-
1
-
-
0027218427
-
Insulin dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a Th2 and not a Th1 mediated event
-
ANDERSON, J.T., CORNELIUS, J.G., JARPE, A.J., WINTER, W.E., and PECK, A.B. (1993). Insulin dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a Th2 and not a Th1 mediated event. Autoimmunity 15, 113-122.
-
(1993)
Autoimmunity
, vol.15
, pp. 113-122
-
-
Anderson, J.T.1
Cornelius, J.G.2
Jarpe, A.J.3
Winter, W.E.4
Peck, A.B.5
-
2
-
-
0030588554
-
Decreased IL-4 production in new onset type 1 insulin-dependent diabetes mellitus
-
BERMAN, M.A., SANDBORG, C.I., WANG, Z., IMFELD, K.L., ZALDIVAR, F., JR., DADUFALZA, V., and BUCKINGHAM, B.A. (1996). Decreased IL-4 production in new onset type 1 insulin-dependent diabetes mellitus. J. Immunol. 157, 4690-4696.
-
(1996)
J. Immunol.
, vol.157
, pp. 4690-4696
-
-
Berman, M.A.1
Sandborg, C.I.2
Wang, Z.3
Imfeld, K.L.4
Zaldivar Jr., F.5
Dadufalza, V.6
Buckingham, B.A.7
-
3
-
-
0029810468
-
Applications of gene therapy to the CNS
-
BLOMER, U., NALDINI, L., VERMA, I.M., TRONO, D., and GAGE, F.H. (1996). Applications of gene therapy to the CNS. Hum. Mol. Genet. 5 (spec. issue), 1397-1404.
-
(1996)
Hum. Mol. Genet.
, vol.5
, Issue.SPEC. ISSUE
, pp. 1397-1404
-
-
Blomer, U.1
Naldini, L.2
Verma, I.M.3
Trono, D.4
Gage, F.H.5
-
4
-
-
1842411367
-
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector
-
BLOMER, U., NALDINI, L., KAFRI, T., TRONO, D., VERMA, I.M., and GAGE, F.H. (1997). Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J. Virol. 71, 6641-6649.
-
(1997)
J. Virol.
, vol.71
, pp. 6641-6649
-
-
Blomer, U.1
Naldini, L.2
Kafri, T.3
Trono, D.4
Verma, I.M.5
Gage, F.H.6
-
5
-
-
0028979063
-
The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro
-
BRADLEY, L.M., YOSHIMOTO, K., and SWAIN, S.L. (1995). The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro. J. Immunol. 155, 1713-1724.
-
(1995)
J. Immunol.
, vol.155
, pp. 1713-1724
-
-
Bradley, L.M.1
Yoshimoto, K.2
Swain, S.L.3
-
6
-
-
0031573072
-
IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
-
CAMERON, M.J., ARREAZA, G.A., ZUCKER, P., CHENSUE, S.W., STRIETER, R.M., CHAKRABARTI, S., and DELOVITCH, T.L. (1997). IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159, 4686-4692.
-
(1997)
J. Immunol.
, vol.159
, pp. 4686-4692
-
-
Cameron, M.J.1
Arreaza, G.A.2
Zucker, P.3
Chensue, S.W.4
Strieter, R.M.5
Chakrabarti, S.6
Delovitch, T.L.7
-
7
-
-
0025981388
-
Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
-
CAMPBELL, I.L., KAY, T.W., OXBROW, L., and HARRISON, L.C. (1991). Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J. Clin. Invest. 87, 739-742.
-
(1991)
J. Clin. Invest.
, vol.87
, pp. 739-742
-
-
Campbell, I.L.1
Kay, T.W.2
Oxbrow, L.3
Harrison, L.C.4
-
8
-
-
0028914351
-
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice
-
DANIEL, D., GILL, R.G., SCHLOOT, N., and WEGMANN, D. (1995). Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25, 1056-1062.
-
(1995)
Eur. J. Immunol.
, vol.25
, pp. 1056-1062
-
-
Daniel, D.1
Gill, R.G.2
Schloot, N.3
Wegmann, D.4
-
9
-
-
0027070567
-
A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: Co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes
-
DEAIZPURUA, H.J., HONEYMAN, M.C., and HARRISON, L.C. (1992). A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: Co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes. J. Autoimmun. 5, 759-770.
-
(1992)
J. Autoimmun.
, vol.5
, pp. 759-770
-
-
Deaizpurua, H.J.1
Honeyman, M.C.2
Harrison, L.C.3
-
10
-
-
0025905088
-
Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma
-
DEBRAY-SACHS, M., CARNAUD, C., BOITARD, C., COHEN, H., GRESSER, I., BEDOSSA, P., and BACH, J.F. (1991). Prevention of diabetes in NOD mice treated with antibody to murine IFN gamma. J. Autoimmun. 4, 237-248.
-
(1991)
J. Autoimmun.
, vol.4
, pp. 237-248
-
-
Debray-Sachs, M.1
Carnaud, C.2
Boitard, C.3
Cohen, H.4
Gresser, I.5
Bedossa, P.6
Bach, J.F.7
-
11
-
-
0030938188
-
Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival
-
DENG, S., KETCHUM, R.J., KUCHER, T., WEBER, M., SHAKED, A., NAJI, A., and BRAYMAN, K.L. (1997a). Adenoviral transfection of canine islet xenografts with immunosuppressive cytokine genes abrogates primary nonfunction and prolongs graft survival. Transplant Proc. 29, 770.
-
(1997)
Transplant Proc.
, vol.29
, pp. 770
-
-
Deng, S.1
Ketchum, R.J.2
Kucher, T.3
Weber, M.4
Shaked, A.5
Naji, A.6
Brayman, K.L.7
-
12
-
-
0030948708
-
IL-10 and TGF-beta gene transfer to rodent islets: Effect on xenogeneic islet graft survival in naive and B-cell-deficient mice
-
DENG, S., KETCHUM, R.J., YANG, Z.D., KUCHER, T., WEBER, M., SHAKED, A., NAJI, A., and BRAYMAN, K.L. (1997b). IL-10 and TGF-beta gene transfer to rodent islets: Effect on xenogeneic islet graft survival in naive and B-cell-deficient mice. Transplant. Proc. 29, 2207-2208.
-
(1997)
Transplant. Proc.
, vol.29
, pp. 2207-2208
-
-
Deng, S.1
Ketchum, R.J.2
Yang, Z.D.3
Kucher, T.4
Weber, M.5
Shaked, A.6
Naji, A.7
Brayman, K.L.8
-
13
-
-
0029125671
-
Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes
-
EFRAT, S., FEJER, G., BROWNLEE, M., and HORWITZ, M.S. (1995). Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes. Proc. Natl. Acad. Sci. U.S.A. 92, 6947-6951.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 6947-6951
-
-
Efrat, S.1
Fejer, G.2
Brownlee, M.3
Horwitz, M.S.4
-
14
-
-
0030960632
-
Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens
-
ELIAS, D., MEILIN, A., ABLAMUNITS, V., BIRK, O.S., CARMI, P., KONEN-WAISMAN, S., and COHEN, I.R. (1997). Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various β-cell antigens. Diabetes 46, 758-764.
-
(1997)
Diabetes
, vol.46
, pp. 758-764
-
-
Elias, D.1
Meilin, A.2
Ablamunits, V.3
Birk, O.S.4
Carmi, P.5
Konen-Waisman, S.6
Cohen, I.R.7
-
15
-
-
0031092631
-
IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice
-
FOX, C.J., and DANSKA, J.S. (1997). IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J. Immunol. 158, 2414-2424.
-
(1997)
J. Immunol.
, vol.158
, pp. 2414-2424
-
-
Fox, C.J.1
Danska, J.S.2
-
16
-
-
0030935124
-
Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival
-
GAINER, A.L., KORBUTT, G.S., RAJOTTE, R.V., WARNOCK, G.L., and ELLIOTT, J.F. (1997). Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet allograft survival. Transplantation 63, 1017-1021.
-
(1997)
Transplantation
, vol.63
, pp. 1017-1021
-
-
Gainer, A.L.1
Korbutt, G.S.2
Rajotte, R.V.3
Warnock, G.L.4
Elliott, J.F.5
-
17
-
-
0031969194
-
Prolongation of allograft survival of transfected islets expressing human CTLA4-Ig, human soluble Fas ligand or a combination of the two
-
GAINER, A.L., SUAREZ-PINZON, W.L., MIN, W.P., HANCOCK-FRIESEN, C., KORBUTT, G.S., RAJOTTE, R.V., RABINOVITCH, A., WARNOCK, G.L., and ELLIOTT, J.F. (1998). Prolongation of allograft survival of transfected islets expressing human CTLA4-Ig, human soluble Fas ligand or a combination of the two. Transplant. Proc. 30, 534.
-
(1998)
Transplant. Proc.
, vol.30
, pp. 534
-
-
Gainer, A.L.1
Suarez-Pinzon, W.L.2
Min, W.P.3
Hancock-Friesen, C.4
Korbutt, G.S.5
Rajotte, R.V.6
Rabinovitch, A.7
Warnock, G.L.8
Elliott, J.F.9
-
18
-
-
0029010646
-
In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice
-
HEALEY, D., OZEGBE, P., ARDEN, S., CHANDLER, P., HUTTON, J., and COOKE, A. (1995). In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J. Clin. Invest. 95, 2979-2985.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2979-2985
-
-
Healey, D.1
Ozegbe, P.2
Arden, S.3
Chandler, P.4
Hutton, J.5
Cooke, A.6
-
19
-
-
0027336689
-
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
-
HSIEH, C.S., MACATONIA, S.E., TRIPP, C.S., WOLF, S.F., O'GARRA, A., and MURPHY, K.M. (1993). Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260, 547-549.
-
(1993)
Science
, vol.260
, pp. 547-549
-
-
Hsieh, C.S.1
Macatonia, S.E.2
Tripp, C.S.3
Wolf, S.F.4
O'Garra, A.5
Murphy, K.M.6
-
20
-
-
0031033767
-
Prevention of autoimmune diabetes mellitus in NOD mice by transgenic expression of soluble tumor necrosis factor receptor p55
-
HUNGER, R.E., CARNAUD, C., GARCIA, I., VASSALLI, P., and MUELLER, C. (1997). Prevention of autoimmune diabetes mellitus in NOD mice by transgenic expression of soluble tumor necrosis factor receptor p55. Eur. J. Immunol. 27, 255-261.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 255-261
-
-
Hunger, R.E.1
Carnaud, C.2
Garcia, I.3
Vassalli, P.4
Mueller, C.5
-
21
-
-
0029959963
-
In vivo administration of IL-4 induces TGF-β-producing cells and protects animals from experimental autoimmune encephalomyelitis
-
INOBE, J.I., CHEN, Y., and WEINER, H.L. (1996). In vivo administration of IL-4 induces TGF-β-producing cells and protects animals from experimental autoimmune encephalomyelitis. Ann. N.Y. Acad. Sci. 778, 390-392.
-
(1996)
Ann. N.Y. Acad. Sci.
, vol.778
, pp. 390-392
-
-
Inobe, J.I.1
Chen, Y.2
Weiner, H.L.3
-
22
-
-
0030716959
-
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors
-
KAFRI, T., BLOMER, U., PETERSON, D.A., GAGE, F.H., and VERMA, I.M. (1997). Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nature Genet. 17, 314-317.
-
(1997)
Nature Genet.
, vol.17
, pp. 314-317
-
-
Kafri, T.1
Blomer, U.2
Peterson, D.A.3
Gage, F.H.4
Verma, I.M.5
-
23
-
-
0029030964
-
T helper cell subsets in insulin-dependent diabetes
-
KATZ, J.D., BENOIST, C., and MATHIS, D. (1995). T helper cell subsets in insulin-dependent diabetes. Science 268, 1185-1188.
-
(1995)
Science
, vol.268
, pp. 1185-1188
-
-
Katz, J.D.1
Benoist, C.2
Mathis, D.3
-
24
-
-
0027368141
-
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
-
KAUFMAN, D.L., CLARE-SALZLER, M., TIAN, J., FORSTHUBER, T., TING, G.S., ROBINSON, P., ATKINSON, M.A., SERCARZ, E.E., TOBIN, A.J., and LEHMANN, P.V. (1993). Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (London) 366, 69-72.
-
(1993)
Nature (London)
, vol.366
, pp. 69-72
-
-
Kaufman, D.L.1
Clare-Salzler, M.2
Tian, J.3
Forsthuber, T.4
Ting, G.S.5
Robinson, P.6
Atkinson, M.A.7
Sercarz, E.E.8
Tobin, A.J.9
Lehmann, P.V.10
-
25
-
-
0029609841
-
Expression of beta-galactosidase in mouse pancreatic islets by adenoviral-mediated gene transfer
-
KORBUTT, G.S., SMITH, D.K., RAJOTTE, R.V., and ELLIOTT, J.F. (1995). Expression of beta-galactosidase in mouse pancreatic islets by adenoviral-mediated gene transfer. Transplant. Proc. 27, 3414.
-
(1995)
Transplant. Proc.
, vol.27
, pp. 3414
-
-
Korbutt, G.S.1
Smith, D.K.2
Rajotte, R.V.3
Elliott, J.F.4
-
26
-
-
0030903088
-
Co-transplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression
-
KORBUTT, G.S., ELLIOTT, J.F., and RAJOTTE, R.V. (1997). Co-transplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression. Diabetes 46, 317-322.
-
(1997)
Diabetes
, vol.46
, pp. 317-322
-
-
Korbutt, G.S.1
Elliott, J.F.2
Rajotte, R.V.3
-
27
-
-
0030017476
-
Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice
-
LAU, H.T., YU, M., FONTANA, A., and STOECKERT, C.J., JR. (1996). Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science 273, 109-112.
-
(1996)
Science
, vol.273
, pp. 109-112
-
-
Lau, H.T.1
Yu, M.2
Fontana, A.3
Stoeckert Jr., C.J.4
-
28
-
-
0025082313
-
Generation of interleukin 4 producing cells in vivo and in vitro: IL-2 and IL-4 are required for generation of IL-4 producing cells
-
LE GROS, G., BEN SASSON, S.Z., SEDER, R., FINKELMAN, F.D., and PAUL, W.E. (1990). Generation of interleukin 4 producing cells in vivo and in vitro: IL-2 and IL-4 are required for generation of IL-4 producing cells. J. Exp. Med. 172, 921-929.
-
(1990)
J. Exp. Med.
, vol.172
, pp. 921-929
-
-
Le Gros, G.1
Ben Sasson, S.Z.2
Seder, R.3
Finkelman, F.D.4
Paul, W.E.5
-
29
-
-
0028890866
-
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
-
LIBLAU, R.S., SINGER, S.M., and McDEVITT, H.O. (1995). Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16, 34-38.
-
(1995)
Immunol. Today
, vol.16
, pp. 34-38
-
-
Liblau, R.S.1
Singer, S.M.2
Mcdevitt, H.O.3
-
30
-
-
0030931963
-
Stable and efficient gene transfer into the retina using an HFV-based lentiviral vector
-
MIYOCHI, H., TAKAHASHI, M., GAGE, F.H., and VERMA, I.M. (1997). Stable and efficient gene transfer into the retina using an HFV-based lentiviral vector. Proc. Natl. Acad. Sci. U.S.A. 94, 10319-10323.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 10319-10323
-
-
Miyochi, H.1
Takahashi, M.2
Gage, F.H.3
Verma, I.M.4
-
31
-
-
0024353079
-
Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
-
MOSMANN, T.R., and COFFMAN, R.L. (1989). Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7, 145-173.
-
(1989)
Annu. Rev. Immunol.
, vol.7
, pp. 145-173
-
-
Mosmann, T.R.1
Coffman, R.L.2
-
32
-
-
0029838995
-
Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
-
MUELLER, R., KRAHL, T., and SARVETNICK, N. (1996). Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184, 1093-1099.
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1093-1099
-
-
Mueller, R.1
Krahl, T.2
Sarvetnick, N.3
-
33
-
-
0030879734
-
Mechanism underlying counterregulation of autoimmune diabetes by IL-4
-
MUELLER, R., BRADLEY, L.M., KRAHL, T., and SARVETNICK, N. (1997a). Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity 7, 411-418.
-
(1997)
Immunity
, vol.7
, pp. 411-418
-
-
Mueller, R.1
Bradley, L.M.2
Krahl, T.3
Sarvetnick, N.4
-
34
-
-
0031571310
-
IL-4 expression by graphs from transgenic mice fails to prevent allograft rejection
-
MUELLER, R., DAVIES, J.D., KRAHL, T., and SARVETNICK, N. (1997b). IL-4 expression by graphs from transgenic mice fails to prevent allograft rejection. J. Immunol. 159, 1599-1603.
-
(1997)
J. Immunol.
, vol.159
, pp. 1599-1603
-
-
Mueller, R.1
Davies, J.D.2
Krahl, T.3
Sarvetnick, N.4
-
35
-
-
0029996147
-
In vivo delivery and stable transduction of nondividing cells by a lentiviral vector
-
NALDINI, L., BLOMER, U., FALLAY, P., ORY, D., MULIGAN, R., GAGE, F.H., VERMA, I.M., and TRONO, D. (1996a). In vivo delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272, 263-267.
-
(1996)
Science
, vol.272
, pp. 263-267
-
-
Naldini, L.1
Blomer, U.2
Fallay, P.3
Ory, D.4
Muligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
-
36
-
-
0029993858
-
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
-
NALDINI, L., BLOMER, U., GAGE, F.H., TRONO, D., and VERMA, I.M. (1996b). Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl Acad. Sci. U.S.A. 93, 11382-11388.
-
(1996)
Proc. Natl Acad. Sci. U.S.A.
, vol.93
, pp. 11382-11388
-
-
Naldini, L.1
Blomer, U.2
Gage, F.H.3
Trono, D.4
Verma, I.M.5
-
37
-
-
0029955714
-
The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses
-
NAVIAUX, R.K., COSTANZI, E., HAAS, M., and VERMA, I.M. (1996). The pCL vector system: Rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol. 70, 5701-5705.
-
(1996)
J. Virol.
, vol.70
, pp. 5701-5705
-
-
Naviaux, R.K.1
Costanzi, E.2
Haas, M.3
Verma, I.M.4
-
38
-
-
0030742237
-
T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
-
PAKALA, S.V., KURRER, M.O., and KATZ, J.D. (1997). T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med. 186, 299-306.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 299-306
-
-
Pakala, S.V.1
Kurrer, M.O.2
Katz, J.D.3
-
39
-
-
0028971717
-
Demonstration of a Th1 cytokine profile in the late phase of NOD insulitis
-
PILSTROM, B., BJORK, L., and BOHME, J. (1995). Demonstration of a Th1 cytokine profile in the late phase of NOD insulitis. Cytokine 7, 806-814.
-
(1995)
Cytokine
, vol.7
, pp. 806-814
-
-
Pilstrom, B.1
Bjork, L.2
Bohme, J.3
-
40
-
-
0031985550
-
Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes
-
PLOIX, C., BERGEROT, I., FABIEN, N., PERCHE, S., MOULIN, V., and THIVOLET, C. (1998). Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type 2 T-cells in the pancreas and pancreatic lymph nodes. Diabetes 47, 39-44.
-
(1998)
Diabetes
, vol.47
, pp. 39-44
-
-
Ploix, C.1
Bergerot, I.2
Fabien, N.3
Perche, S.4
Moulin, V.5
Thivolet, C.6
-
41
-
-
0029922661
-
Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats. Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM
-
RABINOVITCH, A., SUAREZ-PINZON, W., EL-SHEIKH, A., SORENSEN, O., and POWER, R.F. (1996). Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats. Expression of Th1 cytokines correlates with β-cell destructive insulitis and IDDM. Diabetes 45, 749-754.
-
(1996)
Diabetes
, vol.45
, pp. 749-754
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.2
El-Sheikh, A.3
Sorensen, O.4
Power, R.F.5
-
42
-
-
0027272228
-
Interleukin 4 reverses T cell proliferative responsiveness and prevents the onset of diabetes in non-obese diabetic mice
-
RAPOPORT, M.J., JARAMILLO, A., ZIPRIS, D., LAZARUS, A.H., SERREZE, D.V., LEITER, E.H., CYOPICK, P., DANSKA, J.S., and DELOVITCH, T.L. (1993). Interleukin 4 reverses T cell proliferative responsiveness and prevents the onset of diabetes in non-obese diabetic mice. J. Exp. Med. 178, 87-99.
-
(1993)
J. Exp. Med.
, vol.178
, pp. 87-99
-
-
Rapoport, M.J.1
Jaramillo, A.2
Zipris, D.3
Lazarus, A.H.4
Serreze, D.V.5
Leiter, E.H.6
Cyopick, P.7
Danska, J.S.8
Delovitch, T.L.9
-
43
-
-
0025753128
-
Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants
-
SCHARFMANN, R., AXELROD, J.H., and VERMA, I.M. (1991). Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proc. Natl. Acad. Sci. U.S.A. 88, 4626-4630.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 4626-4630
-
-
Scharfmann, R.1
Axelrod, J.H.2
Verma, I.M.3
-
44
-
-
0030918701
-
Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis
-
SHAW, M.K., LORENS, J.B., DHAWAN, A., DALCANTO, R., TSE, Y.H., TRAN, A.B., BONPANE, C., ESWARAN, S.L., BROCKE, S., SARVETNICK, N., STEINMAN, L., NOLAN, G.P., and FATHMAN, C.G. (1997). Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J. Exp. Med. 185, 1711-1714.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 1711-1714
-
-
Shaw, M.K.1
Lorens, J.B.2
Dhawan, A.3
Dalcanto, R.4
Tse, Y.H.5
Tran, A.B.6
Bonpane, C.7
Eswaran, S.L.8
Brocke, S.9
Sarvetnick, N.10
Steinman, L.11
Nolan, G.P.12
Fathman, C.G.13
-
45
-
-
0027291701
-
Altered cytokine activity in adjuvant inhibition of autoimmune diabetes
-
SHEHADEH, N.G., LAROSA, F., and LAFFERTY, K.J. (1993). Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6, 291-300.
-
(1993)
J. Autoimmun.
, vol.6
, pp. 291-300
-
-
Shehadeh, N.G.1
Larosa, F.2
Lafferty, K.J.3
-
46
-
-
0030068383
-
Pathogenic and protective roles of CD45Blow CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse
-
SHIMADA, A., ROHANE, P., FATHMAN, C.G., and CHARLTON, B. (1996). Pathogenic and protective roles of CD45Blow CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes 45, 71-78.
-
(1996)
Diabetes
, vol.45
, pp. 71-78
-
-
Shimada, A.1
Rohane, P.2
Fathman, C.G.3
Charlton, B.4
-
47
-
-
0030773969
-
Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice
-
SMITH, D.K., KORBUTT, G.S., SUAREZ-PINZON, W.L., KAO, D., RAJOTTE, R.V., and ELLIOTT, J.F. (1997). Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice. Transplantation 64, 1040-1049.
-
(1997)
Transplantation
, vol.64
, pp. 1040-1049
-
-
Smith, D.K.1
Korbutt, G.S.2
Suarez-Pinzon, W.L.3
Kao, D.4
Rajotte, R.V.5
Elliott, J.F.6
-
48
-
-
0025222698
-
EL-4 directs the development of different subsets of helper T cells
-
SWAIN, S.L., WEINBERG, A.D., ENGLISH, M., and HUSTON, G. (1990). EL-4 directs the development of different subsets of helper T cells. J. Immunol. 145, 3796.
-
(1990)
J. Immunol.
, vol.145
, pp. 3796
-
-
Swain, S.L.1
Weinberg, A.D.2
English, M.3
Huston, G.4
-
49
-
-
16144361909
-
Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
-
TIAN, J., CLARE-SALZLER, M., HERSCHENFELD, A., MIDDLETON, B., NEWMAN, D., MUELLER, R., ARITA, S., EVANS, C., ATKINSON, M.A., MULLEN, Y., SARVETNICK, N., TOBIN, A.J., LEHMANN, P.V., and KAUFMAN, D.L. (1996). Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nature Med. 2, 1348-1353.
-
(1996)
Nature Med.
, vol.2
, pp. 1348-1353
-
-
Tian, J.1
Clare-Salzler, M.2
Herschenfeld, A.3
Middleton, B.4
Newman, D.5
Mueller, R.6
Arita, S.7
Evans, C.8
Atkinson, M.A.9
Mullen, Y.10
Sarvetnick, N.11
Tobin, A.J.12
Lehmann, P.V.13
Kaufman, D.L.14
-
50
-
-
0031452948
-
Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
-
TIAN, J., LEHMANN, P.V., and KAUFMAN, D.L. (1997). Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J. Exp. Med. 186, 2039-2043.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 2039-2043
-
-
Tian, J.1
Lehmann, P.V.2
Kaufman, D.L.3
-
51
-
-
0031888650
-
Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice
-
TIAN, J., CHAU, C., and KAUFMAN, D.L. (1998). Insulin selectively primes Th2 responses and induces regulatory tolerance to insulin in pre-diabetic mice. Diabetologia 41, 237-240.
-
(1998)
Diabetologia
, vol.41
, pp. 237-240
-
-
Tian, J.1
Chau, C.2
Kaufman, D.L.3
-
52
-
-
0027908753
-
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
-
TISCH, R., YANG, X.D., SINGER, S.M., LIBLAU, R.S., FUGGER, L., and McDEVITT, H.O. (1993). Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature (London) 366, 72-75.
-
(1993)
Nature (London)
, vol.366
, pp. 72-75
-
-
Tisch, R.1
Yang, X.D.2
Singer, S.M.3
Liblau, R.S.4
Fugger, L.5
Mcdevitt, H.O.6
-
53
-
-
0032005416
-
Administration of EL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice
-
TOMINAGA, Y., NAGATA, M., YASUDA, H., OKAMOTO, N., ARISAWA, K., MORIYAMA, H., MIKI, M., YOKONO, K., and KASUGA, M. (1998). Administration of EL-4 prevents autoimmune diabetes but enhances pancreatic insulitis in NOD mice. Clin. Immunol. Immunopathol. 86, 209-218.
-
(1998)
Clin. Immunol. Immunopathol.
, vol.86
, pp. 209-218
-
-
Tominaga, Y.1
Nagata, M.2
Yasuda, H.3
Okamoto, N.4
Arisawa, K.5
Moriyama, H.6
Miki, M.7
Yokono, K.8
Kasuga, M.9
-
54
-
-
0030928619
-
Gene therapy - Promises, problems and prospects
-
VERMA, I.M., and SOMIA, N. (1997). Gene therapy - promises, problems and prospects. Nature (London) 389, 239-242.
-
(1997)
Nature (London)
, vol.389
, pp. 239-242
-
-
Verma, I.M.1
Somia, N.2
-
55
-
-
0031051747
-
Interferon-γ is essential for destruction of β-cells and development of insulin-dependent diabetes mellitus
-
VON HERRATH, M.G., and OLDSTONE, B.A. (1997a). Interferon-γ is essential for destruction of β-cells and development of insulin-dependent diabetes mellitus. J. Exp. Med. 185, 531-539.
-
(1997)
J. Exp. Med.
, vol.185
, pp. 531-539
-
-
Von Herrath, M.G.1
Oldstone, B.A.2
-
56
-
-
0030955355
-
Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes
-
VON HERRATH, M.G., EFRAT, S., OLDSTONE, M.B., and HORWITZ, M.S. (1997b). Expression of adenoviral E3 transgenes in beta cells prevents autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 94, 9808-9813.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 9808-9813
-
-
Von Herrath, M.G.1
Efrat, S.2
Oldstone, M.B.3
Horwitz, M.S.4
-
57
-
-
0031456802
-
Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes
-
WANG, B., ANDRE, I., GONZALEZ, A., KATZ, J.D., AGUET, M., BENOIST, C., and MATHIS, D. (1997). Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 94, 13844-13849.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 13844-13849
-
-
Wang, B.1
Andre, I.2
Gonzalez, A.3
Katz, J.D.4
Aguet, M.5
Benoist, C.6
Mathis, D.7
-
58
-
-
0030741524
-
Scientific and political implediments to successful islet transplantation
-
WEIR, G.C., and BONNER-WEIR, S. (1997). Scientific and political implediments to successful islet transplantation. Diabetes 46, 1247-1256.
-
(1997)
Diabetes
, vol.46
, pp. 1247-1256
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
59
-
-
0028942665
-
Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines. (HIT-T15 and NIT-1 ) confers resistance against interleukin-1-induced nitric oxide production
-
WELSH, N., BENDTZEN, K., and WELSH, M. (1995). Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines. (HIT-T15 and NIT-1 ) confers resistance against interleukin-1-induced nitric oxide production. J. Clin. Invest. 95, 1717-1722.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1717-1722
-
-
Welsh, N.1
Bendtzen, K.2
Welsh, M.3
-
60
-
-
0022492875
-
Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice
-
WICKER, L.S., MILLER, B.J., and MULLEN, Y. (1986). Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes 35, 855-860.
-
(1986)
Diabetes
, vol.35
, pp. 855-860
-
-
Wicker, L.S.1
Miller, B.J.2
Mullen, Y.3
-
61
-
-
0032495536
-
Extreme Th1 bias of invariant Va24JaQ T cells in type 1 diabetes
-
WILSON, S.B., KENT, S.C., PATTON, K.T., ORBAN, T., JACKSON, R.A., EXLEY, M., PORCELLI, S., SCHATZ, D.A., ATKINSON, M.A., BALK, S.P., STROMINGER, J.L., and HAFLER, D.A. (1998). Extreme Th1 bias of invariant Va24JaQ T cells in type 1 diabetes. Nature (London) 391, 177-181.
-
(1998)
Nature (London)
, vol.391
, pp. 177-181
-
-
Wilson, S.B.1
Kent, S.C.2
Patton, K.T.3
Orban, T.4
Jackson, R.A.5
Exley, M.6
Porcelli, S.7
Schatz, D.A.8
Atkinson, M.A.9
Balk, S.P.10
Strominger, J.L.11
Hafler, D.A.12
-
62
-
-
0031968921
-
Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells
-
YOON, J.W., JUN, H.S., and SANTAMARIA, P. (1998). Cellular and molecular mechanisms for the initiation and progression of beta cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 27, 109-122.
-
(1998)
Autoimmunity
, vol.27
, pp. 109-122
-
-
Yoon, J.W.1
Jun, H.S.2
Santamaria, P.3
-
63
-
-
0029919962
-
Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rBL-4 in vivo
-
YOSHIMOTO, K., SWAIN, S.L., and BRADLEY, L.M. (1996). Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rBL-4 in vivo. J. Immunol. 156, 3267-3274.
-
(1996)
J. Immunol.
, vol.156
, pp. 3267-3274
-
-
Yoshimoto, K.1
Swain, S.L.2
Bradley, L.M.3
-
64
-
-
0031985093
-
GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice
-
ZEKZER, D., WONG, F.S., AYALON, O., MILLET, I., ALTIERI, M., SHINTANI, S., SOLIMENA, M., and SHERWIN, R.S. (1998). GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice. J. Clin. Invest. 101, 67-73.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 67-73
-
-
Zekzer, D.1
Wong, F.S.2
Ayalon, O.3
Millet, I.4
Altieri, M.5
Shintani, S.6
Solimena, M.7
Sherwin, R.S.8
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