Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-κB oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig

Journal of Immunology

Volumn 169, Issue 6, 2002, Pages 3382-3391

  Bonham, C Andrew ^a   Peng, Lansha ^a   Liang, Xiaoyan ^a   Chen, Zongyou ^a   Wang, Lianfu ^a   Ma, Linlin ^a   Hackstein, Holger ^a   Robbins, Paul D ^a   Thomson, Angus W ^a   Fung, John J ^a   Qian, Shiguang ^a   Lu, Lina ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GENETIC ENGINEERING; GRAFT REJECTION; GRAFT SURVIVAL; HEART PROTECTION; HEART TRANSPLANTATION; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0037105629     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.6.3382     Document Type: Article

References (50)

1. The dendritic cell system and its role in immunogenicity
2. Dendritic cells and the control of immunity
3. Immunobiology of dendritic cells
4. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo
5. Reciprocal control of T helper cell and dendritic cell differentiation
6. Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo
7. +) dendritic cells: Association with conversion from liver transplant tolerance to acute rejection
8. Differentiation of T regulatory cells by immature dendritic cells
9. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
10. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
11. -) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes
12. -) prolong cardiac allograft survival in nonimmunosuppressed recipients
13. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis
14. Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation
15. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-β, and CTLA41g)
16. Designer dendritic cells for tolerance induction: Guided not misguided missiles
17. Adenoviral delivery of CTLA4Ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients
18. Contrasting effects of myeloid dendritic cells transduced with an adenoviral vector encoding interleukin-10 on organ allograft and tumour rejection
19. Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-β
20. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival
21. A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival
22. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4
23. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis
24. Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness
25. Recombinant adenovirus induces maturation of dendritic cells via an NF-κB-dependent pathway
26. Prolongation of cardiac allograft survival using dendritic cells treated with NF-κB decoy oligodeoxyribonucleotides
27. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
28. Growth of donor-derived dendritic cells from the bone marrow of murine liver allograft recipients in response to granulocyte/macrophage colony-stimulating factor
29. Regulation of gene expression with double-stranded phosphorothioate oligonucleotides
30. Construction of adenovirus vectors through Cre-lox recombination
31. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells
32. In vitro propagation and homing of liver-derived dendritic cell progenitors to lymphoid tissues of allogeneic recipients: Implications for the establishment and maintenance of donor cell chimerism following liver transplantation
33. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
34. - dendritic cells regulate T cell responses
35. Blockade of the CD40-CD40 ligand pathway potentiates the capacity of donor-derived dendritic cell progenitors to induce long-term cardiac allograft survival
36. IL-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance
37. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2
38. Feasibility of CTLA4Ig gene delivery and expression in vivo using retrovitally transduced myeloid dendritic cells that induce alloantigen-specific T cell anergy in vitro
39. Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb
40. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo
41. Dendritic cell tolerogenicity and prospects for dendritic cell-based therapy of allograft rejection and autoimmune disease
42. Cloning and functional characterization of the 5′-regulatory region of the human CD86 gene
43. IL-3 induces B7.2 (CD86) expression and costimulatory activity in human eosinophils
44. Identification of a promoter element that regulates tissue-specific expression of the human CD80 (B7.1) gene
45. Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1
46. Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus
47. Peritransplant tolerance induction in macaques: Early events reflecting the unique synergy between immunotoxin and deoxyspergualin
48. Apoptosis within spontaneously accepted mouse liver allografts: Evidence for deletion of cytotoxic T cells and implications for tolerance induction
49. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
50. Costimulation blockade promotes the apoptotic death of graft-infiltrating T cells and prolongs survival of hepatic allografts from FLT3L-treated donors