Lycopene and cardiovascular diseases: An update

Current Medicinal Chemistry

Volumn 18, Issue 8, 2011, Pages 1146-1163

  Mordente, A ^a   Guantario, B ^b   Meucci, E ^a   Silvestrini, A ^a   Lombardi, E ^a   Martorana, G E ^a   Giardina, B ^a   Bohm V ^c  

^a CATHOLIC UNIVERSITY   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Cardiovascular disease; Clinical studies; Lycopene; Nutritional guidelines; Tomato

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; BETA CAROTENE; LOW DENSITY LIPOPROTEIN; LYCOPENE; PLACEBO; VERY LOW DENSITY LIPOPROTEIN;

ACUTE HEART INFARCTION; ANTIOXIDANT ACTIVITY; ARTERIAL WALL THICKNESS; ATHEROSCLEROSIS; BIOAVAILABILITY; BRAIN HEMORRHAGE; BRAIN INFARCTION; CANCER PREVENTION; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CATARACT; CORONARY ARTERY DISEASE; DIABETIC RETINOPATHY; DIET SUPPLEMENTATION; DIETARY REFERENCE INTAKE; DNA DAMAGE; ENDOTHELIAL DYSFUNCTION; FOOD PROCESSING; HEAT TREATMENT; HUMAN; INCIDENCE; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INTESTINE ABSORPTION; ISOMERIZATION; LIPID PEROXIDATION; LOW DRUG DOSE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL VALUE; OXIDATIVE STRESS; PRIMARY PREVENTION; REVIEW; RISK REDUCTION; STROKE; THROMBOCYTE ACTIVATION; TOMATO;

CARDIOVASCULAR DISEASES; CAROTENOIDS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LYCOPERSICON ESCULENTUM; MOLECULAR STRUCTURE;

EID: 79952811360     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986711795029717     Document Type: Review

References (235)

1. Vasan, S.R.; Benjamin, E.J.; Sullivan, L.M.; D'Agostino, R.B. In: Hurst's The Heart, 12th ed.; Fuster, V.; O'Rourke, R.A.; Walsh, R.A.; Poole-Wilson, P., Eds.; McGraw-Hill: New York, 2008; pp. 89-117.
2. World Health Organization. Cardiovascular diseases (CVDs). 2009 Update. (Accessed September 12, 2010). http://www.who.int/mediacentre/factsheets/fs317/ en/print.html
3. Dahlof, B. Cardiovascular disease risk factors: Epidemiology and risk assessment. Am. J. Cardiol., 2010, 105, 3A-9A.
4. Dzau, V.J.; Antman, E.M.; Black, H.R.; Hayes, D.L.; Manson, J.E.; Plutzky, J.; Popma, J.J.; Stevenson, W. The cardiovascular disease continuum validated: Clinical evidence of improved patient outcomes: Part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation, 2006, 114, 2850-2870. (Pubitemid 46018288)
5. Dzau, V.J.; Antman, E.M.; Black, H.R.; Hayes, D.L.; Manson, J.E.; Plutzky, J.; Popma, J.J.; Stevenson, W. The cardiovascular disease continuum validated: Clinical evidence of improved patient outcomes: Part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions. Circulation, 2006, 114, 2871-2891. (Pubitemid 46018289)
6. Vasan, R.S. Biomarkers of cardiovascular disease: Molecular basis and practical considerations. Circulation, 2006, 113, 2335-2362. (Pubitemid 43947980)
7. Ignarro, L.J.; Balestrieri, M.L.; Napoli, C. Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc. Res., 2007, 73, 326-340. (Pubitemid 44970442)
8. Koenen, R.R.; Weber, C. Therapeutic targeting of chemokine interactions in atherosclerosis. Nat. Rev. Drug Discov., 2010, 9, 141-153.
9. Libby, P.; Ridker, P.M.; Hansson, G.K. Inflammation in atherosclerosis: From pathophysiology to practice. J. Am. Coll. Cardiol., 2009, 54, 2129-2138.
10. Vogiatzi, G.; Tousoulis, D.; Stefanadis, C. The role of oxidative stress in atherosclerosis. Hellenic J. Cardiol., 2009, 50, 402-409.
11. Harrison, D.; Griendling, K.K.; Landmesser, U.; Hornig, B.; Drexler, H. Role of oxidative stress in atherosclerosis. Am. J. Cardiol., 2003, 91, 7A- 11A. (Pubitemid 36351457)
12. Lubos, E.; Handy, D.E.; Loscalzo, J. Role of oxidative stress and nitric oxide in atherothrombosis. Front. Biosci., 2008, 13, 5323-5344.
13. Leopold, J.A.; Loscalzo, J. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic. Biol. Med., 2009, 47, 1673-1706.
14. Victor, V.M.; Rocha, M.; Sola, E.; Banuls, C.; Garcia-Malpartida, K.; Hernandez-Mijares, A. Oxidative stress, endothelial dysfunction and atherosclerosis. Curr. Pharm. Des., 2009, 15, 2988-3002.
15. Despres, J.P.; Arsenault, B.J.; Cote, M.; Cartier, A.; Lemieux, I. Abdominal obesity: The cholesterol of the 21st century? Can. J. Cardiol., 2008, 24, 7D- 12D.
16. Mathieu, P.; Lemieux, I.; Despres, J.P. Obesity, inflammation, and cardiovascular risk. Clin. Pharmacol. Ther., 2010, 87, 407-416.
17. Mathieu, P.; Poirier, P.; Pibarot, P.; Lemieux, I.; Despres, J.P. Visceral obesity: The link among inflammation, hypertension, and cardiovascular disease. Hypertension, 2009, 53, 577-584.
18. Rocha, V.Z.; Libby, P. Obesity, inflammation, and atherosclerosis. Nat. Rev. Cardiol., 2009, 6, 399-409.
19. Ros, E. Nuts and novel biomarkers of cardiovascular disease. Am. J. Clin. Nutr., 2009, 89, 1649S-1656S.
20. Hill, A.M.; Fleming, J.A.; Kris-Etherton, P.M. The role of diet and nutritional supplements in preventing and treating cardiovascular disease. Curr. Opin. Cardiol., 2009, 24, 433-441.
21. Dauchet, L.; Amouyel, P.; Dallongeville, J. Fruits, vegetables and coronary heart disease. Nat. Rev. Cardiol., 2009, 6, 599-608.
22. Waterman, C.L.; Kian-Kai, C.; Griffin, J.L. Metabolomic strategies to study lipotoxicity in cardiovascular disease. Biochim. Biophys. Acta, 2010, 1801, 230-234.
23. Riccioni, G.; Bucciarelli, T.; Mancini, B.; Di Ilio, C.; Capra, V.; D'Orazio, N. The role of the antioxidant vitamin supplementation in the prevention of cardiovascular diseases. Expert Opin. Investig. Drugs, 2007, 16, 25-32. (Pubitemid 44964164)
24. Willcox, B.J.; Curb, J.D.; Rodriguez, B.L. Antioxidants in cardiovascular health and disease: Key lessons from epidemiologic studies. Am. J. Cardiol., 2008, 101, 75D-86D.
25. Raederstorff, D. Antioxidant activity of olive polyphenols in humans: A review. Int. J. Vitam. Nutr. Res., 2009, 79, 152-165.
26. Kaliora, A.C.; Dedoussis, G.V.; Schmidt, H. Dietary antioxidants in preventing atherogenesis. Atherosclerosis, 2006, 187, 1-17. (Pubitemid 43817017)
27. Jackson, H.; Braun, C.L.; Ernst, H. The chemistry of novel xanthophyll carotenoids. Am. J. Cardiol., 2008, 101, 50D-57D.
28. Riccioni, G. Carotenoids and cardiovascular disease. Curr. Atheroscler. Rep., 2009, 11, 434-439.
29. Rao, A.V.; Rao, L.G. Carotenoids and human health. Pharmacol. Res., 2007, 55, 207-216. (Pubitemid 46518154)
30. Voutilainen, S.; Nurmi, T.; Mursu, J.; Rissanen, T.H. Carotenoids and cardiovascular health. Am. J. Clin. Nutr., 2006, 83, 1265-1271. (Pubitemid 44713054)
31. Michalska, M.; Gluba, A.; Mikhailidis, D.P.; Nowak, P.; Bielecka-Dabrowa, A.; Rysz, J.; Banach, M. The role of polyphenols in cardiovascular disease. Med. Sci. Monit., 2010, 16, RA110-119.
32. Mulvihill, E.E.; Huff, M.W. Antiatherogenic properties of flavonoids: Implications for cardiovascular health. Can. J. Cardiol., 2010, 26, 17A-21A.
33. Cicerale, S.; Lucas, L.; Keast, R. Biological activities of phenolic compounds present in virgin olive oil. Int. J. Mol. Sci., 2010, 11, 458-479.
34. Rao, A.V.; Ray, M.R.; Rao, L.G. Lycopene. Adv. Food Nutr. Res., 2006, 51, 99-164. (Pubitemid 44437092)
35. Kong, K.W.; Khoo, H.E.; Prasad, K.N.; Ismail, A.; Tan, C.P.; Rajab, N.F. Revealing the power of the natural red pigment lycopene. Molecules, 2010, 15, 959-987.
36. Howitt, C.A.; Pogson, B.J. Carotenoid accumulation and function in seeds and non-green tissues. Plant Cell Environ., 2006, 29, 435-445.
37. Lenucci, M.S.; Cadinu, D.; Taurino, M.; Piro, G.; Dalessandro, G. Antioxidant composition in cherry and high-pigment tomato cultivars. J. Agric. Food Chem., 2006, 54, 2606-2613.
38. Shi, J.; Le Maguer, M. Lycopene in tomatoes: Chemical and physical properties affected by food processing. Crit. Rev. Biotechnol., 2000, 20, 293-334. (Pubitemid 32056133)
39. Zechmeister, L.; Polgar, A. Cis-trans isomerisation and cis-peak effect in the α-carotene set and in some other stereoisomeric sets. J. Am. Chem. Soc., 1944, 66, 137-144.
40. Guo, W.H.; Tu, C.Y.; Hu, C.H. Cis-trans isomerizations of beta-carotene and lycopene: A theoretical study. J. Phys. Chem. B, 2008, 112, 12158-12167.
41. Willcox, J.K.; Catignani, G.L.; Lazarus, S. Tomatoes and cardiovascular health. Crit. Rev. Food Sci. Nutr., 2003, 43, 1-18. (Pubitemid 38552309)
42. Erdman, J.W., Jr.; Ford, N.A.; Lindshield, B.L. Are the health attributes of lycopene related to its antioxidant function? Arch. Biochem. Biophys., 2009, 483, 229-235.
43. Pennathur, S.; Maitra, D.; Byun, J.; Sliskovic, I.; Abdulhamid, I.; Saed, G.M.; Diamond, M.P.; Abu-Soud, H.M. Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radic. Biol. Med., 2010, 49, 205-213.
44. Story, E.N.; Kopec, R.E.; Schwartz, S.J.; Harris, G.K. An update on the health effects of tomato lycopene. Annu. Rev. Food Sci. Technol., 2010, 1, 189-210.
45. Di Mascio, P.; Kaiser, S.; Sies, H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys., 1989, 274, 532-538. (Pubitemid 19261144)
46. Stahl, W.; Junghans, A.; de Boer, B.; Driomina, E.S.; Briviba, K.; Sies, H. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: Synergistic effects of lycopene and lutein. FEBS Lett., 1998, 427, 305-308. (Pubitemid 28225080)
47. Fuhrman, B.; Volkova, N.; Rosenblat, M.; Aviram, M. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid. Redox Signal, 2000, 2, 491-506.
48. Napolitano, M.; De Pascale, C.; Wheeler-Jones, C.; Botham, K.M.; Bravo, E. Effects of lycopene on the induction of foam cell formation by modified LDL. Am. J. Physiol. Endocrinol. Metab., 2007, 293, E1820-1827. (Pubitemid 350255137)
49. Fuhrman, B.; Elis, A.; Aviram, M. Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem. Biophys. Res. Commun., 1997, 233, 658-662. (Pubitemid 27217707)
50. Bowen, P.; Chen, L.; Stacewicz-Sapuntzakis, M.; Duncan, C.; Sharifi, R.; Ghosh, L.; Kim, H.S.; Christov-Tzelkov, K.; van Breemen, R. Tomato sauce supplementation and prostate cancer: Lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp. Biol. Med. (Maywood), 2002, 227, 886-893. (Pubitemid 35340343)
51. Kim, G.Y.; Kim, J.H.; Ahn, S.C.; Lee, H.J.; Moon, D.O.; Lee, C.M.; Park, Y.M. Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB. Immunology, 2004, 113, 203-211.
52. Cheng, H.C.; Chien, H.; Liao, C.H.; Yang, Y.Y.; Huang, S.Y. Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models. J. Nutr. Biochem., 2007, 18, 667-675. (Pubitemid 47386030)
53. Tang, X.; Yang, X.; Peng, Y.; Lin, J. Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells. Cardiovasc. Drugs Ther., 2009, 23, 439-448.
54. Palozza, P.; Simone, R.; Catalano, A.; Boninsegna, A.; Bohm, V.; Frohlich, K.; Mele, M.C.; Monego, G.; Ranelletti, F.O. Lycopene prevents 7- ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J. Nutr. Biochem., 2010, 21, 34-46.
55. Palozza, P.; Colangelo, M.; Simone, R.; Catalano, A.; Boninsegna, A.; Lanza, P.; Monego, G.; Ranelletti, F.O. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signalling in cancer cell lines. Carcinogenesis, 2010.
56. Aust, O.; Ale-Agha, N.; Zhang, L.; Wollersen, H.; Sies, H.; Stahl, W. Lycopene oxidation product enhances gap junctional communication. Food Chem. Toxicol., 2003, 41, 1399-1407. (Pubitemid 37289189)
57. Wertz, K.; Siler, U.; Goralczyk, R. Lycopene: Modes of action to promote prostate health. Arch. Biochem. Biophys., 2004, 430, 127-134. (Pubitemid 39119787)
58. Heber, D.; Lu, Q.Y. Overview of mechanisms of action of lycopene. Exp. Biol. Med. (Maywood), 2002, 227, 920-923. (Pubitemid 35340348)
59. Chew, B.P.; Park, J.S. Carotenoid action on the immune response. J. Nutr., 2004, 134, 257S-261S. (Pubitemid 38057459)
60. Palozza, P.; Parrone, N.; Catalano, A.; Simone, R. Tomato lycopene and inflammatory cascade: Basic interactions and clinical implications. Curr. Med. Chem., 2010, 17, 2547-2563.
61. Zaripheh, S.; Nara, T.Y.; Nakamura, M.T.; Erdman, J.W., Jr. Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPARgamma in selected rat tissues. J. Nutr., 2006, 136, 932-938.
62. Dingley, K.H.; Ubick, E.A.; Chiarappa-Zucca, M.L.; Nowell, S.; Abel, S.; Ebeler, S.E.; Mitchell, A.E.; Burns, S.A.; Steinberg, F.M.; Clifford, A.J. Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr. Cancer, 2003, 46, 212-221. (Pubitemid 37500513)
63. Denniss, S.G.; Haffner, T.D.; Kroetsch, J.T.; Davidson, S.R.; Rush, J.W.; Hughson, R.L. Effect of short-term lycopene supplementation and postprandial dyslipidemia on plasma antioxidants and biomarkers of endothelial health in young, healthy individuals. Vasc. Health Risk Manag., 2008, 4, 213-222. (Pubitemid 351460862)
64. Haseen, F.; Cantwell, M.M.; O'Sullivan, J.M.; Murray, L.J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic Dis., 2009, 12, 325-332.
65. Seren, S.; Lieberman, R.; Bayraktar, U.D.; Heath, E.; Sahin, K.; Andic, F.; Kucuk, O. Lycopene in cancer prevention and treatment. Am. J. Ther., 2008, 15, 66-81. (Pubitemid 351161184)
66. Scott, K.J.; Thurnham, D.I.; Hart, D.J.; Bingham, S.A.; Day, K. The correlation between the intake of lutein, lycopene and beta-carotene from vegetables and fruits, and blood plasma concentrations in a group of women aged 50-65 years in the UK. Br. J. Nutr., 1996, 75, 409-418. (Pubitemid 26097781)
67. Olmedilla, B.; Granado, F.; Southon, S.; Wright, A.J.; Blanco, I.; Gil- Martinez, E.; Berg, H.; Corridan, B.; Roussel, A.M.; Chopra, M.; Thurnham, D.I. Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries. Br. J. Nutr., 2001, 85, 227-238. (Pubitemid 32236810)
68. Arab, L.; Steck, S. Lycopene and cardiovascular disease. Am. J. Clin. Nutr., 2000, 71, 1691S-1695S.
69. Clinton, S.K. Lycopene: Chemistry, biology, and implications for human health and disease. Nutr. Rev., 1998, 56, 35-51. (Pubitemid 28132684)
70. Lucarini, M.; Lanzi, S.; D'Evoli, L.; Aguzzi, A.; Lombardi-Boccia, G. Intake of vitamin A and carotenoids from the Italian population-results of an Italian total diet study. Int. J. Vitam. Nutr. Res., 2006, 76, 103-109. (Pubitemid 44668645)
71. Frenich, A.G.; Torres, M.E.; Vega, A.B.; Vidal, J.L.; Bolanos, P.P. Determination of ascorbic acid and carotenoids in food commodities by liquid chromatography with mass spectrometry detection. J. Agric. Food Chem., 2005, 53, 7371-7376. (Pubitemid 41413529)
72. Lugasi, A.; Biro, L.; Hovarie, J.; Sagi, K.-V.; Brandt S.; Barna E. Lycopene content of foods and lycopene intake in two groups of the Hungarian population. Nutr. Res., 2003, 23, 1035-1044. (Pubitemid 36936211)
73. Setiawan, B.; Sulaeman, A.; Giraud, D.W.; Driskell, J.A. Carotenoid content of selected Indonesian fruits. J. Food Comp. Anal., 2001, 14, 169-176. (Pubitemid 33664858)
74. Hart, D.J.; Scott, K.J. Development and evaluation of an HPLC method for the analysis of carotenoid in foods, and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem., 1995, 54, 101-111.
75. D'Souza, M.C.; Singha, S.; Ingle, M. Lycopene concentration of tomato fruit can be estimated from chromaticity values. HortScience, 1992, 27, 465-466.
76. Sharma, S.K.; Le Maguer, M. Lycopene in tomatoes and tomato pulp fractions. Ital. J. Food. Sci., 1996, 2, 107-113. (Pubitemid 126332845)
77. Nguyen, M.L.; Schwartz, S.J. Lycopene stability during food processing. Proc. Soc. Exp. Biol. Med., 1998, 218, 101-105.
78. Agarwal, A.; Shen, H.; Agarwal, S.; Rao, A.V. Lycopene content of tomato products: Its stability, bioavailability and in vivo antioxidant properties. J. Med. Food, 2001, 4, 9-15. (Pubitemid 32448727)
79. Brown, E.D.; Micozzi, M.S.; Craft, N.E.; Bieri, J.G.; Beecher, G.; Edwards, B.K.; Rose, A.; Taylor, P.R.; Smith, J.C., Jr. Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am. J. Clin. Nutr., 1989, 49, 1258-1265. (Pubitemid 19169690)
80. Gartner, C.; Stahl, W.; Sies, H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am. J. Clin. Nutr., 1997, 66, 116-122. (Pubitemid 27278908)
81. Stahl, W.; Sies, H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J. Nutr., 1992, 122, 2161-2166.
82. Boileau, T.W.; Boileau, A.C.; Erdman, J.W., Jr. Bioavailability of all-trans and cis-isomers of lycopene. Exp. Biol. Med. (Maywood), 2002, 227, 914-919. (Pubitemid 35340347)
83. Porrini, M.; Riso, P.; Testolin, G. Absorption of lycopene from single or daily portions of raw and processed tomato. Br. J. Nutr., 1998, 80, 353-361. (Pubitemid 28515362)
84. Sanchez-Moreno, C.; Cano, M.P.; de Ancos, B.; Plaza, L.; Olmedilla, B.; Granado, F.; Martin, A. Mediterranean vegetable soup consumption increases plasma vitamin C and decreases F2-isoprostanes, prostaglandin E2 and monocyte chemotactic protein-1 in healthy humans. J. Nutr. Biochem., 2006, 17, 183-189. (Pubitemid 43247412)
85. Kerkhofs, N.S.; Lister, C.E.; Savage, G.P. Change in colour and antioxidant content of tomato cultivars following forced-air drying. Plant Foods Hum. Nutr., 2005, 60, 117-121. (Pubitemid 41413979)
86. Erdman, J.W., Jr.; Fahey, G.C., Jr.; White, C.B. Effects of purified dietary fiber sources on beta-carotene utilization by the chick. J. Nutr., 1986, 116, 2415-2423. (Pubitemid 17006398)
87. Rock, C.L.; Swendseid, M.E. Plasma beta-carotene response in humans after meals supplemented with dietary pectin. Am. J. Clin. Nutr., 1992, 55, 96-99.
88. Deming, D.M.; Boileau, A.C.; Lee, C.M.; Erdman, J.W., Jr. Amount of dietary fat and type of soluble fiber independently modulate postabsorptive conversion of beta-carotene to vitamin A in mongolian gerbils. J. Nutr., 2000, 130, 2789-2796.
89. Weststrate, J.A.; van het Hof, K.H. Sucrose polyester and plasma carotenoid concentrations in healthy subjects. Am. J. Clin. Nutr., 1995, 62, 591-597.
90. Weststrate, J.A.; Meijer, G.W. Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur. J. Clin. Nutr., 1998, 52, 334-343. (Pubitemid 28230699)
91. Elinder, L.S.; Hadell, K.; Johansson, J.; Molgaard, J.; Holme, I.; Olsson, A.G.; Walldius, G. Probucol treatment decreases serum concentrations of diet-derived antioxidants. Arterioscler. Thromb. Vasc. Biol., 1995, 15, 1057-1063.
92. Khachik, F.; Beecher, G.R.; Goli, M.B.; Lusby, W.R.; Smith, J.C., Jr. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Anal. Chem., 1992, 64, 2111-2122.
93. Khachik, F.; Spangler, C.J.; Smith, J.C., Jr.; Canfield, L.M.; Steck, A.; Pfander, H. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem., 1997, 69, 1873-1881.
94. Williams, A.W.; Boileau, T.W.; Erdman, J.W., Jr. Factors influencing the uptake and absorption of carotenoids. Proc. Soc. Exp. Biol. Med., 1998, 218, 106-108.
95. Rao, A.V.; Agarwal, S. Role of antioxidant lycopene in cancer and heart disease. J. Am. Coll. Nutr., 2000, 19, 563-569.
96. Agarwal, S.; Rao, A.V. Tomato lycopene and its role in human health and chronic diseases. Can. Med. Ass. J., 2000, 163, 739-744.
97. Clark, R.M.; Yao, L.; She, L.; Furr, H.C. A comparison of lycopene and astaxanthin absorption from corn oil and olive oil emulsions. Lipids, 2000, 35, 803-806. (Pubitemid 30624547)
98. Fielding, J.M.; Rowley, K.G.; Cooper, P.; K, O.D. Increases in plasma lycopene concentration after consumption of tomatoes cooked with olive oil. Asia Pac. J. Clin. Nutr., 2005, 14, 131-136. (Pubitemid 40769781)
99. Brown, M.J.; Ferruzzi, M.G.; Nguyen, M.L.; Cooper, D.A.; Eldridge, A.L.; Schwartz, S.J.; White, W.S. Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am. J. Clin. Nutr., 2004, 80, 396-403. (Pubitemid 41080013)
100. Parker, R.S. Absorption, metabolism, and transport of carotenoids. FASEB J., 1996, 10, 542-551.
101. Gruenwald, J.; Jaenicke, C.; Freder, J. Lycopene: The modern answer to urban wellness? NutraFoods, 2003, 2, 21-35.
102. Gugger, E.T.; Erdman, J.W., Jr. Intracellular beta-carotene transport in bovine liver and intestine is not mediated by cytosolic proteins. J. Nutr., 1996, 126, 1470-1474. (Pubitemid 26137706)
103. Kaplan, L.A.; Lau, J.M.; Stein, E.A. Carotenoid composition, concentrations, and relationships in various human organs. Clin. Physiol. Biochem., 1990, 8, 1-10. (Pubitemid 20094717)
104. Clinton, S.K.; Emenhiser, C.; Schwartz, S.J.; Bostwick, D.G.; Williams, A.W.; Moore, B.J.; Erdman, J.W., Jr. Cis-trans lycopene isomers, carotenoids, and retinol in the human prostate. Cancer Epidemiol. Biomarkers Prev., 1996, 5, 823-833. (Pubitemid 26346282)
105. Freeman, V.L.; Meydani, M.; Yong, S.; Pyle, J.; Wan, Y.; Arvizu-Durazo, R.; Liao, Y. Prostatic levels of tocopherols, carotenoids, and retinol in relation to plasma levels and self-reported usual dietary intake. Am. J. Epidemiol., 2000, 151, 109-118. (Pubitemid 30463640)
106. Stahl, W.; Sies, H. Lycopene: A biologically important carotenoid for humans? Arch. Biochem. Biophys., 1996, 336, 1-9. (Pubitemid 26423743)
107. Boileau, A.C.; Merchen, N.R.; Wasson, K.; Atkinson, C.A.; Erdman, J.W., Jr. Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets. J. Nutr., 1999, 129, 1176-1181. (Pubitemid 29250167)
108. Schierle, J.; Bretzel, W.; Buhler, I.; Faccin, N.; Hess, D.; Steiner, K.; Schuep, W. Content and isomeric ratios of lycopene in food and human blood plasma. Food Chem., 1997, 59, 459-465. (Pubitemid 27193105)
109. Unlu, N.Z.; Bohn, T.; Francis, D.M.; Nagaraja, H.N.; Clinton, S.K.; Schwartz, S.J. Lycopene from heat-induced cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. Br. J. Nutr., 2007, 98, 140-146. (Pubitemid 47272157)
110. Re, R.; Fraser, P.D.; Long, M.; Bramley, P.M.; Rice-Evans, C. Isomerization of lycopene in the gastric milieu. Biochem. Biophys. Res. Commun., 2001, 281, 576-581. (Pubitemid 32928193)
111. Britton, G. Structure and properties of carotenoids in relation to function. FASEB J., 1995, 9, 1551-1558. (Pubitemid 26012843)
112. Chasse, G.A.; Mak, M.L.; Derety, E.; Farkas, I.; Torday, L.L.; Papp, J.G.; Sarma, D.S.R.; Agarwal, A.; Chakravarthi, S.; Agarwal, S.; Rao, A.V. An ab initio computational study on selected lycopene isomers. J. Mol. Struc., 2001, 571, 27-37. (Pubitemid 32847274)
113. Bohm, V.; Puspitasari-Nienaber, N.L.; Ferruzzi, M.G.; Schwartz, S.J. Trolox equivalent antioxidant capacity of different geometrical isomers of alphacarotene, beta-carotene, lycopene, and zeaxanthin. J. Agric. Food Chem., 2002, 50, 221-226. (Pubitemid 34038535)
114. Tomato products wellness council. 2009 Update. (Accessed September 12, 2010). http://www.tomatowellness.com/report/
115. Ascherio, A.; Rimm, E.B.; Hernan, M.A.; Giovannucci, E.; Kawachi, I.; Stampfer, M.J.; Willett, W.C. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann. Intern. Med., 1999, 130, 963-970. (Pubitemid 29283986)
116. Hirvonen, T.; Virtamo, J.; Korhonen, P.; Albanes, D.; Pietinen, P. Intake of flavonoids, carotenoids, vitamins C and E, and risk of stroke in male smokers. Stroke, 2000, 31, 2301-2306.
117. Osganian, S.K.; Stampfer, M.J.; Rimm, E.; Spiegelman, D.; Manson, J.E.; Willett, W.C. Dietary carotenoids and risk of coronary artery disease in women. Am. J. Clin. Nutr., 2003, 77, 1390-1399. (Pubitemid 39655271)
118. Sesso, H.D.; Liu, S.; Gaziano, J.M.; Buring, J.E. Dietary lycopene, tomatobased food products and cardiovascular disease in women. J. Nutr., 2003, 133, 2336-2341. (Pubitemid 36841562)
119. Tavani, A.; Gallus, S.; Negri, E.; Parpinel, M.; La Vecchia, C. Dietary intake of carotenoids and retinol and the risk of acute myocardial infarction in Italy. Free Radic. Res., 2006, 40, 659-664. (Pubitemid 43832521)
120. Street, D.A.; Comstock, G.W.; Salkeld, R.M.; Schuep, W.; Klag, M.J. Serum antioxidants and myocardial infarction. Are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation, 1994, 90, 1154-1161. (Pubitemid 24284435)
121. Kristenson, M.; Zieden, B.; Kucinskiene, Z.; Elinder, L.S.; Bergdahl, B.; Elwing, B.; Abaravicius, A.; Razinkoviene, L.; Calkauskas, H.; Olsson, A.G. Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: Concomitant cross sectional study of men aged 50. Br. Med. J., 1997, 314, 629-633. (Pubitemid 27099876)
122. Rissanen, T.H.; Voutilainen, S.; Nyyssonen, K.; Lakka, T.A.; Sivenius, J.; Salonen, R.; Kaplan, G.A.; Salonen, J.T. Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: The Kuopio Ischaemic Heart Disease Risk Factor Study. Br. J. Nutr., 2001, 85, 749-754. (Pubitemid 32586506)
123. Hak, A.E.; Stampfer, M.J.; Campos, H.; Sesso, H.D.; Gaziano, J.M.; Willett, W.; Ma, J. Plasma carotenoids and tocopherols and risk of myocardial infarction in a low-risk population of US male physicians. Circulation, 2003, 108, 802-807. (Pubitemid 37022120)
124. Hak, A.E.; Ma, J.; Powell, C.B.; Campos, H.; Gaziano, J.M.; Willett, W.C.; Stampfer, M.J. Prospective study of plasma carotenoids and tocopherols in relation to risk of ischemic stroke. Stroke, 2004, 35, 1584-1588. (Pubitemid 38823629)
125. Sesso, H.D.; Buring, J.E.; Norkus, E.P.; Gaziano, J.M. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am. J. Clin. Nutr., 2005, 81, 990-997. (Pubitemid 41724938)
126. Sesso, H.D.; Buring, J.E.; Norkus, E.P.; Gaziano, J.M. Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in women. Am. J. Clin. Nutr., 2004, 79, 47-53. (Pubitemid 41132061)
127. Ito, Y.; Kurata, M.; Suzuki, K.; Hamajima, N.; Hishida, H.; Aoki, K. Cardiovascular disease mortality and serum carotenoid levels: A Japanese population-based follow-up study. J. Epidemiol., 2006, 16, 154-160. (Pubitemid 44110934)
128. Lidebjer, C.; Leanderson, P.; Ernerudh, J.; Jonasson, L. Low plasma levels of oxygenated carotenoids in patients with coronary artery disease. Nutr. Metab. Cardiovasc. Dis., 2007, 17, 448-456. (Pubitemid 47069912)
129. Kohlmeier, L.; Kark, J.D.; Gomez-Gracia, E.; Martin, B.C.; Steck, S.E.; Kardinaal, A.F.; Ringstad, J.; Thamm, M.; Masaev, V.; Riemersma, R.; Martin-Moreno, J.M.; Huttunen, J.K.; Kok, F.J. Lycopene and myocardial infarction risk in the EURAMIC Study. Am. J. Epidemiol., 1997, 146, 618-626. (Pubitemid 27454549)
130. Gomez-Aracena J.; Sloot S.L.; Garcia-Rodriguez A. Antioxidants in adipose tissue and myocardial infarction in a Mediterranean area. The Euramic study in Malaga. Nutr. Metab. Cardiovasc. Dis., 1997, 7, 376-382. (Pubitemid 127554224)
131. Kohlmeier, L.; Kohlmeier, M. Adipose tissue as a medium for epidemiologic exposure assessment. Environ. Health Perspect., 1995, 103 Suppl 3, 99-106.
132. Cobble, M.; Bale, B. Carotid intima-media thickness: Knowledge and application to everyday practice. Postgrad. Med., 2010, 122, 10-18.
133. Lorenz, M.W.; Markus, H.S.; Bots, M.L.; Rosvall, M.; Sitzer, M. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis. Circulation, 2007, 115, 459-467. (Pubitemid 46184197)
134. Urbina, E.M.; Williams, R.V.; Alpert, B.S.; Collins, R.T.; Daniels, S.R.; Hayman, L.; Jacobson, M.; Mahoney, L.; Mietus-Snyder, M.; Rocchini, A.; Steinberger, J.; McCrindle, B. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: Recommendations for standard assessment for clinical research: A scientific statement from the American Heart Association. Hypertension, 2009, 54, 919-950.
135. Iribarren, C.; Folsom, A.R.; Jacobs, D.R., Jr.; Gross, M.D.; Belcher, J.D.; Eckfeldt, J.H. Association of serum vitamin levels, LDL susceptibility to oxidation, and autoantibodies against MDA-LDL with carotid atherosclerosis. A case-control study. The ARIC Study Investigators. Atherosclerosis Risk in Communities. Arterioscler. Thromb. Vasc. Biol., 1997, 17, 1171-1177. (Pubitemid 27260339)
136. Klipstein-Grobusch, K.; Launer, L.J.; Geleijnse, J.M.; Boeing, H.; Hofman, A.; Witteman, J.C. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis, 2000, 148, 49-56.
137. D'Odorico, A.; Martines, D.; Kiechl, S.; Egger, G.; Oberhollenzer, F.; Bonvicini, P.; Sturniolo, G.C.; Naccarato, R.; Willeit, J. High plasma levels of alpha- and beta-carotene are associated with a lower risk of atherosclerosis: Results from the Bruneck study. Atherosclerosis, 2000, 153, 231-239.
138. Rissanen, T.; Voutilainen, S.; Nyyssonen, K.; Salonen, R.; Salonen, J.T. Low plasma lycopene concentration is associated with increased intima-media thickness of the carotid artery wall. Arterioscler. Throm. Vasc. Biol., 2000, 20, 2677-2681.
139. Rissanen, T.H.; Voutilainen, S.; Nyyssonen, K.; Salonen, R.; Kaplan, G.A.; Salonen, J.T. Serum lycopene concentrations and carotid atherosclerosis: The Kuopio Ischaemic Heart Disease Risk Factor Study. Am. J. Clin. Nutr., 2003, 77, 133-138. (Pubitemid 36015382)
140. McQuillan, B.M.; Hung, J.; Beilby, J.P.; Nidorf, M.; Thompson, P.L. Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS). J. Am. Coll. Cardiol., 2001, 38, 1788-1794. (Pubitemid 33116545)
141. Gianetti, J.; Pedrinelli, R.; Petrucci, R.; Lazzerini, G.; De Caterina, M.; Bellomo, G.; De Caterina, R. Inverse association between carotid intimamedia thickness and the antioxidant lycopene in atherosclerosis. Am. Heart J., 2002, 143, 467-474. (Pubitemid 34185178)
142. Dwyer, J.H.; Paul-Labrador, M.J.; Fan, J.; Shircore, A.M.; Merz, C.N.; Dwyer, K.M. Progression of carotid intima-media thickness and plasma antioxidants: The Los Angeles Atherosclerosis Study. Arterioscler. Thromb. Vasc. Biol., 2004, 24, 313-319. (Pubitemid 38197584)
143. Riccioni, G.; Bucciarelli, T.; D'Orazio, N.; Palumbo, N.; di Ilio, E.; Corradi, F.; Pennelli, A.; Bazzano, L.A. Plasma antioxidants and asymptomatic carotid atherosclerotic disease. Ann. Nutr. Metab., 2008, 53, 86-90. (Pubitemid 50307316)
144. Riccioni, G.; D'Orazio, N.; Palumbo, N.; Bucciarelli, V.; Ilio, E.; Bazzano, L.A.; Bucciarelli, T. Relationship between plasma antioxidant concentrations and carotid intima-media thickness: The Asymptomatic Carotid Atherosclerotic Disease In Manfredonia Study. Eur. J. Cardiovasc. Prev. Rehabil., 2009, 16, 351-357.
145. Riccioni, G.; D'Orazio, N.; Scotti, L.; Petruzzelli, R.; Latino, A.; Bucciarelli, V.; Pennelli, A.; Cicolini, G.; Di Ilio, E.; Bucciarelli, T. Circulating plasma antioxidants, inflammatory markers and asymptomatic carotid atherosclerosis in end-stage renal disease patients: A case control study. Int. J. Immunopathol. Pharmacol., 2010, 23, 327-334.
146. Kim, O.Y.; Yoe, H.Y.; Kim, H.J.; Park, J.Y.; Kim, J.Y.; Lee, S.H.; Lee, J.H.; Lee, K.P.; Jang, Y. Independent inverse relationship between serum lycopene concentration and arterial stiffness. Atherosclerosis, 2010, 208, 581-586.
147. Karppi, J.; Nurmi, T.; Kurl, S.; Rissanen, T.H.; Nyyssonen, K. Lycopene, lutein and beta-carotene as determinants of LDL conjugated dienes in serum. Atherosclerosis, 2010, 209, 565-572.
148. Moriel, P.; Sevanian, A.; Ajzen, S.; Zanella, M.T.; Plavnik, F.L.; Rubbo, H.; Abdalla, D.S. Nitric oxide, cholesterol oxides and endothelium-dependent vasodilation in plasma of patients with essential hypertension. Braz. J. Med. Biol. Res., 2002, 35, 1301-1309. (Pubitemid 36013580)
149. Hozawa, A.; Jacobs, D.R., Jr.; Steffes, M.W.; Gross, M.D.; Steffen, L.M.; Lee, D.H. Circulating carotenoid concentrations and incident hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) study. J. Hypertens., 2009, 27, 237-242.
150. Chasan-Taber, L.; Willett, W.C.; Seddon, J.M.; Stampfer, M.J.; Rosner, B.; Colditz, G.A.; Speizer, F.E.; Hankinson, S.E. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am. J. Clin. Nutr., 1999, 70, 509-516. (Pubitemid 29463445)
151. Brown, L.; Rimm, E.B.; Seddon, J.M.; Giovannucci, E.L.; Chasan-Taber, L.; Spiegelman, D.; Willett, W.C.; Hankinson, S.E. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am. J. Clin. Nutr., 1999, 70, 517-524. (Pubitemid 29463446)
152. Olmedilla, B.; Granado, F.; Gil-Martinez, E.; Blanco, I.; Rojas-Hidalgo, E. Reference values for retinol, tocopherol, and main carotenoids in serum of control and insulin-dependent diabetic Spanish subjects. Clin. Chem., 1997, 43, 1066-1071. (Pubitemid 27247001)
153. Granado, F.; Olmedilla, B.; Gil-Martinez, E.; Blanco, I.; Millan, I.; Rojas-Hidalgo, E. Carotenoids, retinol and tocopherols in patients with insulindependent diabetes mellitus and their immediate relatives. Clin. Sci., 1998, 94, 189-195. (Pubitemid 28052650)
154. Ford, E.S.; Will, J.C.; Bowman, B.A.; Narayan, K.M. Diabetes mellitus and serum carotenoids: Findings from the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol., 1999, 149, 168-176. (Pubitemid 29039520)
155. Polidori, M.C.; Mecocci, P.; Stahl, W.; Parente, B.; Cecchetti, R.; Cherubini, A.; Cao, P.; Sies, H.; Senin, U. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab. Res. Rev., 2000, 16, 15-19. (Pubitemid 30160612)
156. Suzuki, K.; Ito, Y.; Nakamura, S.; Ochiai, J.; Aoki, K. Relationship between serum carotenoids and hyperglycemia: A population-based cross-sectional study. J. Epidemiol., 2002, 12, 357-366. (Pubitemid 44143829)
157. Ylonen, K.; Alfthan, G.; Groop, L.; Saloranta, C.; Aro, A.; Virtanen, S.M. Dietary intakes and plasma concentrations of carotenoids and tocopherols in relation to glucose metabolism in subjects at high risk of type 2 diabetes: The Botnia Dietary Study. Am. J. Clin. Nutr., 2003, 77, 1434-1441. (Pubitemid 39655276)
158. Montonen, J.; Knekt, P.; Jarvinen, R.; Reunanen, A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care, 2004, 27, 362-366. (Pubitemid 38174058)
159. Coyne, T.; Ibiebele, T.I.; Baade, P.D.; Dobson, A.; McClintock, C.; Dunn, S.; Leonard, D.; Shaw, J. Diabetes mellitus and serum carotenoids: Findings of a population-based study in Queensland, Australia. Am. J. Clin. Nutr., 2005, 82, 685-693. (Pubitemid 43759256)
160. Quilliot, D.; Walters, E.; Bonte, J.P.; Fruchart, J.C.; Duriez, P.; Ziegler, O. Diabetes mellitus worsens antioxidant status in patients with chronic pancreatitis. Am. J. Clin. Nutr., 2005, 81, 1117-1125. (Pubitemid 41724954)
161. Hozawa, A.; Jacobs, D.R., Jr.; Steffes, M.W.; Gross, M.D.; Steffen, L.M.; Lee, D.H. Associations of serum carotenoid concentrations with the development of diabetes and with insulin concentration: Interaction with smoking: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am. J. Epidemiol., 2006, 163, 929-937.
162. Wang, L.; Liu, S.; Pradhan, A.D.; Manson, J.E.; Buring, J.E.; Gaziano, J.M.; Sesso, H.D. Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women. Am. J. Epidemiol., 2006, 164, 576-585. (Pubitemid 44412786)
163. Wang, L.; Liu, S.; Manson, J.E.; Gaziano, J.M.; Buring, J.E.; Sesso, H.D. The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women. J. Nutr., 2006, 136, 620-625. (Pubitemid 43363745)
164. Granado-Lorencio, F.; Olmedilla-Alonso, B.; Blanco-Navarro, I.; Botella- Romero, F.; Simal-Anton, A. Assessment of carotenoid status and the relation to glycaemic control in type I diabetics: A follow-up study. Eur. J. Clin. Nutr., 2006, 60, 1000-1008. (Pubitemid 44161022)
165. Sugiura, M.; Nakamura, M.; Ikoma, Y.; Yano, M.; Ogawa, K.; Matsumoto, H.; Kato, M.; Ohshima, M.; Nagao, A. The homeostasis model assessmentinsulin resistance index is inversely associated with serum carotenoids in non-diabetic subjects. J. Epidemiol., 2006, 16, 71-78. (Pubitemid 43414599)
166. Brazionis, L.; Rowley, K.; Itsiopoulos, C.; O'Dea, K. Plasma carotenoids and diabetic retinopathy. Br. J. Nutr., 2009, 101, 270-277.
167. Li, Z.Z.; Lu, X.Z.; Ma, C.C.; Chen, L. Serum lycopene levels in patients with diabetic retinopathy. Eur. J. Ophthalmol., 2010, 20, 719-723.
168. Sluijs, I.; Beulens, J.W.; Grobbee, D.E.; van der Schouw, Y.T. Dietary carotenoid intake is associated with lower prevalence of metabolic syndrome in middle-aged and elderly men. J. Nutr., 2009, 139, 987-992.
169. Boosalis, M.G.; Snowdon, D.A.; Tully, C.L.; Gross, M.D. Acute phase response and plasma carotenoid concentrations in older women: Findings from the nun study. Nutrition, 1996, 12, 475-478. (Pubitemid 26299984)
170. Kritchevsky, S.B.; Bush, A.J.; Pahor, M.; Gross, M.D. Serum carotenoids and markers of inflammation in nonsmokers. Am. J. Epidemiol., 2000, 152, 1065-1071.
171. Rowley, K.; Walker, K.Z.; Cohen, J.; Jenkins, A.J.; O'Neal, D.; Su, Q.; Best, J.D.; O'Dea, K. Inflammation and vascular endothelial activation in an Aboriginal population: Relationships to coronary disease risk factors and nutritional markers. Med. J. Aust., 2003, 178, 495-500. (Pubitemid 36637143)
172. van Herpen-Broekmans, W.M.; Klopping-Ketelaars, I.A.; Bots, M.L.; Kluft, C.; Princen, H.; Hendriks, H.F.; Tijburg, L.B.; van Poppel, G.; Kardinaal, A.F. Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. Eur. J. Epidemiol., 2004, 19, 915-921. (Pubitemid 39434547)
173. Chang, C.Y.; Chen, J.Y.; Ke, D.; Hu, M.L. Plasma levels of lipophilic antioxidant vitamins in acute ischemic stroke patients: Correlation to inflammation markers and neurological deficits. Nutrition, 2005, 21, 987-993. (Pubitemid 41266989)
174. Walston, J.; Xue, Q.; Semba, R.D.; Ferrucci, L.; Cappola, A.R.; Ricks, M.; Guralnik, J.; Fried, L.P. Serum antioxidants, inflammation, and total mortality in older women. Am. J. Epidemiol., 2006, 163, 18-26. (Pubitemid 43007111)
175. Hozawa, A.; Jacobs, D.R., Jr.; Steffes, M.W.; Gross, M.D.; Steffen, L.M.; Lee, D.H. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: The Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Clin. Chem., 2007, 53, 447-455. (Pubitemid 46447941)
176. Shin, M.J.; Park, E. Plasma levels of leptin are associated with the plasma levels of LDL conjugated dienes in children. Ann. Nutr. Metab., 2007, 51, 1-6. (Pubitemid 46633183)
177. Farwell, W.R.; Michael Gaziano, J.; Norkus, E.P.; Sesso, H.D. The relationship between total plasma carotenoids and risk factors for chronic disease among middle-aged and older men. Br. J. Nutr., 2008, 100, 883-889.
178. Watters, J.L.; Satia, J.A.; Kupper, L.L.; Swenberg, J.A.; Schroeder, J.C.; Switzer, B.R. Associations of antioxidant nutrients and oxidative DNA damage in healthy African-American and White adults. Cancer Epidemiol. Biomarkers Prev., 2007, 16, 1428-1436. (Pubitemid 47076874)
179. Wang, L.; Gaziano, J.M.; Norkus, E.P.; Buring, J.E.; Sesso, H.D. Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. Am. J. Clin. Nutr., 2008, 88, 747-754.
180. Agarwal, S.; Rao, A.V. Tomato lycopene and low density lipoprotein oxidation: A human dietary intervention study. Lipids, 1998, 33, 981-984. (Pubitemid 28516475)
181. Steinberg, F.M.; Chait, A. Antioxidant vitamin supplementation and lipid peroxidation in smokers. Am. J. Clin. Nutr., 1998, 68, 319-327. (Pubitemid 28355649)
182. Rao, A.V.; Agarwal, S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr. Cancer, 1998, 31, 199-203. (Pubitemid 28481854)
183. Dugas, T.R.; Morel, D.W.; Harrison, E.H. Dietary supplementation with beta-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. Free Radic. Biol. Med., 1999, 26, 1238-1244. (Pubitemid 29262710)
184. Rehman, A.; Bourne, L.C.; Halliwell, B.; Rice-Evans, C.A. Tomato consumption modulates oxidative DNA damage in humans. Biochem. Biophys. Res. Commun., 1999, 262, 828-831. (Pubitemid 29443743)
185. Riso, P.; Pinder, A.; Santangelo, A.; Porrini, M. Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? Am. J. Clin. Nutr., 1999, 69, 712-718. (Pubitemid 29193395)
186. Sutherland, W.H.; Walker, R.J.; De Jong, S.A.; Upritchard, J.E. Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients. Clin. Nephrol., 1999, 52, 30-36. (Pubitemid 29335822)
187. Bub, A.; Watzl, B.; Abrahamse, L.; Delincee, H.; Adam, S.; Wever, J.; Muller, H.; Rechkemmer, G. Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. J. Nutr., 2000, 130, 2200-2206.
188. Carroll, Y.L.; Corridan, B.M.; Morrissey, P.A. Lipoprotein carotenoid profiles and the susceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. Eur. J. Clin. Nutr., 2000, 54, 500-507. (Pubitemid 30345401)
189. Chopra, M.; O'Neill, M.E.; Keogh, N.; Wortley, G.; Southon, S.; Thurnham, D.I. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Clin. Chem., 2000, 46, 1818-1829.
190. Porrini, M.; Riso, P. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J. Nutr., 2000, 130, 189-192. (Pubitemid 30073793)
191. Upritchard, J.E.; Sutherland, W.H.; Mann, J.I. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care, 2000, 23, 733-738. (Pubitemid 30414184)
192. Hininger, I.A.; Meyer-Wenger, A.; Moser, U.; Wright, A.; Southon, S.; Thurnham, D.; Chopra, M.; Van Den Berg, H.; Olmedilla, B.; Favier, A.E.; Roussel, A.M. No significant effects of lutein, lycopene or beta-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. J. Am. Coll. Nutr., 2001, 20, 232-238. (Pubitemid 32606170)
193. Maruyama, C.; Imamura, K.; Oshima, S.; Suzukawa, M.; Egami, S.; Tonomoto, M.; Baba, N.; Harada, M.; Ayaori, M.; Inakuma, T.; Ishikawa, T. Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification. J. Nutr. Sci. Vitaminol. (Tokyo). 2001, 47, 213-221. (Pubitemid 32785830)
194. Porrini, M.; Riso, P.; Oriani, G. Spinach and tomato consumption increases lymphocyte DNA resistance to oxidative stress but this is not related to cell carotenoid concentrations. Eur. J. Nutr., 2002, 41, 95-100. (Pubitemid 36056329)
195. Rao AV; Shen H. Effect of low dose lycopene intake on lycopene bioavailability and oxidative stress. Nutr. Res., 2002, 22, 1125-1131.
196. Kiokias, S.; Gordon, M.H. Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. Eur. J. Clin. Nutr., 2003, 57, 1135-1140. (Pubitemid 37121011)
197. Ahuja, K.D.; Ashton, E.L.; Ball, M.J. Effects of two lipid-lowering, carotenoid-controlled diets on the oxidative modification of low-density lipoproteins in free-living humans. Clin. Sci., 2003, 105, 355-361. (Pubitemid 37088575)
198. Hadley, C.W.; Clinton, S.K.; Schwartz, S.J. The consumption of processed tomato products enhances plasma lycopene concentrations in association with a reduced lipoprotein sensitivity to oxidative damage. J. Nutr., 2003, 133, 727-732. (Pubitemid 36268346)
199. Visioli, F.; Riso, P.; Grande, S.; Galli, C.; Porrini, M. Protective activity of tomato products on in vivo markers of lipid oxidation. Eur. J. Nutr., 2003, 42, 201-206. (Pubitemid 36999072)
200. Watzl, B.; Bub, A.; Briviba, K.; Rechkemmer, G. Supplementation of a lowcarotenoid diet with tomato or carrot juice modulates immune functions in healthy men. Ann. Nutr. Metab., 2003, 47, 255-261. (Pubitemid 38253102)
201. Briviba, K.; Kulling, S.E.; Moseneder, J.; Watzl, B.; Rechkemmer, G.; Bub, A. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers. Carcinogenesis, 2004, 25, 2373-2378. (Pubitemid 39625177)
202. Briviba, K.; Schnabele, K.; Rechkemmer, G.; Bub, A. Supplementation of a diet low in carotenoids with tomato or carrot juice does not affect lipid peroxidation in plasma and feces of healthy men. J. Nutr., 2004, 134, 1081-1083. (Pubitemid 38619943)
203. Collins, J.K.; Arjmandi, B.H.; Claypool, P.L.; Perkins-Veazie, P.; Baker, R.A.; Clevidence, B.A. Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults. Nutr. J., 2004, 3, 15.
204. Rao, A.V. Processed tomato products as a source of dietary lycopene: Bioavailability and antioxidant properties. Can. J. Diet. Pract. Res., 2004, 65, 161-165.
205. Riso, P.; Visioli, F.; Erba, D.; Testolin, G.; Porrini, M. Lycopene and vitamin C concentrations increase in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection. Eur. J. Clin. Nutr., 2004, 58, 1350-1358. (Pubitemid 39377916)
206. Tyssandier, V.; Feillet-Coudray, C.; Caris-Veyrat, C.; Guilland, J.C.; Coudray, C.; Bureau, S.; Reich, M.; Amiot-Carlin, M.J.; Bouteloup- Demange, C.; Boirie, Y.; Borel, P. Effect of tomato product consumption on the plasma status of antioxidant microconstituents and on the plasma total antioxidant capacity in healthy subjects. J. Am. Coll. Nutr., 2004, 23, 148-156. (Pubitemid 38405973)
207. Bub, A.; Barth, S.W.; Watzl, B.; Briviba, K.; Rechkemmer, G. Paraoxonase 1 Q192R (PON1-192) polymorphism is associated with reduced lipid peroxidation in healthy young men on a low-carotenoid diet supplemented with tomato juice. Br. J. Nutr., 2005, 93, 291-297.
208. Porrini, M.; Riso, P.; Brusamolino, A.; Berti, C.; Guarnieri, S.; Visioli, F. Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection. Br. J. Nutr., 2005, 93, 93-99.
209. Watzl, B.; Kulling, S.E.; Moseneder, J.; Barth, S.W.; Bub, A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am. J. Clin. Nutr., 2005, 82, 1052-1058. (Pubitemid 43779764)
210. Ahuja, K.D.; Pittaway, J.K.; Ball, M.J. Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation. Nutrition, 2006, 22, 259-265. (Pubitemid 43261523)
211. Bose, K.S.; Agrawal, B.K. Effect of long term supplementation of tomatoes (cooked) on levels of antioxidant enzymes, lipid peroxidation rate, lipid profile and glycated haemoglobin in Type 2 diabetes mellitus. West Indian Med. J., 2006, 55, 274-278. (Pubitemid 44823708)
212. Engelhard, Y.N.; Gazer, B.; Paran, E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: A double-blind, placebo-controlled pilot study. Am. Heart J., 2006, 151, 100.
213. O'Kennedy, N.; Crosbie, L.; Whelan, S.; Luther, V.; Horgan, G.; Broom, J.I.; Webb, D.J.; Duttaroy, A.K. Effects of tomato extract on platelet function: A double-blinded crossover study in healthy humans. Am. J. Clin. Nutr., 2006, 84, 561-569. (Pubitemid 44713406)
214. O'Kennedy, N.; Crosbie, L.; van Lieshout, M.; Broom, J.I.; Webb, D.J.; Duttaroy, A.K. Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: A time-course cannulation study in healthy humans. Am. J. Clin. Nutr., 2006, 84, 570-579. (Pubitemid 44713407)
215. Paterson, E.; Gordon, M.H.; Niwat, C.; George, T.W.; Parr, L.; Waroonphan, S.; Lovegrove, J.A. Supplementation with fruit and vegetable soups and beverages increases plasma carotenoid concentrations but does not alter markers of oxidative stress or cardiovascular risk factors. J. Nutr., 2006, 136, 2849-2855. (Pubitemid 44771785)
216. Riso, P.; Visioli, F.; Grande, S.; Guarnieri, S.; Gardana, C.; Simonetti, P.; Porrini, M. Effect of a tomato-based drink on markers of inflammation, immunomodulation, and oxidative stress. J. Agric. Food Chem., 2006, 54, 2563-2566.
217. Zhao, X.; Aldini, G.; Johnson, E.J.; Rasmussen, H.; Kraemer, K.; Woolf, H.; Musaeus, N.; Krinsky, N.I.; Russell, R.M.; Yeum, K.J. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am. J. Clin. Nutr., 2006, 83, 163-169. (Pubitemid 44699250)
218. Blum, A.; Monir, M.; Khazim, K.; Peleg, A.; Blum, N. Tomato-rich (Mediterranean) diet does not modify inflammatory markers. Clin. Invest. Med., 2007, 30, E70-74. (Pubitemid 47535695)
219. Bose, K.S.; Agrawal, B.K. Effect of lycopene from cooked tomatoes on serum antioxidant enzymes, lipid peroxidation rate and lipid profile in coronary heart disease. Singapore Med. J., 2007, 48, 415-420. (Pubitemid 351235389)
220. Bose, K.S.; Agrawal, B.K. Effect of lycopene from tomatoes (cooked) on plasma antioxidant enzymes, lipid peroxidation rate and lipid profile in grade-I hypertension. Ann. Nutr. Metab., 2007, 51, 477-481. (Pubitemid 350212739)
221. Kawashima, A.; Madarame, T.; Koike, H.; Komatsu, Y.; Wise, J.A. Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects. Asia Pac. J. Clin. Nutr., 2007, 16, 411-421. (Pubitemid 47463617)
222. Silaste, M.L.; Alfthan, G.; Aro, A.; Kesaniemi, Y.A.; Horkko, S. Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br. J. Nutr., 2007, 98, 1251-1258. (Pubitemid 350193793)
223. Briviba, K.; Bub, A.; Moseneder, J.; Schwerdtle, T.; Hartwig, A.; Kulling, S.; Watzl, B. No differences in DNA damage and antioxidant capacity between intervention groups of healthy, nonsmoking men receiving 2, 5, or 8 servings/day of vegetables and fruit. Nutr. Cancer, 2008, 60, 164-170. (Pubitemid 351451273)
224. Devaraj, S.; Mathur, S.; Basu, A.; Aung, H.H.; Vasu, V.T.; Meyers, S.; Jialal, I. A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress. J. Am. Coll. Nutr., 2008, 27, 267-273.
225. Jacob, K.; Periago, M.J.; Bohm, V.; Berruezo, G.R. Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation. Br. J. Nutr., 2008, 99, 137-146. (Pubitemid 350286147)
226. Markovits, N.; Ben Amotz, A.; Levy, Y. The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity. Isr. Med. Assoc. J., 2009, 11, 598-601.
227. Paran, E.; Novack, V.; Engelhard, Y.N.; Hazan-Halevy, I. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc. Drugs Ther., 2009, 23, 145-151.
228. Ried, K.; Frank, O.R.; Stocks, N.P. Dark chocolate or tomato extract for prehypertension: A randomised controlled trial. BMC Complement. Altern. Med., 2009, 9, 22.
229. Stangl, V.; Kuhn, C.; Hentschel, S.; Jochmann, N.; Jacob, C.; Bohm, V.; Frohlich, K.; Muller, L.; Gericke, C.; Lorenz, M. Lack of effects of tomato products on endothelial function in human subjects: Results of a randomised, placebo-controlled cross-over study. Br. J. Nutr., 2010, 1-5.
230. Polidori, M.C.; Carrillo, J.C.; Verde, P.E.; Sies, H.; Siegrist, J.; Stahl, W. Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: Implications for optimal antioxidant levels. Nutr. J., 2009, 8, 10.
231. Dillingham, B.L.; Rao, A.V. Biologically active lycopene in human health. Int. J. NM, 2009, 4, 23-27.
232. Heath, E.; Seren, S.; Sahin, K.; Kucuk, O. In: Tomatoes, lycopene & human health.; Rao, A.V., Ed.; Caledonian Science Press: Scotland, 2006; pp. 127- 140.
233. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). Statement on the divergence between the risk assessment of lycopene by EFSA and the Joint FAO/WHO Expert Committee on Food Additives (JECFA). EFSA J., 2010, 8, 1676.
234. Balestrieri, M.L.; De Prisco, R.; Nicolaus, B.; Pari, P.; Moriello, V.S.; Strazzullo, G.; Iorio, E.L.; Servillo, L.; Balestrieri, C. Lycopene in association with alpha-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress. Free Radic. Biol. Med., 2004, 36, 1058-1067. (Pubitemid 38418025)
235. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on establishing Food-Based Dietary Guidelines. EFSA J., 2010, 8, 1460.