Polyplexed flow cytometry protein interaction assay: A novel high-throughput screening paradigm for RGS protein inhibitors

Journal of Biomolecular Screening

Volumn 14, Issue 6, 2009, Pages 610-619

  Roman, David L ^a,c   Ota, Shodai ^a   Neubig, Richard R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

FCPIA; Flow cytometry; G protein; High throughput screening; RGS

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PROTEIN INHIBITOR; RGS PROTEIN; RGS16 PROTEIN; RGS4 PROTEIN; RGS6 PROTEIN; RGS7 PROTEIN; RGS8 PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

BIOLOGICAL ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; KINETICS; PROTEIN BINDING; RGS PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 67651070993     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057109336590     Document Type: Article

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