The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential

Journal of Biological Chemistry

Volumn 279, Issue 24, 2004, Pages 25689-25695

  Orsini, Francesca ^a,b   Migliaccio, Enrica ^a,b   Moroni, Maurizio ^a,b,e   Contursi, Cristina ^a,b,e   Raker, Veronica A ^a   Piccini, Daniele ^a,b   Martin Padura, Ines ^a,b   Pelliccia, Giovanni ^a,b   Trinei, Mirella ^a,b   Bono, Maria ^b,c   Puri, Claudia ^b,c   Tacchetti, Carlo ^b,c   Ferrini, Monica ^d   Mannucci, Roberta ^d   Nicoletti, Ildo ^d   Lanfrancone, Luisa ^a   Giorgio, Marco ^a,b   Pelicci, Pier Giuseppe ^a,b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF PERUGIA   (Italy)

^e Congenia Srl ^*  (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; METABOLISM; PROTEINS; TUMORS;

MITOCHONDRIA; OXIDATIVE STRESS;

BIOCHEMISTRY;

CELL PROTEIN; CYTOCHROME C; HEAT SHOCK PROTEIN 70; PROTEIN P53; PROTEIN P66SHC; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; EMBRYO; ENERGY TRANSFER; LIFESPAN; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; AGING; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CYTOCHROMES C; ENDOPLASMIC RETICULUM; HSP70 HEAT-SHOCK PROTEINS; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; OXIDATIVE STRESS; PROTEIN TRANSPORT; ULTRAVIOLET RAYS;

ANIMALIA; MAMMALIA;

EID: 2942584910     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401844200     Document Type: Article

References (30)

1. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T., and Pelicci, P. G. (1992) Cell 70, 93-104
2. Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Lai, K. M., Superti-Furga, G., Pawson, T., Di Fiore, P. P., Lanfrancone, L., and Pelicci, P. G. (1997) EMBO J. 16, 706-716
3. Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., and Pelicci, P. G. (1999) Nature 402, 309-313
4. Guarente, L., and Kenyon, C. (2000) Nature 408, 255-262
5. Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Miha, E., Padura, I. M., Raker, V. A., Maccarana, M., Petronilli, V., Minucci, S., Bernardi, P., Lanfrancone, L., and Pelicci, P. G. (2002) Oncogene 21, 3872-3878
6. Sastre, J., Pallardo, F. V., and Vina, J. (2003) Free Radic. Biol. Med. 35, 1-8
7. Napoli, C., Martin-Padura, I., De Nigris, F., Giorgio, M., Mansueto, G., Somma, P., Condorelli, M., Sica, G., De Rosa, G., and Pelicci, P. G. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 2112-2116
8. Nemoto, S., and Finkel, T. (2002) Science 295, 2450-2452
9. Harlow, E., and Lane, D. (1988) Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
10. Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X. (1996) Cell 86, 147-157
11. Schiaffino M. V., D'Addio M., Alloni A., Baschirotto C., Valetti C., Cortese K., Puri, C., Bassi, M. T., Colla, C., Luca, M., Tacchetti, C., and Ballabio A. (1999) Nat. Genet. 23, 108-112
12. Pon, L. A., and Schon, E. A. (eds) (2001) Mitochondria: Methods in Cell Biology, Vol. 65, Academic Press, New York
13. Nicolli, A., Basso, E., Petronilli, V., Wenger, R. M., and Bernardi, P. (1996) J. Biol. Chem. 271, 185-192
14. Brown, G. C., and Cooper, C. E. (1995) Bioenergetics: A Practical Approach, IRL Press, Oxford
15. Zou, H., Li, Y., Liu, X., and Wang, X. (1999) J. Biol. Chem. 274, 11549-11556
16. Li, K., Li, Y., Shelton, J. M., Richardson, J. A., Spencer, E., Chen, Z. J., Wang, X., and Sanders, W. R. (2000) Cell 101, 389-399
17. Marchetti, P., Castedo, M., Susin, S. A., Zamzami, N., Hirsh, T., Macho, A., Harffner, A., Hirsh, F., Geuskens, M., and Kroemer, G. (1995) J. Exp. Med. 184, 1155-1160
18. Wang, X. (2001) Gen. Dev. 15, 2922-2933
19. Reers, M., Smiley, S. T., Mottola-Hartshorn, C., Chen, A., Lin, M., and Chen, L. B. (1995) Methods Enzymol. 260, 406-417
20. Gonzalez-Baro, M. R., Granger, D. A., and Coleman, R. A. (2001) J. Biol. Chem. 276, 43182-43188
21. Bruey, J. M., Ducasse, C., Bonniaud, P., Ravagnan, L., Susin, S. A., Diaz-Latoud, C., Gurbuxani, S., Arrigo, A. P., Kroemer, G., Solary, E., and Garrido, C. (2000) Nat. Cell Biol. 2, 645-652
22. Wadhwa, R., Yaguchi, T., Hasan, M. K., Mitsui, Y., Reddel, R. R., and Kaul, S. C. (2002) Exp. Cell Res. 274, 246-253
23. Schwarzer, C., Barnikol-Watanabe, S., Thinnes, F. P., and Hilschmann, N. (2002) Int. J. Biochem. Cell Biol. 34, 1059-1070
24. Mitsumoto, A., Takeuchi, A., Okawa, K., and Nakagawa, Y. (2002) Free Radic. Biol. Med. 32, 22-37
25. Sadekova, S., Lehnert, S., and Chow, T. Y. (1997) Int. J. Radiat. Biol. 72, 653-660
26. Kaul, S. C., Yaguchi, T., Taira, K., Reddel, R. R., and Wadhwa, R. (2003) Exp. Cell Res. 286, 96-101
27. Yokoyama, K., Fukumoto, K., Murakami, T., Harada, S., Hosono, R., Wadhwa, R., Mitsui, Y., and Ohkuma, S. (2002) FEBS Lett. 516, 53-57
28. Bernardi, P. (1999) Physiol. Rev. 79, 1127-1155
29. Ventura, A., Maccarana, M., Raker, V. A., and Pelicci, P. G. (2004) J. Biol. Chem. 279, 2299-2306
30. Rizzuto, R., Pinton, P., Carrington, W., Fay, F. S., Fogarty, K. E., Lifshitz, L. M., Tuft, R. A., and Pozzan, T. (1998) Science 280, 1763-1766