RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate

Circulation Research

Volumn 107, Issue 11, 2010, Pages 1350-1354

  Posokhova, Ekaterina ^a   Wydeven, Nicole ^a   Allen, Kevin L ^a   Wickman, Kevin ^a   Martemyanov, Kirill A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cardiac; G protein; GIRK; Knockout; Muscarinic; Regulators of G protein signaling

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M2 RECEPTOR; POTASSIUM CHANNEL; PROTEIN RGS 6; RGS PROTEIN; UNCLASSIFIED DRUG; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GNB5 PROTEIN, MOUSE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; POTASSIUM CHANNEL PROTEIN I(SK); RGS6 PROTEIN, MOUSE; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CHANNEL GATING; GENE TARGETING; HEART; HEART ATRIUM; HEART MUSCLE CELL; HEART RATE; HEART VENTRICLE PRESSURE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PARASYMPATHETIC FUNCTION; PRIORITY JOURNAL; SINOATRIAL CONDUCTION; SINUS BRADYCARDIA; SINUS NODE; ANIMAL; C57BL MOUSE; CELL STRAIN HEK293; COMPARATIVE STUDY; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; GENETICS; HUMAN; MOUSE MUTANT; PARASYMPATHETIC NERVE; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; DOWN-REGULATION; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEIN BETA SUBUNITS; HEART ATRIA; HEART RATE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; PARASYMPATHETIC FIBERS, POSTGANGLIONIC; POTASSIUM CHANNELS, VOLTAGE-GATED; RGS PROTEINS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 78650414238     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.224212     Document Type: Article

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