A hypoxia complement differentiates the muscle response to endurance exercise

Experimental Physiology

Volumn 95, Issue 6, 2010, Pages 723-735

  Schmutz, Silvia ^a   Däpp, Christoph ^a   Wittwer, Matthias ^a   Durieux, Anne Cécile ^a   Mueller, Matthias ^a   Weinstein, Felix ^a   Vogt, Michael ^a   Hoppeler, Hans ^a   Flück, Martin ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b MANCHESTER METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; ANGIOPOIETIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN 4; CYCLIN DEPENDENT KINASE 5; CYTOCHROME C OXIDASE; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; LACTIC ACID; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MYOSIN HEAVY CHAIN; MYOSIN HEAVY CHAIN TYPE 1; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE ALPHA 2; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; RNA 28S; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR A; TRANSCRIPTOME; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 3;

ADULT; AEROBIC METABOLISM; ARTERIAL OXYGEN SATURATION; ARTICLE; CELL CYCLE REGULATION; CELL ENERGY; CONTROLLED STUDY; ENDURANCE TRAINING; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLYCOLYSIS; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LACTATE BLOOD LEVEL; LIPID METABOLISM; METABOLIC STRESS; MUSCLE CAPILLARY; MUSCLE CELL; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; MUSCLE STRENGTH; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; OXYGENATION; SARCOLEMMA; SARCOPLASM; ULTRASTRUCTURE; VASTUS LATERALIS MUSCLE;

EID: 77952516708     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2009.051029     Document Type: Article

References (35)

1. Beneke R Boning D (2008). The limits of human performance. Essays Biochem 44, 11 25.
2. Bergström J, Hermansen L, Hultman E Saltin B (1967). Diet, muscle glycogen and physical performance. Acta Physiol Scand 71, 140 150.
3. Braun B (2008). Effects of high altitude on substrate use and metabolic economy: cause and effect? Med Sci Sports Exerc 40, 1495 1500.
4. Chilibeck PD, Syrotuik DG Bell GJ (2002). The effect of concurrent endurance and strength training on quantitative estimates of subsarcolemmal and intermyofibrillar mitochondria. Int J Sports Med 23, 33 39.
5. Däpp C, Schmutz S, Hoppeler H Flück M (2004). Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle. Physiol Genomics 20, 97 107.
6. Dufour SP, Ponsot E, Zoll J, Doutreleau S, Lonsdorfer-Wolf E, Geny B, Lampert E, Flück M, Hoppeler H, Billat V, Mettauer B, Richard R Lonsdorfer J (2006). Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity. J Appl Physiol 100, 1238 1248. (Pubitemid 43671482)
7. Flück M (2006). Functional, structural and molecular plasticity of mammalian skeletal muscle in response to exercise stimuli. J Exp Biol 209, 2239 2248.
8. Flück M, Däpp C, Schmutz S, Wit E Hoppeler H (2005). Transcriptional profiling of tissue plasticity: role of shifts in gene expression and technical limitations. J Appl Physiol 99, 397 413.
9. Flück M Hoppeler H (2003). Molecular basis of skeletal muscle plasticity-from gene to form and function. Rev Physiol Biochem Pharmacol 146, 159 216.
10. Flück M, Mund SI, Schittny JC, Klossner S, Durieux AC Giraud MN (2008). Mechano-regulated tenascin-C orchestrates muscle repair. Proc Natl Acad Sci USA 105, 13662 13667.
11. Flueck M (2009). Plasticity of the muscle proteome to exercise at altitude. High Alt Med Biol 10, 183 193.
12. +-ATPase pumps in skeletal muscle with training in normobaric hypoxia. J Appl Physiol 86, 1745 1748.
13. Gustafsson T, Puntschart A, Kaijser L, Jansson E Sundberg CJ (1999). Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Physiol Heart Circ Physiol 276, H679 H685. (Pubitemid 29100638)
14. Hoppeler H, Howald H, Conley K, Lindstedt SL, Claassen H, Vock P Weibel ER (1985). Endurance training in humans: aerobic capacity and structure of skeletal muscle. J Appl Physiol 59, 320 327. (Pubitemid 15249855)
15. Hoppeler H, Vogt M, Weibel ER Flück M (2003). Response of skeletal muscle mitochondria to hypoxia. Exp Physiol 88, 109 119.
16. Jeukendrup AE (2002). Regulation of fat metabolism in skeletal muscle. Ann NY Acad Sci 967, 217 235.
17. Joyner MJ Coyle EF (2008). Endurance exercise performance: the physiology of champions. J Physiol 586, 35 44.
18. Kayar SR, Hoppeler H, Essen-Gustavsson B Schwerzmann K (1988). The similarity of mitochondrial distribution in equine skeletal muscles of differing oxidative capacity. J Exp Biol 137, 253 263.
19. Kraniou Y, Cameron-Smith D, Misso M, Collier G Hargreaves M (2000). Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle. J Appl Physiol 88, 794 796.
20. Levine BD Stray-Gundersen J (2006). Dose-response of altitude training: how much altitude is enough? Adv Exp Med Biol 588, 233 247.
21. Melissa L, MacDougall JD, Tarnopolsky MA, Cipriano N Green HJ (1997). Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. Med Sci Sports Exerc 29, 238 243.
22. Norrbom J, Sundberg CJ, Ameln H, Kraus WE, Jansson E Gustafsson T (2004). PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol 96, 189 194.
23. Pilegaard H, Ordway GA, Saltin B Neufer PD (2000). Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279, E806 E814.
24. Ponsot E, Dufour SP, Zoll J, Doutrelau S, N'Guessan B, Geny B, Hoppeler H, Lampert E, Mettauer B, Ventura-Clapier R Richard R (2006). Exercise training in normobaric hypoxia in endurance runners. II. Improvement of mitochondrial properties in skeletal muscle. J Appl Physiol 100, 1249 1257. (Pubitemid 43671483)
25. 2 transport. J Clin Invest 96, 1916 1926.
26. Roels B, Thomas C, Bentley DJ, Mercier J, Hayot M Millet G (2007). Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers. J Appl Physiol 102, 79 86.
27. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E Wolfe RR (1993). Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol Endocrinol Metab 265, E380 E391.
28. Schmutz S, Däpp C, Wittwer M, Vogt M, Hoppeler H Flück M (2006). Endurance training modulates the muscular transcriptome response to acute exercise. Pflugers Archiv 451, 678 687.
29. Terrados N, Jansson E, Sylven C Kaijser L (1990). Is hypoxia a stimulus for synthesis of oxidative enzymes and myoglobin? J Appl Physiol 68, 2369 2372.
30. Terrados N, Melichna J, Sylven C, Jansson E Kaijser L (1988). Effects of training at simulated altitude on performance and muscle metabolic capacity in competitive road cyclists. Eur J Appl Physiol Occup Physiol 57, 203 209.
31. Ventura N, Hoppeler H, Seiler R, Binggeli A, Mullis P Vogt M (2003). The response of trained athletes to six weeks of endurance training in hypoxia or normoxia. Int J Sports Med 24, 166 172.
32. Vogt M, Puntschart A, Geiser J, Zuleger C, Billeter R Hoppeler H (2001). Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol 91, 173 182.
33. Wittwer M, Flück M, Hoppeler H, Müller S, Desplanches D Billeter R (2002). Prolonged unloading of rat soleus muscle causes distinct adaptations of the gene profile. FASEB J 16, 884 886.
34. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ Holash J (2000). Vascular-specific growth factors and blood vessel formation. Nature 407, 242 248.
35. Zoll J, Ponsot E, Dufour S, Doutreleau S, Ventura-Clapier R, Vogt M, Hoppeler H, Richard R Flück M (2006). Exercise training in normobaric hypoxia in endurance runners. III. Muscular adjustments of selected gene transcripts. J Appl Physiol 100, 1258 1266.