Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gβγ

Science

Volumn 300, Issue 5623, 2003, Pages 1256-1262

  Lodowski, David T ^a   Pitcher, Julie A ^b   Capel, W Darrell ^c   Lefkowitz, Robert J ^c   Tesmer, John J G ^a  

^a University of Texas ^*  (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; CELL MEMBRANES; CRYSTALLOGRAPHY;

PHOSPHORYLATION;

ENZYMES;

G PROTEIN COUPLED RECEPTOR KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE G BETA SIGMA; GUANINE NUCLEOTIDE BINDING PROTEIN; PLECKSTRIN; PROTEIN KINASE; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

BIOCHEMISTRY; PROTEIN;

ARTICLE; CELL MEMBRANE; CRYSTALLOGRAPHY; DESENSITIZATION; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; PROTEIN STRUCTURE; RECEPTOR BINDING; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CATTLE; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

BOVINAE;

EID: 0037799206     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082348     Document Type: Article

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62. 2; J. Barnhill and Q. Li for technical support; and V. M. Tesmer for extensive editorial assistance. Supported by Texas Affiliate American Heart Association grant-in-aid 0060118Y, American Heart Association scientist development grant 0235273N, Welch Foundation chemical research grant F-1487, and a Cottrell Scholar award (Research Corporation) (J.J.G.T.) and by NIH grant HL16037 (R.J.L). R.J.L. is an Investigator of the Howard Hughes Medical Institute. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, Materials Sciences Division, U.S. Department of Energy under contract DE-AC03-76SF00098 at Lawrence Berkeley National Laboratory. Coordinates for the structure reported above have been deposited in the Protein Data Bank (entry 10MW).