Systemic siRNA delivery via hydrodynamic intravascular injection

Advanced Drug Delivery Reviews

Volumn 59, Issue 2-3, 2007, Pages 115-123

  Lewis, David L ^a   Wolff, Jon A ^b  

^a Mirus Bio Corporation   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Gene knockdown; Hydrodynamic injection; siRNA

Indexed keywords

GENE EXPRESSION; GENETIC ENGINEERING; MAMMALS; MOLECULAR BIOLOGY; RNA; TISSUE;

BIOLOGICAL EFFECTS; HYDRODYNAMIC INJECTION; INTRAVASCULAR INJECTION;

DRUG DELIVERY;

ALANINE AMINOTRANSFERASE; CASPASE 3; CASPASE 8; DEXTRAN; ENVELOPE PROTEIN; EXPORTIN 5; FAS ANTIBODY; FAS ANTIGEN; HEPATITIS B SURFACE ANTIGEN; IMMUNOGLOBULIN; INSULIN; PLASMID DNA; POLYLYSINE; POLYMER; POLYPEPTIDE; SMALL INTERFERING RNA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; CELLULAR DISTRIBUTION; CONVALESCENCE; DIABETES MELLITUS; DRUG DISTRIBUTION; DRUG TARGETING; EXPERIMENTAL MODEL; EXTRAVASATION; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; HEPATITIS; HEPATITIS B; HYDRODYNAMICS BASED TRANSFECTION; INFLUENZA; KNOCKOUT MOUSE; LIVER CELL; LIVER ISCHEMIA; LIVER NECROSIS; LIVER TOXICITY; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL; REPERFUSION INJURY; REPORTER GENE; REVIEW; RNA INTERFERENCE; TREATMENT OUTCOME; VIRUS PARTICLE; VIRUS REPLICATION;

ANIMALS; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; HUMANS; INJECTIONS, INTRAVENOUS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 34248637892     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2007.03.002     Document Type: Review

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