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Volumn 52, Issue 11, 2003, Pages 2701-2719

Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; RADICAL; TRANSCRIPTION FACTOR;

EID: 0242363618     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.11.2701     Document Type: Article
Times cited : (201)

References (72)
  • 1
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal-transduction of immune-mediated β-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T: A choice of death: the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44:2115-2133, 2001
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 2
    • 0035124874 scopus 로고    scopus 로고
    • β-cell apoptosis and defense mechanisms: Lessons from type 1 diabetes
    • Eizirik DL, Darville MI: β-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 50 (Suppl. 1):S64-S69, 2001
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Eizirik, D.L.1    Darville, M.I.2
  • 3
    • 0029764082 scopus 로고    scopus 로고
    • Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction
    • Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A: Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction. Diabetes 45:1350-1357, 1996
    • (1996) Diabetes , vol.45 , pp. 1350-1357
    • Suarez-Pinzon, W.1    Rajotte, R.V.2    Mosmann, T.R.3    Rabinovitch, A.4
  • 4
    • 0030920680 scopus 로고    scopus 로고
    • IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice
    • Sandberg JO, Eizirik DL, Sandler S: IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice. Clin Exp Immunol 108:314-317, 1997
    • (1997) Clin Exp Immunol , vol.108 , pp. 314-317
    • Sandberg, J.O.1    Eizirik, D.L.2    Sandler, S.3
  • 5
    • 0032932324 scopus 로고    scopus 로고
    • β-cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets
    • Suarez-Pinzon W, Sorensen O, Bleackley RC, Elliott JF, Rajotte RV, Rabinovitch A: β-Cell destruction in NOD mice correlates with Fas (CD95) expression on β-cells and proinflammatory cytokine expression in islets. Diabetes 48:21-28, 1999
    • (1999) Diabetes , vol.48 , pp. 21-28
    • Suarez-Pinzon, W.1    Sorensen, O.2    Bleackley, R.C.3    Elliott, J.F.4    Rajotte, R.V.5    Rabinovitch, A.6
  • 6
    • 0032589489 scopus 로고    scopus 로고
    • Identification of IL-1β-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA
    • Chen MC, Schuit F, Eizirik DL: Identification of IL-1β-induced messenger RNAs in rat pancreatic beta cells by differential display of messenger RNA. Diabetologia 42:1199-1203, 1999
    • (1999) Diabetologia , vol.42 , pp. 1199-1203
    • Chen, M.C.1    Schuit, F.2    Eizirik, D.L.3
  • 8
    • 0035029867 scopus 로고    scopus 로고
    • Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays
    • Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL: Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50:909-920, 2001
    • (2001) Diabetes , vol.50 , pp. 909-920
    • Cardozo, A.K.1    Kruhoffer, M.2    Leeman, R.3    Orntoft, T.4    Eizirik, D.L.5
  • 9
    • 0037300827 scopus 로고    scopus 로고
    • IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice
    • Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL: IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia 46:255-266, 2003
    • (2003) Diabetologia , vol.46 , pp. 255-266
    • Cardozo, A.K.1    Proost, P.2    Gysemans, C.3    Chen, M.C.4    Mathieu, C.5    Eizirik, D.L.6
  • 10
    • 0035966006 scopus 로고    scopus 로고
    • A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells
    • Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft T, Eizirik DL: A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276:48879-48886, 2001
    • (2001) J Biol Chem , vol.276 , pp. 48879-48886
    • Cardozo, A.K.1    Heimberg, H.2    Heremans, Y.3    Leeman, R.4    Kutlu, B.5    Kruhoffer, M.6    Orntoft, T.7    Eizirik, D.L.8
  • 11
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis
    • Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL: Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis. Diabetes 50:2219-2224, 2001
    • (2001) Diabetes , vol.50 , pp. 2219-2224
    • Heimberg, H.1    Heremans, Y.2    Jobin, C.3    Leemans, R.4    Cardozo, A.K.5    Darville, M.6    Eizirik, D.L.7
  • 12
    • 0034711250 scopus 로고    scopus 로고
    • Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor
    • Giannoukakis N, Rudert WA, Trucco M, Robbins PD: Protection of human islets from the effects of interleukin-1β by adenoviral gene transfer of an IκB repressor. J Biol Chem 275:36509-36513, 2000
    • (2000) J Biol Chem , vol.275 , pp. 36509-36513
    • Giannoukakis, N.1    Rudert, W.A.2    Trucco, M.3    Robbins, P.D.4
  • 13
    • 0036898577 scopus 로고    scopus 로고
    • Microarray data normalization and transformation
    • Quackenbush J: Microarray data normalization and transformation. Nat Genet 32 (Suppl.):496-501, 2002
    • (2002) Nat Genet , vol.32 , Issue.SUPPL. , pp. 496-501
    • Quackenbush, J.1
  • 16
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB: Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130:167-178, 1992
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 18
    • 0029797603 scopus 로고    scopus 로고
    • Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program
    • Hoorens A, Van de Casteele M, Kloppel G, Pipeleers D: Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 98:1568-1574, 1996
    • (1996) J Clin Invest , vol.98 , pp. 1568-1574
    • Hoorens, A.1    Van de Casteele, M.2    Kloppel, G.3    Pipeleers, D.4
  • 20
    • 0030923812 scopus 로고    scopus 로고
    • Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
    • Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL: Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 138:2610-2614, 1997
    • (1997) Endocrinology , vol.138 , pp. 2610-2614
    • Delaney, C.A.1    Pavlovic, D.2    Hoorens, A.3    Pipeleers, D.G.4    Eizirik, D.L.5
  • 21
    • 0036214325 scopus 로고    scopus 로고
    • Double-stranded RNA cooperates with interferon-γ and IL-1β to induce both chemokine expression and nuclear factor-κB-dependent apoptosis in pancreatic β-cells: Potential mechanisms for viral-induced insulitis and β-cell death in type 1 diabetes mellitus
    • Liu D, Cardozo AK, Darville MI, Eizirik DL: Double-stranded RNA cooperates with interferon-γ and IL-1β to induce both chemokine expression and nuclear factor-κB-dependent apoptosis in pancreatic β-cells: potential mechanisms for viral-induced insulitis and β-cell death in type 1 diabetes mellitus. Endocrinology 143:1225-1234, 2002
    • (2002) Endocrinology , vol.143 , pp. 1225-1234
    • Liu, D.1    Cardozo, A.K.2    Darville, M.I.3    Eizirik, D.L.4
  • 23
    • 0032605098 scopus 로고    scopus 로고
    • BioJAKE: A tool for the creation, visualization and manipulation of metabolic pathways
    • Salamonsen W, Mok KY, Kolatkar P, Subbiah S: BioJAKE: a tool for the creation, visualization and manipulation of metabolic pathways. Pac Symp Biocomput 392-400, 1999
    • (1999) Pac Symp Biocomput , pp. 392-400
    • Salamonsen, W.1    Mok, K.Y.2    Kolatkar, P.3    Subbiah, S.4
  • 25
    • 0031827241 scopus 로고    scopus 로고
    • Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
    • Darville MI, Eizirik DL: Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41:1101-1108, 1998
    • (1998) Diabetologia , vol.41 , pp. 1101-1108
    • Darville, M.I.1    Eizirik, D.L.2
  • 26
    • 0037317269 scopus 로고    scopus 로고
    • Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic β-cells
    • Kutlu B, Darville MI, Cardozo AK, Eizirik DL: Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic β-cells. Diabetes 52:348-355, 2003
    • (2003) Diabetes , vol.52 , pp. 348-355
    • Kutlu, B.1    Darville, M.I.2    Cardozo, A.K.3    Eizirik, D.L.4
  • 27
    • 0028596498 scopus 로고
    • Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells
    • Niemann A, Bjorklund A, Eizirik DL: Studies on the molecular regulation of the inducible form of nitric oxide synthase (iNOS) in insulin-producing cells. Mol Cell Endocrinol 106:151-155, 1994
    • (1994) Mol Cell Endocrinol , vol.106 , pp. 151-155
    • Niemann, A.1    Bjorklund, A.2    Eizirik, D.L.3
  • 28
    • 0035981659 scopus 로고    scopus 로고
    • Blockade of NF-κB activation and donation of nitric oxide: New treatment options in inflammatory bowel disease?
    • Dijkstra G, Moshage H, Jansen PL: Blockade of NF-κB activation and donation of nitric oxide: new treatment options in inflammatory bowel disease? Scand J Gastroenterol Suppl 236 (Suppl.):37-41, 2002
    • (2002) Scand J Gastroenterol Suppl , vol.236 , Issue.SUPPL. , pp. 37-41
    • Dijkstra, G.1    Moshage, H.2    Jansen, P.L.3
  • 29
    • 0034013014 scopus 로고    scopus 로고
    • Nitric oxide: An inhibitor of NF-κB/Rel system in glial cells
    • Colasanti M, Persichini T: Nitric oxide: an inhibitor of NF-κB/Rel system in glial cells. Brain Res Bull 52:155-161, 2000
    • (2000) Brain Res Bull , vol.52 , pp. 155-161
    • Colasanti, M.1    Persichini, T.2
  • 31
    • 0032179725 scopus 로고    scopus 로고
    • Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis
    • Hegardt FG: Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. Biochimie 80:803-806, 1998
    • (1998) Biochimie , vol.80 , pp. 803-806
    • Hegardt, F.G.1
  • 33
    • 0034846210 scopus 로고    scopus 로고
    • Factors controlling pancreatic cell differentiation and function
    • Edlund H: Factors controlling pancreatic cell differentiation and function. Diabetologia 44:1071-1079, 2001
    • (2001) Diabetologia , vol.44 , pp. 1071-1079
    • Edlund, H.1
  • 35
    • 0035213530 scopus 로고    scopus 로고
    • Bax and other pro-apoptotic Bcl-2 family "killer-proteins and their victim the mitochondrion
    • Antonsson B: Bax and other pro-apoptotic Bcl-2 family "killer-proteins and their victim the mitochondrion. Cell Tissue Res 306:347-361, 2001
    • (2001) Cell Tissue Res , vol.306 , pp. 347-361
    • Antonsson, B.1
  • 36
    • 0037213368 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
    • Borner C: The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 39:615-647, 2003
    • (2003) Mol Immunol , vol.39 , pp. 615-647
    • Borner, C.1
  • 37
    • 0037219109 scopus 로고    scopus 로고
    • Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells
    • Azevedo-Martins AK, Lortz S, Lenzen S, Curi R, Eizirik DL, Tiedge M: Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-κB activation in insulin-producing cells. Diabetes 52:93-101, 2003
    • (2003) Diabetes , vol.52 , pp. 93-101
    • Azevedo-Martins, A.K.1    Lortz, S.2    Lenzen, S.3    Curi, R.4    Eizirik, D.L.5    Tiedge, M.6
  • 38
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin AS Jr: The NF-κB and IκB proteins: new discoveries and insights. Ann Rev Immunol 14:649-683, 1996
    • (1996) Ann Rev Immunol , vol.14 , pp. 649-683
    • Baldwin A.S., Jr.1
  • 39
    • 0035013235 scopus 로고    scopus 로고
    • Double-stranded ribonucleic acid (RNA) induces β-cell Fas messenger RNA expression and increases cytokine-induced β-cell apoptosis
    • Liu D, Darville M, Eizirik DL: Double-stranded ribonucleic acid (RNA) induces β-cell Fas messenger RNA expression and increases cytokine-induced β-cell apoptosis. Endocrinology 142:2593-2599, 2001
    • (2001) Endocrinology , vol.142 , pp. 2593-2599
    • Liu, D.1    Darville, M.2    Eizirik, D.L.3
  • 40
    • 0029086027 scopus 로고
    • Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: Induction of argininosuccinate synthetase by cytokines
    • Flodstrom M, Niemann A, Bedoya FJ, Morris SM Jr, Eizirik DL: Expression of the citrulline-nitric oxide cycle in rodent and human pancreatic β-cells: induction of argininosuccinate synthetase by cytokines. Endocrinology 136:3200-3206, 1995
    • (1995) Endocrinology , vol.136 , pp. 3200-3206
    • Flodstrom, M.1    Niemann, A.2    Bedoya, F.J.3    Morris S.M., Jr.4    Eizirik, D.L.5
  • 41
    • 0033144011 scopus 로고    scopus 로고
    • Interleukin 1β increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic β cells
    • Flodstrom M, Chen MC, Smismans A, Schuit F, Pipeleers DG, Eizirik DL: Interleukin 1β increases arginine accumulation and activates the citrulline-NO cycle in rat pancreatic β cells. Cytokine 11:400-407, 1999
    • (1999) Cytokine , vol.11 , pp. 400-407
    • Flodstrom, M.1    Chen, M.C.2    Smismans, A.3    Schuit, F.4    Pipeleers, D.G.5    Eizirik, D.L.6
  • 42
    • 0036020219 scopus 로고    scopus 로고
    • Interleukin-1β-induced nitric oxide production and inhibition of insulin secretion in rat islets of Langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin
    • Stickings P, Cunningham JM: Interleukin-1β-induced nitric oxide production and inhibition of insulin secretion in rat islets of Langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin. Cytokine 18:81-85, 2002
    • (2002) Cytokine , vol.18 , pp. 81-85
    • Stickings, P.1    Cunningham, J.M.2
  • 43
    • 0034176921 scopus 로고    scopus 로고
    • Tetrahydrobiopterin biosynthesis, regeneration and functions: Part 1
    • Thony B, Auerbach G, Blau N: Tetrahydrobiopterin biosynthesis, regeneration and functions: part 1 (Review). Biochem J 347:1-16, 2000
    • (2000) Biochem J , vol.347 , pp. 1-16
    • Thony, B.1    Auerbach, G.2    Blau, N.3
  • 45
    • 12444328826 scopus 로고    scopus 로고
    • Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-α transgenic mice
    • Hukkanen M, Platts LA, Haralambous S, Ainola M, Konttinen YT, Kollias G, Polak JM: Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-α transgenic mice. J Rheumatol 30:652-659, 2003
    • (2003) J Rheumatol , vol.30 , pp. 652-659
    • Hukkanen, M.1    Platts, L.A.2    Haralambous, S.3    Ainola, M.4    Konttinen, Y.T.5    Kollias, G.6    Polak, J.M.7
  • 46
    • 0036899286 scopus 로고    scopus 로고
    • From patterns to pathways: Gene expression data analysis comes of age
    • Slonim DK: From patterns to pathways: gene expression data analysis comes of age. Nat Genet 32 (Suppl.):502-508, 2002
    • (2002) Nat Genet , vol.32 , Issue.SUPPL. , pp. 502-508
    • Slonim, D.K.1
  • 47
    • 0036962610 scopus 로고    scopus 로고
    • Historical background and anticipated developments
    • Jordan B: Historical background and anticipated developments. Ann NY Acad Sci 975:24-32, 2002
    • (2002) Ann NY Acad Sci , vol.975 , pp. 24-32
    • Jordan, B.1
  • 48
    • 0026633029 scopus 로고
    • Interleukin-1β increases the activity of superoxide dismutase in rat pancreatic islets
    • Borg LA, Cagliero E, Sandler S, Welsh N, Eizirik DL: Interleukin-1β increases the activity of superoxide dismutase in rat pancreatic islets. Endocrinology 130:2851-2857, 1992
    • (1992) Endocrinology , vol.130 , pp. 2851-2857
    • Borg, L.A.1    Cagliero, E.2    Sandler, S.3    Welsh, N.4    Eizirik, D.L.5
  • 49
    • 0033622323 scopus 로고    scopus 로고
    • Interleukin-1β induces ornithine decarboxylase activity in insulin-producing cells
    • Smismans A, Eizirik DL, Pipeleers DG: Interleukin-1β induces ornithine decarboxylase activity in insulin-producing cells. Cytokine 12:49-54, 2000
    • (2000) Cytokine , vol.12 , pp. 49-54
    • Smismans, A.1    Eizirik, D.L.2    Pipeleers, D.G.3
  • 50
    • 0033625664 scopus 로고    scopus 로고
    • Interleukin-1β-induced alteration in a β-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis
    • Ling Z, Van de Casteele M, Eizirik DL, Pipeleers DG: Interleukin-1β -induced alteration in a β-cell phenotype can reduce cellular sensitivity to conditions that cause necrosis but not to cytokine-induced apoptosis. Diabetes 49:340-345, 2000
    • (2000) Diabetes , vol.49 , pp. 340-345
    • Ling, Z.1    Van de Casteele, M.2    Eizirik, D.L.3    Pipeleers, D.G.4
  • 52
    • 0035079807 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 β-exposed human and rat islet cells
    • Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL: Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 β-exposed human and rat islet cells. Diabetologia 44:325-332, 2001
    • (2001) Diabetologia , vol.44 , pp. 325-332
    • Chen, M.C.1    Proost, P.2    Gysemans, C.3    Mathieu, C.4    Eizirik, D.L.5
  • 53
    • 0032745109 scopus 로고    scopus 로고
    • A20 inhibits cytokine-induced apoptosis and nuclear factor κB-dependent gene activation in islets
    • Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C: A20 inhibits cytokine-induced apoptosis and nuclear factor κB-dependent gene activation in islets. J Exp Med 190:1135-1146, 1999
    • (1999) J Exp Med , vol.190 , pp. 1135-1146
    • Grey, S.T.1    Arvelo, M.B.2    Hasenkamp, W.3    Bach, F.H.4    Ferran, C.5
  • 54
    • 0033976650 scopus 로고    scopus 로고
    • Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells
    • Sayo Y, Hosokawa H, Imachi H, Murao K, Sato M, Wong NC, Ishida T, Takahara J: Transforming growth factor β induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells. Eur J Biochem 267:971-978, 2000
    • (2000) Eur J Biochem , vol.267 , pp. 971-978
    • Sayo, Y.1    Hosokawa, H.2    Imachi, H.3    Murao, K.4    Sato, M.5    Wong, N.C.6    Ishida, T.7    Takahara, J.8
  • 55
    • 0030757299 scopus 로고    scopus 로고
    • Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism
    • Ma Z, Landt M, Bohrer A, Ramanadham S, Kipnis DM, Turk J: Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism. J Biol Chem 272:17827-17835, 1997
    • (1997) J Biol Chem , vol.272 , pp. 17827-17835
    • Ma, Z.1    Landt, M.2    Bohrer, A.3    Ramanadham, S.4    Kipnis, D.M.5    Turk, J.6
  • 56
    • 0025995444 scopus 로고
    • Interleukin-1β induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis
    • Eizirik DL: Interleukin-1β induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis. Autoimmunity 10:107-113, 1991
    • (1991) Autoimmunity , vol.10 , pp. 107-113
    • Eizirik, D.L.1
  • 59
    • 0035863135 scopus 로고    scopus 로고
    • Intercellular signals regulating pancreas development and function
    • Kim SK, Hebrok M: Intercellular signals regulating pancreas development and function. Genes Dev 15:111-127, 2001
    • (2001) Genes Dev , vol.15 , pp. 111-127
    • Kim, S.K.1    Hebrok, M.2
  • 60
    • 0037315195 scopus 로고    scopus 로고
    • BETA2 activates transcription from the upstream glucokinase gene promoter in islet β-cells and gut endocrine cells
    • Moates JM, Nanda S, Cissell MA, Tsai MJ, Stein R: BETA2 activates transcription from the upstream glucokinase gene promoter in islet β-cells and gut endocrine cells. Diabetes 52:403-408, 2003
    • (2003) Diabetes , vol.52 , pp. 403-408
    • Moates, J.M.1    Nanda, S.2    Cissell, M.A.3    Tsai, M.J.4    Stein, R.5
  • 61
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • Naya FJ, Stellrecht CM, Tsai MJ: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019, 1995
    • (1995) Genes Dev , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 62
    • 0032521448 scopus 로고    scopus 로고
    • The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells
    • Mutoh H, Naya FJ, Tsai MJ, Leiter AB: The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev 12:820-830, 1998
    • (1998) Genes Dev , vol.12 , pp. 820-830
    • Mutoh, H.1    Naya, F.J.2    Tsai, M.J.3    Leiter, A.B.4
  • 63
    • 0032493623 scopus 로고    scopus 로고
    • Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2
    • Dumonteil E, Laser B, Constant I, Philippe J: Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J Biol Chem 273:19945-19954, 1998
    • (1998) J Biol Chem , vol.273 , pp. 19945-19954
    • Dumonteil, E.1    Laser, B.2    Constant, I.3    Philippe, J.4
  • 64
    • 0030611347 scopus 로고    scopus 로고
    • Islet regeneration in IFNγ transgenic mice
    • Jones EM, Sarvetnick N: Islet regeneration in IFNγ transgenic mice. Horm Metab Res 29:308-310, 1997
    • (1997) Horm Metab Res , vol.29 , pp. 308-310
    • Jones, E.M.1    Sarvetnick, N.2
  • 66
    • 0037459081 scopus 로고    scopus 로고
    • Mitochondria: Releasing power for life and unleashing the machineries of death
    • Newmeyer DD, Ferguson-Miller S: Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112:481-490, 2003
    • (2003) Cell , vol.112 , pp. 481-490
    • Newmeyer, D.D.1    Ferguson-Miller, S.2
  • 67
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • Friedlander RM: Apoptosis and caspases in neurodegenerative diseases. N Engl J Med 348:1365-1375, 2003
    • (2003) N Engl J Med , vol.348 , pp. 1365-1375
    • Friedlander, R.M.1
  • 68
  • 70
    • 85047685938 scopus 로고    scopus 로고
    • NF-κB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells
    • Darville MI, Ho YS, Eizirik DL: NF-κB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells. Endocrinology 141:153-162, 2000
    • (2000) Endocrinology , vol.141 , pp. 153-162
    • Darville, M.I.1    Ho, Y.S.2    Eizirik, D.L.3
  • 71
    • 0034984262 scopus 로고    scopus 로고
    • Innate immunity and inflammation: A transcriptional paradigm
    • Hawiger J: Innate immunity and inflammation: a transcriptional paradigm. Immunol Res 23:99-109, 2001
    • (2001) Immunol Res , vol.23 , pp. 99-109
    • Hawiger, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.