메뉴 건너뛰기




Volumn 17, Issue 1, 2007, Pages 40-44

Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

EID: 33846196309     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2006.12.002     Document Type: Review
Times cited : (67)

References (50)
  • 1
    • 0031984517 scopus 로고    scopus 로고
    • The many faces of G protein signaling
    • Hamm H.E. The many faces of G protein signaling. J Biol Chem 273 (1998) 669-672
    • (1998) J Biol Chem , vol.273 , pp. 669-672
    • Hamm, H.E.1
  • 2
    • 0347364629 scopus 로고    scopus 로고
    • i protein activation in intact cells involves subunit rearrangement rather than dissociation
    • i protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci USA 100 (2003) 16077-16082
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 16077-16082
    • Bunemann, M.1    Frank, M.2    Lohse, M.J.3
  • 4
    • 1542358991 scopus 로고    scopus 로고
    • Inherited diseases involving G proteins and G protein-coupled receptors
    • Spiegel A.M., and Weinstein L.S. Inherited diseases involving G proteins and G protein-coupled receptors. Annu Rev Med 55 (2004) 27-39
    • (2004) Annu Rev Med , vol.55 , pp. 27-39
    • Spiegel, A.M.1    Weinstein, L.S.2
  • 7
    • 33644662506 scopus 로고    scopus 로고
    • Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression
    • Li S., Huang S., and Peng S.-B. Overexpression of G protein-coupled receptors in cancer cells: involvement in tumor progression. Int J Oncol 27 (2005) 1329-1339
    • (2005) Int J Oncol , vol.27 , pp. 1329-1339
    • Li, S.1    Huang, S.2    Peng, S.-B.3
  • 8
    • 0035952753 scopus 로고    scopus 로고
    • Rho GTPase-dependent transformation by G protein-coupled receptors
    • Whitehead I.P., Zohn I.E., and Der C.J. Rho GTPase-dependent transformation by G protein-coupled receptors. Oncogene 20 (2001) 1547-1555
    • (2001) Oncogene , vol.20 , pp. 1547-1555
    • Whitehead, I.P.1    Zohn, I.E.2    Der, C.J.3
  • 9
    • 0030153427 scopus 로고    scopus 로고
    • Signaling by the G12 class of G proteins
    • Dhanasekaran N., and Dermott J.M. Signaling by the G12 class of G proteins. Cell Signal 8 (1996) 235-245
    • (1996) Cell Signal , vol.8 , pp. 235-245
    • Dhanasekaran, N.1    Dermott, J.M.2
  • 10
    • 0035952689 scopus 로고    scopus 로고
    • Transforming G proteins
    • Radhika V., and Dhanasekaran N. Transforming G proteins. Oncogene 20 (2001) 1607-1614
    • (2001) Oncogene , vol.20 , pp. 1607-1614
    • Radhika, V.1    Dhanasekaran, N.2
  • 11
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
    • Landis C., Masters S., Spada A., Pace A., Bourne H.R., and Vallar L. GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 340 (1989) 692-696
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.1    Masters, S.2    Spada, A.3    Pace, A.4    Bourne, H.R.5    Vallar, L.6
  • 12
    • 33746051169 scopus 로고    scopus 로고
    • Chemokines, chemokine receptors, and cancer metastasis
    • Kakinuma T., and Hwang S. Chemokines, chemokine receptors, and cancer metastasis. J Leukoc Biol 79 (2006) 639-651
    • (2006) J Leukoc Biol , vol.79 , pp. 639-651
    • Kakinuma, T.1    Hwang, S.2
  • 13
    • 0037162093 scopus 로고    scopus 로고
    • Mitogenic action of LPA in prostate
    • Daaka Y. Mitogenic action of LPA in prostate. Biochim Biophys Acta 1582 (2002) 265-269
    • (2002) Biochim Biophys Acta , vol.1582 , pp. 265-269
    • Daaka, Y.1
  • 14
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • Coughlin S.R. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost 3 (2005) 1800-1814
    • (2005) J Thromb Haemost , vol.3 , pp. 1800-1814
    • Coughlin, S.R.1
  • 15
    • 0028889967 scopus 로고
    • Expression cloning of oncogenes by retroviral transfer of cDNA libraries
    • Whitehead I., Kirk H., and Kay R. Expression cloning of oncogenes by retroviral transfer of cDNA libraries. Mol Cell Biol 15 (1995) 704-710
    • (1995) Mol Cell Biol , vol.15 , pp. 704-710
    • Whitehead, I.1    Kirk, H.2    Kay, R.3
  • 16
    • 0013197528 scopus 로고    scopus 로고
    • Role and regulation of the thrombin receptor (PAR-1) in human melanoma
    • Tellez C., and Bar-Eli M. Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 22 (2003) 3130-3137
    • (2003) Oncogene , vol.22 , pp. 3130-3137
    • Tellez, C.1    Bar-Eli, M.2
  • 18
    • 11144231266 scopus 로고    scopus 로고
    • Protease-activated receptor 1: a role in prostate cancer metastasis
    • Yuan T., and Lin M. Protease-activated receptor 1: a role in prostate cancer metastasis. Clin Prostate Cancer 3 (2004) 189-191
    • (2004) Clin Prostate Cancer , vol.3 , pp. 189-191
    • Yuan, T.1    Lin, M.2
  • 20
    • 33646471394 scopus 로고    scopus 로고
    • Thrombin generation and the pathogenesis of cancer
    • Ruf W., and Mueller B. Thrombin generation and the pathogenesis of cancer. Semin Thromb Hemost (2006) 061-068
    • (2006) Semin Thromb Hemost , pp. 061-068
    • Ruf, W.1    Mueller, B.2
  • 21
    • 0034914658 scopus 로고    scopus 로고
    • Suppression of cellular invasion by activated G-protein subunits Gαo, Gαi1, Gαi2 and Gαi3 and sequestration of Gβγ
    • Faivre S., Regnauld K., Bruyneel E., Nguyen Q.-D., Mareel M., Emami S., and Gespach C. Suppression of cellular invasion by activated G-protein subunits Gαo, Gαi1, Gαi2 and Gαi3 and sequestration of Gβγ. Mol Pharmacol 60 (2001) 363-372
    • (2001) Mol Pharmacol , vol.60 , pp. 363-372
    • Faivre, S.1    Regnauld, K.2    Bruyneel, E.3    Nguyen, Q.-D.4    Mareel, M.5    Emami, S.6    Gespach, C.7
  • 22
    • 0036211981 scopus 로고    scopus 로고
    • RhoA- and RhoD-dependent regulatory switch of Gα subunit signaling by PAR-1 receptors in cellular invasion
    • Nguyen Q.-D., Faivre S., Bruyneel E., Rivat C., Seto M., Endo T., Mareel M., Emami S., and Gespach C. RhoA- and RhoD-dependent regulatory switch of Gα subunit signaling by PAR-1 receptors in cellular invasion. FASEB J 16 (2002) 565-576
    • (2002) FASEB J , vol.16 , pp. 565-576
    • Nguyen, Q.-D.1    Faivre, S.2    Bruyneel, E.3    Rivat, C.4    Seto, M.5    Endo, T.6    Mareel, M.7    Emami, S.8    Gespach, C.9
  • 23
    • 20044387216 scopus 로고    scopus 로고
    • Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis
    • Sato H., Takino T., and Miyamori H. Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis. Cancer Sci 96 (2005) 212-217
    • (2005) Cancer Sci , vol.96 , pp. 212-217
    • Sato, H.1    Takino, T.2    Miyamori, H.3
  • 24
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    • The authors linked two important aspects of cancer biology with their discovery that MMP1 is a potent activator of the GPCR PAR1. Targeting of PAR1 was suggested as a more specific way to inhibit the effects of MMP1 in cancer therapy.
    • Boire A., Covic L., Agarwal A., Jacques S., Sherifi S., and Kuliopulos A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120 (2005) 303-313. The authors linked two important aspects of cancer biology with their discovery that MMP1 is a potent activator of the GPCR PAR1. Targeting of PAR1 was suggested as a more specific way to inhibit the effects of MMP1 in cancer therapy.
    • (2005) Cell , vol.120 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3    Jacques, S.4    Sherifi, S.5    Kuliopulos, A.6
  • 27
    • 33748744077 scopus 로고    scopus 로고
    • A role for the G12 family of heterotrimeric G-proteins in prostate cancer invasion
    • Kelly P., Stemmle L.N., Madden J.F., Fields T.A., Daaka Y., and Casey P.J. A role for the G12 family of heterotrimeric G-proteins in prostate cancer invasion. J Biol Chem 281 (2006) 26483-26490
    • (2006) J Biol Chem , vol.281 , pp. 26483-26490
    • Kelly, P.1    Stemmle, L.N.2    Madden, J.F.3    Fields, T.A.4    Daaka, Y.5    Casey, P.J.6
  • 31
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • Gumbiner B.M. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 6 (2005) 622-634
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 33
    • 0035952645 scopus 로고    scopus 로고
    • New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
    • Pierce K.L., Luttrell L.M., and Lefkowitz R.J. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20 (2001) 1532-1539
    • (2001) Oncogene , vol.20 , pp. 1532-1539
    • Pierce, K.L.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 34
    • 0242361581 scopus 로고    scopus 로고
    • Transcriptional regulation by the MAP kinase signaling cascades
    • Yang S.-H., Sharrocks A.D., and Whitmarsh A.J. Transcriptional regulation by the MAP kinase signaling cascades. Gene 320 (2003) 3-21
    • (2003) Gene , vol.320 , pp. 3-21
    • Yang, S.-H.1    Sharrocks, A.D.2    Whitmarsh, A.J.3
  • 35
    • 0035824391 scopus 로고    scopus 로고
    • g-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
    • Ni C.Y., Murphy M.P., and Golde T.E. g-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294 (2001) 2179-2181
    • (2001) Science , vol.294 , pp. 2179-2181
    • Ni, C.Y.1    Murphy, M.P.2    Golde, T.E.3
  • 36
    • 33751328082 scopus 로고    scopus 로고
    • ErbB receptors: new insights on mechanisms and biology
    • Linggi B., and Carpenter G. ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol 16 (2006) 649-656
    • (2006) Trends Cell Biol , vol.16 , pp. 649-656
    • Linggi, B.1    Carpenter, G.2
  • 37
    • 10944232035 scopus 로고    scopus 로고
    • Receptor-mediated reversible translocation of the G Protein βγ complex from the plasma membrane to the golgi complex
    • Akgoz M., Kalyanaraman V., and Gautam N. Receptor-mediated reversible translocation of the G Protein βγ complex from the plasma membrane to the golgi complex. J Biol Chem 279 (2004) 51541-51544
    • (2004) J Biol Chem , vol.279 , pp. 51541-51544
    • Akgoz, M.1    Kalyanaraman, V.2    Gautam, N.3
  • 38
    • 33646342993 scopus 로고    scopus 로고
    • G protein βγ11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the α subunit type
    • Azpiazu I., Akgoz M., Kalyanaraman V., and Gautam N. G protein βγ11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the α subunit type. Cell Signal 18 (2006) 1190-1200
    • (2006) Cell Signal , vol.18 , pp. 1190-1200
    • Azpiazu, I.1    Akgoz, M.2    Kalyanaraman, V.3    Gautam, N.4
  • 39
    • 0033848917 scopus 로고    scopus 로고
    • Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins
    • Willard F.S., and Crouch M.F. Nuclear and cytoskeletal translocation and localization of heterotrimeric G-proteins. Immunol Cell Biol 78 (2000) 387-394
    • (2000) Immunol Cell Biol , vol.78 , pp. 387-394
    • Willard, F.S.1    Crouch, M.F.2
  • 40
    • 33645130538 scopus 로고    scopus 로고
    • R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain
    • Hepler J.R. R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Sci STKE 2005 (2005) pe38
    • (2005) Sci STKE , vol.2005
    • Hepler, J.R.1
  • 41
    • 0035971229 scopus 로고    scopus 로고
    • Nuclear localization of G protein β5 and regulator of G protein signaling 7 in neurons and brain
    • Zhang J.-H., Barr V.A., Mo Y., Rojkova A.M., Liu S., and Simonds W.F. Nuclear localization of G protein β5 and regulator of G protein signaling 7 in neurons and brain. J Biol Chem 276 (2001) 10284-10289
    • (2001) J Biol Chem , vol.276 , pp. 10284-10289
    • Zhang, J.-H.1    Barr, V.A.2    Mo, Y.3    Rojkova, A.M.4    Liu, S.5    Simonds, W.F.6
  • 43
    • 14044273637 scopus 로고    scopus 로고
    • R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family
    • Martemyanov K.A., Yoo P.J., Skiba N.P., and Arshavsky V.Y. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. J Biol Chem 280 (2005) 5133-5136
    • (2005) J Biol Chem , vol.280 , pp. 5133-5136
    • Martemyanov, K.A.1    Yoo, P.J.2    Skiba, N.P.3    Arshavsky, V.Y.4
  • 44
    • 0033565641 scopus 로고    scopus 로고
    • Transcriptional regulation by the γ5 subunit of a heterotrimeric G protein during adipogenesis
    • Park J.-G., Muise A., He G.-P., Kim S.-W., and Ro H.-S. Transcriptional regulation by the γ5 subunit of a heterotrimeric G protein during adipogenesis. EMBO J 18 (1999) 4004-4012
    • (1999) EMBO J , vol.18 , pp. 4004-4012
    • Park, J.-G.1    Muise, A.2    He, G.-P.3    Kim, S.-W.4    Ro, H.-S.5
  • 45
    • 22344454972 scopus 로고    scopus 로고
    • G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
    • A physical and functional interaction between Gβγ and a transcription factor revealed a new role for nuclear heterotrimeric G-proteins. Importantly, GPCR stimulation activated the GR-Gβγ interaction, suggesting that Gβγ mediates a direct communication between receptors at the plasma membrane and the nucleus.
    • Kino T., Tiulpakov A., Ichijo T., Chheng L., Kozasa T., and Chrousos G.P. G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J Cell Biol 169 (2005) 885-896. A physical and functional interaction between Gβγ and a transcription factor revealed a new role for nuclear heterotrimeric G-proteins. Importantly, GPCR stimulation activated the GR-Gβγ interaction, suggesting that Gβγ mediates a direct communication between receptors at the plasma membrane and the nucleus.
    • (2005) J Cell Biol , vol.169 , pp. 885-896
    • Kino, T.1    Tiulpakov, A.2    Ichijo, T.3    Chheng, L.4    Kozasa, T.5    Chrousos, G.P.6
  • 46
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
    • Reiter E., and Lefkowitz R.J. GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17 (2006) 159-165
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 47
    • 28344441550 scopus 로고    scopus 로고
    • β-Arrestin goes nuclear
    • Beaulieu J.-M., and Caron M.G. β-Arrestin goes nuclear. Cell 123 (2005) 755-757
    • (2005) Cell , vol.123 , pp. 755-757
    • Beaulieu, J.-M.1    Caron, M.G.2
  • 48
    • 28344452845 scopus 로고    scopus 로고
    • A nuclear function of β-Arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription
    • β-Arrestin1, classically involved in desensitization of GPCR signaling, was found to translocate to the nucleus upon receptor activation. Novel interactions with a histone acetylase revealed a central role in regulation of gene transcription.
    • Kang J., Shi Y., Xiang B., Qu B., Su W., Zhu M., Zhang M., Bao G., Wang F., and Zhang X. A nuclear function of β-Arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123 (2005) 833-847. β-Arrestin1, classically involved in desensitization of GPCR signaling, was found to translocate to the nucleus upon receptor activation. Novel interactions with a histone acetylase revealed a central role in regulation of gene transcription.
    • (2005) Cell , vol.123 , pp. 833-847
    • Kang, J.1    Shi, Y.2    Xiang, B.3    Qu, B.4    Su, W.5    Zhu, M.6    Zhang, M.7    Bao, G.8    Wang, F.9    Zhang, X.10
  • 49
    • 29244473549 scopus 로고    scopus 로고
    • Gβγ binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity
    • Spiegelberg B.D., and Hamm H.E. Gβγ binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem 280 (2005) 41769-41776
    • (2005) J Biol Chem , vol.280 , pp. 41769-41776
    • Spiegelberg, B.D.1    Hamm, H.E.2
  • 50
    • 0034885934 scopus 로고    scopus 로고
    • Class II histone deacetylases: structure, function, and regulation
    • Bertos N.R., Wang A.H., and Yang X.-J. Class II histone deacetylases: structure, function, and regulation. Biochem Cell Biol 79 (2001) 243-252
    • (2001) Biochem Cell Biol , vol.79 , pp. 243-252
    • Bertos, N.R.1    Wang, A.H.2    Yang, X.-J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.