Role of Antioxidant Lycopene in Cancer and Heart Disease

Journal of the American College of Nutrition

Volumn 19, Issue 5, 2000, Pages 563-569

  Rao, A Venket ^a   Agarwal, Sanjiv ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Antioxidant; Carotenoids; Chronic diseases; Lycopene; Oxidative stress

Indexed keywords

ANTIOXIDANT; CAROTENOID; LYCOPENE;

BLOOD LEVEL; CANCER; CANCER RISK; CARDIOVASCULAR RISK; CHRONIC DISEASE; CLINICAL TRIAL; DIETARY INTAKE; FRUIT; HEART DISEASE; HUMAN; NONHUMAN; OXIDATIVE STRESS; REVIEW; TISSUE LEVEL; TOMATO; VEGETABLE;

ANIMAL; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BIOLOGICAL AVAILABILITY; CAROTENOIDS; FOOD ANALYSIS; HEART DISEASES; HUMAN; LYCOPERSICON ESCULENTUM; NEOPLASMS; OXIDATIVE STRESS; RISK FACTORS;

EID: 0033819464     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2000.10718953     Document Type: Article

References (70)

1. Rao AV, Agarwal S: Role of lycopene as antioxidant carotenoid in the prevention of chronic diseases: a review. Nutr Res 19: 305-323, 1999.
2. Stahl W, Sies H: Lycopene: a biologically important carotenoid for humans? Arch Biochem Biophys 336: 1-9, 1996.
3. Nguyen ML, Schwartz SJ: Lycopene: chemical and biological properties. Food Tech 53: 38-45, 1999.
4. Zhang L-X, Cooney RV, Bertram JS: Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/ 10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 12: 2109-2114, 1991.
5. Zhang L-X, Cooney RV, Bertram JS: Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res 52: 5707-5712, 1992.
6. Levy J, Bosin E, Feldmen B, Giat Y, Miinster A, Danilenko M, Sharoni Y: Lycopene is a more potent inhibitor of human cancer cell proliferation than either a-carotene or b-carotene. Nutr Cancer 24: 257-266, 1995.
7. Nagasawa H, Mitamura T, Sakamoto S, Yamamoto K: Effects of lycopene on spontaneous mammary tumour development in SHN virgin mice. Anticancer Research 15: 1173-1178, 1995.
8. Kobayashi T, Iijima K, Mitamura T, Toriizuka K, Cyong JC, Nagasawa H: Effects of lycopene, a carotenoid, on intrathymic T cell differentian and peripheral CD4/CD8 ratio in a high mammary tumor strain of SHN retired mice. Anti-Cancer Drugs 7: 195-198, 1996.
9. Astrog P, Gradelet S, Berges R, Suschetet M: Dietary lycopene decreases initiation of liver preneoplastic foci by diethylnitrosamine in rat. Nutr Cancer 29: 60-68, 1997.
10. Fuhramn B, Elis A, Aviram M: Hypocholesterolemic effect of lycopene and b-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophage. Biochem Biophys Res Commun 233: 658-662, 1997.
11. Zechmeister L, LeRosen AL, Went FW, Pauling L: Prolycopene, a naturally occuring sterioisomer of lycopene. Proc Natl Acad Sci USA 21: 468-474, 1941.
12. Clinton SK, Emenhiser C, Schwartz SJ, Bostwick DG, Williams AW, Moore BJ, Erdman JW: Cis-trans lycopene isomers, carotenoids and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 5: 823-833, 1996.
13. Stahl W, Sies H: Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J Nutr 122: 2161-2166, 1992.
14. Rao AV, Fleshner N, Agarwal S: Serum and tissue lycopene and biomarkers of oxidation in prostate cancer patients: a case control study. Nutr Cancer 33: 159-164, 1999.
15. Rao AV, Waseem Z, Agarwal S: Lycopene contents of tomatoes and tomato products and their contribution to dietary lycopene. Food Res Intl, in press, 1999.
16. Gärtner C, Stahl W, Sies H: Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am J Clin Nutr 66: 116-122, 1997.
17. Clinton SK. Lycopene: chemistry, biology, and implications for human health and disease. Nutr Rev 56: 35-51, 1998.
18. Johnson EJ, Qin J, Krinsky NI, Russell RM: Ingestion by men of a combined dose of b-carotene and lycopene does not affect the absorption of b-carotene but improves that of lycopene. J Nutr 127: 1833-1837, 1997.
19. Pincemail J: Free radicals and antioxidants in human disease. In Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre J-L (eds): “αAnalysis of Free Radicals in Biological Systems.” Basel, Switzerland: Birkhäuser Verlag, pp 83-98, 1995.
20. Ames BN, Gold LS, Willet WC: Causes and prevention of cancer. Proc Natl Acad Sci USA 92: 5258-5265, 1995.
21. Witztum JL: The oxidation hypothesis of atherosclerosis. Lancet 344: 793-795, 1994.
22. Halliwell B: Free radicals, antioxidants and human disease: curiosity, cause or consequence? Lancet 344: 721-724, 1994.
23. Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA: Antioxidant activities of carotenes and xanthophylls. FEBS Lett 384: 240-246, 1996.
24. Agarwal S, Rao AV: Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lipids 33: 981-984, 1998.
25. Rao AV, Agarwal S: Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr Cancer 31: 199-203, 1998.
26. Pool-Zobel BL, Bub A, Muller H, Wollowski I, Rechkemmer G: Consumption of vegetables reduces genetic damage in humans: first result of a human intervention trial with carotenoid-rich foods. Carcinogenesis 18: 1847-1850, 1997.
27. DiMascio P, Kaiser S, Sies H: Lycopene as the most effective biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 274: 532-538, 1989.
28. Bohm F, Tinkler JH, Truscott TG: Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nature Med 1: 98-99, 1995.
29. Lu Y, Etoh H, Watanabe N: A new carotenoid, hydrogen peroxide oxidation products from lycopene. Biosci Biotech Biochem 59: 2153-2155, 1995.
30. Mortensen A, Skibsted LH: Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals. A real time kinetic study of antioxidant hierarchy. FEBS Lett 417: 261-266, 1997.
31. Stahl W, Junghans A, deBoer B, Driomina ES, Briviba K, Sies H: Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett 427: 305-308, 1998.
32. Parthasarathy S: Mechanism by which dietary antioxidants may prevent cardiovascular diseases. J Med Food 1: 45-51, 1998.
33. Esterbauer H, Gebicki J, Puhl H, Jurgens G: The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic Biol Med 13: 341-390, 1992.
34. Tinkler JH, Bohm F, Schalch W, Truscott TG: Dietary carotenoids protect human cells from damage. J Photochem Photobiol 26: 283-285, 1994.
35. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y: Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutr Cancer 33: 105-112, 1999.
36. Matsushima NR, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y: Suppression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids 30: 1029-1034, 1995.
37. Pastori M, Pfander H, Boscoboinik D, Azzi A: Lycopene in association with a-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun 250: 582-585, 1998.
38. Jain CK, Agarwal S, Rao AV: The effect of dietary lycopene on bioavailability, tissue distribution, in-vivo antioxidant properties and colonic preneoplasia in rats. Nutr Res 19: 1383-1391, 1999.
39. Forssberg A, Lingen C, Ernster L, Lindenberg O: Modification of x-irradiation syndrome by lycopene. Exp Cell Res 16: 7-14, 1959.
40. Lingen C, Ernster L, Lindenberg O: The promoting effects of lycopene on the non-specific resistance of animals. Exp Cell Res 16: 384-393, 1959.
41. Wang CJ, Chou MY, Lin JK: Inhibition of growth and development of the transplantable C-6 glioma cells inoculated in rats by retinoids and carotenoids. Cancer Lett 48: 135-142, 1989.
42. Narisawa T, Fukaura Y, Hasebe M, Nomura S, Oshima S, Sakamoto H, Inakuma T, Ishiguro Y, Takayasu J, Nishino H: Prevention of N-methylnitrosourea-induced colon carcinogenesis in F344 rats by lycopene. Jpn J Cancer Res 89: 1003-1008, 1998.
43. Sharoni Y, Giron E, Rise M, Levy J: Effects of lycopene-enriched tomato oleoresin on 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. Cancer Detect Prev 21: 118-123, 1997.
44. Okajima E, Tsutsumi M, Ozono S, Akai H, Denda A, Nishino H, Oshima S, Sakamoto H, Konishi Y: Inhibitory effect of tomato juice on rat urinary bladder carcinogenesis after N-butyl-N-(4hydroxybutyl)nitrosamine initiation. Jpn J Cancer Res 89: 22-26, 1998.
45. Arimochi H, Kataoka K, Kuwahara T, Nakayama H, Misawa N, Ohnishi Y: Effects of b-glucuronidase-deficient and lycopene producing E coli strains on formation of azoxymethane-induced aberrant crypt foci in the rat colon. Biochem Biophys Res Commun 262: 322-327, 1999.
46. Kim DJ, Takasuka N, Kim JM, Sekine K, Ota T, Asamoto M, Murakoshi M, Nishino H, Nir Z, Tsuda H: Chemoprevention by lycopene of mouse lung neoplasia after combined initiation treatment with DEN, MNU and DMH. Cancer Lett 120: 15-22, 1997.
47. Hecht SS, Kenney PM, Wang M, Trushin M, Agarwal S, Rao AV, Upadhyaya P: Evaluation of butylated hydroxyanisole, myoinositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice. Cancer Lett 137: 123-130, 1999.
48. Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, Ota T, Nir Z, Khachik F, Shimidzu N, Tanaka Y, Osawa T, Uraji T, Murakoshi M, Nishino H, Tsuda H: Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation. Carcinogenesis 19: 81-85, 1998.
49. Gradelet S, LeBon AM, Berges R, Suschetet M, Astrog P: Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in rats: role of modulation of aflatoxin B1 metabolism. Carcinogenesis 19: 403-411, 1998.
50. LaVecchia C: Mediterranean epidemiological evidence on tomatoes and the prevention of digestive tract cancers. Proc Soc Exp Biol Med 218: 125-128, 1997.
51. Giovannucci E: Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. J Natl Cancer Inst 91: 317-331, 1999.
52. Colditz GA, Branch LG, Lipnic RJ: Increased green and yellow vegetables intake and lowered cancer death in an elderly population. Am J Clin Nutr 41: 32-36, 1985.
53. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC: Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 87: 1767-1776, 1995.
54. Gann P, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ: Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 59: 1225-1230, 1999.
55. Franceschi S, Bidoli E, LaVeccia C, Talamini R, D’Avanzo B, Negri E: Tomatoes and risk of digestive-tract cancers. Int J Cancer 59: 181-184, 1994.
56. Potischman N, McCulloch CE, Byers T, Nemoto T, Stubbe N, Milch R, Parker R, Rasmussen KM, Root M, Grahm S, Campbell TC: Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A. Am J Clin Nutr 52: 909-915, 1990.
57. Jarvinen R, Knekt P, Sppanen R, Teppo L: Diet and breast cancer risk in a cohort of Finnish women. Cancer Lett 114: 251-253, 1997.
58. Zhang S, Tang G, Russell RM, Mayzel KA, Stampfer MJ, Willett WC, Hunter DJ: Measurement of retinoids and carotenoids in breast adipose tissue and a comparison of concentrations in breast cancer cases and control subjects. Am J. Clin Nutr 66: 626-632, 1997.
59. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, Stephenson HE Jr: Relationship of serum carotenoids, retinol, a-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control 9: 89-97, 1998.
60. VanEewyck J, Davis FG, Bowen PE: Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer 48: 34-38, 1991.
61. Helzlsouer KJ, Comstock GW, Morris JS: Selenium, lycopene, a-tocopherol, b-carotene, retinol, and subsequent bladder cancer. Cancer Res 49: 6144-6148, 1989.
62. Parthasarathy S, Steinberg D, Witztum JL: The role of oxidized low-density lipoproteins in pathogenesis of atherosclerosis. Ann Rev Med 43: 219-225, 1992.
63. Hodis HN, Mack WJ, LaBree L, Cashin-Hemphill L, Sevanian A, Johnson R, Azen SP: Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 273: 1849-1854, 1995.
64. Morris DL, Kritchevsky SB, Davis CE: Serum carotenoids and coronary heart disease: the Lipid Research Clinics Coronary Primary Prevention Trial and Follow-up Study. JAMA 272: 1439-1441, 1994.
65. Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC: Vitamin E consumption and the risk of coronary heart disease in men. New Eng J Med 328: 1450-1456, 1993.
66. Handelman GJ, Parker L, Cross CE: Destruction of tocopherols, carotenoids and retinol in human plasma by cigarette smoke. Am J Clin Nutr 63: 559-565, 1996.
67. Kohlmeir L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AFM, Ringstad J, Thamm M, Masaev V, Riemersma R, Martin-Moreno JM, Huttunen JK, Kok FJ: Lycopene and myocardial infarction risk in the EURAMIC study. Am J Epidemiol 146: 618-626, 1997.
68. Kristenson M, Zieden B, Kucinskiene Z, Elinder LS, Bergdahl B, Elwing B, Abaravicius A, Razinkoviene L, Calkauskas H, Olsson A: Antioxidant state and mortality from coronary heart disease in Lithuanian and Swedish men: concomitant cross sectional study of men aged 50. BMJ 314: 629-633, 1997.
69. Rao AV, Agarwal S: Effect of diet and smoking on serum lycopene and lipid peroxidation. Nutr Res 18: 713-721, 1998.
70. Kucuk O, Sakr FH, Djuric Z, Li YW, Velazquez F, Banerjee M, Bertram JS, Crissman JD, Wood DP: Lycopene supplementation in men with prostate cancer (Pca) reduces grade of preneoplasia (PIN) and tumor, decreases serum prostate specific antigen and modulates biomarkers of growth and differentiation. Intl Conf Diet Prev Cancer, Tampere, Finland, P1.13, 1999 (abstract).