Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells

Cardiovascular Drugs and Therapy

Volumn 23, Issue 6, 2009, Pages 439-448

  Tang, XiangYu ^a,b   Yang, XiangDong ^b   Peng, YaFei ^a   Lin, JunHua ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Apoptosis; Atherosclerosis; Endothelial cells; Lycopene; Oxidative stress

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; LYCOPENE; MALONALDEHYDE; MESSENGER RNA; PROBUCOL; PROTEIN P53; TETRAZOLIUM; ANTIOXIDANT; CAROTENOID;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL SHAPE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; LIPID PEROXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ATHEROSCLEROSIS; BIOSYNTHESIS; DRUG EFFECT; IN VITRO STUDY; METABOLISM; PATHOPHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ANTIOXIDANTS; APOPTOSIS; ATHEROSCLEROSIS; CAROTENOIDS; CASPASE 3; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FLOW CYTOMETRY; GENES, P53; HUMANS; HYDROGEN PEROXIDE; MALONDIALDEHYDE; OXIDATIVE STRESS; RNA, MESSENGER;

EID: 77649203007     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-009-6206-3     Document Type: Article

References (68)

1. Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004;84:1381-1478
2. Gopaul NK, Anggard EE, Mallet AI, Betteridge DJ, Wolff SP, Nourooz-Zadeh J. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett. 1995;368:225-229
3. Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res. 2000;86:494-501.
4. Morrow JD, Frei B, Longmire AW, Gaziano JM, Lynch SM, Shyr Y, et al. Increase in circulating products of lipid peroxidation (F2- isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med. 1995;332:1198-1203
5. Aoki M, Nata T, Morishita R, Matsushita H, Nakagami H, Yamamoto K, et al. Endothelial apoptosis induced by oxidative stress through activation of NF-kB. Hypertension. 2001;38:48-55.
6. Gibbons GH, Dzau VJ. The emerging concept of vascular remodeling. N Engl J Med. 1994;30:1431-1438
7. Morel DW, Hessler JR, Chisolm GM. Low-density lipoprotein cytotoxicity induced by free radical peroxidation of lipid. J Lipid Res. 1983;24:1070-1076
8. Berliner JA, Territo MC, Sevanian A, Romin S, Kim JA, Bamshad B, et al. Minimally modified LDL stimulates monocyte endothelial interaction. J Clin Invest. 1990;85:1260-1266
9. Hamilton TA, Ma GP, Chisolm GM. Oxidized low-density lipoprotein suppresses the expression of tumor necrosis factor-α mRNA in stimulated murine peritoneal macrophages. J Immunol. 1990;144:2343-2350
10. Malden LT, Chait A, Raines EW, Ross R. The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages. J Biol Chem. 1991;266:13901-13907
11. D'Agnillo F, Wood F, Porras C, Macdonald VW, Alayash AI. Effects of hypoxia and glutathione depletion on hemoglobin- and myoglobin-mediated oxidative stress toward endothelium. Biochim Biophys Acta. 2000;1495:150-159
12. Samarasinghe DA, Tapner M, Ferrell GC. Role of oxidative stress in hypoxia-reoxygenation injury to cultured rat hepatic sinusoidal endothelial cells. Hepatology. 2000;31:160-165
13. Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, An antioxidant and anti-inflammatory agent, induces hemo oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 2000;28:1303-1312
14. Hashida K, Sasaki K, Makino N. Interactions of nitric oxide and oxygenin cytotoxicity: proliferation and antioxidant enzyme activities of endothelial cells in culture. Free Radic Res. 2000;33:147-156
15. Lee YJ, Kang IJ, Bunger R, Kang YH. Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells. Microvasc Res. 2003;66:91-101.
16. Bombeli T, Karsan A, Tait JF, Harlan JM. Apoptotic vascular endothelial cells become procoagulant. Blood. 1997;89:2429-2442
17. Bombeli T, Schwartz BR, Harlan JM. Endothelial cells undergoing apoptosis become proadhesive for nonactivated platelets. Blood. 1999;93:3831-3838
18. Tricot O, Mallat Z, Heymes C, Belmin J, Lesèche G, Tedgui A. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation. 2000;101:2450-2453
19. Dimmeler S, Hermann C, Zeiher AM. Apoptosis of endothelial cells: contribution to the pathophysiology of atherosclerosis. Eur Cytokine Netw. 1998;9:697-698
20. Klipstein Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Witteman JC. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis. 2000;148:49-56.
21. Rissanen TH, Voutilainen S, Nyyssonen K, Salonen R, Kaplan GA, Salonen JT. Serum lycopene concentrations and carotid atherosclerosis: the Kuopis Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr. 2003;77:133-138
22. Rissanen T, Voutilainen S, Nyyssönen K, Salonen JT. Lycopene, atherosclerosis, and coronary heart disease. Exp Biol Med (Maywood). 2002;227:900-907
23. Kohlmeier L, Kark JD, Gomez-Gracia E, Martin BC, Steck SE, Kardinaal AF, et al. Lycopene and myocardial infarction risk in the EURAMIC Study. Am J Epidemiol. 1997;146:618-626 (Pubitemid 27454549)
24. Rao AV. Lycopene, tomatoes, and the prevention of coronary heart disease. Exp Biol Med (Maywood). 2002;227:908-913
25. Heber D, Lu QY. Overview of mechanisms of action of lycopene. Exp Biol Med (Maywood). 2002;227:920-923
26. Luo T, Xia Z. A small dose of hydrogen peroxide enhances tumor necrosis factor-Alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol. Anesth Analg. 2006;103:110-116
27. Aruoma OI, Laughton MJ, Halliwell B. Carnosine, homocarnosine and anserine: could they act as antioxidants in vivo? Biochem J. 1989;264:863-869
28. Gurgul E, Lortz S, Tiedge M, Jörns A, Lenzen S. Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Diabetes. 2004;53:2271-2280
29. Wilson I, Gillinov AM, Curtis WE, DiNatale J, Burch RM, Gardner TJ, et al. Inhibition of neutrophil adherence improves postischemic ventricular performance of the neonatal heart. Circulation. 1993;88:II372-9.
30. Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, et al. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med. 1997;186:1831-1841
31. Aoki M, Morishita R, Matsushita H, Nakano N, Hayashi S, Tomita N, et al. Serum deprivation induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells. Heart Vessels. 1997;Suppl 12:71-75
32. Aoki M, Morishita R, Matsushita H, Hayashi S, Nakagami H, Yamamoto K, et al. Inhibition of the p53 tumor suppressor gene results in growth of human aortic vascular smooth muscle cells: potential role of p53 in the regulation of vascular smooth muscle cells. Hypertension. 1999;34:192-200.
33. Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ. Epidermal Growth Factor Receptor-dependent, NF-κB-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes. J Biol Chem. 2003;278:45737-45745
34. Li Y, Liu J, Zhan X. Tyrosine phosphorylation of cortactin is required for H2O2-mediated injury of human endothelial cells. J Biol Chem. 2000;275:37187-37193
35. Hull DS, Green K, Thomas L, Alderman N. Hydrogen peroxide-mediated corneal endothelial damage. Induction by oxygen free radical. Invest Ophthalmol Vis Sci. 1984;25:1246-1253
36. Schror K, Thiemermann C, Ney P. Protection of the ischemic myocardium from reperfusion injury by prostaglandin E1 inhibition of ischemia-induced neutrophil activation. Naunyn Schmiedebergs Arch Pharmacol. 1988;338:268-274
37. Sacks T, Moldow CF, Craddock PR, Bowers TK, Jacob HS. Oxygen radicals mediate endothelial cell damage by complementstimulated granulocytes. An in vitro model of immune vascular damage. J Clin Invest. 1978;61:1161-1167
38. Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal. 1999;11:1-14.
39. Mates JM, Sanchez-Jimenez F. Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci. 1999;4: D339-45.
40. Azzi A, Davies KJ, Kelly F. Free radical biology-terminology and critical thinking. FEBS Lett. 2004;558:3-6.
41. Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol. 2001;54:176-186
42. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol. 2001;280:C719-41.
43. Gugliesi F, Mondini M, Ravera R, Robotti A, de Andrea M, Gribaudo G, et al. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol. 2005;77:820-829
44. Lopez-Ongil S, Torrecillas G, Perez-Sala D, Gonzalez-Santiago L, Rodriguez-Puyol M, Rodriguez-Puyol D. Mechanisms involved in the contraction of endothelial cells by hydrogen peroxide. Free Radic Biol Med. 1999;26:501-510 (Pubitemid 29146252)
45. Natarajan V, Taher MM, Roehm B, Parinandi NL, Schmid HHO, Kiss Z, et al. Activation of endothelial cell phospholipase-D by hydrogen peroxide and fatty acid hydroperoxide. J Biol Chem. 1993;268:930-937
46. Lum H, Malik AB. Regulation of vascular endothelial barrier function. Am J Physiol. 1994;267:L223-41.
47. Siflinger-Birnboim A, Lum H, Del Vecchio PJ, Malik AB. Involvement of Ca2+ in the H2O2-induced increase in endothelial permeability. Am J Physiol. 1996;270:L973-8.
48. Kevil CG, Oshima T, Alexander B, Coe LL, Alexander JS. H2O2- mediated permeability: role of MAPK and occluding. Am J Physiol Cell Physiol. 2000;279:C21-30.
49. Andersson Y, Le H, Juell S, Fodstad Ø. AMP-activated protein kinase protects against anti-epidermal growth factor receptor- Pseudomonas exotoxin A immunotoxin-induced MA11 breast cancer cell death. Mol Cancer Ther. 2006;5:1050-1059
50. Vogelstein B, Kinzler KW. P53 function and dysfunction. Cell. 1992;70:523-526
51. Lane DP. Cancer. p53, guardian of the genome. Nature. 1992;358:15-16
52. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T, et al. p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell. 1994;78:703-711
53. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, et al. WAF 1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817-825
54. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 2000;29:323-333
55. Marston NJ, Crook T, Vousden KH. Interaction of p53 with MDM2 is independent of E6 and does not mediate wild-type transformation suppression function. Oncogene. 1994;9:2707-2716
56. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-1312
57. Lorenzo E, Ruiz-Ruiz C, Quesada AJ, Hernandez G, Rodriguez A, Lopez-Rivas A, et al. Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. J Biol Chem. 2002;277:10883-10892
58. Alves Da Costa C, Mattson MP, Ancolio K, Checler F. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. J Biol Chem. 2003;278:12064-12069
59. Havre PA, O'Reilly S, McCormick JJ, Brash DE. Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine. Cancer Res. 2002;62:1443-1449
60. Hermann C, Zeiher AM, Dimmeler S. Shear stress inhibits H2O2- induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase. Arterioscler Thromb Vasc Biol. 1997;17:3588-3592
61. Asada S, Fukuda K, Nishisaka F, Matsukawa M, Hamanisi C. Hydrogen peroxide induces apoptosis of chondmcytes;involvement of calxium ion and extracellular signal regulated protein kinase. Inflamm Res. 2001;50:19-23.
62. Slee Elizabeth A, Adrain C, Martin SJ. Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis. J Biol Chem. 2001;276:7320-7326
63. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316
64. Nicholson DW. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 1999;6:1028-1042
65. Slee EA, Adrain C, Martin SJ. Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 1999;6:1067-1074
66. Martin SJ, Green DR. Protease activation during apoptosis: death by a thousand cuts? Cell. 1995;82:349-352
67. Paran E, Novack V, Engelhard YN, Hazan-Halevy I. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Drugs Ther. 2009;23:145-151
68. de Leeuw PW, Bast A. Tomato extract for hypertension? Cardiovasc Drugs Ther. 2009;23:107-108