Overview of mechanisms of action of lycopene

Experimental Biology and Medicine

Volumn 227, Issue 10, 2002, Pages 920-923

  Heber, David ^a   Lu, Qing Yi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer prevention; Carotenoids, tomato products; Lycopene

Indexed keywords

ANTIOXIDANT; CONNEXIN 43; LYCOPENE; PROSTAGLANDIN SYNTHASE; SINGLET OXYGEN; XANTHOPHYLL; XENOBIOTIC AGENT;

APOPTOSIS; CANCER CELL; CANCER RISK; CARCINOGENESIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL GROWTH; CELL INTERACTION; CELL MEMBRANE; CELL PROLIFERATION; CHOLESTEROL SYNTHESIS; CONCENTRATION RESPONSE; CONFERENCE PAPER; DIETARY INTAKE; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME INHIBITION; GAP JUNCTION; GENE EXPRESSION; INFLAMMATION; LUNG CARCINOMA; MUTAGENESIS; PHYTOCHEMISTRY; PROSTATE CARCINOMA; RISK FACTOR; TOMATO; UPREGULATION; XENOBIOTIC METABOLISM;

ANIMALIA; LYCOPERSICON ESCULENTUM;

EID: 0036846616     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020222701013     Document Type: Conference Paper

References (22)

1. Ronen G, Cohen M, Zamir D, Hirschberg J. Regulation of carotenoid biosynthesis during tomato fruit development: Expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Δ. Plant J 17:341-351, 1999.
2. Steinmetz KA, Potter JD. Vegetables, fruits, and cancer. I. Epidemiology. Cancer Causes Control. 2:325-337, 1991.
3. Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention. A review of the epidemiological evidence. Nutr Cancer 18:1-29, 1992.
4. Cohen JH, Kristal AR, Stanford JL. Fruit and vegetable intakes and prostate cancer risk. J Natl Cancer Inst 92(1):61-68, 2000.
5. Giovanucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett VC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87:1767-1776, 1995.
6. Kucuk O, Sakr W, Sarkar F, Djuric Z, Li YW, Khachik F, Velazquez F, Heilbrun L, Bertram JS, Crissman JD, Pontes E, Wood DP. Lycopene supplementation in men with prostate cancer (Pca) reduced grade and volume of preneoplasia (PIN) and tumor, decreases serum prostate specific antigen (PSA) and modulates biomarkers of growth and differentiation. International Carotenoid Meeting, Cairns, Australia, August 1999.
7. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274:532-538, 1989.
8. Stahl W, Junghans A, de Boer B, Driomina ES, Briviba K, Sies H. Carotenoid mixtures protect multilamellar liposomes against oxidative damage: Synergistic effects of lycopene and lutein. FEBS Lett 427: 305-308, 1998.
9. Rao AV, Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 31:199-203, 1998.
10. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer 33:105-112, 1999.
11. Karas M, Amir H, Fishman D, Danilenko M, Segal S, Nahum A, Koifmann A, Giat Y, Levy J, Sharoni Y. Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells. Nutr Cancer 36:101-111, 2000.
12. Stahl W, von Laar J, Martin HD, Emmerich T, Sies H. Stimulation of gap junctional communication: Comparison of acyclo-retinoic acid and lycopene. Arch Biochem Biophys 373:271-274, 2000.
13. Fuhrman B, Elis A, Aviram M. Hypocholesterolemic effect of lycopene and β-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages. Biochem Biophys Res Commun 233:658-662, 1997.
14. Elson CE, Peffley DM, Hentosh P, Mo H. Isoprenoid-mediated inhibition of mevalonate synthesis: Potential application to cancer. Proc Soc Exp Biol Med 22:294-310, 1999.
15. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Acute phase response and plasma carotenoid concentrations in older women: Findings from the nun study. Nutrition 12:475-478, 1996.
16. Porrini M, Riso P. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr 130:189-192, 2000.
17. Wright AJ, Hughes DA, Bailey AL, Southon S. β-Carotene and lycopene, but not lutein, supplementation changes the plasma fatty acid profile of healthy male non-smokers. J Lab Clin Med 134:592-598, 1999.
18. Heber D, Go VLW. Gene-nutrient interaction and the xenobiotic hypothesis of cancer. In: Heber D. Blackburn GL, Go VLW, Eds. Nutritional Oncology. San Diego, CA: Academic Press, 1999.
19. World Cancer Research Fund: American Institute for Cancer Research. Food, Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research, 1997.
20. Heber D. Colorful cancer prevention: α-carotene, lycopene, and lung cancer. Am J Clin Nutr 72:901-902, 2000.
21. Broekmans WM, Klopping-Ketelaars IA, Schuurman CR, Verhagen H, van den Berg H, Kok FJ, von Poppel G. Fruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans. J Nutr 130:1578-1583, 2000.
22. Heber D, Bowerman S. What Color is Your Diet? New York: Harper-Collins/Regan Books, 2001.