RGS4 is a negative regulator of insulin release from pancreatic β-cells in vitro and in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 17, 2010, Pages 7999-8004

  De Azua, Inigo Ruiz ^a   Scarselli, Marco ^a,d   Rosemond, Erica ^a,e   Gautam, Dinesh ^a   Jou, William ^b   Gavrilova, Oksana ^b   Ebert, Philip J ^c,f   Levitt, Pat ^c,g   Wess, Jürgen ^a  

^a Laboratory of Medicinal Chemistry   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d EPFL   (Switzerland)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^f ELI LILLY AND COMPANY   (United States)

^g UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

G protein coupled receptor; Knockout mice; Muscarinic receptor; RGS proteins

Indexed keywords

BETHANECHOL; INSULIN; MUSCARINIC M3 RECEPTOR; RGS4 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; BETHANECHOL; BLOOD GLUCOSE; BLOTTING, WESTERN; CALCIUM; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ELECTROPORATION; IMMUNOPRECIPITATION; INSULIN; INSULIN-SECRETING CELLS; MICE; RECEPTOR, MUSCARINIC M3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RGS PROTEINS;

MUS;

EID: 77952340101     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003655107     Document Type: Article

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