The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Gα-interaction face

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1774, Issue 9, 2007, Pages 1213-1220

  Kimple, Adam J ^a   Willard, Francis S ^a   Giguère, Patrick M ^a   Johnston, Christopher A ^a   Mocanu, Viorel ^b   Siderovski, David P ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

CCG 4986; Regulator of G protein signaling; RGS protein inhibitor; RGS4; Thiol adduct

Indexed keywords

CCG 4986; CYSTEINE; G PROTEIN COUPLED RECEPTOR; GLUTAMINE; GUANOSINE TRIPHOSPHATE; METHYL N[(4 CHLOROPHENYL)SULFONYL] 4 NITROBENZENESULFINIMIDOATE; PROTEIN INHIBITOR; RGS PROTEIN; RGS4 PROTEIN; RGS8 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROLYSIS; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; SURFACE PLASMON RESONANCE; WILD TYPE;

AMINO ACID SEQUENCE; CYSTEINE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RGS PROTEINS; SEQUENCE ALIGNMENT; SULFONAMIDES;

EID: 34548289765     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2007.06.002     Document Type: Article

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