EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins

Cell

Volumn 84, Issue 1, 1996, Pages 115-125

  Koelle, Michael R ^a   Horvitz, H Robert ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROTRANSMITTER; REGULATOR PROTEIN;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAENORHABDITIS ELEGANS; CELLULAR DISTRIBUTION; EGG LAYING; EMBRYO; GENE CONTROL; GENE DOSAGE; GENE STRUCTURE; LOCOMOTION; MAMMAL; MULTIGENE FAMILY; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0030032001     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80998-8     Document Type: Article

References (47)

1. Angleson, J.K., and Wensel, T.G. (1993). A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes. Neuron 11, 939-949.
2. Avery, L., and Horvitz, H.R. (1990). Effects of starvation and neuroactive drugs on feeding in Caenorhabditis elegans. J. Exp. Zool. 253, 263-270.
3. Bailey, C.H., Alberini, C., Ghirardi, M., and Kandel, E.R. (1994). Molecular and structural changes underlying long-term memory storage in Aplysia. Adv. Second Messenger Phosphoprotein Res. 29, 529-544.
4. Barstead, R.J., and Waterston, R.H. (1989). The basal component of the nematode dense-body is vinculin. J. Biol. Chem. 264, 10177-10185.
5. Bauer, P.M., Muller, S., Puzicha, M., Pippig, S., Obermaier, B.,Helmreich, E.J., and Lohse, M.J. (1992). Phosducin is a protein kinase A-regulated G-protein regulator. Nature 358, 73-76.
6. Blinder, D., and Jenness, D.D. (1989). Regulation of postreceptor signaling in the pheromone response pathway of Saccharomyces cerevisiae. Mol. Cell. Biol. 9, 3720-3726.
7. Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
8. Catty, D., ed. (1988). Antibodies: A Practical Approach (Washington, D.C.: IRL Press).
9. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W.W., and Prasher, D.C. (1994). Green fluorescent protein as a marker for gene expression. Science 263, 802-805.
10. Chan, R.K., and Otte, C.A. (1982a). Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol. Cell. Biol. 2, 11-20.
11. Chan, R.K., and Otte, C.A. (1982b). Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol. Cell. Biol. 2, 21-29.
12. Croll, N.A. (1975). Components and patterns in the behaviour of the nematode Caenorhabditis elegans. J. Zool. Lond. 776, 159-176.
13. Desai, C., and Horvitz, H.R. (1989). Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying. Genetics 121, 703-721.
14. Desai, C., Garriga, G., Mclntire, S.L., and Horvitz, H.R. (1988). A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.
15. Dietzel, C., and Kurjan, J. (1987). Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone. Mol. Cell. Biol. 7, 4169-4177.
16. Dohlman, H.G., Apaniesk, D., Chen, Y., Song, J., and Nusskern, D. (1995). Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol. Cell. Biol. 15, 3635-3643.
17. Finney, M., and Ruvkun, G. (1990). The unc-86gene product couples cell lineage and cell identity in C. elegans. Cell 63, 895-905.
18. Hasson, M.S., Blinder, D., Thorner, J., and Jenness, D.D. (1994). Mutational activation of the STE5 gene product bypasses the requirement for G protein β and γ subunits in the yeast pheromone response pathway. Mol. Cell. Biol. 14, 1054-1065.
19. Hille, B. (1992). Ionic Channels of Excitable Membranes, Second Edition (Sunderland, Massachusetts: Sinauer Associates, Incorporated).
20. Hong, J.X., Wilson, G.L., Fox, C.H., and Kehrl, J.H. (1993). Isolation and characterization of a novel B cell activation gene. J. Immunol. 150, 3895-3904.
21. Horvitz, H.R., Chalfie, M., Trent, C., Sulston, J.E., and Evans, P.D. (1982). Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216, 1012-1014.
22. Inglese, J., Freedman, N.J., Koch, W.J., and Lefkowitz, R.J. (1993). Structure and mechanism of the G protein-coupled receptor kinases. J. Biol. Chem. 268, 23735-23738.
23. Konopka, J.B., Jenness, D.D., and Hartwell, L.H. (1988). The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone. Cell 54, 609-620.
24. Krause, M., and Hirsh, D. (1987). A trans-spliced leader sequence on actin mRNA in C. elegans. Cell 49, 753-761.
25. Kurjan, J. (1993). The pheromone response pathway in Saccharomyces cerevisiae. Annu. Rev. Genet. 27, 147-179.
26. Lee, B.N., and Adams, T.H. (1994). Overexpression of flbA, an early regulator of Aspergillus asexual sporulation, leads to activation of brlA and premature initiation of development. Mol. Microbiol. 14, 323-334.
27. Lee, R.H., Ting, T.D., Lieberman, B.S., Tobias, D.E., Lolley, R.N., and Ho, Y.K. (1992). Regulation of retinal cGMP cascade by phosducin in bovine rod photoreceptor cells: interaction of phosducin and transducin. J. Biol. Chem. 267, 25104-25112.
28. Lochrie, M.A., Mendel, J.E., Sternberg, P.W., and Simon, M.I. (1991). Homologous and unique G protein a subunits in the nematode Caenorhabditis elegans. Cell Regul. 2, 135-154.
29. Mello, G.G., Kramer, J.M., Stinchcomb, D., and Ambros, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
30. 0 in multiple aspects of behavior in C. elegans. Science 267, 1652-1655.
31. Murphy, J.J., and Norton, J.D. (1990). Cell-type-specific early response gene expression during plasmacytoid differentiation of human B lymphocytic leukemia cells. Biochim. Biophys. Acta 1049, 261-271.
32. Neer, E.J. (1995). Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80, 249-257.
33. Newton, J.S., Deed, R.W., Mitchell, E.L., Murphy, J.J., and Norton, J.D. (1993). AB cell specific immediate early human gene is located on chromosome band 1q31 and encodes an α-helical basic phosphoprotein. Biochim. Biophys. Acta 7276, 314-316.
34. Otto-Bruc, A., Antonny, B., and Vuong, T.M. (1994). Modulation of the GTPase activity of transducin: kinetic studies of reconstituted systems. Biochemistry 33, 15215-15222.
35. Reneke, J.E., Blumer, K.J., Courchesne, W.E., and Thorner, J. (1988). The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain. Cell 55, 221-234.
36. Rimm, D.L., and Pollard, T.D. (1989). New plasmid vectors for high level synthesis of eukaryotic fusion proteins in Escherichia coli. Gene 75, 323-327.
37. Ross, E.M. (1995). Palmitoylation in G-protein signaling pathways. Curr. Biol. 5, 107-109.
38. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
39. 0 in Caenorhabditis elegans. Science 267, 1648-1651.
40. Siderovski, D.P., Heximer, S.P., and Forsdyke, D.R. (1994). A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells. DNA Cell Biol. 13, 125-147.
41. Sprague, G.F., Jr., and Thorner, J. (1992). Pheromone response and signal transduction during the mating process of Saccharomyces cerevisiae, In The Molecular and Cellular Biology of the Yeast Saccharomyces, Volume II: Gene Expression. J.R. Broach, J.R. Pringle, and E.W. Jones, ed. (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press), pp. 657-744.
42. Thomas, J.H. (1990). Genetic analysis of defecation in Caenorhabditis elegans. Genetics 124, 855-872.
43. Trent, C. (1982). Genetic and behavioral studies of the egg-laying system of Caenorhabditis elegans. PhD thesis, Massachusetts Institute of Technology, Cambridge, Massachusetts.
44. Trent, C., Tsung, N., and Horvitz, H.R. (1983). Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 104, 619-647.
45. White, J.G., Southgate, E., Thomson, J.N., and Brenner, S. (1986). The structure of the nervous system of the nematode Caenorhabditis elegans. Phil. Trans. Roy. Soc. (Lond.) B 314, 1-340.
46. Wilson, R., Ainscough, R., Anderson, K., Baynes, C., Berks, M., Bonfield, J., Burton, J., Connell, M., Copsey, T., Cooper, J., et al. (1994). 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans. Nature 368, 32-38.
47. Wood, W.B., and the Community of C. elegans Researchers, eds. (1988). The Nematode Caenorhabditis elegans (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).