Structural basis for the specific inhibition of heterotrimeric G q protein by a small molecule

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 31, 2010, Pages 13666-13671

  Nishimura, Akiyuki ^a   Kitano, Ken ^a   Takasaki, Jun ^b   Taniguchi, Masatoshi ^b   Mizuno, Norikazu ^a   Tago, Kenji ^a   Hakoshima, Toshio ^a   Itoh, Hiroshi ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Crystal structure; G protein; Specific inhibitor

Indexed keywords

CYCLODEPSIPEPTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; UNCLASSIFIED DRUG; YM 254890; CYCLOPEPTIDE; YM-254890;

ARTICLE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT;

EID: 77956373483     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003553107     Document Type: Article

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