Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes

Pharmaceutical Research

Volumn 25, Issue 7, 2008, Pages 1654-1662

  De Wolf, Holger K ^a   Johansson, Nina ^a   Thong, Anh Thy ^a   Snel, Cor J ^a   Mastrobattista, Enrico ^a   Hennink, Wim E ^a   Storm, Gert ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

CpG dinucleotides; Gene delivery; Gene expression; Immune stimulation; Intravenous; Lipoplexes; Plasmid DNA; Polyplexes; Tumor

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CPG OLIGODEOXYNUCLEOTIDE; DIOLEOYLPHOSPHATIDYLETHANOLAMINE; INTERLEUKIN 12; LIPOPLEX; LIPOSOME; LUCIFERASE; PLASMID DNA; POLYETHYLENEIMINE; PROPYLENE GLYCOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CPG ISLAND; CYTOTOXICITY; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSFECTION; IMMUNOSTIMULATION; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMID; PRIORITY JOURNAL; PROTEIN MOTIF; TRANSGENE; TUMOR GENE;

ANIMALS; CELL LINE; CELL SURVIVAL; CPG ISLANDS; DNA; DRUG DELIVERY SYSTEMS; EXCIPIENTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TRANSFER TECHNIQUES; INFLAMMATION; INJECTIONS, INTRAVENOUS; LIPOSOMES; MALE; MICE; MICE, INBRED A; PLASMIDS; POLYMERS; TISSUE DISTRIBUTION; TRANSFECTION; TRANSGENES;

EID: 44749084853     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9558-7     Document Type: Article

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