Differential Contribution of GTPase Activation and Effector Antagonism to the Inhibitory Effect of RGS Proteins on Gq-mediated Signaling in Vivo

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 3906-3915

  Anger, Thomas ^a   Zhang, Wei ^a   Mende, Ulrike ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; CHEMICAL ACTIVATION; ENZYMES; HYDROLYSIS;

PROTEIN-MEDIATED SIGNALING; SIGNAL PRODUCTION;

BIOCHEMISTRY;

CARBACHOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MUSCARINIC M3 RECEPTOR; PHOSPHOLIPASE C; RGS PROTEIN;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; DRUG ANTAGONISM; EFFECTOR CELL; ENZYME ACTIVATION; GENETIC TRANSFECTION; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALIA;

EID: 1042266676     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309496200     Document Type: Article

References (54)

1. Neer, E. J. (1995) Cell 80, 249-257
2. Gilman, A. G. (1995) Biosci. Rep. 15, 65-97
3. Hollinger, S., and Hepler, J. R. (2002) Pharmacol. Rev. 54, 527-559
4. Ross, E. M., and Wilkie, T. M. (2000) Annu. Rev. Biochem. 69, 795-827
5. Wieland, T., and Mittmann, C. (2003) Pharmacol. Ther. 97, 95-115
6. Hepler, J. R., Berman, D. M., Gilman, A. G., and Kozasa, T. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 428-432
7. Yan, Y., Chi, P. P., and Bourne, H. R. (1997) J. Biol. Chem. 272, 11924-11927
8. Kehrl, J. H., Srikumar, D., Harrison, K., Wilson, G. L., and Shi, C. S. (2002) Genomics 79, 860-868
9. Reif, K., and Cyster, J. G. (2000) J. Immunol. 164, 4720-4729
10. De Vries, L., Zheng, B., Fischer, T., Elenko, E., and Farquhar, M. G. (2000) Annu. Rev. Pharmacol. Toxicol. 40, 235-271
11. Heximer, S. P., Watson, N., Linder, M. E., Blumer, K. J., and Hepler, J. R. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 14389-14393
12. Qian, N. X., Winitz, S., and Johnson, G. L. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 4077-4081
13. Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F. J., and Neer, E. J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13893-13898
14. Druey, K. M., Blumer, K. J., Kang, V. H., and Kehrl, J. H. (1996) Nature 379, 742-746
15. Kardestuncer, T., Wu, H., Lim, A. L., and Neer, E. J. (1998) FEBS Lett. 438, 285-288
16. Zhang, W., and Neer, E. J. (2001) J. Biol. Chem. 276, 2503-2508
17. Rebecchi, M. J., and Pentyala, S. N. (2000) Physiol. Rev. 80, 1291-1335
18. Rhee, S. G. (2001) Annu. Rev. Biochem. 70, 281-312
19. Wu, D., Katz, A., and Simon, M. I. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5297-5301
20. Wilson, P. T., and Bourne, H. R. (1995) J. Biol. Chem. 270, 9667-9675
21. Berman, D. M., Wilkie, T. M., and Gilman, A. G. (1996) Cell 86, 445-452
22. Chen, C., Zheng, B., Han, J., and Lin, S. C. (1997) J. Biol. Chem. 272, 8679-8685
23. Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M., and Lefkowitz, R. J. (1994) J. Biol. Chem. 269, 6193-6197
24. Natochin, M., McEntaffer, R. L., and Artemyev, N. O. (1998) J. Biol. Chem. 273, 6731-6735
25. Srinivasa, S. P., Watson, N., Overton, M. C., and Blumer, K. J. (1998) J. Biol. Chem. 273, 1529-1533
26. Chen, Z., Singer, W. D., Wells, C. D., Sprang, S. R., and Sternweis, P. C. (2003) J. Biol. Chem. 278, 9912-9919
27. Arkinstall, S., Chabert, C., Maundrell, K., and Peitsch, M. (1995) FEBS Lett. 364, 45-50
28. Tesmer, J. J., Berman, D. M., Gilman, A. G., and Sprang, S. R. (1997) Cell 89, 251-261
29. Berstein, G., Blank, J. L., Jhon, D. Y., Exton, J. H., Rhee, S. G., and Ross, E. M. (1992) Cell 70, 411-418
30. Biddlecome, G. H., Berstein, G., and Ross, E. M. (1996) J. Biol. Chem. 271, 7999-8007
31. Litosch, I. (2002) IUBMB Life 54, 253-260
32. Kehrl, J. H., and Sinnarajah, S. (2002) Int. J. Biochem. Cell Biol. 34, 432-438
33. Zmijewski, J. W., Song, L., Harkins, L., Cobbs, C. S., and Jope, R. S. (2001) Biochim. Biophys. Acta 1541, 201-211
34. Benzing, T., Brandes, R., Sellin, L., Schermer, B., Lecker, S., Walz, G., and Kim, E. (1999) Nat. Med. 5, 913-918
35. Garrison, T. R., Zhang, Y., Pausch, M., Apanovitch, D., Aebersold, R., and Dohlman, H. G. (1999) J. Biol. Chem. 274, 36387-36391
36. Cunningham, M. L., Waldo, G. L., Hollinger, S., Hepler, J. R., and Harden, T. K. (2001) J. Biol. Chem. 276, 5438-5444
37. Salim, S., Sinnarajah, S., Kehrl, J. H., and Dessauer, C. W. (2003) J. Biol. Chem. 278, 15842-15849
38. Heximer, S. P., Srinivasa, S. P., Bernstein, L. S., Bernard, J. L., Linder, M. E., Hepler, J. R., and Blumer, K. J. (1999) J. Biol. Chem. 274, 34253-34259
39. Chatterjee, T. K., Eapen, A. K., and Fisher, R. A. (1997) J. Biol. Chem. 272, 15481-15487
40. Scheschonka, A., Dessauer, C. W., Sinnarajah, S., Chidiac, P., Shi, C. S., and Kehrl, J. H. (2000) Mol. Pharmacol. 58, 719-728
41. Shi, C. S., Lee, S. B., Sinnarajah, S., Dessauer, C. W., Rhee, S. G., and Kehrl, J. H. (2001) J. Biol. Chem. 276, 24293-24300
42. Buckbinder, L., Velasco-Miguel, S., Chen, Y., Xu, N., Talbott, R., Gelbert, L., Gao, J., Seizinger, B. R., Gutkind, J. S., and Kley, N. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7868-7872
43. Zhou, J., Moroi, K., Nishiyama, M., Usui, H., Seki, N., Ishida, J., Fukamizu, A., and Kimura, S. (2001) Life Sci. 68, 1457-1469
44. Cho, H., Kozasa, T., Bondjers, C., Betsholtz, C., and Kehrl, J. H. (2003) FASEB J. 17, 440-442
45. Wang, Q., Liu, M., Mullah, B., Siderovski, D. P., and Neubig, R. R. (2002) J. Biol. Chem. 277, 24949-24958
46. Heximer, S. P., Lim, H., Bernard, J. L., and Blumer, K. J. (2001) J. Biol. Chem. 276, 14195-14203
47. Chen, C., Seow, K. T., Guo, K., Yaw, L. P., and Lin, S. C. (1999) J. Biol. Chem. 274, 19799-19806
48. Druey, K. M., Ugur, O., Caron, J. M., Chen, C. K., Backlund, P. S., and Jones, T. L. (1999) J. Biol. Chem. 274, 18836-18842
49. Niu, J., Scheschonka, A., Druey, K. M., Davis, A., Reed, E., Kolenko, V., Bodnar, R., Voyno-Yasenetskaya, T., Du, X., Kehrl, J., and Dulin, N. O. (2002) Biochem. J. 365, 677-684
50. Chen, C., Wang, H., Fong, C. W., and Lin, S. C. (2001) FEBS Lett. 504, 16-22
51. Chen, C. A., and Manning, D. R. (2001) Oncogene 20, 1643-1652
52. Tu, Y., Wang, J., and Ross, E. M. (1997) Science 278, 1132-1135
53. Wang, J., Ducret, A., Tu, Y., Kozasa, T., Aebersold, R., and Ross, E. M. (1998) J. Biol. Chem. 273, 26014-26025
54. Hoffman, G. A., Garrison, T. R., and Dohlman, H. G. (2000) J. Biol. Chem. 275, 37533-37541