GΒ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

Nature Neuroscience

Volumn 13, Issue 6, 2010, Pages 661-663

  Xie, Keqiang ^a   Allen, Kevin L ^a   Kourrich, Sad ^a   Colón Saez, José ^a   Thomas, Mark J ^a   Wickman, Kevin ^a   Martemyanov, Kirill A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACLOFEN; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; NEUROTRANSMITTER; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHOLIPASE C BETA2; POTASSIUM CHANNEL; RGS PROTEIN; RGS7 PROTEIN; RGS9 PROTEIN; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; GNB5 PROTEIN, MOUSE; RGS7 PROTEIN, MOUSE;

ARTICLE; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KINETICS; LOCOMOTION; NERVE CELL INHIBITION; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG EFFECT; GENETICS; INHIBITORY POSTSYNAPTIC POTENTIAL; METABOLISM; MOTOR ACTIVITY; MOUSE; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; SYNAPTIC TRANSMISSION; TIME;

ANIMALS; BACLOFEN; CELL LINE; CELLS, CULTURED; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GABA AGONISTS; GTP-BINDING PROTEIN BETA SUBUNITS; HIPPOCAMPUS; HUMANS; INHIBITORY POSTSYNAPTIC POTENTIALS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURAL INHIBITION; NEURONS; RECEPTORS, GABA-B; RGS PROTEINS; SYNAPTIC TRANSMISSION; TIME FACTORS;

EID: 77952886365     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2549     Document Type: Article

References (15)

1. Sondek J. Siderovski D.P. Biochem. Pharmacol. 61, 1329-1337, 2001
2. Anderson, G.R., Posokhova, E. & Martemyanov, K.A. Cell Biochem. Biophys. 54, 33-46 (2009).
3. Chen, C.K. et al. Proc. Natl. Acad. Sci. USA 100, 6604-6609 (2003).
4. Cheever, M.L. et al. Nat. Struct. Mol. Biol. 15, 155-162 (2008).
5. Lüscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C. & Nicoll, R.A. Neuron 19, 687-695 (1997).
6. Pravetoni, M. & Wickman, K. Genes Brain Behav. 7, 523-531 (2008).
7. Chung, H.J. et al. Proc. Natl. Acad. Sci. USA 106, 635-640 (2009).
8. Karschin, C., Dissmann, E., Stuhmer, W. & Karschin, A. J. Neurosci. 16, 3559-3570 (1996).
9. Chung, H.J., Qian, X., Ehlers, M., Jan, Y.N. & Jan, L.Y. Proc. Natl. Acad. Sci. USA 106, 629-634 (2009).
10. Vacher, C.-M. & Bettler, B. Curr. Drug Targets CNS Neurol. Disord. 2, 248-259 (2003).
11. Costa, A.C., Stasko, M.R., Stoffel, M. & Scott-McKean, J.J. J. Neurosci. 25, 7801-7804 (2005).
12. Kovoor, A. et al. J. Biol. Chem. 275, 3397-3402 (2000).
13. Rahman, Z. et al. Neuron 38, 941-952 (2003).
14. Drenan, R.M. et al. J. Biol. Chem. 281, 28222-28231 (2006)
15. Keren-Raifman, T. FEBS Lett. 492, 20-28 (2001).