The effect of tomato-derived lycopene on low carotenoids and enhanced systemic inflammation and oxidation in severe obesity

Israel Medical Association Journal

Volumn 11, Issue 10, 2009, Pages 598-601

  Markovits, Noa ^a,b   Amotz, Ami Ben ^c   Levy, Yishai ^a,b  

^a Rambam Health Care Campus ^*  (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c NATIONAL INSTITUTE OF OCEANOGRAPHY   (Israel)

Author keywords

C reactive protein; Carotenoids; Inflammation; Lycopene; Obesity

Indexed keywords

ALKADIENE; ALPHA TOCOPHEROL; C REACTIVE PROTEIN; CAROTENOID; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; LYC O MATO; LYCOPENE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE SEVERITY; FEMALE; HUMAN; INFLAMMATION; LEAN BODY WEIGHT; MALE; OBESITY; OXIDATION; SEX DIFFERENCE; TOMATO; TREATMENT OUTCOME;

ANTIOXIDANTS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CAROTENOIDS; CASE-CONTROL STUDIES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; LYCOPERSICON ESCULENTUM; MALE; MIDDLE AGED; OBESITY; OXIDATIVE STRESS; VITAMIN E;

EID: 70350625212     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Leibovici OK, Atamna A, Lubin F, et al. Obesity among Arabs and Jews in Israel: a population-based study. IMAJ Isr Med Assoc J 2007; 9: 525-530 (Pubitemid 47193381)
2. Yusuf S, Hawken S, Ounpuu S, et al. INTEHEART Study Investigators. Obesity and risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 2005; 366: 1640-1649 (Pubitemid 41552419)
3. Trayhurn P. Adipose tissue in obesity - an inflammatory issue. Endocrinology 2007; 146: 1003-1005
4. Costman I, Stabholz A, Planer D, et al. Serum cytokine tumor necrosis factor-alpha and interleukin-6 associated with the severity of coronary artery disease: indicators of an active inflammatory burden. IMAJ Isr Med Assoc J 2008; 10: 494-498
5. Blum A, Monir M, Wirsansky I, Ben-Arzi S. The beneficial effects of tomatoes. Eur J Int Med 2005; 16: 402-404
6. Herzog A, Siler U, Spitzer V, et al. Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J 2005; 19: 272-274 (Pubitemid 40189279)
7. Walfish Y, Walfish S, Agbaria R, Levy J, Sharoni Y. Lycopene in serum, skin and adipose tissues after tomato-oleoresin supplementation in patients undergoing haemorrhoidectomy or peri-anal fistulotomy. Br J Nutr 2003; 90: 759-766 (Pubitemid 37270758)
8. Blum S, Aviram M, Ben-Amotz A, Levy Y. Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels. Ann Nutr Metab 2006; 50: 20-24 (Pubitemid 43097639)
9. Aronson D, Bartha P, Zinder O, et al. Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome. Int J Obes 2004; 28: 674-679 (Pubitemid 38580975)
10. Ben-Amotz A, Levy Y. Bioavailability of a natural isomer mixture compared with synthetic all-trans β-carotene in human serum. Am J Clin Nutr 1996; 63: 729-734 (Pubitemid 26126592)
11. Maachi M, Pieroni L, Bruckert E, et al. Systemic low-grade inflammation is related to both circulating and adipose tissue TNF-α, leptin and IL-6 levels in obese women. Int J Obes 2004; 28: 993-997 (Pubitemid 38998704)
12. Yesilbursa D, Serdar Z, Serdar A, Sarac M, Coskun S, Jale C. Lipid peroxides in obese patients and effects of weight loss with orlistat on lipid peroxides levels. Int J Obes 2005; 29: 142-145 (Pubitemid 40065477)
13. Reitman A, Friedrich I, Ben-Amotz A, Levy Y. Low plasma antioxidants and normal plasma B vitamins and homocysteine in patients with severe obesity. IMAJ Isr Med Assoc J. 2002; 4: 590-593 (Pubitemid 34873766)
14. Walston J, Xue Q, Semba RD, et al. Serum antioxidants, inflammation, and total mortality in older women. Am J Epidemiol 2006; 163: 18-26. (Pubitemid 43007111)
15. Van Herpen-Broekmans WM, Klopping-Ketelaars IA, Bots ML, et al. Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. Eur J Epidemiol 2004; 19: 915-921
16. Krajcovicova-Kudlackova M, Spustova V, Paukova V. Lipid peroxidation and nutrition. Physiol Res 2004; 53: 219-224
17. Watzl B, Kulling SE, Moseneder J, Barth SW, Bub A. A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men. Am J Clin Nutr 2005; 82: 1052-1058 (Pubitemid 43779764)
18. Watzl B, Bub A, Brivia K, Reckemmer G. Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men. Ann Nutr Metab 2003; 47: 255-261 (Pubitemid 38253102)
19. Jacob K, Priago MJ, Bohm V, Berruezo GR. Influence of lycopene and vitamin C from tomato juice on biomarkers of oxidative stress and inflammation. Br J Nutr 2007; 99: 137-146
20. Elmadfa I, Rust P, Majchrzak D, et al. Effect of beta -carotene supplementation on free radical mechanism in healthy adult subjects. Int J Vitam Nutr Res 2004; 74: 147-152 (Pubitemid 38788782)
21. Riso P, Visioli F, Erba D, et al. Lycopene and vitamin C concentrations increase in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection. Eur J Clin Nutr 2004; 58: 1350-1358 (Pubitemid 39377916)
22. Kohlmeier L, Kark JD, Gomez-Gracia E, et al. Lycopene and myocardial infarction risk in the EURAMIC study. Am J Epidemiol 1997; 146: 618-626 (Pubitemid 27454549)
23. Rissanen TH, Voutilainen S, Nyyssonen K, et al . Serum lycopene concentrations and carotoid atherosclerosis: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2003; 77: 133-138 (Pubitemid 36015382)
24. Wallstrom P, Wirflat TE, Lahmann PH, Gullberg B, Janson L, Berglund G. Serum concentration of f β-carotene and α-tocopherol are associated with diet, smoking and general and central adiposity. Am J Clin Nutr 2001; 73: 777-785 (Pubitemid 32239232)
25. Hozawa A, Jacobs DR, Stefes MW, Gross MD, Steffen LM, Lee DH. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the coronary artery risk development in young adults (CARDIA) young adult longitudinal trends in antioxidants (YALTA) study. Clin Chem 2007; 53: 447-455 (Pubitemid 46447941)