BCL-2 gene family and the regulation of programmed cell death

Cancer Research

Volumn 59, Issue 7 SUPPL., 1999, Pages

  Korsmeyer, Stanley J ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; B CELL LYMPHOMA; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOME BREAKAGE; CONFERENCE PAPER; FOLLICULAR LYMPHOMA; HOMEOSTASIS; HUMAN; HUMAN CELL; MULTIGENE FAMILY; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; GENES, BCL-2; GENES, TUMOR SUPPRESSOR; HOMEOSTASIS; HUMANS; HYPERPLASIA; IMMUNOGLOBULINS; LYMPHOMA, FOLLICULAR; LYMPHOMA, HIGH-GRADE; MICE; MICE, TRANSGENIC; MULTIGENE FAMILY; SIGNAL TRANSDUCTION; TRANSLOCATION, GENETIC;

EID: 0033119372     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (73)

1. Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E., and Croce, C. M. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (Washington DC), 229: 1390-1393, 1985.
2. H on chromosome 14 and near a transcriptional unit on 18. Cell, 41: 889-906, 1985.
3. Cleary, M. L., and Sklar, J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint cluster region near a transcriptionally active locus on chromosome 18. Proc. Natl. Acad. Sci. USA, 82: 7439-7443, 1985.
4. Cleary, M. L., Smith, S. D., and Sklar, J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14:18) translocation. Cell, 47: 19-28, 1986.
5. Seto, M., Jaeger, U., Hockett, R. D., Graninger, W., Bennett. S., Goldman, P., and Korsmeyer, S. J. Alternative promoters and exons, somatic mutation and transcriptional deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J., 7: 123-131, 1988.
6. McDonnell, T. J., Dean, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., and Korsmeyer, S. J. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell, 57: 79-88, 1989.
7. McDonnell, T. J., Nunez, G., Platt, F. M., Hockenbery, D., London, L., McKearn, J. P., and Korsmeyer, S. J. Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expression B-cell population. Mol. Cell. Biol., 10: 1901-1907, 1990.
8. McDonnell, T. J., and Korsmeyer, S. J. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14:18). Nature (Lond.), 349: 254-257, 1991.
9. Strasser, A., Harris, A. W., Bath, M. L., and Cory, S. Novel primitive lymphoid tumors induced in transgenic mice by cooperation between myc and bcl-2. Nature (Lond.), 348: 331-333, 1990.
10. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.
11. Linette, G. P., Hess, J. L., Sentman, C. L., and Korsmeyer, S. J. Peripheral T-cell lymphoma in lckPr-bcl-2 transgenic mice. Blood, 86: 1255-1260, 1995.
12. Sentman, C. L., Shutter, J. R., Hockenbery, D., Kanagawa, O., and Korsmeyer, S. J. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell, 67: 879-888, 1991.
13. Strasser, A., Harris, A. W., and Cory, S. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell, 67: 889-899, 1991.
14. Vaux, D. L., Cory, S., and Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature (Lond.), 335: 440-442, 1988.
15. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D., and Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (Lond.), 348: 334-336, 1990.
16. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J., and Korsmeyer, S. J. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hematopoietic cell lines. J. Immunol., 144: 3602-3610, 1990.
17. Wyllie, A. H. Apoptosis. Cell death in tissue regulation. J. Pathol., 153: 313-316, 1987.
18. Bishop, J. M. The molecular genetics of cancer. Science (Washington DC), 235: 305-311, 1987.
19. Knudson, A. G., Jr. Heredity cancer, oncogenes antioncogenes. Cancer Res., 45: 1437-1443, 1985.
20. Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. Bcl-2 heterodimerizes in vivo with a conserved homologue, Bax, that accelerates programmed cell death. Cell, 74: 609-619, 1993.
21. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74: 597-608, 1993.
22. Kozopas, K. M., Yang, T., Buchan, H. L., Zhou, P., and Craig, R. W. MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. USA, 90: 3516-3520, 1993.
23. Lin, E. Y., Orlofsky, A., Berger, M. S., and Prystowsky, M. B. Characterization of Al, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. J. Immunol., 151: 1979-1988, 1993.
24. Farrow, S. N., White, J. H. M., Martinou, I., Raven, T., Pun, K-T., Grinham, C. J., Martinou, J-C., and Brown, R. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature (Lond.), 374: 731-733, 1995.
25. Chittenden, T., Harrington, E. A., O'Connor, R., Flemington, C., Lutz, R. J., Evan, G. I., and Guild, B. C. Induction of apoptosis by the Bcl-2 homologue Bak. Nature (Lond.), 374: 733-736, 1995.
26. Kiefer, M. C., Brauer, M. J., Powers, V. c., Wu, J. J., Umansky, S. R., Tomei, L. D., and Barr, P. J. Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (Lond.), 374: 736-739, 1995.
27. Golemis, E., Fong, L., Wang, H. G., and Reed, J. C. Interactions among members of the BCL-2 protein family analyzed with a yeast two-hybrid system. Proc. Natl. Acad. Sci. USA, 91: 9238-9242, 1994.
28. Sedlak, T. W., Oltvai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl. Acad. Sci. USA, 92: 7834-7838, 1995.
29. Yin, X-M., Oltvai, Z. N., and Korsmeyer, S. J. BH1 and BH2 domains of Bl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (Lond.), 369: 321-323.
30. Cheng, E. H., Levine, B., Boise, L. H., Thompson, C. B., and Hardwick, J. M. Bax-independent inhibition of apoptosis by Bcl-XL. Nature (Lond.), 379: 554-556, 1996.
31. Chinnadurai, G., and Lutz, R. J. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J., 14: 5589-5596, 1996.
32. Hunter, J. J., and Parslow, T. G. A peptide sequence from Bax that converts Bcl-2 into an activator of apoptosis. J. Biol. Chem., 271: 8521-8524, 1996.
33. Wang, K., Gross, A., Waksman, G., and Korsmeyer, S. J. Mutagenesis of the BH3 domain of BAX identifies critical residues for dimerization and killing. Mol. Cell Biol., 18: 6083-6089, 1998.
34. Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., Harlan, J. E., Yoon, H. S., Nettesheim, D., Chang, B. S., Thompson, C. B., Wong, S., Ng, S., and Fesik, S. W. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature (Lond.), 381: 335-341, 1996.
35. Sattler, M., Liang, H., Nettesheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., Thompson, C. B., and Fesik, S. W. Structure of Bcl-x(L)-Bak peptide complex-recognition between regulators of apoptosis. Science (Washington DC), 275: 983-986, 1997.
36. Veis, D. J., Sorenson, C. M., Shutter, J. R., and Korsmeyer, S. J. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell, 75: 229-240, 1993.
37. Nakayama, K., Negishi, I., Kuida, K., Sawa, H., and Loh, D. Y. Targeted disruption of Bcl-2 ab in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc. Natl. Acad. Sci. USA, 91: 3700-3704, 1994.
38. Kamada, S., Shimono, A., Shinto, Y., Tsujimura, T., Takahashi, T., Noda, T., Kitamura, Y., Kondoh, H., and Tsujimoto, Y. Bcl-2 deficiency in mice leads to pleitrophic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res., 55: 354-359, 1995.
39. Sorenson, C. M., Rogers, S. A., Korsmeyer, S. J., and Hammerman, M. R. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am. J. Physiol., 268: F73-F81, 1995.
40. Knudson, C. M., Tung, K. S., Tourtellotte, W. G., Brown, G. A., and Korsmeyer, S. J. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (Washington DC), 270: 96-99, 1995.
41. Perez, G. I., Knudson, C. M., Leykin, L., Korsmeyer, S. J., and Tilly, J. L. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat. Med., 3: 1228-1232, 1997.
42. Deckwerth, T. L., Elliot, J. L., Knudson, C. M., Johnson, E. M., Jr., Snider, W. D., and Korsmeyer, S. J. Bax is required for neuronal death after trophic factor deprivation and during development. Neuron, 17: 401-411, 1996.
43. Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
44. Symonds, H., Krall, L., Remington, L., Saenz-Robles, M., Lowe, S., Jack, T., and Van Dyke, T. P53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell, 78: 703-711, 1994.
45. Miyashita, T., and Reed. J. C. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293-299, 1995.
46. McCurrach, M. E., Connor, T. M., Knudson, C. M., Korsmeyer, S. J., and Lowe, S. W. Bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA, 94: 2345-2349, 1997.
47. Yin, C. Y., Knudson, C. M., Korsmeyer, S. J., and VanDyke, T. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (Lond.), 385: 637-640, 1997.
48. Meijerink, J. P. P., Mensink, E. J. B. M., Wang, K., Sedlak, T. W., Sloetjes, A. W., de Witte, T., Waksman, G., and Korsmeyer, S. J. Hematopoietic malignancies demonstrate Loss-of-function mutations of Bax. Blood, 91: 2991-2997, 1998.
49. Rampino, N., Yamamoto, H., Ionov, Y., Li, Y, Sawai, H. Reed, J. C., and Perucho, M. Somatic frameshift mutations in the bax gene in colon cancers of the microsatellite mutator phenotype. Science (Washington DC), 275: 967-969, 1997.
50. Boyd, J. M., Gallo, G. J., Elangovan, B., Houghton, A. B., Malstrom, S., Avery, B. J., Ebb, R. G., Subramanian, T., Chittenden, T., Lutz, R. J., et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene, 11: 1921-1928, 1995.
51. Han, J., Sabbatini, P., and White, E. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K. Mol. Cell. Biol., 16: 5857-5864, 1996.
52. Wang, K., Yin, X-M., Chao, D. T., Milliman, C. L., and Korsmeyer, S. J. BID: a novel BH3 domain-only death agonist. Genes Dev., 10: 2859-2869, 1996.
53. Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell, 80: 285-291, 1995.
54. Zha, J. P., Jockel, J., and Korsmeyer, S. J. BH3 domain of BAD is required for death promotion and heterodimerization with BCL-XL. J. Biol. Chem., 272: 24, 101-104, 1997.
55. O'Connor, L., Strasser, A., O'Reilly, L. A., Hausmann, G., Adams, J. M., Cory, S., and Huang, D. C. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J., 17: 384-395, 1998.
56. Onohara, N., Ding, L., Chen, S., and Nunez, G. Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and BcI-X(L). EMBO J., 16: 1686-1694, 1997.
57. Hegde, R., Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. BIk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist. J. Biol. Chem., 273: 7783-7786, 1998.
58. Zha, J. P., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S. J. Serine phosphorylation of death agonist Bad in response to survival factor results in binding to 14-3-3 not Bcl-XL. Cell, 87: 619-628, 1996.
59. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91: 231-241, 1997.
60. Xiang, J., Chao, D. T., and Korsmeyer, S. J. Bax-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc. Natl. Acad. Sci. USA, 93: 14559-14563, 1996.
61. McCarthy, N. J., Whyte, M. K., Gilbert, C. S., and Evan, G. I. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol., 136: 215-227, 1997.
62. Wolter, K. G., Hsu, Y. T., Smilh, C. L, Nechushtan, A., Xi, Z. G., and Youle, R. J. Movement of Bax from the cytosol to mitochondria during apoptosis. J. Cell Biol., 139: 1281-1292, 1997.
63. Gross, A., Jockel, J., Wei, M. C., and Korsmeyer, S. J. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J., 17: 3878-3885, 1998.
64. Hsu, Y. T., and Youle, R. J. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J. Biol. Chem., 273: 10777-10783, 1998.
65. Knudson, C. M., and Korsmeyer, S. J. Bcl-2 and Bax function independently to regulate cell death. Nat. Genet., 16: 358-363, 1997.
66. Antonsson, B., Conti, F., Ciavatta, A., Montessuit, S., Lewis, S., Martinou, I., Bernasconi, L., Bernard, A., Mermod, J. J., Mazzei, G. Maundrell, K., Gambale, F., Sadoul, R., and Martinou, J. C. Inhibition of Bax channel-forming activity by Bcl-2. Science (Washington DC), 277: 370-372, 1997.
67. Schlesinger, P. H., Gross, A., Yin, X-M., Yamamoto, K., Saito, M., Waksman, G., and Korsmeyer, S. J. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc. Natl. Acad. Sci. USA, 94: 11357-11362, 1997.
68. Hengartner, M. O., and Horvitz, H. R. Programmed cell death in Caenorhabditis elegans. Curr. Opin. Genet. Dev., 4: 581-586, 1994.
69. Hengartner, M. O., and Horvitz, H. R. C. elegans cell survival gene ced-9 encodes a functional homologue of the mammalian proto-oncogene bcl-2. Cell, 76: 665-676, 1994.
70. Conradt, B., and Horvitz, H. R. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell, 93: 519-529, 1998.
71. Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M., and Horvitz, H. R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell, 75: 641-652, 1993.
72. Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G. S., Thornberry, N. A., Wong, W. W., and Yuan, J. Human ICE/CED-3 protease nomenclature. Cell, 87: 171, 1996.
73. Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell, 90: 405-413, 1997.