RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of Gα(o)

Biochemical Journal

Volumn 350, Issue 1, 2000, Pages 19-29

  Traver, S ^a   Bidot, C ^a   Spassky, N ^a   Baltauss, T ^a   De Tand, M F ^a   Thomas, J L ^a   Zalc, B ^a   Janoueix Lerosey, I ^a   De Gunzburg, J ^a  

^a INSTITUT CURIE   (France)

Author keywords

Heterotrimeric G proteins; Ras family; Signal transduction; Two hybrid

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; RAF PROTEIN; RAP PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME SUBUNIT; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; DNA PRIMERS; GTP PHOSPHOHYDROLASES; HELA CELLS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RGS PROTEINS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0034663469     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3500019     Document Type: Article

References (54)

1. Increasing complexity of the Ras signaling pathway
2. How receptors talk to trimeric G proteins
3. Proteins regulating Ras and its relatives
4. RGS proteins: More than just GAPs for heterotrimeric G proteins
5. Distinct pathways of G(l)- and G(q)-mediated mitogen-activated protein kinase activation
6. Lysophosphatidic acid: G-protein signalling and cellular responses
7. p115 RhoGEF, a GTPase activating protein for G alpha(12) and G alpha(13)
8. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by G alpha(13)
9. Modulation of rap activity by direct interaction of G alpha(O) with Rap1 GTPase-activating protein
10. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with Gα
11. Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region
12. The 2,2A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A ard a GTP analogue
13. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
14. Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTP gamma S
15. A ras-related gene with transformation suppressor activity
16. Normal and oncogenic p21(ras) proteins bind to the amino-terminal regulatory domain of c. Raf-1
17. Differential interaction of the ras family GTP·binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
18. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes
19. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G
20. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
21. A family of cAMP-binding proteins that directly activate Rap1
22. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
23. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2
24. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans
25. cAMP Activates MAP kinase and Elk-1 through a B-Raf- and Rap1 dependent pathway
26. Effects of the ras-related rap2 protein on cellular proliferation
27. Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2
28. Identification of a specific effector of the small GTP-binding protein Rap2
29. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling
30. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
31. Molecular cloning and expression analysis of Rat Rgs12 and RgS14
32. RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG
33. A rapid and sensitive method for the quantitation of protein utilizing the principle of protein-dye binding
34. The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis
35. Association of the ras-antagonistic Rap1/Krev-1 proteins with the Golgi complex
36. Post-translational processing and subcellular localization of the ras-related rap2 protein
37. GAIP and RGS4 are GTPase-activating proteins for the G(l) subfamily of G protein α subunits
38. Oligodendroglial expression and deposition of tour major myelin constituents in the myelin sheath during development
39. A new family of G-protein regulators - The RGS proteins
40. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo
41. Identification of the sites of interaction between c-Raf-1 and Ras-GTP
42. Discrimination of amino acids mediating Ras binding from noninteracting residues affecting Raf activation by double mutant analysis
43. In vitro inhibition of Ras-Raf association by short peptides
44. Activation of brain B-Raf protein kinase by Rap1B small GTP-binding protein
45. Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf
46. RaIGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein
47. GAIP, a protein that specilically interacts with the trimeric G protein Gα(i3), is a member of a protein family with a highly conserved core domain
48. RGS2/G0S8 is a selective inhibitor of Gq alpha function
49. RGSZ1, a G(z)-selective RGS protein in brain - Structure, membrane association, regulation by G alpha(z) phosphorylation, and relationship to a G(z) GTPase-activating protein subfamily
50. The alpha-helical domain of G alpha(T) determines specific interaction with regulator of G protein signaling 9
51. Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain
52. G(o), a guanine nucleotide-binding protein: Immunohistochemical localization in rat brain resembles distribution of second messenger systems
53. Localization of mRNAs encoding the α-subunits of signal-transducing G-proteins within rat brain and among peripheral tissues
54. Immunocytochemical localization of the guanine nucleotide-binding protein G(o) in primary cultures of neuronal and glial cells