Induction of RNA interference in dendritic cells

Immunologic Research

Volumn 30, Issue 2, 2004, Pages 215-230

  Li, Mu ^a,b   Qian, Hua ^a,b   Ichim, Thomas E ^a,b   Ge, Wei Wen ^d   Popov, Igor A ^a,b   Rycerz, Katarzyna ^a   Neu, John ^c   White, David ^a,b,c,d   Zhong, Robert ^a,b,c,d   Min, Wei Ping ^a,b,c,d  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Cytokines; Dendritic cells; Gene silencing; Gene therapy; RNA interference; SiRNA

Indexed keywords

GAMMA INTERFERON; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; SMALL INTERFERING RNA;

DENDRITIC CELL; ENDOCYTOSIS; GENE SILENCING; GENE THERAPY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA CLEAVAGE; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

ANIMALS; DENDRITIC CELLS; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY, ADOPTIVE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 7044286236     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:30:2:215     Document Type: Review

References (87)

1. Steinman RM, Adams JC, Cohn ZA: Identification of a novel cell type in peripheral lymphoid organs of mice. IV. Identification and distribution in mouse spleen. J Exp Med 1975;141:804-820.
2. Steinman RM, Gutchinov B, Witmer MD, et al.: Nussenzweig MC. Dendritic cells are the principal stimulators of the primary mixed leukocyte reaction in mice. J Exp Med 1983;157:613-627.
3. Platsoucas CD, Fincke JE, Pappas J, et al.: Immune responses to human tumors: development of tumor vaccines. Anticancer Res 2003;23:1969-1996.
4. MacLennan I, Vinuesa C: Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 2002;17:235-238.
5. Mailliard RB, Son YI, Redlinger R, et al.: Dendritic cells mediate NK cell help for Th1 and CTL responses: two-signal requirement for the induction of NK cell helper function. J Immunol 2003;171:2366-2373.
6. Moretta A: Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol 2002;2:957-964.
7. Nishimura T, Kitamura H, Iwakabe K, et al.: The interface between innate and acquired immunity: glycolipid antigen presentation by CDld-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes. Int Immunol 2000;12:987-994.
8. Chun T, Page MJ, Gapin L, et al.: CDld-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med 2003;197:907-918.
9. Kufer P, Zettl F, Borschert K, et al.: Minimal costimulatory requirements for T cell priming and TH1 differentiation: activation of naive human T lymphocytes by tumor cells armed with bifunctional antibody constructs. Cancer Immun 2001;1:10.
10. Morel Y, Truneh A, Sweet RW, et al.: The TNF super-family members LIGHT and CD 154 (CD40 ligand) costimulate induction of dendritic cell maturation and elicit specific CTL activity. J Immunol 2001;167:2479-2486.
11. Taams L, Vukmanovic-Stejic M, Salmon M, et al.: Immune regulation by CD4+CD25+ regulatory T cells: implications for transplantation tolerance. Transpl Immunol 2003;11:277-285.
12. Ichim TE, Zhong R, Min WP: Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells. Transpl Immunol 2003;11:295-306.
13. Steinman RM, Hawiger D, Nussenzweig MC: Tolerogenic dendritic cells. Annu Rev Immunol 2003;21:685-711.
14. Morelli AE, Thomson AW: Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 2003;196:125-146.
15. Sato K, Yamashita N, Baba M, et al.: Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 2003;18:367-379.
16. Min WP, Zhou D, Ichim TE, et al.: Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol 2003;170:1304-1312.
17. Levings MK, Bacchetta R, Schulz U, Roncarolo MG: The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Int Arch Allergy Immunol 2002;129:263-276.
18. Lutz MB, Suri RM, Niimi M, et al.: Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol 2000;30:1813-1822.
19. Bonham CA, Peng L, Liang X, et al.: Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol 2002;169:3382-3391.
20. Min WP, Zhou D, Ichim TE, et al.: Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 2003;75:1160-1165.
21. Yang J, Bernier SM, Ichim TE, et al.: LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol 2003;74:438-447.
22. Takayama T, Kaneko K, Morelli AE, et al.: Retroviral delivery of transforming growth factor-beta1 to myeloid dendritic cells: inhibition of T-cell priming ability and influence on allograft survival. Transplantation 2002;74:112-119.
23. Min WP, Gorczynski R, Huang XY, et al.: Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol 2000;164:161-167.
24. Yoshimura S, Bondeson J, Foxwell BM, et al.: Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int Immunol 2001;13:675-683.
25. Liang X, Lu L, Chen Z, et al.: Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival. Transplantation 2003;76:721-729.
26. Knosalla C, Gollackner B, Cooper DK: Anti-CD154 monoclonal antibody and thromboembolism revisted. Transplantation 2002;74:416-417.
27. Jorgensen RA, Cluster PD, English J, et al.: Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences. Plant Mol Biol 1996;31:957-973.
28. Fire A, Xu S, Montgomery MK, et al.: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-811.
29. Proud CG: PKR: a new name and new roles. Trends Biochem Sci 1995;20:241-246.
30. Elbashir SM, Harborth J, Lendeckel W, et al.: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-498.
31. Adah SA, Bayly SF, Cramer H, et al.: Chemistry and biochemistry of 2′,5′-oligoadenylate-based antisense strategy. Curr Med Chem 2001;8:1189-1212.
32. Williams BR: Signal integration via PKR. Sci STKE 2001;2001:RE2.
33. Saunders LR, Barber GN: The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J 2003;17:961-983.
34. Timmons L: The long and short of siRNAs. Mol Cell 2002;10:435-437.
35. Bertrand J, Pottier M, Vekris A, et al.: Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo. Biochem Biophys Res Commun 2002;296:1000.
36. Celotto AM, Graveley BR: Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing. RNA 2002;8:718-724.
37. Grishok A, Tabara H, Mello CC: Genetic requirements for inheritance of RNAi in C. elegans. Science 2000;287:2494-2497.
38. Brummelkamp TR, Bernards R, Agami R: A system for stable expression of short interfering RNAs in mammalian cells. Science 2002;296:550-553.
39. Paul CP, Good PD, Winer I, et al.: Effective expression of small interfering RNA in human cells. Nat Biotechnol 2002;20:505-508.
40. Devroe E, Silver PA: Retrovirus-delivered siRNA. BMC Biotechnol 2002;2:15.
41. Yang D, Buchholz F, Huang Z, et al.: Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells. Proc Natl Acad Sci USA 2002;99:9942-9947.
42. Harborth J, Elbashir SM, Vandenburgh K, et al.: Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. Antisense Nucleic Acid Drug Dev 2003;13:83-105.
43. Amarasinghe AK, Calin-Jageman I, Harmouch A, et al.: Escherichia coli ribonuclease III: affinity purification of hexahistidine-tagged enzyme and assays for substrate binding and cleavage. Methods Enzymol 2001;342:143-158.
44. Kawasaki H, Suyama E, Iyo M, et al.: siRNAs generated by recombinant human Dicer induce specific and significant but target site-independent gene silencing in human cells. Nucleic Acids Res 2003;31:981-987.
45. Tuschl T: Expanding small RNA interference. Nat Biotechnol 2002;20:446-448.
46. Matsukura S, Jones PA, Takai D: Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Res 2003;31:e77.
47. Lee NS, Dohjima T, Bauer G, et al.: Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol 2002;20:500-505.
48. Paddison PJ, Caudy AA, Bernstein E, et al.: Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev 2002;16:948-958.
49. Boden D, Pusch O, Lee F, et al.: Promoter choice affects the potency of HIV-1 specific RNA interference. Nucleic Acids Res 2003;31:5033-5038.
50. Kobayashi N, Matsui Y, Kawase A, et al.: Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression. J Pharmacol Exp Ther 2003.
51. Hasuwa H, Kaseda K, Einarsdottir T, et al.: Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Lett 2002;532:227-230.
52. Brummelkamp TR, Nijman SM, Dirac AM, et al.: Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003;424:797-801.
53. Xu ZX, Zhao RX, Ding T, et al.: PMLA induces apoptosis by inhibition of survivin expression. J Biol Chem 2003;279:1838-1844.
54. Riss D, Jin L, Qian X, Bayliss J, et al.: Differential expression of galectin-3 in pituitary tumors. Cancer Res 2003;63:2251-2255.
55. Oruetxebarria I, Venturini F, Kekarainen T, et al.: p16INK4a is required for hSNF5 chromatin-remodeler induced cellular senescence in malignant rhabdoid tumor cells. J Biol Chem 2003;279:3807-3816.
56. Sarkar SN, Das HK: Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis. J Neurochem 2003;87:333-343.
57. Calegari F, Haubensak W, Yang D, et al.: Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc Natl Acad Sci USA 2002;99:14236-14240.
58. Barton GM, Medzhitov R: Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci USA 2002;99:14943-14945.
59. Xia H, Mao Q, Paulson HL, et al.: siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002;20:1006-1010.
60. Abbas-Terki T, Blanco-Bose W, Deglon N, et al.: Lentiviral-mediated RNA interference. Hum Gene Ther 2002;13:2197-2201.
61. Qin XF, An DS, Chen IS, et al.: Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci USA 2003;100:183-188.
62. Lee MT, Coburn GA, McClure MO, et al.: Inhibition of human immunodeficiency virus type 1 replication in primary macrophages by using Tat- or CCR5-specific small interfering RNAs expressed from a lentivirus vector. J Virol 2003;77:11964-11972.
63. Rubinson DA, Dillon CP, Kwiatkowski AV, et al.: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 2003;33:401-406.
64. Tomar RS, Matta H, Chaudhary PM: Use of adeno-associated viral vector for delivery of small interfering RNA. Oncogene 2003;22:5712-5715.
65. Sorensen DR, Leirdal M, Sioud M: Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 2003;327:761-766.
66. Wong AW, Brickey WJ, Taxman DJ, et al.: CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nat Immunol 2003;4:891-898.
67. Urban BC, Willcox N, Roberts DJ: A role for CD36 in the regulation of dendritic cell function. Proc Natl Acad Sci USA 2001;98:8750-8755.
68. Harshyne LA, Zimmer MI, Watkins SC, et al.: A role for class A scavenger receptor in dendritic cell nibbling from live cells. J Immunol 2003;170:2302-2309.
69. Norbury CC, Chambers BJ, Prescott AR, et al.: Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells. Eur J Immunol 1997;27:280-288.
70. Kato M, Neil TK, Fearnley DB, et al.: Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells. Int Immunol 2000;12:1511-1519.
71. Condon C, Watkins SC, Celluzzi CM, et al.: DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 1996;2:1122-1128.
72. Sullenger BA, Gilboa E: Emerging clinical applications of RNA. Nature 2002;418:252-258.
73. McCaffrey AP, Meuse L, Pham TT, et al.: RNA interference in adult mice. Nature 2002;418:38-39.
74. Song E, Lee SK, Wang J, et al.: RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003;9:347-351.
75. Zender L, Hutker S, Liedtke C, et al.: Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 2003;100:7797-7802.
76. Wojtkowiak A, Siek A, Alejska M, et al.: RNAi and viral vectors as useful tools in the functional genomics of plants. Construction of BMV-based vectors for RNA delivery into plant cells. Cell Mol Biol Lett 2002;7:511-522.
77. Pickford AS, Cogoni C: RNA-mediated gene silencing. Cell Mol Life Sci 2003;60:871-882.
78. Timmons L, Court DL, Fire A: Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene 2001;263:103-112.
79. McManus MT, Haines BB, Dillon CP, et al.: Small interfering RNA-mediated gene silencing in T lymphocytes. J Immunol 2002;169:5754-5760.
80. Martin-Lluesma S, Stucke VM, Nigg EA: Role of Hec 1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science 2002;297:2267-2270.
81. Pal-Bhadra M, Bhadra U, Birchler JA: RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila. Mol Cell 2002;9:315-327.
82. D'Andrea A, Rengaraju M, Valiante NM, et al.: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-1398.
83. Holscher C: The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases. Med Microbiol Immunol (Berl) 2004;193:1-17.
84. Hill JA WD, Ichim TE, Min WP: A novel mechanism of immune modulation through the use of small interering RNA. Arthritis Rheum 2002;46:S563.
85. Kohka H, Iwagaki H, Yoshino T, et al.: Involvement of interleukin-18 (IL-18) in mixed lymphocyte reactions (MLR). J Interferon Cytokine Res 1999;19:1053-1057.
86. Trinchieri G: Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 1998;70:83-243.
87. Laderach D, Compagno D, Danos O, et al.: RNA interference shows critical requirement for NF-kappaB p50 in the production of IL-12 by human dendritic cells. J Immunol 2003;171:1750-1757.