Mechanisms and optimization of in vivo delivery of lipophilic siRNAs

Nature Biotechnology

Volumn 25, Issue 10, 2007, Pages 1149-1157

  Wolfrum, Christian ^a,b   Shi, Shuanping ^b   Jayaprakash, K Narayanannair ^c   Jayaraman, Muthusamy ^c   Wang, Gang ^c   Pandey, Rajendra K ^c   Rajeev, Kallanthottathil G ^c   Nakayama, Tomoko ^c   Charrise, Klaus ^c   Ndungo, Esther M ^b   Zimmermann, Tracy ^c   Koteliansky, Victor ^c   Manoharan, Muthiah ^c   Stoffel, Markus ^a,b  

^a ETH ZURICH   (Switzerland)

^b ROCKEFELLER UNIVERSITY   (United States)

^c ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; CELLS; CHOLESTEROL; FATTY ACIDS; GENES; PROTEINS;

BILE ACIDS; LIPOPROTEIN RECEPTORS; SIRNA; TRANSMEMBRANE PROTEINS;

RNA;

BILE ACID CONJUGATE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LIPOPROTEIN RECEPTOR; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN; MEMBRANE PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE SILENCING; IN VIVO GENE TRANSFER; INTESTINE; KIDNEY; LIPOPHILICITY; LIVER; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN TRANSPORT; RNA SYNTHESIS;

ANIMALS; APOLIPOPROTEINS B; CHOLESTEROL; CRICETINAE; GENE TRANSFER TECHNIQUES; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MESOCRICETUS; MICE; RECEPTORS, LIPOPROTEIN; RNA INTERFERENCE; RNA, SMALL INTERFERING;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 35148815670     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1339     Document Type: Article

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