Cell loss during pseudoislet formation hampers profound improvements in islet lentiviral transduction efficacy for transplantation purposes

Cell Transplantation

Volumn 16, Issue 5, 2007, Pages 527-537

  Callewaert, H ^a   Gysemans, C ^a   Cardozo, A K ^b   Elsner, M ^c   Tiedge, M ^c,d   Eizirik, D L ^b   Mathieu, Chantal ^a,e  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d UNIVERSITY OF ROSTOCK   (Germany)

^e LEGENDO   (Belgium)

Author keywords

Gene therapy; Islet transplantation; Lentiviral vector; Pancreatic cells; Pseudoislet aggregates; Type 1 diabetes

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; INSULIN; LENTIVIRUS VECTOR; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGGREGATION; CELL LOSS; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIABETES MELLITUS; GENE EXPRESSION; GENE FUNCTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTION; ANIMAL; CELL DEATH; CELL LINE; CELL SEPARATION; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; GENETIC TRANSDUCTION; GENETICS; LENTIVIRINAE; PANCREAS ISLET; RAT; SECRETION; TIME; WISTAR RAT;

ANIMALS; CELL AGGREGATION; CELL DEATH; CELL LINE; CELL SEPARATION; CELL SURVIVAL; CYTOKINES; FLOW CYTOMETRY; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LENTIVIRUS; MALE; MICE; RATS; RATS, WISTAR; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 34548427326     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000007783464948     Document Type: Article

References (36)

1. Barbu, A. R.; Akusjarvi, G.; Welsh, N. Adenoviral-induced islet cell cytotoxicity is not counteracted by Bcl-2 overexpression. Mol. Med. 8:733-741; 2002.
2. Castaing, M.; Guerci, A.; Mallet, J.; Czernichow, P.; Ravassard, P.; Scharfmann, R. Efficient restricted gene expression in beta cells by lentivirus-mediated gene transfer into pancreatic stem/progenitor cells. Diabetologia 48: 709-719; 2005.
3. Cnop, M.; Welsh, N.; Jonas, J. C.; Jorns, A.; Lenzen, S.; Eizirik, D. L. Mechanisms of pancreatic {beta}-cell death in type 1 and type 2 diabetes: Many differences, few similarities. Diabetes 54(Suppl. 2):S97-S107; 2005.
4. Eizirik, D. L.; Kutlu, B.; Rasschaert, J.; Darville, M.; Cardozo, A. K. Use of microarray analysis to unveil transcription factor and gene networks contributing to beta cell dysfunction and apoptosis. Ann. NY Acad. Sci. 1005: 55-74; 2003.
5. Eizirik, D. L.; Mandrup-Poulsen, T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133; 2001.
6. Fernandes, J. R.; Duvivier-Kali, V. F.; Keegan, M.; Hollister-Lock, J.; Omer, A.; Su, S.; Bonner-Weir, S.; Feng, S.; Lee, J. S.; Mulligan, R. C.; Weir, G. C. Transplantation of islets transduced with CTLA4-Ig and TGF-beta using adenovirus and lentivirus vectors. Transpl. Immunol. 13:191-200; 2004.
7. Gallichan, W. S.; Kafri, T.; Krahl, T.; Verma, I. M.; Sarvetnick, N. Lentivirus-mediated transduction of islet grafts with interleukin 4 results in sustained gene expression and protection from insulitis. Hum. Gene Ther. 9:2717-2726; 1998.
8. Giannoukakis, N.; Robbins, P. D. Gene and cell therapies for diabetes mellitus: Strategies and clinical potential. BioDrugs 16:149-173; 2002.
9. Giannoukakis, N.; Rudert, W. A.; Robbins, P. D.; Trucco, M. Targeting autoimmune diabetes with gene therapy. Diabetes 48:2107-2121; 1999.
10. Goins, W. F.; Krisky, D.; Marconi, P.; Oligino, T.; Ramakrishnan, R.; Poliani, P. L.; Fink, D. J.; Glorioso, J. C. Herpes simplex virus vectors for gene transfer to the nervous system. J. Neurovirol. 3(Suppl. 1):S80-S88; 1997.
11. Gysemans, C.; Waer, M.; Laureys, J.; Depovere, J.; Pipeleers, D.; Bouillon, R.; Mathieu, C. Islet xenograft destruction in the hu-PBL-severe combined immunodeficient (SCID) mouse necessitates anti-CD3 preactivation of human immune cells. Clin. Exp. Immunol. 121:557-565; 2000.
12. Gysemans, C. A.; Ladriere, L.; Callewaert, H.; Rasschaert, J.; Flamez, D.; Levy, D. E.; Matthys, P.; Eizirik, D. L.; Mathieu, C. Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes 54:2396-2403; 2005.
13. Gysemans, C. A.; Waer, M.; Valckx, D.; Laureys, J. M.; Mihkalsky, D.; Bouillon, R.; Mathieu, C. Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-beta mRNA in the grafts. Diabetes 49: 1992-1997; 2000.
14. Heimberg, H.; Heremans, Y.; Jobin, C.; Leemans, R.; Cardozo, A. K.; Darville, M.; Eizirik, D. L. Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes 50:2219-2224; 2001.
15. Hopcroft, D. W.; Mason, D. R.; Scott, R. S. Structure-function relationships in pancreatic islets: support for intraislet modulation of insulin secretion. Endocrinology 117:2073-2080; 1985.
16. Leibowitz, G.; Beattie, G. M.; Kafri, T.; Cirulli, V.; Lopez, A. D.; Hayek, A.; Levine, F. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes 48:745-753; 1999.
17. Lopez-Talavera, J. C.; Garcia-Ocana, A.; Sipula, I.; Takane, K. K.; Cozar-Castellano, I.; Stewart, A. F. Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation. Endocrinology 145:467-474; 2004.
18. Maes, E.; Pipeleers, D. Effects of glucose and 3′,5′-cyclic adenosine monophosphate upon reaggregation of single pancreatic B-cells. Endocrinology 114:2205-2209; 1984.
19. Mizuno, M.; Ryuke, Y.; Yoshida, J. Cationic liposomes conjugation to recombinant adenoviral vectors containing herpes simplex virus thymidine kinase gene followed by ganciclovir treatment reduces viral antigenicity and maintains antitumor activity in mouse experimental glioma models. Cancer Gene Ther. 9:825-829; 2002.
20. Nguyen, T. H.; Bellodi-Privato, M.; Aubert, D.; Pichard, V.; Myara, A.; Trono, D.; Ferry, N. Therapeutic lentivirus-mediated neonatal in vivo gene therapy in hyperbilirubinemic Gunn rats. Mol. Ther. 12:852-859; 2005.
21. Okitsu, T.; Kobayashi, N.; Totsugawa, T.; Maruyama, M.; Noguchi, H.; Watanabe, T.; Matsumura, T.; Fujiwara, T.; Tanaka, N. Lentiviral vector mediated gene delivery into non-dividing isolated islet cells. Transplant. Proc. 35:483; 2003.
22. Pavlovic, D.; Chen, M. C.; Gysemans, C. A.; Mathieu, C.; Eizirik, D. L. The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells. Eur. Cytokine Netw. 10:403-412; 1999.
23. Pear, W. S.; Nolan, G. P.; Scott, M. L.; Baltimore, D. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392-8396; 1993.
24. Pipeleers, D.; Keymeulen, B.; Chatenoud, L.; Hendrieckx, C.; Ling, Z.; Mathieu, C.; Roep, B.; Ysebaert, D. A view on beta cell transplantation in diabetes. Ann. NY Acad. Sci. 958:69-76; 2002.
25. Pipeleers, D. G.; Pipeleers-Marichal, M.; Vanbrabandt, B.; Duys, S. Transplantation of purified islet cells in diabetic rats. II. Immunogenicity of allografted islet beta-cells. Diabetes 40:920-930; 1991.
26. Rasschaert, J.; Ladriere, L.; Urbain, M.; Dogusan, Z.; Katabua, B.; Sato, S.; Akira, S.; Gysemans, C.; Mathieu, C.; Eizirik, D. L. Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells. J. Biol. Chem. 280:33984-33991; 2005.
27. Ricordi, C.; Inverardi, L.; Kenyon, N. S.; Goss, J.; Bertuzzi, F.; Alejandro, R. Requirements for success in clinical islet transplantation. Transplantation 79:1298-1300; 2005.
28. Robbins, P. D.; Ghivizzani, S. C. Viral vectors for gene therapy. Pharmacol. Ther. 80:35-47; 1998.
29. Ryan, E. A.; Lakey, J. R.; Paty, B. W.; Imes, S.; Korbutt, G. S.; Kneteman, N. M.; Bigam, D.; Rajotte, R. V.; Shapiro, A. M. Successful islet transplantation: Continued insulin reserve provides long-term glycemic control. Diabetes 51:2148-2157; 2002.
30. Ryan, E. A.; Paty, B. W.; Senior, P. A.; Bigam, D.; Alfadhli, E.; Kneteman, N. M.; Lakey, J. R.; Shapiro, A. M. Five-year follow-up after clinical islet transplantation. Diabetes 54:2060-2069; 2005.
31. Sastry, L.; Johnson, T.; Hobson, M. J.; Smucker, B.; Cornetta, K. Titering lentiviral vectors: comparison of DNA, RNA and marker expression methods. Gene Ther. 9:1155-1162; 2002.
32. Shai, E.; Palmon, A.; Panet, A.; Marmary, Y.; Sherman, Y.; Curran, M. A.; Galun, E.; Condiotti, R. Prolonged transgene expression in murine salivary glands following non-primate lentiviral vector transduction. Mol. Ther. 12: 137-143; 2005.
33. Shapiro, A. M.; Lakey, J. R.; Paty, B. W.; Senior, P. A.; Bigam, D. L.; Ryan, E. A. Strategic opportunities in clinical islet transplantation. Transplantation 79:1304-1307; 2005.
34. Sinn, P. L.; Sauter, S. L.; McCray, Jr., P. B. Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors - design, biosafety, and production. Gene Ther. 12:1089-1098; 2005.
35. Yang, Y.; Li, Q.; Ertl, H. C.; Wilson, J. M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69:2004-2015; 1995.
36. Zufferey, R.; Dull, T.; Mandel, R. J.; Bukovsky, A.; Quiroz, D.; Naldini, L.; Trono, D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J. Virol. 72:9873-9880; 1998.