Regulators of G-protein signaling and their Gα substrates: Promises and challenges in their use as drug discovery targets

Pharmacological Reviews

Volumn 63, Issue 3, 2011, Pages 728-749

  Kimple, Adam J ^a   Bosch, Dustin E ^a   Giguère, Patrick M ^a   Siderovski, David P ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1,3 BENZOTHIAZOL 2 YL) 3 [9 METHYL 2 (3 METHYLPHENOXY) 4 OXO 4H PYRIDO(1,2 A)PYRIMIDIN 3 YL]PROP 2 ENENITRILE; 2 (1,3 BENZOTHIAZOL 2 YL) 3 [9 METHYL 2 (4 FLUOROLPHENOXY) 4 OXO 4H PYRIDO(1,2 A)PYRIMIDIN 3 YL]PROP 2 ENENITRILE; 4 [(4 FLUOROPHENYL)METHYL] 2 (4 METHYLPHENYL) 1,2,4 THIADIAZOLIDINE 3,5 DIONE; BMS 192364; BMS 195270; CCG 4986; CCG 50014; CCG 63802; CCG 63808; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; GUANOSINE TRIPHOSPHATASE; PROTEIN INHIBITOR; RGS PROTEIN; RGS4 PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VEMURAFENIB; YM 254890;

ALLOSTERISM; ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; COMPETITIVE INHIBITION; DRUG RESEARCH; DRUG TARGETING; ENZYME ASSAY; ENZYME SUBSTRATE; FLUORESCENCE POLARIZATION; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENE THERAPY; HIGH THROUGHPUT SCREENING; HUMAN; MELANOMA; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE BINDING SITE; ONCOGENE; PATHOPHYSIOLOGY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ANALYSIS; URINE INCONTINENCE; UVEA MELANOMA; X RAY CRYSTALLOGRAPHY;

ANIMALS; DRUG DISCOVERY; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MOLECULAR TARGETED THERAPY; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 79960671811     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.110.003038     Document Type: Article

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