Lycopene, lutein and β-carotene as determinants of LDL conjugated dienes in serum

Atherosclerosis

Volumn 209, Issue 2, 2010, Pages 565-572

  Karppi, Jouni ^a   Nurmi, Tarja ^a   Kurl, Sudhir ^a   Rissanen, Tiina H ^a   Nyyssönen, Kristiina ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Tocopherol; Carotene; Carotenoids; Low density lipoprotein; Lutein; Lycopene; Retinol; Serum LDL conjugated dienes

Indexed keywords

ACETYLSALICYLIC ACID; ALKADIENE; ALPHA CAROTENE; ALPHA TOCOPHEROL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA CAROTENE; BETA CRYPTOXANTHIN; CALCIUM CHANNEL BLOCKING AGENT; CONJUGATED DIENE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; LYCOPENE; RETINOL; UNCLASSIFIED DRUG; XANTHOPHYLL; ZEAXANTHIN;

ADULT; AGE; AGED; ARTICLE; ATHEROGENESIS; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LEUKOCYTE COUNT; LIPID PEROXIDATION; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ANTIOXIDANTS; BETA CAROTENE; BODY MASS INDEX; CAROTENOIDS; CHOLESTEROL, LDL; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPOPROTEINS, LDL; LUTEIN; MALE; MIDDLE AGED; POLYENES;

EID: 77950020680     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.10.007     Document Type: Article

References (58)

1. Steinberg D. The LDL modification hypothesis of atherogenesis: an update. J Lipid Res 2008, 15:1-25.
2. Stocker R., Keaney J.F. Role of oxidative modifications in atherosclerosis. Physiol Rev 2004, 84:1381-1478.
3. Abbey M., Noakes M., Nestel P.J. Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidized low-density lipoproteins. J Am Diet Assoc 1995, 95:671-675.
4. Salonen J.T., Nyyssonen K., Salonen R., et al. Lipoprotein oxidation and progression of carotid atherosclerosis. Circulation 1997, 95:840-845.
5. Halliwell B. Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward?. Cardiovasc Res 2000, 47:410-418.
6. Hulthe J. Antibodies to oxidized LDL in atherosclerosis development-clinical and animal studies. Clin Chim Acta 2004, 348:1-8.
7. Ahotupa M., Vasankari T.J. Baseline diene conjugation in LDL lipids: an indicator of circulating oxidized LDL. Free Radic Biol Med 1999, 27:1141-1150.
8. Kaikkonen J., Tuomainen T.P., Nyyssonen K., Morrow J.D., Salonen J.T. C18 hydroxy fatty acids as markers of lipid peroxidation ex vivo and in vivo. Scand J Clin Lab Invest 2004, 64:457-468.
9. Ahotupa M., Ruutu M., Mantyla E. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin Biochem 1996, 29:139-144.
10. Ahotupa M., Marniemi J., Lehtimaki T., et al. Baseline diene conjugation in LDL lipids as a direct measure of in vivo LDL oxidation. Clin Biochem 1998, 31:257-261.
11. Vasankari T., Lehtonen-Veromaa M., Mottonen T., et al. Reduced mildly oxidized LDL in young female athletes. Atherosclerosis 2000, 151:399-405.
12. Tapiero H., Townsend D.M., Tew K.D. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother 2004, 58:100.
13. Upritchard J.E., Sutherland W.H., Mann J.I. Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes. Diabetes Care 2000, 23:733-738.
14. Agarwal S., Rao A.V. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Lipids 1998, 33:981-984.
15. Levy Y., Kaplan M., Ben-Amotz A., Aviram M. Effect of dietary supplementation of beta-carotene on human monocyte-macrophage-mediated oxidation of low density lipoprotein. Isr J Med Sci 1996, 32:473-478.
16. Dugas T.R., Morel D.W., Harrison E. Dietary supplementation with beta-carotene, but not with lycopene, inhibits endothelial cell-mediated oxidation of low-density lipoprotein. Free Radic Biol Med 1999, 26:1238-1244.
17. Salonen J.T. Is there a continuing need for longitudinal epidemiologic research? The kuopio ischaemic heart disease risk factor study. Ann Clin Res 1988, 20:46-50.
18. Mursu J., Voutilainen S., Nurmi T., et al. Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Radic Biol Med 2004, 37:1351-1359.
19. Karppi J., Nurmi T., Olmedilla-Alonso B., Granado-Lorencio F., Nyyssonen K. Simultaneous measurement of retinol, alpha-tocopherol and six carotenoids in human plasma by using an isocratic reversed-phase HPLC method. J Chromatogr B: Anal Technol Biomed Life Sci 2008, 867:226-232.
20. International Federation of Clinical Chemistry and Laboratory Medicine IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 degrees C. International federation of clinical chemistry and laboratory medicine. Part 7. Certification of four reference materials for the determination of enzymatic activity of gamma-glutamyltransferase, lactate dehydrogenase, alanine aminotransferase and creatine kinase accord. Clin Chem Lab Med 2002, 40:739-745.
21. Mursu J., Nurmi T., Tuomainen T.P., et al. The intake of flavonoids and carotid atherosclerosis: the kuopio ischaemic heart disease risk factor study. Br J Nutr 2007, 98:814-818.
22. Jordan P., Brubacher D., Moser U., Stahelin H.B., Gey K.F. Vitamin E and vitamin A concentrations in plasma adjusted for cholesterol and triglycerides by multiple regression. Clin Chem 1995, 41:924-927.
23. Porkkala-Sarataho E., Nyyssonen K., Salonen J.T. Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men. Atherosclerosis 1996, 124:83-94.
24. Parks E.J., German J.B., Davis P.A., et al. Reduced oxidative susceptibility of LDL from patients participating in an intensive atherosclerosis treatment program. Am J Clin Nutr 1998, 68:778-785.
25. Carpenter K.L., van der Veen C., Hird R., et al. The carotenoids beta-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDL oxidation. FEBS Lett 1997, 401:262-266.
26. Hininger I.A., Meyer-Wenger A., Moser U., et al. No significant effects of lutein, lycopene or beta-carotene supplementation on biological markers of oxidative stress and LDL oxidizability in healthy adult subjects. J Am Coll Nutr 2001, 20:232-238.
27. Silaste M.L., Alfthan G., Aro A., Kesaniemi Y.A., Horkko S. Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br J Nutr 2007, 98:1251-1258.
28. Visioli F., Riso P., Grande S., Galli C., Porrini M. Protective activity of tomato products on in vivo markers of lipid oxidation. Eur J Nutr 2003, 42:201-206.
29. Porrini M., Riso P., Brusamolino A., et al. Daily intake of a formulated tomato drink affects carotenoid plasma and lymphocyte concentrations and improves cellular antioxidant protection. Br J Nutr 2005, 93:93-99.
30. Wolters M., Hahn A. LDL susceptibility to copper-induced oxidation after administration of a single dose of free or esterified beta-cryptoxanthin. Ann Nutr Metab 2004, 48:163-168.
31. Kioskias S., Gordon M.H. Dietary supplementation with a natural carotenoid mixture decreases oxidative stress. Eur J Clin Nutr 2003, 57:1135-1140.
32. Lin Y., Burri B.J., Neidlinger T.R., et al. Estimating the concentration of β-carotene required for maximal protection of low-density lipoproteins in women. Am J Clin Nutr 1998, 67:837-845.
33. Milde J., Elstner E.F., Grassmann J. Synergistic effects of phenolics and carotenoids on human low-density lipoprotein oxidation. Mol Nutr Food Res 2007, 51:956-961.
34. Peroxidation mechanism. Available at (read 1.4.2009). http://www.cyberlipid.org/perox/oxid0006.htm.
35. McNulty H., Jacob R.F., Mason R.P. Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Am J Cardiol 2008, 22:20D-29D.
36. Miller N.J., Sampson J., Candeias L.P., Bramley P.M., Rice-Evans C.A. Antioxidant activities of carotenes and xanthophylls. FEBS Lett 1996, 22:240-242.
37. Holvoet P., Mertens A., Verhamme P., et al. Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2001, 21:844-848.
38. Keaney J.F., Larson M.G., Vasan R.S., et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the framingham study. Arterioscler Thromb Vasc Biol 2003, 23:434-439.
39. Linna M.S., Borg P., Kukkonen-Harjula K., et al. Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men. Int J Obes (Lond) 2007, 31:245-253.
40. Vasankari T., Fogelholm M., Kukkonen-Harjula K., et al. Reduced oxidized low-density lipoprotein after weight reduction in obese premenopausal women. Int J Obes Relat Metab Disord 2001, 25:205-211.
41. Krajcovicova-Kudlackova M., Valachovicova M., Paukova V., Dusinska M. Effects of diet and age on oxidative damage products in healthy subjects. Physiol Res 2008, 57:647-651.
42. Wakatsuki A., Okatani Y., Ikenoue N., et al. Effect of lower dose of oral conjugated equine estrogen on size and oxidative susceptibility of low-density lipoprotein particles in postmenopausal women. Circulation 2003, 108:808-813.
43. Memon R.A., Staprans I., Noor M., et al. Infection and inflammation induce LDL oxidation in vivo. Arterioscler Thromb Vasc Biol 2000, 20:1536-1542.
44. Panza J.A., Garcia C.E., Kilcoyne C.M., Quyyumi A.A., Cannon R.O. Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 1995, 91:1732-1738.
45. Engelhard Y.N., Gazer B., Paran E. Natural antioxidants from tomato extract reduce blood pressure in patients with grade-1 hypertension: a double-blind, placebo-controlled pilot study. Am Heart J 2006, 151:100.
46. Rosenson R.S. Statins in atherosclerosis: lipid-lowering agents with antioxidant capabilities. Atherosclerosis 2004, 173:1-12.
47. Lapointe A., Couillard C., Piche M.E., et al. Circulating oxidized LDL is associated with parameters of the metabolic syndrome in postmenopausal women. Atherosclerosis 2007, 191:362-368.
48. Muda P., Kampus P., Teesalu R., et al. Effects of amlodipine and candesartan on oxidized LDL level in patients with mild to moderate essential hypertension. Blood Press 2006, 15:313-318.
49. Vasankari T., Ahotupa M., Viikari J., et al. Effects of statin therapy on circulating conjugated dienes, a measure of LDL oxidation. Atherosclerosis 2005, 179:207-209.
50. Jula A., Marniemi J., Huupponen R., et al. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial. JAMA 2002, 287:598-605.
51. Mates J.M. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000, 153:83-104.
52. Caner M., Karter Y., Uzun H., et al. Oxidative stress in human in sustained and white coat hypertension. Int J Clin Pract 2006, 60:1565-1571.
53. Forstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008, 5:338-349.
54. Uzun H., Karter Y., Aydin S., et al. Oxidative stress in white coat hypertension; role of paraoxonase. J Hum Hypertens 2004, 18:523-528.
55. Nyyssonen K., Porkkala-Sarataho E., Kaikkonen J., Salonen J.T. Ascorbate and urate are the strongest determinants of plasma antioxidative capacity and serum lipid resistance to oxidation in Finnish men. Atherosclerosis 1997, 130:223-233.
56. Niskanen L.K., Laaksonen D.E., Nyyssonen K., et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med 2004, 164:1546-1551.
57. Rissanen T.H., Voutilainen S., Virtanen J.K., et al. Low intake of fruits, berries and vegetables is associated with excess mortality in men: the kuopio ischaemic heart disease risk factor (KIHD) study. J Nutr 2003, 133:199-204.
58. Rissanen T. Association of lycopene and dietary intake of fruits, berries and vegetables with atherosclerosis and cardiovascular diseases: epidemiologic evidence, Kuopio; 2003, p. 73 [36]s.