메뉴 건너뛰기




Volumn 63, Issue 1-2, 2011, Pages 47-68

RNA interference for improving the outcome of islet transplantation

Author keywords

Islet transplantation; RNA interference; ShRNA; SiRNA

Indexed keywords

BIO-CONJUGATION; COMPLEX FORMATIONS; CRITICAL DESIGN; GENE SILENCING; IMMUNE REJECTION; INFLAMMATORY CYTOKINES; INFLAMMATORY REACTION; ISLET TRANSPLANTATION; NOVEL STRATEGIES; RNA INTERFERENCE; SHORT HAIRPIN RNA (SHRNA); SHRNA; SIRNA; TYPE 1 DIABETES; VIRAL VECTORS;

EID: 79953026793     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2010.11.003     Document Type: Review
Times cited : (31)

References (263)
  • 1
    • 0001529118 scopus 로고
    • Notes on diabetes treated with extract and by grafts of sheep's pancreas
    • Williams P.W. Notes on diabetes treated with extract and by grafts of sheep's pancreas. Br. Med. J. 1894, 2:1303-1304.
    • (1894) Br. Med. J. , vol.2 , pp. 1303-1304
    • Williams, P.W.1
  • 2
    • 0014093712 scopus 로고
    • Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy
    • Kelly W.D., Lillehei R.C., Merkel F.K., Idezuki Y., Goetz F.C. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 1967, 61:827-837.
    • (1967) Surgery , vol.61 , pp. 827-837
    • Kelly, W.D.1    Lillehei, R.C.2    Merkel, F.K.3    Idezuki, Y.4    Goetz, F.C.5
  • 4
    • 75749096346 scopus 로고    scopus 로고
    • Complications after pancreas transplantation
    • Troppmann C. Complications after pancreas transplantation. Curr. Opin. Organ Transplant. 2010, 15:112-118.
    • (2010) Curr. Opin. Organ Transplant. , vol.15 , pp. 112-118
    • Troppmann, C.1
  • 6
    • 58849102225 scopus 로고    scopus 로고
    • 2008 update from the Collaborative Islet Transplant Registry
    • Alejandro R., Barton F.B., Hering B.J., Wease S. 2008 update from the Collaborative Islet Transplant Registry. Transplantation 2008, 86:1783-1788.
    • (2008) Transplantation , vol.86 , pp. 1783-1788
    • Alejandro, R.1    Barton, F.B.2    Hering, B.J.3    Wease, S.4
  • 7
    • 33744947093 scopus 로고    scopus 로고
    • Current status of pancreatic islet transplantation
    • Merani S., Shapiro A.M. Current status of pancreatic islet transplantation. Clin. Sci. (Lond) 2006, 110:611-625.
    • (2006) Clin. Sci. (Lond) , vol.110 , pp. 611-625
    • Merani, S.1    Shapiro, A.M.2
  • 9
    • 70349645780 scopus 로고    scopus 로고
    • Current advances and travails in islet transplantation
    • Harlan D.M., Kenyon N.S., Korsgren O., Roep B.O. Current advances and travails in islet transplantation. Diabetes 2009, 58:2175-2184.
    • (2009) Diabetes , vol.58 , pp. 2175-2184
    • Harlan, D.M.1    Kenyon, N.S.2    Korsgren, O.3    Roep, B.O.4
  • 10
    • 33646735392 scopus 로고    scopus 로고
    • Biological and biomaterial approaches for improved islet transplantation
    • Narang A.S., Mahato R.I. Biological and biomaterial approaches for improved islet transplantation. Pharmacol. Rev. 2006, 58:194-243.
    • (2006) Pharmacol. Rev. , vol.58 , pp. 194-243
    • Narang, A.S.1    Mahato, R.I.2
  • 12
    • 33746142446 scopus 로고    scopus 로고
    • Stem cell sources for clinical islet transplantation in type 1 diabetes: embryonic and adult stem cells
    • Miszta-Lane H., Mirbolooki M., James Shapiro A.M., Lakey J.R. Stem cell sources for clinical islet transplantation in type 1 diabetes: embryonic and adult stem cells. Med. Hypotheses 2006, 67:909-913.
    • (2006) Med. Hypotheses , vol.67 , pp. 909-913
    • Miszta-Lane, H.1    Mirbolooki, M.2    James Shapiro, A.M.3    Lakey, J.R.4
  • 13
    • 4243066440 scopus 로고    scopus 로고
    • Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets
    • Cheng K., Fraga D., Zhang C., Kotb M., Gaber A.O., Guntaka R.V., Mahato R.I. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther. 2004, 11:1105-1116.
    • (2004) Gene Ther. , vol.11 , pp. 1105-1116
    • Cheng, K.1    Fraga, D.2    Zhang, C.3    Kotb, M.4    Gaber, A.O.5    Guntaka, R.V.6    Mahato, R.I.7
  • 16
    • 62649174290 scopus 로고    scopus 로고
    • Bipartite vector encoding hVEGF and hIL-1Ra for ex vivo transduction into human islets
    • Panakanti R., Mahato R.I. Bipartite vector encoding hVEGF and hIL-1Ra for ex vivo transduction into human islets. Mol. Pharm. 2009, 6:274-284.
    • (2009) Mol. Pharm. , vol.6 , pp. 274-284
    • Panakanti, R.1    Mahato, R.I.2
  • 17
    • 60049083974 scopus 로고    scopus 로고
    • Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation
    • Panakanti R., Mahato R.I. Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation. Pharm. Res. 2009, 26:587-596.
    • (2009) Pharm. Res. , vol.26 , pp. 587-596
    • Panakanti, R.1    Mahato, R.I.2
  • 18
    • 70449704916 scopus 로고    scopus 로고
    • Gene expression and silencing for improved islet transplantation
    • Mahato R.I. Gene expression and silencing for improved islet transplantation. J. Control. Release 2009, 140:262-267.
    • (2009) J. Control. Release , vol.140 , pp. 262-267
    • Mahato, R.I.1
  • 19
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 20
    • 0032417618 scopus 로고    scopus 로고
    • RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans
    • Montgomery M.K., Xu S., Fire A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 1998, 95:15502-15507.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 15502-15507
    • Montgomery, M.K.1    Xu, S.2    Fire, A.3
  • 23
    • 34047190259 scopus 로고    scopus 로고
    • Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
    • De Paula D., Bentley M.V., Mahato R.I. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA 2007, 13:431-456.
    • (2007) RNA , vol.13 , pp. 431-456
    • De Paula, D.1    Bentley, M.V.2    Mahato, R.I.3
  • 24
    • 38049161918 scopus 로고    scopus 로고
    • RNAi for treating hepatitis B viral infection
    • Chen Y., Cheng G., Mahato R.I. RNAi for treating hepatitis B viral infection. Pharm. Res. 2008, 25:72-86.
    • (2008) Pharm. Res. , vol.25 , pp. 72-86
    • Chen, Y.1    Cheng, G.2    Mahato, R.I.3
  • 25
    • 0348014774 scopus 로고    scopus 로고
    • Approaches for the sequence-specific knockdown of mRNA
    • Scherer L.J., Rossi J.J. Approaches for the sequence-specific knockdown of mRNA. Nat. Biotechnol. 2003, 21:1457-1465.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 1457-1465
    • Scherer, L.J.1    Rossi, J.J.2
  • 26
    • 1842579654 scopus 로고    scopus 로고
    • RNAi applications in mammalian cells
    • Scherer L., Rossi J.J. RNAi applications in mammalian cells. Biotechniques 2004, 36:557-561.
    • (2004) Biotechniques , vol.36 , pp. 557-561
    • Scherer, L.1    Rossi, J.J.2
  • 28
    • 24144445346 scopus 로고    scopus 로고
    • Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells
    • Miyagishi M., Hayashi M., Taira K. Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev. 2003, 13:1-7.
    • (2003) Antisense Nucleic Acid Drug Dev. , vol.13 , pp. 1-7
    • Miyagishi, M.1    Hayashi, M.2    Taira, K.3
  • 29
    • 34547402496 scopus 로고    scopus 로고
    • Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies
    • van der Windt D.J., Bottino R., Casu A., Campanile N., Cooper D.K. Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation 2007, 14:288-297.
    • (2007) Xenotransplantation , vol.14 , pp. 288-297
    • van der Windt, D.J.1    Bottino, R.2    Casu, A.3    Campanile, N.4    Cooper, D.K.5
  • 30
    • 0034576863 scopus 로고    scopus 로고
    • Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes
    • Bennet W., Groth C.G., Larsson R., Nilsson B., Korsgren O. Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes. Ups. J. Med. Sci. 2000, 105:125-133.
    • (2000) Ups. J. Med. Sci. , vol.105 , pp. 125-133
    • Bennet, W.1    Groth, C.G.2    Larsson, R.3    Nilsson, B.4    Korsgren, O.5
  • 35
    • 0034653591 scopus 로고    scopus 로고
    • Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin
    • Bennet W., Sundberg B., Lundgren T., Tibell A., Groth C.G., Richards A., White D.J., Elgue G., Larsson R., Nilsson B., Korsgren O. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000, 69:711-719.
    • (2000) Transplantation , vol.69 , pp. 711-719
    • Bennet, W.1    Sundberg, B.2    Lundgren, T.3    Tibell, A.4    Groth, C.G.5    Richards, A.6    White, D.J.7    Elgue, G.8    Larsson, R.9    Nilsson, B.10    Korsgren, O.11
  • 36
    • 25444463829 scopus 로고    scopus 로고
    • Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood
    • Moberg L., Korsgren O., Nilsson B. Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABO-compatible blood. Clin. Exp. Immunol. 2005, 142:125-131.
    • (2005) Clin. Exp. Immunol. , vol.142 , pp. 125-131
    • Moberg, L.1    Korsgren, O.2    Nilsson, B.3
  • 37
    • 7044229738 scopus 로고    scopus 로고
    • Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death
    • Contreras J.L., Eckstein C., Smyth C.A., Bilbao G., Vilatoba M., Ringland S.E., Young C., Thompson J.A., Fernandez J.A., Griffin J.H., Eckhoff D.E. Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. Diabetes 2004, 53:2804-2814.
    • (2004) Diabetes , vol.53 , pp. 2804-2814
    • Contreras, J.L.1    Eckstein, C.2    Smyth, C.A.3    Bilbao, G.4    Vilatoba, M.5    Ringland, S.E.6    Young, C.7    Thompson, J.A.8    Fernandez, J.A.9    Griffin, J.H.10    Eckhoff, D.E.11
  • 38
    • 0036464689 scopus 로고    scopus 로고
    • Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo
    • Szaba F.M., Smiley S.T. Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood 2002, 99:1053-1059.
    • (2002) Blood , vol.99 , pp. 1053-1059
    • Szaba, F.M.1    Smiley, S.T.2
  • 41
    • 0023147156 scopus 로고
    • Secretory products of macrophages
    • Nathan C.F. Secretory products of macrophages. J. Clin. Invest. 1987, 79:319-326.
    • (1987) J. Clin. Invest. , vol.79 , pp. 319-326
    • Nathan, C.F.1
  • 43
    • 18244364592 scopus 로고    scopus 로고
    • Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts
    • Barshes N.R., Wyllie S., Goss J.A. Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J. Leukoc. Biol. 2005, 77:587-597.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 587-597
    • Barshes, N.R.1    Wyllie, S.2    Goss, J.A.3
  • 45
    • 0031890972 scopus 로고    scopus 로고
    • Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation
    • Bottino R., Fernandez L.A., Ricordi C., Lehmann R., Tsan M.F., Oliver R., Inverardi L. Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 1998, 47:316-323.
    • (1998) Diabetes , vol.47 , pp. 316-323
    • Bottino, R.1    Fernandez, L.A.2    Ricordi, C.3    Lehmann, R.4    Tsan, M.F.5    Oliver, R.6    Inverardi, L.7
  • 46
    • 33947391397 scopus 로고    scopus 로고
    • Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation
    • Montolio M., Biarnes M., Tellez N., Escoriza J., Soler J., Montanya E. Interleukin-1beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation. J. Endocrinol. 2007, 192:169-177.
    • (2007) J. Endocrinol. , vol.192 , pp. 169-177
    • Montolio, M.1    Biarnes, M.2    Tellez, N.3    Escoriza, J.4    Soler, J.5    Montanya, E.6
  • 47
    • 0033664094 scopus 로고    scopus 로고
    • Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts
    • Gysemans C.A., Waer M., Valckx D., Laureys J.M., Mihkalsky D., Bouillon R., Mathieu C. Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts. Diabetes 2000, 49:1992-1997.
    • (2000) Diabetes , vol.49 , pp. 1992-1997
    • Gysemans, C.A.1    Waer, M.2    Valckx, D.3    Laureys, J.M.4    Mihkalsky, D.5    Bouillon, R.6    Mathieu, C.7
  • 50
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis
    • Eizirik D.L., Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001, 44:2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 51
    • 0033389248 scopus 로고    scopus 로고
    • Biologic functions of the IFN-gamma receptors
    • Tau G., Rothman P. Biologic functions of the IFN-gamma receptors. Allergy 1999, 54:1233-1251.
    • (1999) Allergy , vol.54 , pp. 1233-1251
    • Tau, G.1    Rothman, P.2
  • 53
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: a beautiful pathway
    • Chen G., Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 2002, 296:1634-1635.
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 55
    • 0033451738 scopus 로고    scopus 로고
    • TNF-induced signaling in apoptosis
    • Rath P.C., Aggarwal B.B. TNF-induced signaling in apoptosis. J. Clin. Immunol. 1999, 19:350-364.
    • (1999) J. Clin. Immunol. , vol.19 , pp. 350-364
    • Rath, P.C.1    Aggarwal, B.B.2
  • 56
    • 0032603405 scopus 로고    scopus 로고
    • Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor
    • Saklatvala J., Dean J., Finch A. Protein kinase cascades in intracellular signalling by interleukin-I and tumour necrosis factor. Biochem. Soc. Symp. 1999, 64:63-77.
    • (1999) Biochem. Soc. Symp. , vol.64 , pp. 63-77
    • Saklatvala, J.1    Dean, J.2    Finch, A.3
  • 57
    • 0242363618 scopus 로고    scopus 로고
    • Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
    • Kutlu B., Cardozo A.K., Darville M.I., Kruhoffer M., Magnusson N., Orntoft T., Eizirik D.L. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 2003, 52:2701-2719.
    • (2003) Diabetes , vol.52 , pp. 2701-2719
    • Kutlu, B.1    Cardozo, A.K.2    Darville, M.I.3    Kruhoffer, M.4    Magnusson, N.5    Orntoft, T.6    Eizirik, D.L.7
  • 58
    • 1942507406 scopus 로고    scopus 로고
    • Use of microarray analysis to unveil transcription factor and gene networks contributing to beta cell dysfunction and apoptosis
    • Eizirik D.L., Kutlu B., Rasschaert J., Darville M., Cardozo A.K. Use of microarray analysis to unveil transcription factor and gene networks contributing to beta cell dysfunction and apoptosis. Ann. NY Acad. Sci. 2003, 1005:55-74.
    • (2003) Ann. NY Acad. Sci. , vol.1005 , pp. 55-74
    • Eizirik, D.L.1    Kutlu, B.2    Rasschaert, J.3    Darville, M.4    Cardozo, A.K.5
  • 59
    • 0035966006 scopus 로고    scopus 로고
    • A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells
    • Cardozo A.K., Heimberg H., Heremans Y., Leeman R., Kutlu B., Kruhoffer M., Orntoft T., Eizirik D.L. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J. Biol. Chem. 2001, 276:48879-48886.
    • (2001) J. Biol. Chem. , vol.276 , pp. 48879-48886
    • Cardozo, A.K.1    Heimberg, H.2    Heremans, Y.3    Leeman, R.4    Kutlu, B.5    Kruhoffer, M.6    Orntoft, T.7    Eizirik, D.L.8
  • 60
    • 33746594835 scopus 로고    scopus 로고
    • Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation
    • Ortis F., Cardozo A.K., Crispim D., Storling J., Mandrup-Poulsen T., Eizirik D.L. Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation. Mol. Endocrinol. 2006, 20:1867-1879.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1867-1879
    • Ortis, F.1    Cardozo, A.K.2    Crispim, D.3    Storling, J.4    Mandrup-Poulsen, T.5    Eizirik, D.L.6
  • 61
  • 62
    • 33747038451 scopus 로고    scopus 로고
    • Interventional strategies to prevent beta-cell apoptosis in islet transplantation
    • Emamaullee J.A., Shapiro A.M. Interventional strategies to prevent beta-cell apoptosis in islet transplantation. Diabetes 2006, 55:1907-1914.
    • (2006) Diabetes , vol.55 , pp. 1907-1914
    • Emamaullee, J.A.1    Shapiro, A.M.2
  • 63
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 64
    • 0034616946 scopus 로고    scopus 로고
    • Apoptotic pathways: paper wraps stone blunts scissors
    • Green D.R. Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000, 102:1-4.
    • (2000) Cell , vol.102 , pp. 1-4
    • Green, D.R.1
  • 65
    • 0022416666 scopus 로고
    • Dissociation between pancreatic islet blood flow and insulin release in the rat
    • Jansson L. Dissociation between pancreatic islet blood flow and insulin release in the rat. Acta Physiol. Scand. 1985, 124:223-228.
    • (1985) Acta Physiol. Scand. , vol.124 , pp. 223-228
    • Jansson, L.1
  • 66
    • 0027533914 scopus 로고
    • Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis
    • Sezai S., Sakurabayashi S., Yamamoto Y., Morita T., Hirano M., Oka H. Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis. Liver 1993, 13:31-35.
    • (1993) Liver , vol.13 , pp. 31-35
    • Sezai, S.1    Sakurabayashi, S.2    Yamamoto, Y.3    Morita, T.4    Hirano, M.5    Oka, H.6
  • 67
    • 0034907589 scopus 로고    scopus 로고
    • Factors influencing islet of Langerhans graft function and monitoring
    • Pileggi A., Ricordi C., Alessiani M., Inverardi L. Factors influencing islet of Langerhans graft function and monitoring. Clin. Chim. Acta 2001, 310:3-16.
    • (2001) Clin. Chim. Acta , vol.310 , pp. 3-16
    • Pileggi, A.1    Ricordi, C.2    Alessiani, M.3    Inverardi, L.4
  • 68
    • 0035010349 scopus 로고    scopus 로고
    • Revascularization and microcirculation of freely grafted islets of Langerhans
    • Menger M.D., Yamauchi J., Vollmar B. Revascularization and microcirculation of freely grafted islets of Langerhans. World J. Surg. 2001, 25:509-515.
    • (2001) World J. Surg. , vol.25 , pp. 509-515
    • Menger, M.D.1    Yamauchi, J.2    Vollmar, B.3
  • 69
    • 0347683430 scopus 로고    scopus 로고
    • Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species
    • Li X., Chen H., Epstein P.N. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. J. Biol. Chem. 2004, 279:765-771.
    • (2004) J. Biol. Chem. , vol.279 , pp. 765-771
    • Li, X.1    Chen, H.2    Epstein, P.N.3
  • 70
    • 0021873134 scopus 로고
    • Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases
    • Sibley R.K., Sutherland D.E., Goetz F., Michael A.F. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest. 1985, 53:132-144.
    • (1985) Lab. Invest. , vol.53 , pp. 132-144
    • Sibley, R.K.1    Sutherland, D.E.2    Goetz, F.3    Michael, A.F.4
  • 71
    • 0026565852 scopus 로고
    • Characterization of T lymphocytes infiltrating human pancreas allograft affected by isletitis and recurrent diabetes
    • Santamaria P., Nakhleh R.E., Sutherland D.E., Barbosa J.J. Characterization of T lymphocytes infiltrating human pancreas allograft affected by isletitis and recurrent diabetes. Diabetes 1992, 41:53-61.
    • (1992) Diabetes , vol.41 , pp. 53-61
    • Santamaria, P.1    Nakhleh, R.E.2    Sutherland, D.E.3    Barbosa, J.J.4
  • 72
    • 0033561560 scopus 로고    scopus 로고
    • Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice
    • Mora C., Wong F.S., Chang C.H., Flavell R.A. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: studies using NOD/CIITA-deficient mice. J. Immunol. 1999, 162:4576-4588.
    • (1999) J. Immunol. , vol.162 , pp. 4576-4588
    • Mora, C.1    Wong, F.S.2    Chang, C.H.3    Flavell, R.A.4
  • 73
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • Trapani J.A., Smyth M.J. Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2002, 2:735-747.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 74
    • 0034694091 scopus 로고    scopus 로고
    • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
    • Sutton V.R., Davis J.E., Cancilla M., Johnstone R.W., Ruefli A.A., Sedelies K., Browne K.A., Trapani J.A. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J. Exp. Med. 2000, 192:1403-1414.
    • (2000) J. Exp. Med. , vol.192 , pp. 1403-1414
    • Sutton, V.R.1    Davis, J.E.2    Cancilla, M.3    Johnstone, R.W.4    Ruefli, A.A.5    Sedelies, K.6    Browne, K.A.7    Trapani, J.A.8
  • 77
    • 0031897507 scopus 로고    scopus 로고
    • Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation
    • Loweth A.C., Williams G.T., James R.F., Scarpello J.H., Morgan N.G. Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 1998, 47:727-732.
    • (1998) Diabetes , vol.47 , pp. 727-732
    • Loweth, A.C.1    Williams, G.T.2    James, R.F.3    Scarpello, J.H.4    Morgan, N.G.5
  • 81
    • 0035451607 scopus 로고    scopus 로고
    • The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity
    • Morel Y., Truneh A., Sweet R.W., Olive D., Costello R.T. The TNF superfamily members LIGHT and CD154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity. J. Immunol. 2001, 167:2479-2486.
    • (2001) J. Immunol. , vol.167 , pp. 2479-2486
    • Morel, Y.1    Truneh, A.2    Sweet, R.W.3    Olive, D.4    Costello, R.T.5
  • 82
    • 67649122193 scopus 로고    scopus 로고
    • Costimulatory blockade with belatacept in clinical and experimental transplantation - a review
    • Emamaullee J., Toso C., Merani S., Shapiro A.M. Costimulatory blockade with belatacept in clinical and experimental transplantation - a review. Expert Opin. Biol. Ther. 2009, 9:789-796.
    • (2009) Expert Opin. Biol. Ther. , vol.9 , pp. 789-796
    • Emamaullee, J.1    Toso, C.2    Merani, S.3    Shapiro, A.M.4
  • 83
    • 12744279325 scopus 로고    scopus 로고
    • Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets
    • Hui H., Khoury N., Zhao X., Balkir L., D'Amico E., Bullotta A., Nguyen E.D., Gambotto A., Perfetti R. Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets. Diabetes 2005, 54:424-433.
    • (2005) Diabetes , vol.54 , pp. 424-433
    • Hui, H.1    Khoury, N.2    Zhao, X.3    Balkir, L.4    D'Amico, E.5    Bullotta, A.6    Nguyen, E.D.7    Gambotto, A.8    Perfetti, R.9
  • 84
    • 0037105629 scopus 로고    scopus 로고
    • Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig
    • Bonham C.A., Peng L., Liang X., Chen Z., Wang L., Ma L., Hackstein H., Robbins P.D., Thomson A.W., Fung J.J., Qian S., Lu L. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J. Immunol. 2002, 169:3382-3391.
    • (2002) J. Immunol. , vol.169 , pp. 3382-3391
    • Bonham, C.A.1    Peng, L.2    Liang, X.3    Chen, Z.4    Wang, L.5    Ma, L.6    Hackstein, H.7    Robbins, P.D.8    Thomson, A.W.9    Fung, J.J.10    Qian, S.11    Lu, L.12
  • 85
    • 0035022325 scopus 로고    scopus 로고
    • Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines
    • Yoshimura S., Bondeson J., Foxwell B.M., Brennan F.M., Feldmann M. Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int. Immunol. 2001, 13:675-683.
    • (2001) Int. Immunol. , vol.13 , pp. 675-683
    • Yoshimura, S.1    Bondeson, J.2    Foxwell, B.M.3    Brennan, F.M.4    Feldmann, M.5
  • 89
    • 0042837874 scopus 로고    scopus 로고
    • Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival
    • Liang X., Lu L., Chen Z., Vickers T., Zhang H., Fung J.J., Qian S. Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival. Transplantation 2003, 76:721-729.
    • (2003) Transplantation , vol.76 , pp. 721-729
    • Liang, X.1    Lu, L.2    Chen, Z.3    Vickers, T.4    Zhang, H.5    Fung, J.J.6    Qian, S.7
  • 90
    • 53949095999 scopus 로고    scopus 로고
    • Immune modulation through silencing CD80 and CD86 in dendritic cells using siRNA
    • Suzuki M., Zhang X., Zheng X., Vladau C., Li M., Chen D., Min W. Immune modulation through silencing CD80 and CD86 in dendritic cells using siRNA. J. Immunol. 2007, 178:84.
    • (2007) J. Immunol. , vol.178 , pp. 84
    • Suzuki, M.1    Zhang, X.2    Zheng, X.3    Vladau, C.4    Li, M.5    Chen, D.6    Min, W.7
  • 91
    • 38049153066 scopus 로고    scopus 로고
    • Graded function of CD80 and CD86 in initiation of T-cell immune response and cardiac allograft survival
    • Xiang J., Gu X., Qian S., Chen Z. Graded function of CD80 and CD86 in initiation of T-cell immune response and cardiac allograft survival. Transpl. Int. 2008, 21:163-168.
    • (2008) Transpl. Int. , vol.21 , pp. 163-168
    • Xiang, J.1    Gu, X.2    Qian, S.3    Chen, Z.4
  • 94
    • 45449085234 scopus 로고    scopus 로고
    • Myeloid differentiation factor 88-silenced bone marrow-derived dendritic cells exhibit enhanced tolerogenicity in intestinal transplantation in rats
    • Zhu C., Xu H., Zhang G., Lu C., Ji M., Wu W. Myeloid differentiation factor 88-silenced bone marrow-derived dendritic cells exhibit enhanced tolerogenicity in intestinal transplantation in rats. Transplant. Proc. 2008, 40:1625-1628.
    • (2008) Transplant. Proc. , vol.40 , pp. 1625-1628
    • Zhu, C.1    Xu, H.2    Zhang, G.3    Lu, C.4    Ji, M.5    Wu, W.6
  • 95
    • 57549106223 scopus 로고    scopus 로고
    • Donor bone-marrow suppressor of cytokine signaling-1-silenced dendritic cells prolong rat intestinal allograft survival
    • Zhu C., Xu H., Zhang J., Wang K., Zhu P. Donor bone-marrow suppressor of cytokine signaling-1-silenced dendritic cells prolong rat intestinal allograft survival. Transplant. Proc. 2008, 40:3707-3710.
    • (2008) Transplant. Proc. , vol.40 , pp. 3707-3710
    • Zhu, C.1    Xu, H.2    Zhang, J.3    Wang, K.4    Zhu, P.5
  • 96
    • 20444407325 scopus 로고    scopus 로고
    • HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors
    • Bouwman L.H., Ling Z., Duinkerken G., Pipeleers D.G., Roep B.O. HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors. Hum. Immunol. 2005, 66:494-500.
    • (2005) Hum. Immunol. , vol.66 , pp. 494-500
    • Bouwman, L.H.1    Ling, Z.2    Duinkerken, G.3    Pipeleers, D.G.4    Roep, B.O.5
  • 98
    • 69849105156 scopus 로고    scopus 로고
    • Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation
    • Hacke K., Falahati R., Flebbe-Rehwaldt L., Kasahara N., Gaensler K.M. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol. Res. 2009, 44:112-126.
    • (2009) Immunol. Res. , vol.44 , pp. 112-126
    • Hacke, K.1    Falahati, R.2    Flebbe-Rehwaldt, L.3    Kasahara, N.4    Gaensler, K.M.5
  • 99
    • 79953028248 scopus 로고    scopus 로고
    • Stable knock down of non-acceptable HLA mismatches in solid organ transplantation
    • Figueiredo C., Seltsam A., Holtkamp U., Blasczyk R. Stable knock down of non-acceptable HLA mismatches in solid organ transplantation. Hum. Immunol. 2004, 65:S7.
    • (2004) Hum. Immunol. , vol.65
    • Figueiredo, C.1    Seltsam, A.2    Holtkamp, U.3    Blasczyk, R.4
  • 100
    • 33646369190 scopus 로고    scopus 로고
    • Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery
    • Figueiredo C., Seltsam A., Blasczyk R. Class-, gene-, and group-specific HLA silencing by lentiviral shRNA delivery. J. Mol. Med. 2006, 84:425-437.
    • (2006) J. Mol. Med. , vol.84 , pp. 425-437
    • Figueiredo, C.1    Seltsam, A.2    Blasczyk, R.3
  • 104
    • 3843086047 scopus 로고    scopus 로고
    • Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice
    • Contreras J.L., Vilatoba M., Eckstein C., Bilbao G., Anthony Thompson J., Eckhoff D.E. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. Surgery 2004, 136:390-400.
    • (2004) Surgery , vol.136 , pp. 390-400
    • Contreras, J.L.1    Vilatoba, M.2    Eckstein, C.3    Bilbao, G.4    Anthony Thompson, J.5    Eckhoff, D.E.6
  • 105
    • 64649100459 scopus 로고    scopus 로고
    • Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets
    • Cheng G., Zhu L., Mahato R.I. Caspase-3 gene silencing for inhibiting apoptosis in insulinoma cells and human islets. Mol. Pharm. 2008, 5:1093-1102.
    • (2008) Mol. Pharm. , vol.5 , pp. 1093-1102
    • Cheng, G.1    Zhu, L.2    Mahato, R.I.3
  • 106
    • 30644480118 scopus 로고    scopus 로고
    • Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis
    • Burkhardt B.R., Lyle R., Qian K., Arnold A.S., Cheng H., Atkinson M.A., Zhang Y.C. Efficient delivery of siRNA into cytokine-stimulated insulinoma cells silences Fas expression and inhibits Fas-mediated apoptosis. FEBS Lett. 2006, 580:553-560.
    • (2006) FEBS Lett. , vol.580 , pp. 553-560
    • Burkhardt, B.R.1    Lyle, R.2    Qian, K.3    Arnold, A.S.4    Cheng, H.5    Atkinson, M.A.6    Zhang, Y.C.7
  • 107
    • 0038095650 scopus 로고    scopus 로고
    • Fas siRNA reduces apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen
    • Wang J., Li W., Min J., Ou Q., Chen J. Fas siRNA reduces apoptotic cell death of allogeneic-transplanted hepatocytes in mouse spleen. Transplant. Proc. 2003, 35:1594-1595.
    • (2003) Transplant. Proc. , vol.35 , pp. 1594-1595
    • Wang, J.1    Li, W.2    Min, J.3    Ou, Q.4    Chen, J.5
  • 108
    • 34247586108 scopus 로고    scopus 로고
    • Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas
    • Li X., Zhang J.F., Lu M.Q., Yang Y., Xu C., Li H., Wang G.S., Cai C.J., Chen G.H. Alleviation of ischemia-reperfusion injury in rat liver transplantation by induction of small interference RNA targeting Fas. Langenbecks Arch. Surg. 2007, 392:345-351.
    • (2007) Langenbecks Arch. Surg. , vol.392 , pp. 345-351
    • Li, X.1    Zhang, J.F.2    Lu, M.Q.3    Yang, Y.4    Xu, C.5    Li, H.6    Wang, G.S.7    Cai, C.J.8    Chen, G.H.9
  • 111
    • 34247163456 scopus 로고    scopus 로고
    • Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery
    • McCabe C., O'Brien T. Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery. Biochem. Biophys. Res. Commun. 2007, 357:75-80.
    • (2007) Biochem. Biophys. Res. Commun. , vol.357 , pp. 75-80
    • McCabe, C.1    O'Brien, T.2
  • 112
    • 35848964770 scopus 로고    scopus 로고
    • The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression
    • McCabe C., O'Brien T. The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression. Mol. Biotechnol. 2007, 37:38-47.
    • (2007) Mol. Biotechnol. , vol.37 , pp. 38-47
    • McCabe, C.1    O'Brien, T.2
  • 113
    • 46449092492 scopus 로고    scopus 로고
    • INOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis
    • Li F., Mahato R.I. iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. Mol. Pharm. 2008, 5:407-417.
    • (2008) Mol. Pharm. , vol.5 , pp. 407-417
    • Li, F.1    Mahato, R.I.2
  • 114
    • 34249989381 scopus 로고    scopus 로고
    • Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function
    • De Paula D., Bentley M.V., Mahato R.I. Effect of iNOS and NF-kappaB gene silencing on beta-cell survival and function. J. Drug Target. 2007, 15:358-369.
    • (2007) J. Drug Target. , vol.15 , pp. 358-369
    • De Paula, D.1    Bentley, M.V.2    Mahato, R.I.3
  • 115
    • 70349512724 scopus 로고    scopus 로고
    • Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene
    • Li F., Mahato R.I. Bipartite vectors for co-expression of a growth factor cDNA and short hairpin RNA against an apoptotic gene. J. Gene Med. 2009, 11:764-771.
    • (2009) J. Gene Med. , vol.11 , pp. 764-771
    • Li, F.1    Mahato, R.I.2
  • 116
    • 3242787905 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB mediated inflammation by siRNA expressed by recombinant adeno-associated virus
    • Pinkenburg O., Platz J., Beisswenger C., Vogelmeier C., Bals R. Inhibition of NF-kappaB mediated inflammation by siRNA expressed by recombinant adeno-associated virus. J. Virol. Meth. 2004, 120:119-122.
    • (2004) J. Virol. Meth. , vol.120 , pp. 119-122
    • Pinkenburg, O.1    Platz, J.2    Beisswenger, C.3    Vogelmeier, C.4    Bals, R.5
  • 118
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • Lee Y.S., Nakahara K., Pham J.W., Kim K., He Z., Sontheimer E.J., Carthew R.W. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell 2004, 117:69-81.
    • (2004) Cell , vol.117 , pp. 69-81
    • Lee, Y.S.1    Nakahara, K.2    Pham, J.W.3    Kim, K.4    He, Z.5    Sontheimer, E.J.6    Carthew, R.W.7
  • 119
    • 4444264981 scopus 로고    scopus 로고
    • A web-based design center for vector-based siRNA and siRNA cassette
    • Wang L., Mu F.Y. A web-based design center for vector-based siRNA and siRNA cassette. Bioinformatics 2004, 20:1818-1820.
    • (2004) Bioinformatics , vol.20 , pp. 1818-1820
    • Wang, L.1    Mu, F.Y.2
  • 120
    • 3242889236 scopus 로고    scopus 로고
    • SiDirect: highly effective, target-specific siRNA design software for mammalian RNA interference
    • Naito Y., Yamada T., Ui-Tei K., Morishita S., Saigo K. siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res. 2004, 32:W124-W129.
    • (2004) Nucleic Acids Res. , vol.32
    • Naito, Y.1    Yamada, T.2    Ui-Tei, K.3    Morishita, S.4    Saigo, K.5
  • 121
    • 3242890471 scopus 로고    scopus 로고
    • SiRNA selection server: an automated siRNA oligonucleotide prediction server
    • Yuan B., Latek R., Hossbach M., Tuschl T., Lewitter F. siRNA selection server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res. 2004, 32:W130-W134.
    • (2004) Nucleic Acids Res. , vol.32
    • Yuan, B.1    Latek, R.2    Hossbach, M.3    Tuschl, T.4    Lewitter, F.5
  • 122
    • 3242891277 scopus 로고    scopus 로고
    • DEQOR: a web-based tool for the design and quality control of siRNAs
    • Henschel A., Buchholz F., Habermann B. DEQOR: a web-based tool for the design and quality control of siRNAs. Nucleic Acids Res. 2004, 32:W113-W120.
    • (2004) Nucleic Acids Res. , vol.32
    • Henschel, A.1    Buchholz, F.2    Habermann, B.3
  • 123
    • 34748823119 scopus 로고    scopus 로고
    • Defining the optimal parameters for hairpin-based knockdown constructs
    • Li L., Lin X., Khvorova A., Fesik S.W., Shen Y. Defining the optimal parameters for hairpin-based knockdown constructs. RNA 2007, 13:1765-1774.
    • (2007) RNA , vol.13 , pp. 1765-1774
    • Li, L.1    Lin, X.2    Khvorova, A.3    Fesik, S.W.4    Shen, Y.5
  • 125
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA 'off-target' transcript silencing mediated by seed region sequence complementarity
    • Jackson A.L., Burchard J., Schelter J., Chau B.N., Cleary M., Lim L., Linsley P.S. Widespread siRNA 'off-target' transcript silencing mediated by seed region sequence complementarity. RNA 2006, 12:1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 126
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge A.D., Sood V., Shaw J.R., Fang D., McClintock K., MacLachlan I. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat. Biotechnol. 2005, 23:457-462.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 128
    • 0035920155 scopus 로고    scopus 로고
    • Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription
    • Hernandez N. Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription. J. Biol. Chem. 2001, 276:26733-26736.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26733-26736
    • Hernandez, N.1
  • 129
    • 4544380838 scopus 로고    scopus 로고
    • Poly(U) and polyadenylation termination signals are interchangeable for terminating the expression of shRNA from a pol II promoter
    • Song J., Pang S., Lu Y., Chiu R. Poly(U) and polyadenylation termination signals are interchangeable for terminating the expression of shRNA from a pol II promoter. Biochem. Biophys. Res. Commun. 2004, 323:573-578.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 573-578
    • Song, J.1    Pang, S.2    Lu, Y.3    Chiu, R.4
  • 130
    • 0036294527 scopus 로고    scopus 로고
    • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
    • Zeng Y., Wagner E.J., Cullen B.R. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 2002, 9:1327-1333.
    • (2002) Mol. Cell , vol.9 , pp. 1327-1333
    • Zeng, Y.1    Wagner, E.J.2    Cullen, B.R.3
  • 131
    • 3042854926 scopus 로고    scopus 로고
    • A new vector, based on the PolII promoter of the U1 snRNA gene, for the expression of siRNAs in mammalian cells
    • Denti M.A., Rosa A., Sthandier O., De Angelis F.G., Bozzoni I. A new vector, based on the PolII promoter of the U1 snRNA gene, for the expression of siRNAs in mammalian cells. Mol. Ther. 2004, 10:191-199.
    • (2004) Mol. Ther. , vol.10 , pp. 191-199
    • Denti, M.A.1    Rosa, A.2    Sthandier, O.3    De Angelis, F.G.4    Bozzoni, I.5
  • 132
    • 33646469581 scopus 로고    scopus 로고
    • Transactivated minimal E1b promoter is capable of driving the expression of short hairpin RNA
    • Huang M., Jia F.J., Yan Y.C., Guo L.H., Li Y.P. Transactivated minimal E1b promoter is capable of driving the expression of short hairpin RNA. J. Virol. Meth. 2006, 134:48-54.
    • (2006) J. Virol. Meth. , vol.134 , pp. 48-54
    • Huang, M.1    Jia, F.J.2    Yan, Y.C.3    Guo, L.H.4    Li, Y.P.5
  • 134
    • 29244455664 scopus 로고    scopus 로고
    • Hybrid cytomegalovirus enhancer-h1 promoter-based plasmid and baculovirus vectors mediate effective RNA interference
    • Ong S.T., Li F., Du J., Tan Y.W., Wang S. Hybrid cytomegalovirus enhancer-h1 promoter-based plasmid and baculovirus vectors mediate effective RNA interference. Hum. Gene Ther. 2005, 16:1404-1412.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 1404-1412
    • Ong, S.T.1    Li, F.2    Du, J.3    Tan, Y.W.4    Wang, S.5
  • 137
    • 65749112775 scopus 로고    scopus 로고
    • Conditional RNAi: towards a silent gene therapy
    • Lee S.K., Kumar P. Conditional RNAi: towards a silent gene therapy. Adv. Drug Deliv. Rev. 2009, 61:650-664.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 650-664
    • Lee, S.K.1    Kumar, P.2
  • 140
    • 3042545272 scopus 로고    scopus 로고
    • Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity
    • Higuchi M., Tsutsumi R., Higashi H., Hatakeyama M. Conditional gene silencing utilizing the lac repressor reveals a role of SHP-2 in cagA-positive Helicobacter pylori pathogenicity. Cancer Sci. 2004, 95:442-447.
    • (2004) Cancer Sci. , vol.95 , pp. 442-447
    • Higuchi, M.1    Tsutsumi, R.2    Higashi, H.3    Hatakeyama, M.4
  • 141
    • 22044438934 scopus 로고    scopus 로고
    • Inducible H1 promoter-driven lentiviral siRNA expression by Stuffer reporter deletion
    • Heinonen J.E., Mohamed A.J., Nore B.F., Smith C.I. Inducible H1 promoter-driven lentiviral siRNA expression by Stuffer reporter deletion. Oligonucleotides 2005, 15:139-144.
    • (2005) Oligonucleotides , vol.15 , pp. 139-144
    • Heinonen, J.E.1    Mohamed, A.J.2    Nore, B.F.3    Smith, C.I.4
  • 142
    • 58149116519 scopus 로고    scopus 로고
    • Delivery of hypoxia-inducible VEGF gene to rat islets using polyethylenimine
    • Kim H.A., Lee B.W., Kang D., Kim J.H., Ihm S.H., Lee M. Delivery of hypoxia-inducible VEGF gene to rat islets using polyethylenimine. J. Drug Target. 2009, 17:1-9.
    • (2009) J. Drug Target. , vol.17 , pp. 1-9
    • Kim, H.A.1    Lee, B.W.2    Kang, D.3    Kim, J.H.4    Ihm, S.H.5    Lee, M.6
  • 143
    • 67649515538 scopus 로고    scopus 로고
    • A comparison of non-viral vectors for gene delivery to pancreatic beta-cells: delivering a hypoxia-inducible vascular endothelial growth factor gene to rat islets
    • Lee B.W., Chae H.Y., Tuyen T.T., Kang D., Kim H.A., Lee M., Ihm S.H. A comparison of non-viral vectors for gene delivery to pancreatic beta-cells: delivering a hypoxia-inducible vascular endothelial growth factor gene to rat islets. Int. J. Mol. Med. 2009, 23:757-762.
    • (2009) Int. J. Mol. Med. , vol.23 , pp. 757-762
    • Lee, B.W.1    Chae, H.Y.2    Tuyen, T.T.3    Kang, D.4    Kim, H.A.5    Lee, M.6    Ihm, S.H.7
  • 144
    • 70350187073 scopus 로고    scopus 로고
    • Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter
    • Chai R., Chen S., Ding J., Grayburn P.A. Efficient, glucose responsive and islet-specific transgene expression by a modified rat insulin promoter. Gene Ther. 2009, 16:1202-1209.
    • (2009) Gene Ther. , vol.16 , pp. 1202-1209
    • Chai, R.1    Chen, S.2    Ding, J.3    Grayburn, P.A.4
  • 147
    • 64549163250 scopus 로고    scopus 로고
    • The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas
    • Avnit-Sagi T., Kantorovich L., Kredo-Russo S., Hornstein E., Walker M.D. The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS ONE 2009, 4:e5033.
    • (2009) PLoS ONE , vol.4
    • Avnit-Sagi, T.1    Kantorovich, L.2    Kredo-Russo, S.3    Hornstein, E.4    Walker, M.D.5
  • 149
    • 34548299760 scopus 로고    scopus 로고
    • Optimization of short hairpin RNA for lentiviral-mediated RNAi against WAS
    • Jeanson-Leh L., Blondeau J., Galy A. Optimization of short hairpin RNA for lentiviral-mediated RNAi against WAS. Biochem. Biophys. Res. Commun. 2007, 362:498-503.
    • (2007) Biochem. Biophys. Res. Commun. , vol.362 , pp. 498-503
    • Jeanson-Leh, L.1    Blondeau, J.2    Galy, A.3
  • 150
  • 152
    • 24944560377 scopus 로고    scopus 로고
    • A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells
    • Stegmeier F., Hu G., Rickles R.J., Hannon G.J., Elledge S.J. A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc. Natl Acad. Sci. USA 2005, 102:13212-13217.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13212-13217
    • Stegmeier, F.1    Hu, G.2    Rickles, R.J.3    Hannon, G.J.4    Elledge, S.J.5
  • 153
    • 50649121877 scopus 로고    scopus 로고
    • Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs
    • Boudreau R.L., Monteys A.M., Davidson B.L. Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs. RNA 2008, 14:1834-1844.
    • (2008) RNA , vol.14 , pp. 1834-1844
    • Boudreau, R.L.1    Monteys, A.M.2    Davidson, B.L.3
  • 154
    • 58149232358 scopus 로고    scopus 로고
    • Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo
    • Boudreau R.L., Martins I., Davidson B.L. Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol. Ther. 2009, 17:169-175.
    • (2009) Mol. Ther. , vol.17 , pp. 169-175
    • Boudreau, R.L.1    Martins, I.2    Davidson, B.L.3
  • 155
    • 68949213635 scopus 로고    scopus 로고
    • Neuron-specific RNA interference using lentiviral vectors
    • Nielsen T.T., Marion I., Hasholt L., Lundberg C. Neuron-specific RNA interference using lentiviral vectors. J. Gene Med. 2009, 11:559-569.
    • (2009) J. Gene Med. , vol.11 , pp. 559-569
    • Nielsen, T.T.1    Marion, I.2    Hasholt, L.3    Lundberg, C.4
  • 157
    • 56349155978 scopus 로고    scopus 로고
    • Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs
    • Aagaard L.A., Zhang J., von Eije K.J., Li H., Saetrom P., Amarzguioui M., Rossi J.J. Engineering and optimization of the miR-106b cluster for ectopic expression of multiplexed anti-HIV RNAs. Gene Ther. 2008, 15:1536-1549.
    • (2008) Gene Ther. , vol.15 , pp. 1536-1549
    • Aagaard, L.A.1    Zhang, J.2    von Eije, K.J.3    Li, H.4    Saetrom, P.5    Amarzguioui, M.6    Rossi, J.J.7
  • 158
    • 34250357616 scopus 로고    scopus 로고
    • Optimization and characterization of tRNA-shRNA expression constructs
    • Scherer L.J., Frank R., Rossi J.J. Optimization and characterization of tRNA-shRNA expression constructs. Nucleic Acids Res. 2007, 35:2620-2628.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 2620-2628
    • Scherer, L.J.1    Frank, R.2    Rossi, J.J.3
  • 159
    • 0037440160 scopus 로고    scopus 로고
    • Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells
    • Kawasaki H., Taira K. Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acids Res. 2003, 31:700-707.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 700-707
    • Kawasaki, H.1    Taira, K.2
  • 161
    • 0035668756 scopus 로고    scopus 로고
    • Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells
    • Kuwabara T., Warashina M., Sano M., Tang H., Wong-Staal F., Munekata E., Taira K. Recognition of engineered tRNAs with an extended 3' end by Exportin-t (Xpo-t) and transport of tRNA-attached ribozymes to the cytoplasm in somatic cells. Biomacromolecules 2001, 2:1229-1242.
    • (2001) Biomacromolecules , vol.2 , pp. 1229-1242
    • Kuwabara, T.1    Warashina, M.2    Sano, M.3    Tang, H.4    Wong-Staal, F.5    Munekata, E.6    Taira, K.7
  • 164
    • 74049124186 scopus 로고    scopus 로고
    • Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
    • Jackson A.L., Linsley P.S. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 2010, 9:57-67.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 57-67
    • Jackson, A.L.1    Linsley, P.S.2
  • 168
    • 17844387370 scopus 로고    scopus 로고
    • A computational study of off-target effects of RNA interference
    • Qiu S., Adema C.M., Lane T. A computational study of off-target effects of RNA interference. Nucleic Acids Res. 2005, 33:1834-1847.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 1834-1847
    • Qiu, S.1    Adema, C.M.2    Lane, T.3
  • 169
    • 15044358407 scopus 로고    scopus 로고
    • A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites
    • Du Q., Thonberg H., Wang J., Wahlestedt C., Liang Z. A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Res. 2005, 33:1671-1677.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 1671-1677
    • Du, Q.1    Thonberg, H.2    Wang, J.3    Wahlestedt, C.4    Liang, Z.5
  • 171
    • 42449091989 scopus 로고    scopus 로고
    • Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
    • Ui-Tei K., Naito Y., Zenno S., Nishi K., Yamato K., Takahashi F., Juni A., Saigo K. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 2008, 36:2136-2151.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 2136-2151
    • Ui-Tei, K.1    Naito, Y.2    Zenno, S.3    Nishi, K.4    Yamato, K.5    Takahashi, F.6    Juni, A.7    Saigo, K.8
  • 174
    • 27944459341 scopus 로고    scopus 로고
    • Activation of the mammalian immune system by siRNAs
    • Marques J.T., Williams B.R. Activation of the mammalian immune system by siRNAs. Nat. Biotechnol. 2005, 23:1399-1405.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1399-1405
    • Marques, J.T.1    Williams, B.R.2
  • 175
    • 0037711199 scopus 로고    scopus 로고
    • The dsRNA binding protein family: critical roles, diverse cellular functions
    • Saunders L.R., Barber G.N. The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J. 2003, 17:961-983.
    • (2003) FASEB J. , vol.17 , pp. 961-983
    • Saunders, L.R.1    Barber, G.N.2
  • 179
    • 44749084853 scopus 로고    scopus 로고
    • Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes
    • de Wolf H.K., Johansson N., Thong A.T., Snel C.J., Mastrobattista E., Hennink W.E., Storm G. Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes. Pharm. Res. 2008, 25:1654-1662.
    • (2008) Pharm. Res. , vol.25 , pp. 1654-1662
    • de Wolf, H.K.1    Johansson, N.2    Thong, A.T.3    Snel, C.J.4    Mastrobattista, E.5    Hennink, W.E.6    Storm, G.7
  • 180
    • 36849087968 scopus 로고    scopus 로고
    • Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?
    • Grimm D., Kay M.A. Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?. J. Clin. Invest. 2007, 117:3633-3641.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3633-3641
    • Grimm, D.1    Kay, M.A.2
  • 181
    • 67249090051 scopus 로고    scopus 로고
    • TGF-beta1 gene silencing for treating liver fibrosis
    • Cheng K., Yang N., Mahato R.I. TGF-beta1 gene silencing for treating liver fibrosis. Mol. Pharm. 2009, 6:772-779.
    • (2009) Mol. Pharm. , vol.6 , pp. 772-779
    • Cheng, K.1    Yang, N.2    Mahato, R.I.3
  • 182
    • 39449092763 scopus 로고    scopus 로고
    • SiRNA pool targeting different sites of human hepatitis B surface antigen efficiently inhibits HBV infection
    • Chen Y., Mahato R.I. siRNA pool targeting different sites of human hepatitis B surface antigen efficiently inhibits HBV infection. J. Drug Target. 2008, 16:140-148.
    • (2008) J. Drug Target. , vol.16 , pp. 140-148
    • Chen, Y.1    Mahato, R.I.2
  • 183
    • 34247278567 scopus 로고    scopus 로고
    • Combinatorial RNAi: a winning strategy for the race against evolving targets?
    • Grimm D., Kay M.A. Combinatorial RNAi: a winning strategy for the race against evolving targets?. Mol. Ther. 2007, 15:878-888.
    • (2007) Mol. Ther. , vol.15 , pp. 878-888
    • Grimm, D.1    Kay, M.A.2
  • 185
    • 28644450043 scopus 로고    scopus 로고
    • An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi
    • Zhou H., Xia X.G., Xu Z. An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Res. 2005, 33:e62.
    • (2005) Nucleic Acids Res. , vol.33
    • Zhou, H.1    Xia, X.G.2    Xu, Z.3
  • 186
    • 33645788618 scopus 로고    scopus 로고
    • Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice
    • Xia X.G., Zhou H., Samper E., Melov S., Xu Z. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet. 2006, 2:e10.
    • (2006) PLoS Genet. , vol.2
    • Xia, X.G.1    Zhou, H.2    Samper, E.3    Melov, S.4    Xu, Z.5
  • 187
    • 33747603277 scopus 로고    scopus 로고
    • Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown
    • Sun D., Melegari M., Sridhar S., Rogler C.E., Zhu L. Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques 2006, 41:59-63.
    • (2006) Biotechniques , vol.41 , pp. 59-63
    • Sun, D.1    Melegari, M.2    Sridhar, S.3    Rogler, C.E.4    Zhu, L.5
  • 189
    • 49749095063 scopus 로고    scopus 로고
    • The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA
    • Saayman S., Barichievy S., Capovilla A., Morris K.V., Arbuthnot P., Weinberg M.S. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA. PLoS ONE 2008, 3:e2602.
    • (2008) PLoS ONE , vol.3
    • Saayman, S.1    Barichievy, S.2    Capovilla, A.3    Morris, K.V.4    Arbuthnot, P.5    Weinberg, M.S.6
  • 190
    • 34848814237 scopus 로고    scopus 로고
    • Design of extended short hairpin RNAs for HIV-1 inhibition
    • Liu Y.P., Haasnoot J., Berkhout B. Design of extended short hairpin RNAs for HIV-1 inhibition. Nucleic Acids Res. 2007, 35:5683-5693.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 5683-5693
    • Liu, Y.P.1    Haasnoot, J.2    Berkhout, B.3
  • 192
    • 0037303455 scopus 로고    scopus 로고
    • Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors
    • Yu J.Y., Taylor J., DeRuiter S.L., Vojtek A.B., Turner D.L. Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors. Mol. Ther. 2003, 7:228-236.
    • (2003) Mol. Ther. , vol.7 , pp. 228-236
    • Yu, J.Y.1    Taylor, J.2    DeRuiter, S.L.3    Vojtek, A.B.4    Turner, D.L.5
  • 196
    • 54249143034 scopus 로고    scopus 로고
    • A construct with fluorescent indicators for conditional expression of miRNA
    • Qiu L., Wang H., Xia X., Zhou H., Xu Z. A construct with fluorescent indicators for conditional expression of miRNA. BMC Biotechnol. 2008, 8:77.
    • (2008) BMC Biotechnol. , vol.8 , pp. 77
    • Qiu, L.1    Wang, H.2    Xia, X.3    Zhou, H.4    Xu, Z.5
  • 197
    • 67249122712 scopus 로고    scopus 로고
    • Biological barriers to therapy with antisense and siRNA oligonucleotides
    • Juliano R., Bauman J., Kang H., Ming X. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol. Pharm. 2009, 6:686-695.
    • (2009) Mol. Pharm. , vol.6 , pp. 686-695
    • Juliano, R.1    Bauman, J.2    Kang, H.3    Ming, X.4
  • 198
    • 34248637892 scopus 로고    scopus 로고
    • Systemic siRNA delivery via hydrodynamic intravascular injection
    • Lewis D.L., Wolff J.A. Systemic siRNA delivery via hydrodynamic intravascular injection. Adv. Drug Deliv. Rev. 2007, 59:115-123.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 115-123
    • Lewis, D.L.1    Wolff, J.A.2
  • 201
    • 57349134691 scopus 로고    scopus 로고
    • Chemical modification of siRNAs for in vivo use
    • Behlke M.A. Chemical modification of siRNAs for in vivo use. Oligonucleotides 2008, 18:305-319.
    • (2008) Oligonucleotides , vol.18 , pp. 305-319
    • Behlke, M.A.1
  • 202
    • 36849094017 scopus 로고    scopus 로고
    • Chemical modification: the key to clinical application of RNA interference?
    • Corey D.R. Chemical modification: the key to clinical application of RNA interference?. J. Clin. Invest. 2007, 117:3615-3622.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3615-3622
    • Corey, D.R.1
  • 205
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung S., Kim Y.J., Kim S., Park H.O., Choi Y.C. Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun. 2006, 342:919-927.
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.O.4    Choi, Y.C.5
  • 208
    • 33845530239 scopus 로고    scopus 로고
    • MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity
    • Turner J.J., Jones S.W., Moschos S.A., Lindsay M.A., Gait M.J. MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity. Mol. Biosyst. 2007, 3:43-50.
    • (2007) Mol. Biosyst. , vol.3 , pp. 43-50
    • Turner, J.J.1    Jones, S.W.2    Moschos, S.A.3    Lindsay, M.A.4    Gait, M.J.5
  • 209
    • 32944454941 scopus 로고    scopus 로고
    • Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
    • Judge A.D., Bola G., Lee A.C., MacLachlan I. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 2006, 13:494-505.
    • (2006) Mol. Ther. , vol.13 , pp. 494-505
    • Judge, A.D.1    Bola, G.2    Lee, A.C.3    MacLachlan, I.4
  • 212
    • 12344253784 scopus 로고    scopus 로고
    • Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells
    • Narang A.S., Thoma L., Miller D.D., Mahato R.I. Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells. Bioconjug. Chem. 2005, 16:156-168.
    • (2005) Bioconjug. Chem. , vol.16 , pp. 156-168
    • Narang, A.S.1    Thoma, L.2    Miller, D.D.3    Mahato, R.I.4
  • 213
    • 65749119809 scopus 로고    scopus 로고
    • Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
    • Takahashi Y., Nishikawa M., Takakura Y. Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Adv. Drug Deliv. Rev. 2009, 61:760-766.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 760-766
    • Takahashi, Y.1    Nishikawa, M.2    Takakura, Y.3
  • 214
    • 35448973736 scopus 로고    scopus 로고
    • Breaking up the correlation between efficacy and toxicity for nonviral gene delivery
    • Breunig M., Lungwitz U., Liebl R., Goepferich A. Breaking up the correlation between efficacy and toxicity for nonviral gene delivery. Proc. Natl Acad. Sci. USA 2007, 104:14454-14459.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 14454-14459
    • Breunig, M.1    Lungwitz, U.2    Liebl, R.3    Goepferich, A.4
  • 215
    • 33846446410 scopus 로고    scopus 로고
    • Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery
    • Lee Y., Mo H., Koo H., Park J.Y., Cho M.Y., Jin G.W., Park J.S. Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery. Bioconjug. Chem. 2007, 18:13-18.
    • (2007) Bioconjug. Chem. , vol.18 , pp. 13-18
    • Lee, Y.1    Mo, H.2    Koo, H.3    Park, J.Y.4    Cho, M.Y.5    Jin, G.W.6    Park, J.S.7
  • 217
    • 48749113674 scopus 로고    scopus 로고
    • Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo
    • Breunig M., Hozsa C., Lungwitz U., Watanabe K., Umeda I., Kato H., Goepferich A. Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo. J. Control. Release 2008, 130:57-63.
    • (2008) J. Control. Release , vol.130 , pp. 57-63
    • Breunig, M.1    Hozsa, C.2    Lungwitz, U.3    Watanabe, K.4    Umeda, I.5    Kato, H.6    Goepferich, A.7
  • 219
    • 34447311893 scopus 로고    scopus 로고
    • A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery
    • Wang X.L., Jensen R., Lu Z.R. A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery. J. Control. Release 2007, 120:250-258.
    • (2007) J. Control. Release , vol.120 , pp. 250-258
    • Wang, X.L.1    Jensen, R.2    Lu, Z.R.3
  • 220
    • 41149179556 scopus 로고    scopus 로고
    • Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity
    • Ou M., Wang X.L., Xu R., Chang C.W., Bull D.A., Kim S.W. Novel biodegradable poly(disulfide amine)s for gene delivery with high efficiency and low cytotoxicity. Bioconjug. Chem. 2008, 19:626-633.
    • (2008) Bioconjug. Chem. , vol.19 , pp. 626-633
    • Ou, M.1    Wang, X.L.2    Xu, R.3    Chang, C.W.4    Bull, D.A.5    Kim, S.W.6
  • 222
    • 40949100345 scopus 로고    scopus 로고
    • Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells
    • Jere D., Xu C.X., Arote R., Yun C.H., Cho M.H., Cho C.S. Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells. Biomaterials 2008, 29:2535-2547.
    • (2008) Biomaterials , vol.29 , pp. 2535-2547
    • Jere, D.1    Xu, C.X.2    Arote, R.3    Yun, C.H.4    Cho, M.H.5    Cho, C.S.6
  • 224
    • 34648825525 scopus 로고    scopus 로고
    • Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing
    • Tseng S.J., Tang S.C. Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing. Bioconjug. Chem. 2007, 18:1383-1390.
    • (2007) Bioconjug. Chem. , vol.18 , pp. 1383-1390
    • Tseng, S.J.1    Tang, S.C.2
  • 226
    • 33645225035 scopus 로고    scopus 로고
    • Design of polyphosphoester-DNA nanoparticles for non-viral gene delivery
    • Mao H.Q., Leong K.W. Design of polyphosphoester-DNA nanoparticles for non-viral gene delivery. Adv. Genet. 2005, 53:275-306.
    • (2005) Adv. Genet. , vol.53 , pp. 275-306
    • Mao, H.Q.1    Leong, K.W.2
  • 227
    • 0036738998 scopus 로고    scopus 로고
    • Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier
    • Wang J., Zhang P.C., Mao H.Q., Leong K.W. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Ther. 2002, 9:1254-1261.
    • (2002) Gene Ther. , vol.9 , pp. 1254-1261
    • Wang, J.1    Zhang, P.C.2    Mao, H.Q.3    Leong, K.W.4
  • 228
    • 50349087243 scopus 로고    scopus 로고
    • Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery
    • Sun T.M., Du J.Z., Yan L.F., Mao H.Q., Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials 2008, 29:4348-4355.
    • (2008) Biomaterials , vol.29 , pp. 4348-4355
    • Sun, T.M.1    Du, J.Z.2    Yan, L.F.3    Mao, H.Q.4    Wang, J.5
  • 230
    • 39749099838 scopus 로고    scopus 로고
    • Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine
    • Shim M.S., Kwon Y.J. Controlled delivery of plasmid DNA and siRNA to intracellular targets using ketalized polyethylenimine. Biomacromolecules 2008, 9:444-455.
    • (2008) Biomacromolecules , vol.9 , pp. 444-455
    • Shim, M.S.1    Kwon, Y.J.2
  • 233
    • 4444220551 scopus 로고    scopus 로고
    • Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells
    • Lorenz C., Hadwiger P., John M., Vornlocher H.P., Unverzagt C. Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg. Med. Chem. Lett. 2004, 14:4975-4977.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 4975-4977
    • Lorenz, C.1    Hadwiger, P.2    John, M.3    Vornlocher, H.P.4    Unverzagt, C.5
  • 234
  • 235
    • 4344651353 scopus 로고    scopus 로고
    • Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells
    • Chiu Y.L., Ali A., Chu C.Y., Cao H., Rana T.M. Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. Chem. Biol. 2004, 11:1165-1175.
    • (2004) Chem. Biol. , vol.11 , pp. 1165-1175
    • Chiu, Y.L.1    Ali, A.2    Chu, C.Y.3    Cao, H.4    Rana, T.M.5
  • 237
    • 0842346326 scopus 로고    scopus 로고
    • Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
    • Muratovska A., Eccles M.R. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. 2004, 558:63-68.
    • (2004) FEBS Lett. , vol.558 , pp. 63-68
    • Muratovska, A.1    Eccles, M.R.2
  • 238
    • 34247153120 scopus 로고    scopus 로고
    • Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide
    • Lee S.H., Kim S.H., Park T.G. Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide. Biochem. Biophys. Res. Commun. 2007, 357:511-516.
    • (2007) Biochem. Biophys. Res. Commun. , vol.357 , pp. 511-516
    • Lee, S.H.1    Kim, S.H.2    Park, T.G.3
  • 240
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • Kim S.H., Jeong J.H., Lee S.H., Kim S.W., Park T.G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control. Release 2008, 129:107-116.
    • (2008) J. Control. Release , vol.129 , pp. 107-116
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 241
    • 13644254495 scopus 로고    scopus 로고
    • Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
    • Oishi M., Nagasaki Y., Itaka K., Nishiyama N., Kataoka K. Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J. Am. Chem. Soc. 2005, 127:1624-1625.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 1624-1625
    • Oishi, M.1    Nagasaki, Y.2    Itaka, K.3    Nishiyama, N.4    Kataoka, K.5
  • 242
    • 42149163566 scopus 로고    scopus 로고
    • Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes
    • Oishi M., Nagasaki Y., Nishiyama N., Itaka K., Takagi M., Shimamoto A., Furuichi Y., Kataoka K. Enhanced growth inhibition of hepatic multicellular tumor spheroids by lactosylated poly(ethylene glycol)-siRNA conjugate formulated in PEGylated polyplexes. ChemMedChem 2007, 2:1290-1297.
    • (2007) ChemMedChem , vol.2 , pp. 1290-1297
    • Oishi, M.1    Nagasaki, Y.2    Nishiyama, N.3    Itaka, K.4    Takagi, M.5    Shimamoto, A.6    Furuichi, Y.7    Kataoka, K.8
  • 244
    • 33750591089 scopus 로고    scopus 로고
    • Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function
    • Narang A.S., Sabek O., Gaber A.O., Mahato R.I. Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm. Res. 2006, 23:1970-1982.
    • (2006) Pharm. Res. , vol.23 , pp. 1970-1982
    • Narang, A.S.1    Sabek, O.2    Gaber, A.O.3    Mahato, R.I.4
  • 245
    • 4344608398 scopus 로고    scopus 로고
    • An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans
    • Bain J.R., Schisler J.C., Takeuchi K., Newgard C.B., Becker T.C. An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. Diabetes 2004, 53:2190-2194.
    • (2004) Diabetes , vol.53 , pp. 2190-2194
    • Bain, J.R.1    Schisler, J.C.2    Takeuchi, K.3    Newgard, C.B.4    Becker, T.C.5
  • 246
    • 24944458103 scopus 로고    scopus 로고
    • Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
    • Iezzi M., Eliasson L., Fukuda M., Wollheim C.B. Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets. FEBS Lett. 2005, 579:5241-5246.
    • (2005) FEBS Lett. , vol.579 , pp. 5241-5246
    • Iezzi, M.1    Eliasson, L.2    Fukuda, M.3    Wollheim, C.B.4
  • 248
    • 77953262899 scopus 로고    scopus 로고
    • Recombinant adenovirus-mediated RNA silencing of tissue factor expression in human islet: an in vitro study
    • Li Z.L., Xu W.J., Tian P.X., Ding X.M., Tian X.H., Feng X.S., Hou J. Recombinant adenovirus-mediated RNA silencing of tissue factor expression in human islet: an in vitro study. Nan Fang Yi Ke Da Xue Xue Bao 2007, 27:1299-1302.
    • (2007) Nan Fang Yi Ke Da Xue Xue Bao , vol.27 , pp. 1299-1302
    • Li, Z.L.1    Xu, W.J.2    Tian, P.X.3    Ding, X.M.4    Tian, X.H.5    Feng, X.S.6    Hou, J.7
  • 249
    • 58149343826 scopus 로고    scopus 로고
    • Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture
    • Marzban L., Tomas A., Becker T.C., Rosenberg L., Oberholzer J., Fraser P.E., Halban P.A., Verchere C.B. Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes 2008, 57:3045-3055.
    • (2008) Diabetes , vol.57 , pp. 3045-3055
    • Marzban, L.1    Tomas, A.2    Becker, T.C.3    Rosenberg, L.4    Oberholzer, J.5    Fraser, P.E.6    Halban, P.A.7    Verchere, C.B.8
  • 250
    • 0032191380 scopus 로고    scopus 로고
    • Lentiviruses as gene transfer agents for delivery to non-dividing cells
    • Naldini L. Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr. Opin. Biotechnol. 1998, 9:457-463.
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 457-463
    • Naldini, L.1
  • 251
    • 0027228422 scopus 로고
    • Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
    • Burns J.C., Friedmann T., Driever W., Burrascano M., Yee J.K. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl Acad. Sci. USA 1993, 90:8033-8037.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 8033-8037
    • Burns, J.C.1    Friedmann, T.2    Driever, W.3    Burrascano, M.4    Yee, J.K.5
  • 255
    • 34548083701 scopus 로고    scopus 로고
    • Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine)
    • Park I.K., Lasiene J., Chou S.H., Horner P.J., Pun S.H. Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). J. Gene Med. 2007, 9:691-702.
    • (2007) J. Gene Med. , vol.9 , pp. 691-702
    • Park, I.K.1    Lasiene, J.2    Chou, S.H.3    Horner, P.J.4    Pun, S.H.5
  • 258
    • 0032506750 scopus 로고    scopus 로고
    • Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis
    • Gallichan W.S., Kafri T., Krahl T., Verma I.M., Sarvetnick N. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum. Gene Ther. 1998, 9:2717-2726.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2717-2726
    • Gallichan, W.S.1    Kafri, T.2    Krahl, T.3    Verma, I.M.4    Sarvetnick, N.5
  • 259
    • 33744720341 scopus 로고    scopus 로고
    • Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets
    • He Z., Wang F., Kumagai-Braesch M., Permert J., Holgersson J. Long-term gene expression and metabolic control exerted by lentivirus-transduced pancreatic islets. Xenotransplantation 2006, 13:195-203.
    • (2006) Xenotransplantation , vol.13 , pp. 195-203
    • He, Z.1    Wang, F.2    Kumagai-Braesch, M.3    Permert, J.4    Holgersson, J.5
  • 260
    • 34548427326 scopus 로고    scopus 로고
    • Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes
    • Callewaert H., Gysemans C., Cardozo A.K., Elsner M., Tiedge M., Eizirik D.L., Mathieu C. Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes. Cell Transplant. 2007, 16:527-537.
    • (2007) Cell Transplant. , vol.16 , pp. 527-537
    • Callewaert, H.1    Gysemans, C.2    Cardozo, A.K.3    Elsner, M.4    Tiedge, M.5    Eizirik, D.L.6    Mathieu, C.7
  • 261
    • 33748508808 scopus 로고    scopus 로고
    • A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans
    • Barbu A.R., Bodin B., Welsh M., Jansson L., Welsh N. A perfusion protocol for highly efficient transduction of intact pancreatic islets of Langerhans. Diabetologia 2006, 49:2388-2391.
    • (2006) Diabetologia , vol.49 , pp. 2388-2391
    • Barbu, A.R.1    Bodin, B.2    Welsh, M.3    Jansson, L.4    Welsh, N.5
  • 263
    • 40449124972 scopus 로고    scopus 로고
    • Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection
    • Macedo G.C., Magnani D.M., Carvalho N.B., Bruna-Romero O., Gazzinelli R.T., Oliveira S.C. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. J. Immunol. 2008, 180:1080-1087.
    • (2008) J. Immunol. , vol.180 , pp. 1080-1087
    • Macedo, G.C.1    Magnani, D.M.2    Carvalho, N.B.3    Bruna-Romero, O.4    Gazzinelli, R.T.5    Oliveira, S.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.