-
1
-
-
0035283073
-
Orphan G protein-coupled receptors and natural ligand discovery
-
Howard AD, et al. Orphan G protein-coupled receptors and natural ligand discovery. Trends Pharmacol Sci 2001; 22: 132-40.
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 132-140
-
-
Howard, A.D.1
-
3
-
-
0037944275
-
Constitutive activated G protein-coupled receptors: A novel approach to CNS drug discovery
-
Menzaghi F, Behau DP, Chalmers DT. Constitutive activated G protein-coupled receptors: a novel approach to CNS drug discovery. Curr Drug Target CNS Neurol Disord 2002; 1: 105-21.
-
(2002)
Curr. Drug Target CNS Neurol. Disord.
, vol.1
, pp. 105-121
-
-
Menzaghi, F.1
Behau, D.P.2
Chalmers, D.T.3
-
4
-
-
0034644539
-
Cell Signaling by Receptor Tyrosine Kinases
-
Schlessinger J. Cell Signaling by Receptor Tyrosine Kinases. Cell 2000; 103: 211-25.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
6
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
Slamon DJ, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-82.
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
-
7
-
-
0037264633
-
Targeting Ras Signalling Pathways in Cancer Therapy
-
Downward J. Targeting Ras Signalling Pathways in Cancer Therapy. Nat Rev 2003; 3: 11-22.
-
(2003)
Nat. Rev.
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
8
-
-
0033590636
-
Constitutive activation of the 41-/43- kDa mitogen-activated protein kinase signaling pathway in human tumors
-
Hoshino R. et al. Constitutive activation of the 41-/43- kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene 1999; 18: 813-22.
-
(1999)
Oncogene
, vol.18
, pp. 813-822
-
-
Hoshino, R.1
-
9
-
-
0034799139
-
A Novel Approach in the Treatment of Cancer: Targeting the Epidermal Growth Factor receptor
-
Ciardillo F, Tortora G. A Novel Approach in the Treatment of Cancer: Targeting the Epidermal Growth Factor receptor. Clin Cancer Res 2001; 7: 2958-70.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 2958-2970
-
-
Ciardillo, F.1
Tortora, G.2
-
10
-
-
0034905925
-
Signal Transduction: Multiple Pathways, Multiple Options for Therapy
-
Heldin CH. Signal Transduction: Multiple Pathways, Multiple Options for Therapy. Stem Cells 2001; 19: 295-303.
-
(2001)
Stem Cells
, vol.19
, pp. 295-303
-
-
Heldin, C.H.1
-
11
-
-
0034988184
-
The epidermal growth factor receptor as a target for cancer therapy
-
Mendelsohn J. The epidermal growth factor receptor as a target for cancer therapy. Endocrine-related Cancer 2001, 8: 3-9.
-
(2001)
Endocrine-related Cancer
, vol.8
, pp. 3-9
-
-
Mendelsohn, J.1
-
12
-
-
0034789517
-
Receptor tyrosine kinase signalling as a target for cancer intervention strategies
-
Zwick F, Bange J, Ullrich A. receptor tyrosine kinase signalling as a target for cancer intervention strategies. Endocrine-Related Cancer 2001; 8: 161-73.
-
(2001)
Endocrine-Related Cancer
, vol.8
, pp. 161-173
-
-
Zwick, F.1
Bange, J.2
Ullrich, A.3
-
13
-
-
0036044979
-
HER-Targeted Tyrosine-Kinase Inhibition
-
Baselga J, Hammond LA. HER-Targeted Tyrosine-Kinase Inhibition. Oncology 2002; 63 (Suppl. 1): 6-16.
-
(2002)
Oncology
, vol.63
, Issue.SUPPL. 1
, pp. 6-16
-
-
Baselga, J.1
Hammond, L.A.2
-
14
-
-
0036165251
-
Pharmacological Inhibition of MAPK pathways
-
English JM, Cobb MH. Pharmacological Inhibition of MAPK pathways. Trends Pharmacol Sci 2002; 23: 40-45.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 40-45
-
-
English, J.M.1
Cobb, M.H.2
-
15
-
-
0037242466
-
New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transduction
-
Lee AV, et al. New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transduction. Clin Canc Res 2003, 9 (suppl): 516-23.
-
(2003)
Clin. Canc. Res.
, vol.9
, Issue.SUPPL.
, pp. 516-523
-
-
Lee, A.V.1
-
16
-
-
0037392444
-
Issues and Progress with Protein Kinase Inhibitors for Cancer Treatment
-
Dancey J, Sansville EA. Issues and Progress with Protein Kinase Inhibitors for Cancer Treatment. Nat Rev 2003; 2: 296-313.
-
(2003)
Nat. Rev.
, vol.2
, pp. 296-313
-
-
Dancey, J.1
Sansville, E.A.2
-
17
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold JS, et al. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat med 1999, 5: 810-815.
-
(1999)
Nat. Med.
, vol.5
, pp. 810-815
-
-
Sebolt-Leopold, J.S.1
-
19
-
-
0030987069
-
How receptor talk to trimeric G proteins
-
Bourne H. How receptor talk to trimeric G proteins. Curr Opin Cell Biol 1997; 9: 134-42.
-
(1997)
Curr. Opin. Cell Biol.
, vol.9
, pp. 134-142
-
-
Bourne, H.1
-
20
-
-
0032504237
-
G protein-coupled receptors: I. Diversity of receptor ligand interaction
-
Ji TH, Grossmann M, Ji I. G protein-coupled receptors: I. Diversity of receptor ligand interaction. J Biol Chem 1999, 237: 17299-302.
-
(1999)
J. Biol. Chem.
, vol.237
, pp. 17299-17302
-
-
Ji, T.H.1
Grossmann, M.2
Ji, I.3
-
21
-
-
0034464742
-
Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
-
Gether U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocrinol Rev 2000; 21: 90-113.
-
(2000)
Endocrinol. Rev.
, vol.21
, pp. 90-113
-
-
Gether, U.1
-
23
-
-
0036780743
-
G-Protein-Coupled Receptor Oligomerization and its Potential for Drug Discovery
-
George SR, O'Dowd BF, Lee SP. G-Protein-Coupled Receptor Oligomerization and its Potential for Drug Discovery. Nat Rev Drug Disc 2002; 1: 808-20.
-
(2002)
Nat. Rev. Drug Disc.
, vol.1
, pp. 808-820
-
-
George, S.R.1
O'Dowd, B.F.2
Lee, S.P.3
-
24
-
-
0037762755
-
G Protein Selectivity is regulated by Multiple Intracellular Regions of GPCRs
-
Wong SKF. G Protein Selectivity is regulated by Multiple Intracellular Regions of GPCRs. Neurosignals 2003; 12: 1-12.
-
(2003)
Neurosignals
, vol.12
, pp. 1-12
-
-
Wong, S.K.F.1
-
25
-
-
0035895505
-
Sequence of the human genome
-
Venter JC, et al. Sequence of the human genome. Science 2001; 291: 1304-50.
-
(2001)
Science
, vol.291
, pp. 1304-1350
-
-
Venter, J.C.1
-
26
-
-
0037022309
-
Calcium signaling. A tale for all seasons
-
Carafoli E. Calcium signaling. A tale for all seasons. Proc Natl Acad Sci USA 2002; 99: 115-22.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 115-122
-
-
Carafoli, E.1
-
27
-
-
0032555778
-
Protein kinase C: A paradigm for regulation of protein function by two membrane-targeting molecules
-
Newton AC, Johnson JE. Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting molecules. Biochim Biophys Acta 1998; 1376: 155-72.
-
(1998)
Biochim. Biophys. Acta
, vol.1376
, pp. 155-172
-
-
Newton, A.C.1
Johnson, J.E.2
-
28
-
-
0035101820
-
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in receptor Desensitization and Signaling
-
Ferguson SG. Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in receptor Desensitization and Signaling. Pharmacol Rev 2001; 53: 1-24.
-
(2001)
Pharmacol. Rev.
, vol.53
, pp. 1-24
-
-
Ferguson, S.G.1
-
29
-
-
0032033682
-
G protein-coupled-receptor cross-talk: The fine tuning of multiple receptor-signalling pathways
-
Selbie LA, Hill SJ. G protein-coupled-receptor cross-talk: The fine tuning of multiple receptor-signalling pathways. Trends Pharmacol Sci 1998; 19: 87-93.
-
(1998)
Trends Pharmacol. Sci.
, vol.19
, pp. 87-93
-
-
Selbie, L.A.1
Hill, S.J.2
-
30
-
-
0036360144
-
Mechanisms of Cross-Talk between G-Protein-Coupled Receptors
-
Cordeaux Y, Hill SJ. Mechanisms of Cross-Talk between G-Protein-Coupled Receptors. Neurosignals 2002; 11: 45-57.
-
(2002)
Neurosignals
, vol.11
, pp. 45-57
-
-
Cordeaux, Y.1
Hill, S.J.2
-
31
-
-
0036189809
-
G protein-coupled signalling and cross-talk achieving rapidity and specificity
-
Hur EM, Kim KT. G protein-coupled signalling and cross-talk achieving rapidity and specificity. Cellular Signalling 2002; 14: 397-405.
-
(2002)
Cellular Signalling
, vol.14
, pp. 397-405
-
-
Hur, E.M.1
Kim, K.T.2
-
32
-
-
0033578005
-
G-protein-coupled receptor heterodimerization modulates receptor function
-
Jordan BA, Devi LA. G-protein-coupled receptor heterodimerization modulates receptor function. Nature 1999; 399: 697-700.
-
(1999)
Nature
, vol.399
, pp. 697-700
-
-
Jordan, B.A.1
Devi, L.A.2
-
33
-
-
0028050530
-
Complex information processing by the transmembrane signaling system involving G proteins
-
Offermanns S, Schultz G. Complex information processing by the transmembrane signaling system involving G proteins. Naunyn-Schmiedeberg's Arch Pharmacol 1994; 350: 329-38.
-
(1994)
Naunyn-Schmiedeberg's Arch. Pharmacol.
, vol.350
, pp. 329-338
-
-
Offermanns, S.1
Schultz, G.2
-
34
-
-
0030613761
-
2-adrenergjc receptor to different G proteins by protein kinase A
-
2-adrenergjc receptor to different G proteins by protein kinase A. Nature 1997; 390: 88-91.
-
(1997)
Nature
, vol.390
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
35
-
-
0035204534
-
2 Receptors Results in Cooperative Regulation of Cyclic AMP Accumulation and Mitogen-Activated Protein Kinase Activity
-
2 Receptors Results in Cooperative Regulation of Cyclic AMP Accumulation and Mitogen-Activated Protein Kinase Activity. Mol Cell Biol 2001; 21: 8452-60.
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 8452-8460
-
-
Hanke, S.1
Nürnberg, B.2
Groll, D.H.3
Liebmann, C.4
-
36
-
-
0031893949
-
The pathways connecting G protein-coupled rceptors to the nucleus through divergent mitogen-activated protein kinase cascades
-
Gutkind JS. The pathways connecting G protein-coupled rceptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998; 273: 159-61.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 159-161
-
-
Gutkind, J.S.1
-
37
-
-
0034807142
-
Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity
-
Liebmann C. Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity. Cellular Signalling 2001; 13: 777-85.
-
(2001)
Cellular Signalling
, vol.13
, pp. 777-785
-
-
Liebmann, C.1
-
38
-
-
0035952656
-
Cell communication networks: Epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission
-
Gschwind A, Zwick E, Prenzel N, Leserer M, Ullrich A. Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 2001; 20: 1594-1600.
-
(2001)
Oncogene
, vol.20
, pp. 1594-1600
-
-
Gschwind, A.1
Zwick, E.2
Prenzel, N.3
Leserer, M.4
Ullrich, A.5
-
39
-
-
0036364093
-
Diversity of G Protein-Coupled Receptor Signalimg Pathways to ERK/MAP Kinase
-
Belcheva MM, Coscia CJ. Diversity of G Protein-Coupled Receptor Signalimg Pathways to ERK/MAP Kinase. Neurosignals 2002; 11: 34-44.
-
(2002)
Neurosignals
, vol.11
, pp. 34-44
-
-
Belcheva, M.M.1
Coscia, C.J.2
-
40
-
-
0038702295
-
G Protein-Coupled Receptor Signalling in Neuroendocrine Systems. "Location, location, location": Activation and targeting of MAP kinases by G protein-coupled receptors
-
Luttrell LM. G Protein-Coupled Receptor Signalling in Neuroendocrine Systems. "Location, location, location": activation and targeting of MAP kinases by G protein-coupled receptors. J Mol Endocrinel 2003; 30: 117-126.
-
(2003)
J. Mol. Endocrinol.
, vol.30
, pp. 117-126
-
-
Luttrell, L.M.1
-
41
-
-
0043172403
-
Transactivation joins multiple tracks to the ERK/MAPK cascade
-
Wetzker R, Böhmer FD. Transactivation joins multiple tracks to the ERK/MAPK cascade. Nat Rev Mol Cell Biol 2003; 4: 1-6.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 1-6
-
-
Wetzker, R.1
Böhmer, F.D.2
-
42
-
-
0037044582
-
Gα and Gβγ require distinct Src-dependent pathways to activate Rap1 and Ras
-
Schmitt JM, Stork PJS. Gα and Gβγ require distinct Src-dependent pathways to activate Rap1 and Ras. J Biol. Chem 2002; 277: 43024-43032.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43024-43032
-
-
Schmitt, J.M.1
Stork, P.J.S.2
-
43
-
-
0041836339
-
Epac: A new cAMP target and new avenues in cAMP research
-
Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 2003; 4: 733-38.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 733-738
-
-
Bos, J.L.1
-
44
-
-
0039791449
-
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schönwasser DC, Marais RM, Marshall CJ, Parker PJ. Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol 1998; 18: 790-98.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 790-798
-
-
Schönwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
45
-
-
0029907265
-
A role for Pyk2 and Src in linking G protein-coupled receptors with MAP kinase activation
-
Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G protein-coupled receptors with MAP kinase activation. Nature 1996; 383: 547-50.
-
(1996)
Nature
, vol.383
, pp. 547-550
-
-
Dikic, I.1
Tokiwa, G.2
Lev, S.3
Courtneidge, S.A.4
Schlessinger, J.5
-
46
-
-
0033599039
-
EGF receptor transactivation by G-protein-coupled receptors require metalloproteinase cleavage of proHB-EGF
-
Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF receptor transactivation by G-protein-coupled receptors require metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-88.
-
(1999)
Nature
, vol.402
, pp. 884-888
-
-
Prenzel, N.1
Zwick, E.2
Daub, H.3
Leserer, M.4
Abraham, R.5
Wallasch, C.6
Ullrich, A.7
-
47
-
-
0033555859
-
Emerging properties of networks of biological signaling pazhways
-
Bhalla US, Iyengar R. Emerging properties of networks of biological signaling pazhways. Science 1999, 283: 381-87.
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
48
-
-
0034644509
-
Signaling networks: The origin of cellular multitasking
-
Jordan JD, Landau EM, Iyengar R. Signaling networks: the origin of cellular multitasking Cell 2000; 103: 193-200.
-
(2000)
Cell
, vol.103
, pp. 193-200
-
-
Jordan, J.D.1
Landau, E.M.2
Iyengar, R.3
-
49
-
-
0036901518
-
Modeling of signaling networks
-
Neves SR, Iyengar R. Modeling of signaling networks. BioEssays 2002; 24: 1110-17.
-
(2002)
BioEssays
, vol.24
, pp. 1110-1117
-
-
Neves, S.R.1
Iyengar, R.2
-
50
-
-
0035799381
-
βBlockers in congestive heart failure. A Bayersian meta-analysis
-
Brophy JM, Joseph L, Rouleau JL. βBlockers in congestive heart failure. A Bayersian meta-analysis. Ann Intern Med 2001; 134: 550-60.
-
(2001)
Ann. Intern. Med.
, vol.134
, pp. 550-560
-
-
Brophy, J.M.1
Joseph, L.2
Rouleau, J.L.3
-
52
-
-
0033624872
-
Cardiovascular alpha 1-adrenoceptor subtyps: Functions and signaling
-
Varma DR, Deng XF. Cardiovascular alpha 1-adrenoceptor subtyps: functions and signaling. Can J Physiol Pharmacol 2000; 78: 267-92.
-
(2000)
Can. J. Physiol. Pharmacol.
, vol.78
, pp. 267-292
-
-
Varma, D.R.1
Deng, X.F.2
-
55
-
-
0028982948
-
Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation
-
Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Letkowitz RJ. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. J Biol Chem 1995; 270: 17148-53.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 17148-17153
-
-
Hawes, B.E.1
van Biesen, T.2
Koch, W.J.3
Luttrell, L.M.4
Letkowitz, R.J.5
-
56
-
-
0036016946
-
α-Adrenoceptor Antagonists in the Treatment of Benign Prostate Hyperplasia
-
Thiyagarajan M. α-Adrenoceptor Antagonists in the Treatment of Benign Prostate Hyperplasia. Pharmacology 2002; 65: 119-28.
-
(2002)
Pharmacology
, vol.65
, pp. 119-128
-
-
Thiyagarajan, M.1
-
61
-
-
0033870604
-
2-Adrenoceptor agonists in anaesthesia: A new paradigm
-
2-Adrenoceptor agonists in anaesthesia: a new paradigm. Curr Op Anesthesiol 2000; 13: 437-42.
-
(2000)
Curr. Op. Anesthesiol.
, vol.13
, pp. 437-442
-
-
Scholz, J.1
Tonner, P.H.2
-
62
-
-
0029758145
-
2A adrenoceptor subtype to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat
-
2A adrenoceptor subtype to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat. J Clin Invest 1996; 98: 1076-80.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1076-1080
-
-
Mizobe, T.1
Maghsoudi, K.2
Sitwala, K.3
Thianzi, G.4
Ou, J.5
Maze, M.6
-
63
-
-
0036490942
-
Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
-
Christopoulos A. Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nat rev Drug Disc 2002; 1: 198-210.
-
(2002)
Nat. Rev. Drug Disc.
, vol.1
, pp. 198-210
-
-
Christopoulos, A.1
-
64
-
-
0036258990
-
G Protein-Coupled Receptor Allosterism and Complexing
-
Christopoulos A, Kenakin T. G Protein-Coupled Receptor Allosterism and Complexing. Pharmacol rev 2002; 54: 323-74.
-
(2002)
Pharmacol. Rev.
, vol.54
, pp. 323-374
-
-
Christopoulos, A.1
Kenakin, T.2
-
67
-
-
0033784977
-
2A-adrenoceptor: Allosteric modulation by amilorids
-
2A-adrenoceptor: allosteric modulation by amilorids. Mol Pharmacol 2000; 58: 1091-99.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1091-1099
-
-
Leppik, R.A.1
Birdsall, N.J.2
-
68
-
-
0031443549
-
Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide
-
Thomas EA, Canson MJ, Neal MJ, Sutcliffle JG. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. Proc Natl Acad Sci USA 1997, 94: 14115-19.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 14115-14119
-
-
Thomas, E.A.1
Canson, M.J.2
Neal, M.J.3
Sutcliffle, J.G.4
-
69
-
-
0030066731
-
A new peptide, 5-HT-moduline, isolated and purified form mammalian brain specifically interacts with 5-HT1B/1D receptors
-
Fillion G, et al. A new peptide, 5-HT-moduline, isolated and purified form mammalian brain specifically interacts with 5-HT1B/1D receptors. Behav Brain Res 1996; 73: 313-17.
-
(1996)
Behav. Brain Res.
, vol.73
, pp. 313-317
-
-
Fillion, G.1
-
70
-
-
0141730394
-
Tyr-c[D-Orn-Tyr(Bzl)-Pro Gly]: A novel antiproliferative acting somatostatin receptor agonist with μ-opioid receptor-sensitizing properties
-
Stirnweiss J, Hartrodt B, Greksch G, Stürzebecher U, Böhmer FD, Neubert K, Liebmann C. Tyr-c[D-Orn-Tyr(Bzl)-Pro Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ-opioid receptor-sensitizing properties. Brit J Pharmacol 2003; 140: 13-22.
-
(2003)
Brit. J. Pharmacol.
, vol.140
, pp. 13-22
-
-
Stirnweiss, J.1
Hartrodt, B.2
Greksch, G.3
Stürzebecher, U.4
Böhmer, F.D.5
Neubert, K.6
Liebmann, C.7
-
72
-
-
0036174898
-
G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction
-
Brady AE, Limbird LE. G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction. Cell Signal 2002; 14: 297-309.
-
(2002)
Cell Signal
, vol.14
, pp. 297-309
-
-
Brady, A.E.1
Limbird, L.E.2
-
73
-
-
0032574982
-
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
-
McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998; 393: 333-39.
-
(1998)
Nature
, vol.393
, pp. 333-339
-
-
McLatchie, L.M.1
-
74
-
-
0036672521
-
Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs)
-
Fischer JA, Muff R, Born W. Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs). Biochem Soc Trans 2002; 4: 455-60.
-
(2002)
Biochem. Soc. Trans.
, vol.4
, pp. 455-460
-
-
Fischer, J.A.1
Muff, R.2
Born, W.3
-
75
-
-
0036379870
-
Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: The contributions of novel receptor-activity-modifying proteins
-
Born W, Fischer JA, Muff R. Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins. Receptor Channels 2002; 8: 201-9.
-
(2002)
Receptor Channels
, vol.8
, pp. 201-209
-
-
Born, W.1
Fischer, J.A.2
Muff, R.3
-
76
-
-
0037177801
-
Respective Roles of Calcitonin Receptor-like Receptor (CRLR) and Receptor Activity-modifying Proteins (RAMP) in Cell Surface Expression of CRLR/RAMP Heterodimeric Receptors
-
Flahaut M, Rossier BC, Firsov D. Respective Roles of Calcitonin Receptor-like Receptor (CRLR) and Receptor Activity-modifying Proteins (RAMP) in Cell Surface Expression of CRLR/RAMP Heterodimeric Receptors. J Biol Chem 2002, 277: 14731-7.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 14731-14737
-
-
Flahaut, M.1
Rossier, B.C.2
Firsov, D.3
-
77
-
-
0037300990
-
Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins
-
Kikumoto K, Katafuchi T, Minamino N. Specificity of porcine calcitonin receptor and calcitonin receptor-like receptor in the presence of receptor-activity-modifying proteins. Hypertens Res 2003; 26: S15-23.
-
(2003)
Hypertens. Res.
, vol.26
-
-
Kikumoto, K.1
Katafuchi, T.2
Minamino, N.3
-
78
-
-
0038265460
-
Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity
-
Kuwasako K, Kitamura K, Nagoshi Y, Cao YN, Eto T. Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity. J Biol Chem 2003; 278: 22623-30.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22623-22630
-
-
Kuwasako, K.1
Kitamura, K.2
Nagoshi, Y.3
Cao, Y.N.4
Eto, T.5
-
79
-
-
0037474327
-
Novel Receptor Partners and Function of Receptor Activity-modifying Proteins
-
Christopoulos A, et al. Novel Receptor Partners and Function of Receptor Activity-modifying Proteins. J Biol Chem 2003, 278: 3293-7.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3293-3297
-
-
Christopoulos, A.1
-
80
-
-
0034812699
-
Orphan G protein-coupled receptors: From DNA to drug targets
-
Shaaban S, Benton B. Orphan G protein-coupled receptors: from DNA to drug targets. Curr Opin Drug Discov Devel 2001; 4: 535-47.
-
(2001)
Curr. Opin. Drug Discov. Devel.
, vol.4
, pp. 535-547
-
-
Shaaban, S.1
Benton, B.2
-
81
-
-
0037944275
-
Constitutively activbated G protein-coupled receptors: A novel approach to CNS drug discovery
-
Menzaghi F, Behan DP, Chalmers DT. Constitutively activbated G protein-coupled receptors: a novel approach to CNS drug discovery. Curr Drug Target CNS Neurol Disord 2002; 1: 104-21.
-
(2002)
Curr. Drug Target CNS Neurol. Disord.
, vol.1
, pp. 104-121
-
-
Menzaghi, F.1
Behan, D.P.2
Chalmers, D.T.3
-
82
-
-
0037215631
-
Emergine roles for orphan G-protein-coupled recetors in the cardiovascular system
-
Katugampola S, Davemport A. Emergine roles for orphan G-protein-coupled recetors in the cardiovascular system. Trends Pharmacol Sci 2003; 24 : 30-5.
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, pp. 30-35
-
-
Katugampola, S.1
Davemport, A.2
-
83
-
-
0031792950
-
Orphan G-protein-coupled receptors: The next generation of drug targets?
-
Wilson S, et al. Orphan G-protein-coupled receptors: the next generation of drug targets? Brit J Pharmacol 1998; 125: 1387-92.
-
(1998)
Brit. J. Pharmacol.
, vol.125
, pp. 1387-1392
-
-
Wilson, S.1
-
84
-
-
0036669944
-
Strategies to identify ligands for orphan G-protein-coupled receptors
-
Milligan G. Strategies to identify ligands for orphan G-protein-coupled receptors. Biochem Soc Transact 2002; 30: 789-93.
-
(2002)
Biochem. Soc. Transact.
, vol.30
, pp. 789-793
-
-
Milligan, G.1
-
85
-
-
0037385367
-
Peptide and trace amine orphan receptors: Prospects for new therapeutic targets
-
Davenport AP. Peptide and trace amine orphan receptors: prospects for new therapeutic targets. Curr Opin Pharmacol 2003; 3: 127-34.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 127-134
-
-
Davenport, A.P.1
-
86
-
-
0032489093
-
Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour
-
Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 1998; 92: 573-85.
-
(1998)
Cell
, vol.92
, pp. 573-585
-
-
Sakurai, T.1
-
87
-
-
0035997205
-
Orexins: From neuropeptides to energy homeostasis and sleep/wake regulation
-
Beuckmann CT, Yanagisawa M. Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med 2002; 80: 329-42.
-
(2002)
J. Mol. Med.
, vol.80
, pp. 329-342
-
-
Beuckmann, C.T.1
Yanagisawa, M.2
-
88
-
-
0141920775
-
Orexin Receptors and G-Protein Coupling: Evidence for Another "Promiscuous" Seven Transmembrane Domain Receptor
-
Karteris E, Randevy HS. Orexin Receptors and G-Protein Coupling: Evidence for Another "Promiscuous" Seven Transmembrane Domain Receptor. J Pharmacol Sci 2003; 93: 126-8.
-
(2003)
J. Pharmacol. Sci.
, vol.93
, pp. 126-128
-
-
Karteris, E.1
Randevy, H.S.2
-
89
-
-
0033575930
-
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
-
Amers RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 1999; 401: 282-6.
-
(1999)
Nature
, vol.401
, pp. 282-286
-
-
Amers, R.S.1
-
90
-
-
0032552988
-
Isolation and characterization of a novel endogenous pwptide ligand for the human APJ receptor
-
Tatemoto K, et al. Isolation and characterization of a novel endogenous pwptide ligand for the human APJ receptor. Biochem Biophys Res Common 1998; 251: 471-6.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.251
, pp. 471-476
-
-
Tatemoto, K.1
-
91
-
-
0033540056
-
Ghrelin is a growth-hirmone-releasing acylated peptide from stomach
-
Kojima M, Hosoda H, Date Y, Nakazato M, Kanagawa K. Ghrelin is a growth-hirmone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
-
(1999)
Nature
, vol.402
, pp. 656-660
-
-
Kojima, M.1
Hosoda, H.2
Date, Y.3
Nakazato, M.4
Kanagawa, K.5
-
93
-
-
0036671721
-
G-protein-coupled receptors in human artherosclerosis: Comparison of vasoconstrictors (endothelin and thromboxane) with recently deorphanized (urotensin-II, apelin and ghrelin) receptors
-
Katagampola SD, Kuc RE Maguire JJ, Davenport AP. G-protein-coupled receptors in human artherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently deorphanized (urotensin-II, apelin and ghrelin) receptors. Clin Sci 2002; 103: 171S-5S.
-
(2002)
Clin. Sci.
, vol.103
-
-
Katagampola, S.D.1
Kuc, R.E.2
Maguire, J.J.3
Davenport, A.P.4
-
94
-
-
0029812311
-
The classification of seven transmembrane receptors in recombinant expression systems
-
Kenakin T. The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol Rev 1996; 48: 1210-25.
-
(1996)
Pharmacol. Rev.
, vol.48
, pp. 1210-1225
-
-
Kenakin, T.1
-
95
-
-
0036033424
-
Constitutive activity of G-protein-coupled receptors: Cause of disease and common property of wild-type receptors
-
Seifert R, Wenzel-Seifert K. Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors. Naunyn-Schmiedeberg's Arch Pharmacol 2002; 366: 381-416.
-
(2002)
Naunyn-Schmiedeberg's Arch. Pharmacol.
, vol.366
, pp. 381-416
-
-
Seifert, R.1
Wenzel-Seifert, K.2
-
96
-
-
3242662870
-
Molecular pharmacology, regulation and function of mammalian melatonin receptors
-
Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI. Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci 2003; 8: 1093-108
-
(2003)
Front Biosci.
, vol.8
, pp. 1093-1108
-
-
Dubocovich, M.L.1
Rivera-Bermudez, M.A.2
Gerdin, M.J.3
Masana, M.I.4
-
97
-
-
0035083109
-
Inverse, protean, and ligand-selective agonism: Matters of receptor conformation
-
Kenakin T. Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J 2001; 15: 598-611.
-
(2001)
FASEB J.
, vol.15
, pp. 598-611
-
-
Kenakin, T.1
-
98
-
-
0036468505
-
Mechanisms of inverse agonism at G-protein-coupled receptors
-
Strange PG. Mechanisms of inverse agonism at G-protein-coupled receptors. Trends Pharmacol Sci 2002, 23: 89-95.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 89-95
-
-
Strange, P.G.1
-
99
-
-
0034741106
-
2Λ receptor inverse agonists as antipsychotics
-
2Λ receptor inverse agonists as antipsychotics. J Pharmacol Exp Ther 2001; 299: 268-76.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 268-276
-
-
Weiner, D.M.1
-
101
-
-
0034006475
-
Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor
-
Rosenkilde MM, Schwartz TW. Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor. Mol Pharmacol 2000; 57: 602-9.
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 602-609
-
-
Rosenkilde, M.M.1
Schwartz, T.W.2
-
102
-
-
0033151694
-
Chimeric G proteins allow a high-throughput signaling assay of Gicoupled receptors
-
Coward P, Chan SD, Wada HG, Humphries GM, Conklin BR. Chimeric G proteins allow a high-throughput signaling assay of Gicoupled receptors. Anal Biochem 1999; 270: 242-8.
-
(1999)
Anal. Biochem.
, vol.270
, pp. 242-248
-
-
Coward, P.1
Chan, S.D.2
Wada, H.G.3
Humphries, G.M.4
Conklin, B.R.5
-
104
-
-
0031940393
-
Controlling signaling with a specifically designed Gicoupled receptor
-
Coward P, Wada HG, Falk MS, Chan SDH, Meng F, Akil H, Conklin BR. Controlling signaling with a specifically designed Gicoupled receptor. Proc Natl Acad Sci USA 1998; 95: 352-7.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 352-357
-
-
Coward, P.1
Wada, H.G.2
Falk, M.S.3
Chan, S.D.H.4
Meng, F.5
Akil, H.6
Conklin, B.R.7
-
105
-
-
0035943605
-
Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy
-
Small KM, Brown KM, Forbes SL, Liggett SB. Modification of the beta 2-adrenergic receptor to engineer a receptor-effector complex for gene therapy. J Biol Chem 2001; 276: 31596-601.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31596-31601
-
-
Small, K.M.1
Brown, K.M.2
Forbes, S.L.3
Liggett, S.B.4
-
108
-
-
0034989781
-
Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein α -subunits
-
Galeotti N, Ghelardini C, Bartolini A. Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein α-subunits. Brit J Pharmacol 2001; 133: 267-74.
-
(2001)
Brit. J. Pharmacol.
, vol.133
, pp. 267-274
-
-
Galeotti, N.1
Ghelardini, C.2
Bartolini, A.3
-
109
-
-
0032859735
-
Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling
-
Cismowski MJ, et al. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling. Nature Biotechnol 1999; 17: 878-83.
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 878-883
-
-
Cismowski, M.J.1
-
110
-
-
0033584844
-
Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways
-
Takesono A, et al. Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways. J Biol Chem 1999; 274: 33202-5.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 33202-33205
-
-
Takesono, A.1
-
111
-
-
0038047055
-
Influence of Cytosolic AGS3 on Receptor-G Protein Coupling
-
Ma H, Perterson YK, Bernard ML, Lanier SM, Graber SG. Influence of Cytosolic AGS3 on Receptor-G Protein Coupling. Biochemistry 2003; 42: 8085-93.
-
(2003)
Biochemistry
, vol.42
, pp. 8085-8093
-
-
Ma, H.1
Perterson, Y.K.2
Bernard, M.L.3
Lanier, S.M.4
Graber, S.G.5
-
112
-
-
0037593654
-
Interaction of Activator of G-protein Signaling 3 (AGS3) with LKB1, a Serine/Threonine Kinase Involved in Cell Polarity and Cell Cycle Progression
-
Blumer JB, et al. Interaction of Activator of G-protein Signaling 3 (AGS3) with LKB1, a Serine/Threonine Kinase Involved in Cell Polarity and Cell Cycle Progression. J Biol Chem 2003; 278: 23217-20.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23217-23220
-
-
Blumer, J.B.1
-
113
-
-
0035865394
-
Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors
-
Scott JK, et al. Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. EMBO J 2001; 20: 767-76.
-
(2001)
EMBO J.
, vol.20
, pp. 767-776
-
-
Scott, J.K.1
-
114
-
-
0037827724
-
Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides
-
Goubaeva F, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem 2003; 278: 19634-41.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19634-19641
-
-
Goubaeva, F.1
-
115
-
-
0041315914
-
Receptor- and Nucleotide Exchange-indeperident Mechanisms for Promoting G Protein Subunit Dissociation
-
Ghosh M, Peterson YK, Lanier SM, Smreka AV. Receptor- and Nucleotide Exchange-indeperident Mechanisms for Promoting G Protein Subunit Dissociation. J Biol Chem 2003; 278: 34747-50.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34747-34750
-
-
Ghosh, M.1
Peterson, Y.K.2
Lanier, S.M.3
Smreka, A.V.4
-
116
-
-
0036490096
-
Regulators of G-protein signaling as new central nervous system drug targets
-
Neubig RR, Siderovski DP. Regulators of G-protein signaling as new central nervous system drug targets. Nature Rev Drug Discov 2002; 11: 187-97.
-
(2002)
Nature Rev. Drug Discov.
, vol.11
, pp. 187-197
-
-
Neubig, R.R.1
Siderovski, D.P.2
-
117
-
-
0032569051
-
P115RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
-
Kozasa T, et al. P115RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science 1998; 280: 2109-11.
-
(1998)
Science
, vol.280
, pp. 2109-2111
-
-
Kozasa, T.1
-
118
-
-
0030881687
-
D-AKAP2, a novel protein kinase anchoring protein with a putative RGS domain
-
Huang LS, Durick K, Weiner JA, Chun J, Taylor SS. D-AKAP2, a novel protein kinase anchoring protein with a putative RGS domain. Proc Natl Acad Sci USA 1997; 94: 11184-9.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 11184-11189
-
-
Huang, L.S.1
Durick, K.2
Weiner, J.A.3
Chun, J.4
Taylor, S.S.5
-
119
-
-
0033607326
-
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2
-
Wedegaertner PB, Gilman AG, Benovic JL, Kozasa T. Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem 1999; 274: 34483-92.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34483-34492
-
-
Wedegaertner, P.B.1
Gilman, A.G.2
Benovic, J.L.3
Kozasa, T.4
-
120
-
-
0038193543
-
RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity
-
Hooks SB, Waldo GL, Corbitt J, Bodor ET, Krumins AM, Harden TK. RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity. J Biol Chem 2003; 278: 10087-93.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10087-10093
-
-
Hooks, S.B.1
Waldo, G.L.2
Corbitt, J.3
Bodor, E.T.4
Krumins, A.M.5
Harden, T.K.6
-
121
-
-
0037569639
-
The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling
-
Cho H, Harrison K, Schwartz O, Kehrl H. The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. Biochem J 2003; 371: 973-80.
-
(2003)
Biochem. J.
, vol.371
, pp. 973-980
-
-
Cho, H.1
Harrison, K.2
Schwartz, O.3
Kehrl, H.4
-
122
-
-
0037860972
-
RGS9 Modulates Dopamine Signaling in the Basal Ganglia
-
Rahman Z, et al. RGS9 Modulates Dopamine Signaling in the Basal Ganglia. Neuron 2003; 38: 941-52.
-
(2003)
Neuron.
, vol.38
, pp. 941-952
-
-
Rahman, Z.1
-
123
-
-
0035013840
-
Regulators of G Protein Signaling Proteins: Novel Multifunctional Drug Targets
-
Zhong H, Neubig RR. Regulators of G Protein Signaling Proteins: Novel Multifunctional Drug Targets. J Pharmacol Exp Ther 2001; 297: 837-45.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 837-845
-
-
Zhong, H.1
Neubig, R.R.2
-
124
-
-
0034705237
-
Ca2+/calmodulin reverses phsophatidylinositol 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity
-
Popov SG, Krishna UM, Falk JR, Wilkie TM. Ca2+/calmodulin reverses phsophatidylinositol 3,4,5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J Biol Chem 2000; 275: 18962-8.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18962-18968
-
-
Popov, S.G.1
Krishna, U.M.2
Falk, J.R.3
Wilkie, T.M.4
-
125
-
-
0030995012
-
Regulation of Phosphoinositide-specific Phospholipase C Isozymes
-
Rhee SG, Bae YS. Regulation of Phosphoinositide-specific Phospholipase C Isozymes. J Biol Chem 1997; 273: 15045-8.
-
(1997)
J. Biol. Chem.
, vol.273
, pp. 15045-15048
-
-
Rhee, S.G.1
Bae, Y.S.2
-
126
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 2003; 370: 361-71.
-
(2003)
Biochem. J.
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
127
-
-
0035474310
-
Adaptor proteins in protein kinase C-mediated signal transduction
-
Schechtman D, Mochly-Rosen D. Adaptor proteins in protein kinase C-mediated signal transduction. Oncogene 2001; 20: 6339-47.
-
(2001)
Oncogene
, vol.20
, pp. 6339-6347
-
-
Schechtman, D.1
Mochly-Rosen, D.2
-
128
-
-
0036632368
-
The Phosphatidylinositol 3-Kinase-Akt Pathway in Human Cancer
-
Vivanco I, Sawyers CL. The Phosphatidylinositol 3-Kinase-Akt Pathway in Human Cancer, Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
129
-
-
18644372367
-
Regulation of Myocardial Contractility and Cell Size by Distinct P13K-PTEN Signaling Pathways
-
Crackower MA, et al. Regulation of Myocardial Contractility and Cell Size by Distinct P13K-PTEN Signaling Pathways. Cell 2002; 110: 737-49.
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
-
130
-
-
0033835813
-
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
-
Defer N, Best-Belpomme M, Hanoune J. Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am J Physiol Renal Physiol 2000; 279: F400-F416.
-
(2000)
Am. J. Physiol. Renal Physiol.
, vol.279
-
-
Defer, N.1
Best-Belpomme, M.2
Hanoune, J.3
-
132
-
-
0037952847
-
Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunit of PKA
-
Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor SS. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunit of PKA. Biochemistry 2003; 42: 5754-63.
-
(2003)
Biochemistry
, vol.42
, pp. 5754-5763
-
-
Burns, L.L.1
Canaves, J.M.2
Pennypacker, J.K.3
Blumenthal, D.K.4
Taylor, S.S.5
-
133
-
-
0034617282
-
Mechanisms of regulation of the Epac family of cAMP-dependent RapGEFs
-
de Rooji J, et al. Mechanisms of regulation of the Epac family of cAMP-dependent RapGEFs. J Biol Chem 2000 275: 20829-36.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20829-20836
-
-
de Rooji, J.1
-
134
-
-
0030974622
-
Tailoring cAMP signaling responses through isoform multiplicity
-
Houslay MD, Milligan G. Tailoring cAMP signaling responses through isoform multiplicity. Trends Biochem Sci 1997 22: 217-24.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 217-224
-
-
Houslay, M.D.1
Milligan, G.2
-
135
-
-
0037443097
-
PDE4 cAMP phosphodiesterases: Modular enzymes that orchstrate signaling cross-talk, desensitization and compartmentalization
-
Houslay MD, Adams DR. PDE4 cAMP phosphodiesterases: modular enzymes that orchstrate signaling cross-talk, desensitization and compartmentalization. Biochem J 2003; 370: 1-18.
-
(2003)
Biochem. J.
, vol.370
, pp. 1-18
-
-
Houslay, M.D.1
Adams, D.R.2
-
137
-
-
0037214293
-
Isoform-targeted regulation of cardiac adenylyl cyclase
-
Ishikawa Y. Isoform-targeted regulation of cardiac adenylyl cyclase. J Cradiovasc Pharmacol 2003; 41: S1-S4.
-
(2003)
J. Cradiovasc. Pharmacol.
, vol.41
-
-
Ishikawa, Y.1
-
138
-
-
0035897590
-
Molecular biological approaches to unravel adenylyl cyclase signaling
-
Patel TB, Du Z, Pierre S, Cartin L, Scholich K. Molecular biological approaches to unravel adenylyl cyclase signaling. Gene 2001; 269: 13-25.
-
(2001)
Gene
, vol.269
, pp. 13-25
-
-
Patel, T.B.1
Du, Z.2
Pierre, S.3
Cartin, L.4
Scholich, K.5
-
139
-
-
12444331581
-
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules
-
Celano M, et al. Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. Mol Cell Endocrinol 2003; 203: 129-35.
-
(2003)
Mol. Cell Endocrinol.
, vol.203
, pp. 129-135
-
-
Celano, M.1
-
140
-
-
0042856454
-
Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa
-
Baxendale RW, Fraser LR. Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa. Mol Reprod Dev 2003; 66: 181-9.
-
(2003)
Mol. Reprod. Dev.
, vol.66
, pp. 181-189
-
-
Baxendale, R.W.1
Fraser, L.R.2
-
141
-
-
0042691820
-
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload
-
Okumura S, et al. Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload. Proc Natl Acad Sci USA 2003; 100: 9986-90.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9986-9990
-
-
Okumura, S.1
-
142
-
-
1842335067
-
Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates
-
Johnson RA, et al. Isozyme-dependent sensitivity of adenylyl cyclases to P-site-mediated inhibition by adenine nucleosides and nucleoside 3′-polyphosphates. J Biol Chem 1997; 272: 8962-6.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 8962-8966
-
-
Johnson, R.A.1
-
143
-
-
0033520942
-
Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents
-
Shoshani I, Laux WH, Perigaud C, Gosselin G, Johnson RA. Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents. J Biol Chem 1999; 274: 34742-4.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34742-34744
-
-
Shoshani, I.1
Laux, W.H.2
Perigaud, C.3
Gosselin, G.4
Johnson, R.A.5
-
144
-
-
0031940268
-
Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase
-
Toya Y, Schwencke C, Ishikawa Y. Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J Mol Cell Cardiol 1998; 30: 97-108.
-
(1998)
J. Mol. Cell Cardiol.
, vol.30
, pp. 97-108
-
-
Toya, Y.1
Schwencke, C.2
Ishikawa, Y.3
-
145
-
-
0035930583
-
Type-specific Regulation of Adenylyl Cyclase
-
Onda T, et al. Type-specific Regulation of Adenylyl Cyclase. J Biol Chem 2001; 276: 47785-93.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47785-47793
-
-
Onda, T.1
-
146
-
-
0037334541
-
Small ligands modulating the activity of mammalian adenylyl cyclases: A novel mode of inhibition by calmidazolium
-
Haunso A, Simpson J, Antoni FA. Small ligands modulating the activity of mammalian adenylyl cyclases: a novel mode of inhibition by calmidazolium. Mol Pharmacol 2003; 63: 624-31.
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 624-631
-
-
Haunso, A.1
Simpson, J.2
Antoni, F.A.3
-
148
-
-
0032555138
-
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
-
Soderling SH, Bayuga SJ, Beavo JA. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci USA 1998; 95: 8991-6.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8991-8996
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
-
149
-
-
0033536020
-
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A
-
Soderling SH, Bayuga SJ, Beavo JA. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci USA 1999; 96: 7071-6.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 7071-7076
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
-
150
-
-
0034724177
-
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
-
Fawcett L, et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 2000; 97: 3702-7.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3702-3707
-
-
Fawcett, L.1
-
151
-
-
0036134416
-
Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling
-
Mehats C, Andersen CB, Filopanti M, Jin SLC, Conti M. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrin Metab 2002; 13: 29-35.
-
(2002)
Trends Endocrin. Metab.
, vol.13
, pp. 29-35
-
-
Mehats, C.1
Andersen, C.B.2
Filopanti, M.3
Jin, S.L.C.4
Conti, M.5
-
152
-
-
0037458648
-
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling
-
Conti M, Richter W, Mehats C, Livera G, Park J-Y, Jin C. Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling. J Biol Chem 2003; 278: 5493-6.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 5493-5496
-
-
Conti, M.1
Richter, W.2
Mehats, C.3
Livera, G.4
Park, J.-Y.5
Jin, C.6
-
153
-
-
0036265607
-
Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs
-
Burnouf C, Pruniaux MP. Recent advances in PDE4 inhibitors as immunoregulators and anti-inflammatory drugs. Curr Pharm Des 2002; 8: 1255-96.
-
(2002)
Curr. Pharm. Des.
, vol.8
, pp. 1255-1296
-
-
Burnouf, C.1
Pruniaux, M.P.2
-
154
-
-
0031045482
-
Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD
-
Keatings VM, et al. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997; 155: 542-8.
-
(1997)
Am. J. Respir. Crit. Care Med.
, vol.155
, pp. 542-548
-
-
Keatings, V.M.1
-
155
-
-
0031914520
-
Phosphodiesterase isozymes: Molecular targets for novel antiasthma agents
-
Torphy TJ. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am J Respir Crit Care Med 1998; 157: 351-370.
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.157
, pp. 351-370
-
-
Torphy, T.J.1
-
156
-
-
0035078823
-
In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor
-
Bundschuh DS, Eltze M, Barsig J, Wollin L, Hatzelmann A, Beume R. In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor. J Pharmacol Exp Ther 2001; 297: 280-90.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.297
, pp. 280-290
-
-
Bundschuh, D.S.1
Eltze, M.2
Barsig, J.3
Wollin, L.4
Hatzelmann, A.5
Beume, R.6
-
157
-
-
0031911575
-
SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions
-
Barnette MS, Christensen SB, Essayan DM, Grous M, Prabhakar U, Rush JA, et al. SB 207499 (Ariflo), a Potent and Selective Second-Generation Phosphodiesterase 4 Inhibitor: In Vitro Anti-inflammatory Actions. J Pharmacol Exp Ther 1998; 284: 420-6.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.284
, pp. 420-426
-
-
Barnette, M.S.1
Christensen, S.B.2
Essayan, D.M.3
Grous, M.4
Prabhakar, U.5
Rush, J.A.6
-
158
-
-
0036264724
-
Phosphodiesterase 4 Inhibitors for the Treatment of COPD
-
Sturton G, Fitzgerald M. Phosphodiesterase 4 Inhibitors for the Treatment of COPD. Chest 2002; 121: 192S-6S.
-
(2002)
Chest
, vol.121
-
-
Sturton, G.1
Fitzgerald, M.2
-
159
-
-
0037308172
-
Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells
-
Smith SJ, Brookes-Fazakerley S, Donnelly LE. Barnes PJ, Barnette MS, Giembycz MA. Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells. Am J Physiol Lung Cell Mol Physiol 2002; 294: L279-89.
-
(2002)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.294
-
-
Smith, S.J.1
Brookes-Fazakerley, S.2
Donnelly, L.E.3
Barnes, P.J.4
Barnette, M.S.5
Giembycz, M.A.6
-
160
-
-
0036277784
-
Potential role of phosphodiesterase 7 in human T cell function: Comparative effects of two phosphodiesterase inhibitors
-
Nakata A, Ogawa K, Sasaki T, Koyama N, Wada K, Kotera J, et al. Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol 2002; 128: 460-6.
-
(2002)
Clin. Exp. Immunol.
, vol.128
, pp. 460-466
-
-
Nakata, A.1
Ogawa, K.2
Sasaki, T.3
Koyama, N.4
Wada, K.5
Kotera, J.6
-
161
-
-
0035257843
-
Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: Urologic and cardiovascular implications
-
Nehra A, Colreavy F, Khandheria BK, Chandrasekaran K. Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications. World J Urol 2001; 19: 40-5.
-
(2001)
World J. Urol.
, vol.19
, pp. 40-45
-
-
Nehra, A.1
Colreavy, F.2
Khandheria, B.K.3
Chandrasekaran, K.4
-
162
-
-
0035257809
-
Phosphodiesterase isozymes as pharmacological targets in the treatment of male erectile dysfunction
-
Ückert S, Küthe A, Stief CG, Jonas U. Phosphodiesterase isozymes as pharmacological targets in the treatment of male erectile dysfunction. World J Urol 2001; 19: 14-22.
-
(2001)
World J. Urol.
, vol.19
, pp. 14-22
-
-
Ückert, S.1
Küthe, A.2
Stief, C.G.3
Jonas, U.4
-
163
-
-
0036136463
-
Molecular mechanisms for protein kinase A-mediated modulation of immune function
-
Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Tasken K. Molecular mechanisms for protein kinase A-mediated modulation of immune function. Cell Signalling 2002; 14: 1-9.
-
(2002)
Cell Signalling
, vol.14
, pp. 1-9
-
-
Torgersen, K.M.1
Vang, T.2
Abrahamsen, H.3
Yaqub, S.4
Tasken, K.5
-
164
-
-
0037178847
-
Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
-
Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laslo GS, et al. Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo, J Biol Chem 2002; 277: 27294-304.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 27294-27304
-
-
Amieux, P.S.1
Howe, D.G.2
Knickerbocker, H.3
Lee, D.C.4
Su, T.5
Laslo, G.S.6
-
165
-
-
0036293582
-
The essential role of RI alpha in the maintenance of regulated PKA activity
-
Amieux PS, McKnight GS. The essential role of RI alpha in the maintenance of regulated PKA activity. Ann NY Acad Sci 2002; 968: 75-95.
-
(2002)
Ann. NY Acad. Sci.
, vol.968
, pp. 75-95
-
-
Amieux, P.S.1
McKnight, G.S.2
-
166
-
-
0037341359
-
Antisense Protein Kinase A RIα Acts Synergistically with Hydroxycamptothecin to Inhibit Growth and Induce Apoptosis in Human Cancer Cells: Molecular Basis for Combinatorial Therapy
-
Cho YSW, Cho-Chung YS. Antisense Protein Kinase A RIα Acts Synergistically with Hydroxycamptothecin to Inhibit Growth and Induce Apoptosis in Human Cancer Cells: Molecular Basis for Combinatorial Therapy. Clin Cancer Res 2003; 9: 1171-8.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1171-1178
-
-
Cho, Y.S.W.1
Cho-Chung, Y.S.2
-
167
-
-
0037386547
-
Designing isoform-specific peptide disruptors of protein kinase A localization
-
Burns-Hamuro LL, et al. Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci USA 2003; 100: 4072-7.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4072-4077
-
-
Burns-Hamuro, L.L.1
-
168
-
-
0034907636
-
Pharmacologic Interruption of the Mitogen-activated Extraceliular-regulated Kinase/Mitogen-activated Protein Kinase Signal Transduction Pathway: Potential Role in Promoting Cytotoxic Drug Action
-
Dent P, Grant S. Pharmacologic Interruption of the Mitogen- activated Extraceliular-regulated Kinase/Mitogen-activated Protein Kinase Signal Transduction Pathway: Potential Role in Promoting Cytotoxic Drug Action. Clin Cancer Res 2001; 7: 775-83.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 775-783
-
-
Dent, P.1
Grant, S.2
-
169
-
-
18744380415
-
The Future of Trageted Therapy: Combining Novel Agents
-
Gianni L. The Future of Trageted Therapy: Combining Novel Agents. Oncology 2002; 63(suppl 1): 47-56.
-
(2002)
Oncology
, vol.63
, Issue.SUPPL. 1
, pp. 47-56
-
-
Gianni, L.1
-
170
-
-
0141538107
-
Cyclooxygenase-2 biology
-
Claria J. Cyclooxygenase-2 biology. Curr Pharm Design 2003; 9(27): 2177-90.
-
(2003)
Curr. Pharm. Design
, vol.9
, Issue.27
, pp. 2177-2190
-
-
Claria, J.1
-
171
-
-
0141761371
-
Novel protein targeted therapy of metastatic melanoma
-
Frankel AE, Koo HM, Leppla SH, Duesbery NS, Wounde GF. Novel protein targeted therapy of metastatic melanoma. Curr Pharm Design 2003, 9(25): 2060-6.
-
(2003)
Curr. Pharm. Design
, vol.9
, Issue.25
, pp. 2060-2066
-
-
Frankel, A.E.1
Koo, H.M.2
Leppla, S.H.3
Duesbery, N.S.4
Wounde, G.F.5
-
172
-
-
0038804193
-
Ghrelin as a potential anti-obesity target
-
Horvath TL, Castaneda T, Tang-Christensen M, Pagotto U, Tschop MH. Ghrelin as a potential anti-obesity target. Curr Pharm Design 2003; 9(17): 1383-95.
-
(2003)
Curr. Pharm. Design
, vol.9
, Issue.17
, pp. 1383-1395
-
-
Horvath, T.L.1
Castaneda, T.2
Tang-Christensen, M.3
Pagotto, U.4
Tschop, M.H.5
|