of female rats
5. Effects of age on enzyme-histochemical fibre spectra and contractile properties of fast- and slow-twitch muscles in the rat
6. Effects of ageing on the total number of muscle fibers and motoneurons of the tibialis anterior and soleus muscles in the rat
7. The mitochondrial genome-breaking the magic circle
8. Sequence and organization of the human mitochondrial genome
9. Mitochondrial free radical generation, oxidative stress, and aging
10. Do mitochondrial DNA fragments promote cancer and aging
11. Mitochondrial DNA repair pathways
12. Oxidants in mitochondria; from physiology to diseases
13. Mitochondrial decay in aging
14. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
15. A mitochondrial DNA mutation as a cause of Leber's hereditary optic neuropathy
16. Kearns-Sayre syndrome with muscle mitochondrial DNA deletion
17. Deletions of mitochondrial DNA in Kearns-Sayre syndrome
18. Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome
19. LYS mutation
20. Mitochondrial encephalomyopathies: Clinical and molecular analysis
21. Mitochondrial gene mutation: The aging process and degenerative diseases
22. Detection of a specific mitochondrial DNA deletion in tissues of older individuals
23. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
24. Deleted mitochondrial DNA ion the skeletal muscle of aged individuals
25. Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR
26. Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing
27. Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing
28. Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during aging
29. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys
30. Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice
31. Multiple deletions in mitochondrial DNA are present in senescent mouse brain
32. Multiple deletions are detectable in mitochondrial DNA of aging mice
33. Age-associated mitochondrial DNA deletions in mouse skeletal muscle: Comparison of different regions of the mitochondrial genome
34. Multiple, large deletions in rat mito chondrial DNA: Evidence for a major hot spot
35. Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle
36. Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting and oxidative damage in sarcopenia
37. Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection
38. Different in situ hybridization patterns of mito chondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibers in the elderly
39. Late-onset mitochondrial myopathy
40. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys
41. Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre syndrome: Morphological, immunological, and biochemical studies in muscle biopsies and autopsy tissues
42. A partial deficiency of cytochrome c oxidase in chronic progressive external ophthalmoplegia
43. Focal deficiency of cytochrome-c-oxidase in skeletal muscle of patients with progressive external ophthalmoplegia. Cytochemical-fine-structural study
44. Fatal mitochondrial cardiomyopathy in Kearns-Sayre syndrome with deficiency of cytochrome-c-oxidase in cardiac and skeletal muscle. An enzymehistochemical - Ultrammunocytochemical fine structural study in longterm frozen autopsy tissue
45. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - An age-related phenomenon. A histochemical ultracytochemical study
46. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
47. Cellular phenotypes of age-associated skeletal muscle mitochondrial abnormalities in rhesus monkeys
48. Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions
49. A proposed refinement of the mitochondrial free radical theory of aging
50. Association of age-related mitochondrial abnormalities with skeletal muscle fiber atrophy
51. Mechanisms of human mitochondrial DNA maintenance: The determining role of primary sequence and length over function
52. Mitochondrial abnormalities accumulate in muscles that undergo sarcopenia