A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins

Biochemistry

Volumn 50, Issue 15, 2011, Pages 3181-3192

  Blazer, Levi L ^a   Zhang, Haoming ^a   Casey, Emma M ^d   Husbands, Stephen M ^d   Neubig, Richard R ^a,b,c  

^a Department of Pharmacology ^*  (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c University of Bath   (United Kingdom)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEASE; CYSTEINE RESIDUES; DISULFIDE BONDS; G PROTEIN; G PROTEIN COUPLED RECEPTORS; GTP HYDROLYSIS; HIGH POTENCY; MECHANISM OF ACTION; NANOMOLAR; REGULATORS OF G-PROTEIN SIGNALING; SMALL MOLECULE INHIBITOR; SMALL MOLECULES;

AMINO ACIDS; COVALENT BONDS; HYDROLYSIS; MOLECULES; SIGNAL TRANSDUCTION; SIGNALING;

PROTEINS;

4 [( 4 FLUOROPHENYL)METHYL] 2 ( 4 METHYLPHENYL) 1,2,4 THIADIAZOLIDINE 3,5 DIONE; CCG 50014; CYSTEINE; DISULFIDE; G PROTEIN COUPLED RECEPTOR; IODOACETAMIDE; N ETHYLMALEIMIDE; PAPAIN; PROTEIN INHIBITOR; REGULATOR OF G PROTEIN SIGNALING PROTEIN INHIBITOR; RGS PROTEIN; RGS4 PROTEIN; RGS8 PROTEIN; THIADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; DISULFIDE BOND; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN FUNCTION;

ALKYLATION; BIOCATALYSIS; CELL SURVIVAL; CYSTEINE; FLOW CYTOMETRY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RGS PROTEINS; SUBSTRATE SPECIFICITY; THIADIAZOLES; THIAZOLIDINEDIONES;

EID: 79953878856     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1019622     Document Type: Article

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